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A retrospective analysis of 405 autopsy cases (1985) Dig. Dis. Sci., 30, pp. 1005-1018; \n\nMalech, H.L., Gallin, J.I., Current concepts: Immunology. Neutrophils in human disease (1987) N. Engl. J. Med., 317, pp. 678-694; \n\nWeiss, S.J., Tissue destruction by neutrophils (1989) N. Engl. J. Med., 320, pp. 365-376; \n\nMcGowan, S.E., Murray, J.J., Direct effects of neutrophil oxidants on elastase-induced extracellular matrix proteolysis (1987) Am. Rev. Respir. Dis., 135, pp. 1286-1293; \n\nMcDonald, J.A., Kelley, D.G., Degradation of fibronectin by human leukocyte elastase. Release of biologically active fragments (1980) J. Biol. Chem., 255, pp. 8848-8858; \n\nMainardi, C.L., Hasty, D.L., Sever, J.M., Kang, A.H., Specific cleavage of human type III collagen by human polymorphonuclear leukocyte elastase (1980) J. Biol. Chem., 255, pp. 12006-12010; \n\nLankish, P.G., Rahlf, G., Koop, H., Pulmonary complications in fatal hemorrhage acute pancreatitis (1983) Dig. Dis. Sci., 28, pp. 111-116; \n\nTsujimoto, M., Yokota, S., Vilcek, J., Wiessman, G., Tumor necrosis factor provokes superoxide generation from neutrophils (1986) Biochem. Biophys. Res. Commun., 137, pp. 1094-1099; \n\nSaitoh, Y., Yamamoto, M., Evaluation of severity of acute pancreatitis. According to a report of the cooperative national survey in Japan (1991) Int. J. Pancreatol., 9, pp. 51-58; \n\nNathan, C.F., Secretory products of macrophages (1987) J. Clin. Invest., 79, pp. 319-326; \n\nDe Beaux, A.C., Ross, J.A., Maingay, J.P., Fearon, K.C., Carter, D.C., Proinflammatory cytokine release by peripheral blood mononuclear cells from patients with acute pancreatitis (1996) Br. J. Surg., 83, pp. 1071-1075; \n\nMcKay, C., Imrie, C.W., Baxter, J.N., Mononuclear phagocyte activation and acute pancreatitis (1996) Scand. J. Gastroenterol., 219 (SUPPL.), pp. 32-36; \n\nInagaki, T., Hoshino, M., Hayakawa, T., Interleukin-6 is a useful marker for early prediction of the severity of acute pancreatitis (1997) Pancreas, 14, pp. 1-8; \n\nUomo, G., Spada, O.A., Manes, G., Neopterin in acute pancreatitis (1996) Scand. J. Gastroenterol., 31, pp. 1032-1036; \n\nTakacs, T., Farkas G., Jr., Czako, L., Jarmay, K., Mandi, Y., Lonovics, J., Time-course changes in serum cytokine levels in two experimental acute pancreatitis models in rats (1996) Res. Exp. Med., 196, pp. 153-161; \n\nGross, V., Leser, H.G., Heinisch, A., Scholmerich, J., Inflammatory mediators and cytokines: New aspects of the pathophysiology and assessment of severity of acute pancreatitis? (1993) Hepatogastroenterology, 40, pp. 522-530; \n\nMurata, A., Ogawa, M., Yasuda, T., Serum interleukin-6, C-reactive protein and pancreatic secretory trypsin inhibitor (PSTI) as acute phase reactants after major thoraco-abdominal surgery (1990) Immunol. Invest., 19, pp. 271-278; \n\nLeser, H.G., Gross, V., Scheibenbogen, C., Elevation of interleukin-6 concentration precedes acute-phase response and reflects severity in acute pancreatitis (1991) Gastroenterology, 191, pp. 782-785; \n\nPezzilli, R., Billi, P., Miniero, R., Serum interleukin-6, interleukin-8, and beta 2-microglobulin in early assessment of severity of acute pancreatitis. Comparison with serum C-reactive protein (1995) Dig. Dis. Sci., 40, pp. 2341-2348; \n\nHeath, D.I., Cruickshank, A., Gudgeon, M., Jehanli, A., Shenkin, A., Imrie, C.W., Role of interleukin-6 in mediating the acute phase protein response and potential as an early means of severity assessment in acute pancreatitis (1993) Gut, 34, pp. 41-45; \n\nScholmerich, J., Interleukins in acute pancreatitis (1996) Scand. J. Gastroenterol., 219 (SUPPL.), pp. 37-42; \n\nLiras, G., Carballo, F., An impaired phagocytic function is associated with leukocyte activation in the early stages of severe acute pancreatitis (1996) Gut, 39, pp. 39-42; \n\nWillemer, S., Feldderson, C.O., Karges, W., Adler, G., Lung injury in acute pancreatitis in rats. I. Morphological studies (1991) Int. J. Pancreatol., 8, pp. 305-321; \n\nSibille, Y., Reynolds, H.Y., Macrophages and polymorphonuclear neutrophils in lung defense and injury (1990) Am. Rev. Respir. Dis., 141, pp. 471-501; \n\nWeiland, J.E., Davis, W.E., Holter, J.F., Mohammed, J.R., Dorinsky, P.M., Gadek, J.S., Lung neutrophils in the adult respiratory distress syndrome. Clinical and pathophysiologic significance (1986) Am. Rev. Respir. Dis., 133, pp. 218-225; \n\nBergenfeldt, M., Berling, R., Ohlsson, K., Levels of leukocyte proteases in plasma and peritoneal exudate in severe, acute pancreatitis (1994) Can. J. Gastroenterol., 29, pp. 371-375; \n\nDominguez-Munoz, J.E., Carballo, F., Garcia, M.J., Monitoring of serum proteinase: Antiproteinase balance and systemic inflammatory response in prognostic evaluation of acute pancreatitis. Results of a prospective multicenter study (1993) Dig. Dis. Sci., 38, pp. 507-513; \n\nBuchler, M., Uhl, W., Berger, H.G., Surgical strategies in acute pancreatitis (1993) Hepatogastroenterology, 40, pp. 563-568; \n\nGrewal, H.P., Din, A.M., Gaber, L., Kotb, M., Gaber, O., Amelioration of physiologic and biochemical changes of acute pancreatitis using an anti-TNF-α polyclonal antibody (1994) Am. J. Surg., 167, pp. 214-219; \n\nSameshima, H., Ikei, S., Mori, K., The role of tumor necrosis factor-α in the aggravation of cerulein-induced pancreatitis in rats (1993) Int. J. Pancreatol., 14, pp. 107-115; \n\nBanks, R.E., Evans, S.W., Alexander, D., McMahon, M.J., Whicher, J.T., Is fatal acute pancreatitis a consequence of excessive leucocyte stimulation? The role of tumor necrosis factor alpha (1991) Cytokine, 3, pp. 12-16; \n\nOgawa, M., Pancreatic secretory trypsin inhibitor as an acute phase reactant (1988) Clin. Biochem., 21, pp. 19-25; \n\nMessori, A., Rampazzo, R., Scroccar, G., Effectiveness of gabexate mesilate in acute pancreatitis. A metaanalysis (1995) Dig. Dis. Sci., 40, pp. 734-738; \n\nBuchler, M., Malfertheiner, P., Uhl, W., Gabexate mesilate in human acute pancreatitis. German Pancreatitis Study Group (1993) Gastroenterology, 104, pp. 1165-1170; \n\nCavallii, G., Tittobello, A., Frulloni, L., Masci, E., Mariana, A., Di Francesco, V., Gabexate for the prevention of pancreatic damage related to endoscopic retrograde cholangiopancreatography. Gabexate in digestive endoscopy: Italian group (1996) N. Engl. J. Med., 335, pp. 919-923; \n\nShimazaki, E., Tanaka, H., Ohta, S., Yukioka, T., Matsuda, H., Shimazaki, S., Effects of the antiprotease ulinastatin on mortality and oxidant injury in scalded rats (1995) Arch. Surg., 130, pp. 994-997; \n\nAibiki, M., Cook, J.A., Ulinastatin, a human trypsin inhibitor, inhibits endotoxin-induced thromboxane B2 production in human monocytes (1997) Crit. Care Med., 25, pp. 430-434; \n\nKawamura, T., Inada, K., Akasaka, N., Wakusawa, R., Ulinastatin reduces elevation of cytokines and soluble adhesion molecules during cardiac surgery (1996) Can. J. Anaesthesia, 43, pp. 456-460; \n\nUchiba, M., Okajima, K., Murakami, K., Okabe, H., Takatsuki, K., Effect of nafamostat mesilate on pulmonary vascular injury induced by lipopolysaccharide in rats (1997) Am. J. Respir. Crit. Care Med., 155, pp. 711-718; \n\nUsui, A., Hiroura, M., Kawamura, M., Nafamostat mesilate reduces blood-foreign surface reactions similar to biocompatible materials (1996) Ann. Thorac. Surg., 62, pp. 1404-1411; \n\nShimada, M., Matsumura, T., Shirabe, K., Kamakura, T., Taketomi, A., Sugimachi, K., Effect of nafamostat mesilate on coagulation and fibrinolysis in hepatic resection (1994) J. Am. Coll. Surg., 178, pp. 498-502; \n\nUchiba, M., Okajima, K., Abe, H., Okabe, H., Takatsuki, K., Effect of nafamostat mesilate, a synthetic protease inhibitor, on tissue factor-factor VIIa complex activity (1994) Thromb. Res., 74, pp. 155-161; \n\nTaoka, Y., Okajima, K., Uchiba, M., Gabexate mesilate, a synthetic protease inhibitor, prevents compression-induced spinal cord injury by inhibiting activation of leukocytes in rats (1997) Crit. Care Med., 25, pp. 874-879; \n\nOkamura, T., Niho, Y., Itoga, T., Treatment of disseminated coagulation and its prodromal stage with gabexate mesilate (FOY): A multi-center trial (1993) Acta Haematologica, 90, pp. 120-124; \n\nOhashi, I., Nishijima, J., Murata, A., Toda, H., Kato, T., Inhibitory effect of a synthetic protease inhibitor (gabexate mesilate) on the respiratory burst oxidase in human neutrophils (1995) J. Biochem., 118, pp. 1001-1006; \n\nWada, Y., Zaima, M., Mori, K., Effect of gabexate mesilate on thrombin and plasmin generation after hepatic resection in cirrhotic patients (1995) Eur. Surg. Res., 27, pp. 57-62; \n\nMikawa, K., Akamatsu, H., Maekawa, N., Nishina, K., Obara, H., Niwa, Y., Acceleration of phagocytosis in human neutrophils incubated with gabexate mesilate (1994) J. Int. Med. Res., 22, pp. 292-295; \n\nMikawa, K., Akamatsu, H., Maekawa, N., Nishina, K., Obara, H., Niwa, Y., Inhibitory effect of gabexate mesilate on human neutrophil function (1994) J. Int. Med. Res., 22, pp. 245-254; \n\nNishiyama, T., Aibiki, M., Hanaoka, K., The effect of ulinastatin, a human protease inhibitor, on the transfusion-induced increase of plasma polymorphonuclear granulocyte elastase (1996) Anesthesia Analgesia, 82, pp. 108-112; \n\nBinns, O.A., Delima, N.F., Buchanan, S.A., Neutrophil endopeptidase inhibitor improves pulmonary function during reperfusion after eighteen-hour preservation (1996) J. Thorac. Cardiovasc. Surg., 112, pp. 607-613; \n\nOkumura, Y., Inoue, H., Fujiyama, Y., Bamba, T., Effects of serine protease inhibitors on accumulation of polymorphonuclear leukocytes in the lung induced by acute pancreatitis in rats (1995) J. Gastroenterol., 30, pp. 379-386; \n\nMatsuda, Y., Kawata, S., Nagase, T., Interleukin-6 in transcatheter arterial embolization for patients with hepatocellular carcinoma (1994) Cancer, 73, pp. 53-57; \n\nIto, N., Kawata, S., Tamura, S., Induction of interleukin-6 by interferon alpha and its abrogation by a serine protease inhibitor in patients with chronic hepatitis C (1996) Hepatology, 23, pp. 669-675; \n\nHamazaki, K., Matsubara, N., Yunoki, Y., Mori, M., Mimura, H., Orita, K., Effects of ulinastatin on polymorphonuclear leukocyte elastase and interleukin 6 levels after hepatectomy (1994) Clin. Therapeutics, 16, pp. 680-685; \n\nTakeda, K., Matsuno, S., Sunamura, M., Kakugawa, Y., Continuous regional arterial infusion of protease inhibitor and antibiotics in acute necrotizing pancreatitis (1996) Am. J. 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