https://m2.mtmt.hu/hun2024-03-29 16:29JournalArticle25647743APPROVEDtrueUniversity of Copenhagen, Department of Public Health, Section of Environmental Health, ∅ster Farimagsgade 5A, Copenhagen, 1014, Denmark
Institute of Occupational Medicine, Heriot Watt Research Park, Edinburgh, United Kingdom
National Research Centre for Working Environment, Copenhagen, Denmark
Export Date: 22 April 2021
CODEN: CRTXB
Correspondence Address: Kermanizadeh, A.; University of Copenhagen, ∅ster Farimagsgade 5A, Denmark; email: alke@sund.ku.dk02018-01-05T15:49:40.000+0000false156477432023-04-27T09:34:35.685+00002023-04-27T09:29:57.225+00002016-05-19T16:42:20.000+0000true10046183BihariPéter
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REVIEWEDtruefalse1225false1225true1040-84441547-6898JournalFOREIGN4510837872837362015Engineered nanomaterials (NMs) offer great technological advantages but their risks to human health are still not fully understood. An increasing body of evidence suggests that some NMs are capable of distributing from the site of exposure to a number of secondary organs. The research into the toxicity posed by the NMs in these secondary organs is expanding due to the realisation that some materials may reach and accumulate in these target sites. The translocation to secondary organs includes, but is not limited to, the hepatic, central nervous, cardiovascular and renal systems. Current data indicates that pulmonary exposure is associated with low (inhalation route-0.00001-1% of total applied dose-24 h) translocation of virtually insoluble NMs such as iridium, carbon black, gold and polystyrene, while slightly higher translocation has been observed for NMs with either slow (e.g. silver, cerium dioxide and quantum dots) or fast (e.g. zinc oxide) solubility. The translocation of NMs following intratracheal, intranasal and pharyngeal aspiration is higher (up to 10% of administered dose), however the relevance of these routes for risk assessment is questionable. Uptake of the materials from the gastrointestinal tract seems to follow the same pattern as inhalation translocation, whereas the dermal uptake of NMs is generally reported to be low. The toxicological effects in secondary organs include oxidative stress, inflammation, cytotoxicity and dysfunction of cellular and physiological processes. For toxicological and risk evaluation, further information on the toxicokinetics and persistence of NMs is crucial. The overall aim of this review is to outline the data currently available in the literature on the biokinetics, accumulation, toxicity and eventual fate of NMs in order to assess the potential risks posed by NMs to secondary organs.2016truetruetruefalsefalsefalseNONE2023-04-27false00000000000066D1falsefalsefalsefalse2016-08-17T16:42:20.000+00002016-05-19T16:42:20.000+00002568050trueLanguage10002
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" > Kermanizadeh, Ali </span> <span class="author-type"> </span> ; <span class="author-name" > Balharry, Dominique </span> <span class="author-type"> </span> ; <span class="author-name" > Wallin, Hakan </span> <span class="author-type"> </span> ; <span class="author-name" > Loft, Steffen </span> <span class="author-type"> </span> ; <span class="author-name" > Moller, Peter </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;25647743" mtid="25647743" target="_blank">Nanomaterial translocation-the biokinetics, tissue accumulation, toxicity and fate of materials in secondary organs-a review</a></div> <div class="pub-info"> <span class="journal-title">CRITICAL REVIEWS IN TOXICOLOGY</span> <span class="journal-volume">45</span> : <span class="journal-issue">10</span> <span class="page"> pp. 837-872. , 36 p. </span> <span class="year">(2015)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3109/10408444.2015.1058747" target="_blank" href="https://doi.org/10.3109/10408444.2015.1058747"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000366214500002" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000366214500002"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84949225160" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84949225160"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="26140391" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=26140391&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:25647743 </span> <span class="status-holder"><span class="status-data status-APPROVED"> Nyilvános </span></span> <span class="pub-core"> Idéző </span> <span class="pub-type">Folyóiratcikk (Összefoglaló cikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> </div> </div> </div><div class="JournalArticle Publication long-list">
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<div class="autype autype0"> <span class="author-name" >Kermanizadeh Ali
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<span class="author-name" >Balharry Dominique
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<span class="author-name" >Loft Steffen
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;
<span class="author-name" >Moller Peter
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<div class="title"><a href="/gui2/?mode=browse¶ms=publication;25647743" target="_blank">Nanomaterial translocation-the biokinetics, tissue accumulation, toxicity and fate of materials in secondary organs-a review</a></div> <div> <span class="journal-title">CRITICAL REVIEWS IN TOXICOLOGY</span>
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Idézett közlemények száma: 6
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<div class="mtid"><span class="long-pub-mtid">Közlemény: 25647743</span>
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<div class="lastModified">Utolsó módosítás: 2023.04.27. 11:29 Zolnai Dóra (ATKI admin)
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<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: University of Copenhagen, Department of Public Health, Section of Environmental Health, ∅ster Farimagsgade 5A, Copenhagen, 1014, Denmark
Institute of Occupational Medicine, Heriot Watt Research Park, Edinburgh, United Kingdom
National Research Centre for Working Environment, Copenhagen, Denmark
Export Date: 22 April 2021 ...</pre>
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