https://m2.mtmt.hu/eng2026-10-23 19:35JournalArticle2555086APPROVEDtrueDepartment of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37212, United States
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37212, United States
Vanderbilt Brain Institute, Vanderbilt University School of Medicine, Nashville, TN 37212, United States
Momentum Laboratory of Molecular Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
Gill Institute and Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, United States
Department of Anatomy, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan
Cited By :66
Export Date: 13 March 2024
CODEN: NERNE
Correspondence Address: Patel, S.; Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37212, United States; email: sachin.patel@vanderbilt.edu
Chemicals/CAS: calcium ion, 14127-61-8; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4
Funding details: National Institutes of Health, NIH, DA011322, DA021696, MH090412
Funding details: National Institute of Mental Health, NIMH, R01MH100096
Funding details: European Research Council, ERC, 243153
Funding details: Magyar Tudományos Akadémia, MTA, LP2013-54
Funding text 1: These studies were supported by NIH Grants MH090412 (S.P.), DA011322 and DA021696 (K.M.), the Momentum Program of the Hungarian Academy of Sciences (LP2013-54), and the European Research Council Grant 243153 (I.K.). I.K. is the recipient of a Wellcome Trust International Senior Research Fellowship. Confocal microscopy was performed at the VUMC Cell Imaging Shared Resource. The authors are also indebted to Erika Tischler and Balázs Pintér for their excellent technical assistance. The authors also wish to thank Mr. László Barna and the Nikon Microscopy Center at IEM.02016-07-14T09:18:00.000+0000false25550862026-10-16T10:16:56.846+00002024-01-04T10:42:39.376+00002014-03-19T08:23:55.000+0000true10011502KatonaIstván
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REVIEWEDtruefalse3357false3357true0896-62731097-4199JournalFOREIGN815111111251111152014The central amygdala (CeA) is a key structure at the limbic-motor interface regulating stress responses and emotional learning. Endocannabinoid (eCB) signaling is heavily implicated in the regulation of stress-response physiology and emotional learning processes; however, the role of eCBs in the modulation of synaptic efficacy in the CeA is not well understood. Here we describe the subcellular localization of CB1 cannabinoid receptors and eCB synthetic machinery at glutamatergic synapses in the CeA and find that CeA neurons exhibit multiple mechanistically and temporally distinct modes of postsynaptic eCB mobilization. These data identify a prominent role for eCBs in the modulation of excitatory drive to CeA neurons and provide insight into the mechanisms by which eCB signaling and exogenous cannabinoids could regulate stress responses and emotional learning.2014788343truetruetruefalsetruefalseGREENGREEN2026-10-16truehttps://real.mtak.hu/10966true10039736xRadóNikolett
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" > Ramikie, TS </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10014051"> <a href="/gui2/?type=authors&mode=browse&sel=10014051" target="_blank">Nyilas, R</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Bluett, RJ </span> <span class="author-type"> </span> ; <span class="author-name" > Gamble-George, JC </span> <span class="author-type"> </span> ; <span class="author-name" > Hartley, ND </span> <span class="author-type"> </span> ; <span class="author-name" > Mackie, K </span> <span class="author-type"> </span> ; <span class="author-name" > Watanabe, M </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10011502"> <a href="/gui2/?type=authors&mode=browse&sel=10011502" target="_blank">Katona, I</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Patel, S </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;2555086" mtid="2555086" target="_blank">Multiple mechanistically distinct modes of endocannabinoid mobilization at central amygdala glutamatergic synapses.</a></div> <div class="pub-info"> <span class="journal-title">NEURON</span> <span class="journal-volume">81</span> : <span class="journal-issue">5</span> <span class="page"> pp. 1111-1125. , 15 p. </span> <span class="year">(2014)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_PAY" title=" Pay "> <a style="color:blue" title="10.1016/j.neuron.2014.01.012" target="_blank" href="https://doi.org/10.1016/j.neuron.2014.01.012"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="10966" target="_blank" href="https://real.mtak.hu/10966"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000332526700014" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000332526700014"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84895425510" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84895425510"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="24607231" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=24607231&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Publication:2555086 </span> <span class="status-holder"><span class="status-data status-APPROVED"> Published </span></span> <span class="pub-core">Core Citing </span> <span class="pub-type">Journal Article (Article ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Scientific</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 74</span> | Independent citation: 59 | Self citation: 15 | Unknown citation: 0 | Number of citations in WoS: 67 | Number of citations in Scopus: 73 | WoS/Scopus assigned: 74 | Number of citations with DOI: 74 </div> </div> </div> </div><div class="JournalArticle Publication long-list">
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<div class="autype autype0"> <span class="author-name" >Ramikie TS
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<span class="authorAux-mtmt"> Neurobiológia</span>)
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<span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Gene Technology and Developmental Neurobiology">DGTDN</span>/Laboratory of Molecular Neurobiology</span>
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;
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<span class="authorAux-mtmt"> Neurobiológia</span>)
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<span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Gene Technology and Developmental Neurobiology">DGTDN</span>/Laboratory of Molecular Neurobiology</span>
;
<span class="author-name" >Patel S
</span>
</div>
</div>
<div class="title"><a href="/gui2/?mode=browse¶ms=publication;2555086" target="_blank">Multiple mechanistically distinct modes of endocannabinoid mobilization at central amygdala glutamatergic synapses.</a></div> <div> <span class="journal-title">NEURON</span>
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<div class="publication-citation" style="margin-left: 0.5cm;">
<span title="" class="citingPub-count">Citing papers: 74</span>
| Independent citation: 59
| Self citation: 15
| Unknown citation: 0
| Number of citations in WoS: 67
| Number of citations in Scopus: 73
| WoS/Scopus assigned: 74
| Number of citations with DOI: 74
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Number of cited publications: 8
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<div class="mtid"><span class="long-pub-mtid">Publication: 2555086</span>
| <span class="status-data status-APPROVED"> Published
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<span class="oldId">Old id: 2555086</span> |
Core Citing
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<div class="lastModified">Last Modified: 2024.01.04. 11:42 Márta Turek (KOKI admin 4)
</div>
<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37212, United States
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37212, United States
Vanderbilt Brain Institute, Vanderbilt University School of Medicine, Nashville, TN 37212, United States
...</pre>
</div></div>