https://m2.mtmt.hu/ eng 2026-10-25 01:10 JournalArticle 2593320 VALIDATED true Laboratory of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Preclinical Imaging Center, Gedeon Richter Ltd., Budapest, Hungary Faculty of Information Technology, Pázmány Péter Catholic University, Budapest, Hungary Cited By :15 Export Date: 28 January 2025 CODEN: POLNC Chemicals/CAS: ghrelin, 304853-26-7; rimonabant, 158681-13-1, 168273-06-1; estradiol, 50-28-2; Estradiol; Ghrelin; Receptor, Cannabinoid, CB1 Funding details: Seventh Framework Programme, FP7, 245009 0 2018-09-10T07:19:12.000+0000 false 2593320 2026-10-16T12:00:00.531+0000 2024-12-06T17:34:58.185+0000 2014-05-26T12:14:45.000+0000 true 10002755 Liposits Zsolt /api/author/10002755 Author true 10002755 2026-08-18T07:13:53.234+0000 2026-08-18T07:13:53.234+0000 2024-12-06T17:34:58.652+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Sarvari, M Ghrelin Modulates the fMRI BOLD Response of Homeostatic and Hedonic Brain Centers Regulating Energy Balance in the Rat. true true /api/journal/10007440 REVIEWED true false 10007440 false 10007440 true 1932-6203 Journal FOREIGN 9 5 e97651 e97651 9 2014 The orexigenic gut-brain peptide, ghrelin and its G-protein coupled receptor, the growth hormone secretagogue receptor 1a (GHS-R1A) are pivotal regulators of hypothalamic feeding centers and reward processing neuronal circuits of the brain. These systems operate in a cooperative manner and receive a wide array of neuronal hormone/transmitter messages and metabolic signals. Functional magnetic resonance imaging was employed in the current study to map BOLD responses to ghrelin in different brain regions with special reference on homeostatic and hedonic regulatory centers of energy balance. Experimental groups involved male, ovariectomized female and ovariectomized estradiol-replaced rats. Putative modulation of ghrelin signaling by endocannabinoids was also studied. Ghrelin-evoked effects were calculated as mean of the BOLD responses 30 minutes after administration. In the male rat, ghrelin evoked a slowly decreasing BOLD response in all studied regions of interest (ROI) within the limbic system. This effect was antagonized by pretreatment with GHS-R1A antagonist JMV2959. The comparison of ghrelin effects in the presence or absence of JMV2959 in individual ROIs revealed significant changes in the prefrontal cortex, nucleus accumbens of the telencephalon, and also within hypothalamic centers like the lateral hypothalamus, ventromedial nucleus, paraventricular nucleus and suprachiasmatic nucleus. In the female rat, the ghrelin effects were almost identical to those observed in males. Ovariectomy and chronic estradiol replacement had no effect on the BOLD response. Inhibition of the endocannabinoid signaling by rimonabant significantly attenuated the response of the nucleus accumbens and septum. In summary, ghrelin can modulate hypothalamic and mesolimbic structures controlling energy balance in both sexes. The endocannabinoid signaling system contributes to the manifestation of ghrelin's BOLD effect in a region specific manner. In females, the estradiol milieu does not influence the BOLD response to ghrelin. true true 2014 781392 true true true false true false GOLD GOLD 2026-10-16 true https://doi.org/10.1371/journal.pone.0097651 18 0 18 18 0 17 18 17 14 18 18 18 18 18 0 0 18 18 18 18 0 13 13 Folyóiratcikk Journal Article 24 17 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2015 0 2 2 2 2 2016 0 3 3 3 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true false 19720763 true PersonAuthorship 5144273 /api/authorship/5144273 9 0.111 false true true Author 10002755 /api/author/10002755 Liposits Zsolt true 10002755 true Liposits Z true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 19720762 true PublicationIdentifier 14797324 /api/publicationidentifier/14797324 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1371/journal.pone.0097651 https://doi.org/10.1371/journal.pone.0097651 false 18157223 true PublicationIdentifier 806843 /api/publicationidentifier/806843 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000336789500094 https://www.webofscience.com/wos/woscc/full-record/000336789500094 false 920041 true 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true MtaRating 11551131 /api/mtarating/11551131 RatingType 10010 /api/ratingtype/10010 RegTB Institute 14100 /api/institute/14100 0 false true false Regionális Tudományok Bizottsága Committee on Regional Studies true 14100 true true true B nemzetközi false true SjrRating 11058740 /api/sjrrating/11058740 24 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1101 /api/classificationexternal/1101 true 1101 true D1 DIRECT true true /api/publication/2593320 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10014210"><a href="/gui2/?type=authors&mode=browse&sel=10014210" target="_blank">Sarvari M ✉ (<span class="authorship-author-name">Sárvári Miklós</span> <span class="authorAux-mtmt"> Endokrin neurobiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Endocrine Neurobiology">DEN</span>/Laboratory of Endocrine Neurobiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kocsis P<sup>*</sup> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Deli L </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gajari D </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >David S </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pozsgay Z </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10039580"><a href="/gui2/?type=authors&mode=browse&sel=10039580" target="_blank">Hegedus N (<span class="authorship-author-name">Hegedűs Nikolett</span> <span class="authorAux-mtmt"> fMRI képalkotás, farmakológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10008277"><a href="/gui2/?type=authors&mode=browse&sel=10008277" target="_blank">Tihanyi K (<span class="authorship-author-name">Tihanyi Károly</span> <span class="authorAux-mtmt"> Gyógyszerkutatás-fejlesztés</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002755"><a href="/gui2/?type=authors&mode=browse&sel=10002755" target="_blank">Liposits Z ✉ (<span class="authorship-author-name">Liposits Zsolt</span> <span class="authorAux-mtmt"> Neurobiológia, neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Endocrine Neurobiology">DEN</span>/Laboratory of Endocrine Neurobiology; <span title="Pázmány Péter Catholic University">PPCU</span>/Információs Technológiai és Bionikai Kar</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2593320" target="_blank">Ghrelin Modulates the fMRI BOLD Response of Homeostatic and Hedonic Brain Centers Regulating Energy Balance in the Rat.</a></div> <div> <span class="journal-title">PLOS ONE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1932-6203">1932-6203</a>)</span>: <span class="journal-volume">9</span> <span class="journal-issue">5</span> <span class="page"> Paper e97651. 9 p. </span> <span class="year">(2014)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1371/journal.pone.0097651" target="_blank" href="https://doi.org/10.1371/journal.pone.0097651"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000336789500094" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000336789500094"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84901329458" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84901329458"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="24830778" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=24830778&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="PMC4022590" target="_blank" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022590"> Pubmed Central </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Agricultural and Biological Sciences (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Pedagógiai Tudományos Bizottság HASSPHSII PedTB [1901-]&nbsp;&nbsp;&nbsp;A</div> <div class="journal-subject">Committee on Sociology HASSELIX SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Committee on Regional Studies HASSELIX RTB [1901-]&nbsp;&nbsp;&nbsp;B nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 18</span> | Independent citation: 18 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 17 | Number of citations in Scopus:&nbsp;14 | WoS/Scopus assigned:&nbsp;18 | Number of citations with DOI:&nbsp;18 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2593320&sort=publishedYear,desc&sort=title"> Number of cited publications: 13 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 2593320</span> | <span class="status-data status-VALIDATED"> Validated </span> <span class="oldId">Old id: 2593320</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Last Modified: 2024.12.06. 18:34 Róbert Milánkovics (PTE ÁOK admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Laboratory of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Preclinical Imaging Center, Gedeon Richter Ltd., Budapest, Hungary Faculty of Information Technology, Pázmány Péter Catholic University, Budapest, Hungary Cited By :15 Export Dat...</pre> </div></div>