https://m2.mtmt.hu/ eng 2026-10-23 19:25 JournalArticle 2539846 VALIDATED true 0 2017-02-14T13:05:39.000+0000 false 2539846 2026-10-16T09:30:54.272+0000 2025-11-20T13:39:21.272+0000 2014-02-25T13:56:46.000+0000 true 10002755 Liposits Zsolt /api/author/10002755 Author Zsolt Liposits (Neurobiológia, neuroendokrinológia) true 10002755 2026-08-18T07:13:52.107+0000 2026-08-18T07:13:52.107+0000 2024-12-06T17:34:02.363+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin Róbert Milánkovics (PTE ÁOK admin 4) true 10039043 Admin 10073918 /api/admin/10073918 Marcell Kovács (MTMT Közp., admin) Kovács Marcell true true 2025-10-30T07:42:22.848+0000 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Sarvari, M true true /api/journal/10007440 REVIEWED PLOS ONE 1932-6203 true false 10007440 false 10007440 true 1932-6203 Journal FOREIGN 9 2 e88540 e88540 12 2014 The innate immune system including microglia has a major contribution to maintenance of the physiological functions of the hippocampus by permanent monitoring of the neural milieu and elimination of tissue-damaging threats. The hippocampus is vulnerable to age-related changes ranging from gene expression to network connectivity. The risk of hippocampal deterioration increases with the decline of gonadal hormone supply. To explore the impact of hormone milieu on the function of the innate immune system in middle-aged female rats, we compared mRNA expression in the hippocampus after gonadal hormone withdrawal, with or without subsequent estrogen replacement using estradiol and isotype-selective estrogen receptor (ER) agonists. Targeted profiling assessed the status of the innate immune system (macrophage-associated receptors, complement, inhibitory neuronal ligands), local estradiol synthesis (P450 aromatase) and estrogen reception (ER). Results established upregulation of macrophage-associated (Cd45, Iba1, Cd68, Cd11b, Cd18, Fcgr1a, Fcgr2b) and complement (C3, factor B, properdin) genes in response to ovariectomy. Ovariectomy upregulated Cd22 and downregulated semaphorin3A (Sema3a) expression, indicating altered neuronal regulation of microglia. Ovariectomy also led to downregulation of aromatase and upregulation of ERalpha gene. Of note, analogous changes were observed in the hippocampus of postmenopausal women. In ovariectomized rats, estradiol replacement attenuated Iba1, Cd11b, Fcgr1a, C3, increased mannose receptor Mrc1, Cd163 and reversed Sema3a expression. In contrast, reduced expression of aromatase was not reversed by estradiol. While the effects of ERalpha agonist closely resembled those of estradiol, ERbeta agonist was also capable of attenuating the expression of several macrophage-associated and complement genes. These data together indicate that the innate immune system of the aging hippocampus is highly responsive to the gonadal hormone milieu. In ovariectomized female rats, estradiol replacement exerts potent immunomodulatory effects including attenuation of microglia sensitization, initiation of M2-like activation and modulation of complement expression by targeting hippocampal neurons and glial cells through ERalpha and ERbeta. true true 2014 781392 true true true false true false GOLD 2026-10-16 true https://doi.org/10.1371/journal.pone.0088540 44 0 44 38 7 44 44 40 42 43 43 37 37 38 6 0 44 38 44 38 0 3 3 Folyóiratcikk Journal Article 24 42 Könyvrészlet Chapter in Book 25 2 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2015 0 2 1 2 1 2016 0 8 6 8 6 2017 0 6 5 6 5 2018 0 4 4 4 4 2019 0 6 4 6 4 2020 0 4 4 4 4 2021 0 2 2 2 2 2022 0 2 2 2 2 2023 0 2 2 2 2 2024 0 5 5 5 5 2025 0 3 3 3 3 D1 A false false false false 2014-06-16T14:00:35.000+0000 2014-03-18T15:00:35.000+0000 Endokrin Neurobiológiai Kutatócsoport (KOKI / ENO); Információs Technológiai Kar (PPKE); Információs Technológiai és Bionikai Kar (PPKE) 5 45 3 5 0 true 10073918 Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 4984615 /api/authorship/4984615 Sarvari, M ✉ [Sárvári, Miklós (Endokrin neurobio...), author] Laboratory of Endocrine Neurobiology (IEM / DEN) 1 0.2 true false true Author 10014210 /api/author/10014210 Miklós Sárvári (Endokrin neurobiológia) Sárvári Miklós true 10014210 true Sarvari M true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 19441087 true PersonAuthorship 4984616 /api/authorship/4984616 Kallo, I [Kalló, Imre (Neuroendokrinológia), author] Laboratory of Endocrine Neurobiology (IEM / DEN); Faculty of Information Technology (PPCU) 2 0.2 false false Author 10011501 /api/author/10011501 Imre Kalló (Neuroendokrinológia) Kalló Imre true 10011501 true Kallo I true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 19441086 true PersonAuthorship 4984617 /api/authorship/4984617 Hrabovszky, E [Hrabovszky, Erik (Reproduktív endok...), author] Laboratory of Endocrine Neurobiology (IEM / DEN) 3 0.2 false false Author 10011472 /api/author/10011472 Erik Hrabovszky (Reproduktív endokrinológia) Hrabovszky Erik true 10011472 true Hrabovszky E true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 19441085 true PersonAuthorship 4984618 /api/authorship/4984618 Solymosi, N [Solymosi, Norbert (bioinformatika, e...), author] 4 0.2 false false Author 10017846 /api/author/10017846 Norbert Solymosi (bioinformatika, epidemiológia) Solymosi Norbert true 10017846 true Solymosi N true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 19441084 true PersonAuthorship 4984619 /api/authorship/4984619 Liposits, Z [Liposits, Zsolt (Neurobiológia, ne...), author] Laboratory of Endocrine Neurobiology (IEM / DEN); Információs Technológiai és Bionikai Kar (PPCU) 5 0.2 false true Author 10002755 /api/author/10002755 Zsolt Liposits (Neurobiológia, neuroendokrinológia) Liposits Zsolt true 10002755 true Liposits Z true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 19441083 true PublicationIdentifier 779492 /api/publicationidentifier/779492 DOI: 10.1371/journal.pone.0088540 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1371/journal.pone.0088540 https://doi.org/10.1371/journal.pone.0088540 false 635460 true PublicationIdentifier 779494 /api/publicationidentifier/779494 REAL: 14321 SwordSource 36 /api/publicationsource/36 REAL PublicationSourceType 10007 /api/publicationsourcetype/10007 Repozitórium true true true REAL REAL https://real.mtak.hu/@@@ true true 36 true GREEN true IDENTICAL 14321 https://real.mtak.hu/14321 false 937123 true PublicationIdentifier 779490 /api/publicationidentifier/779490 WoS: 000331266000043 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000331266000043 https://www.webofscience.com/wos/woscc/full-record/000331266000043 false 655566 true PublicationIdentifier 779491 /api/publicationidentifier/779491 Scopus: 84895836218 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 84895836218 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84895836218 false 973920 true PublicationIdentifier 779493 /api/publicationidentifier/779493 PubMed: 24551115 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false IDENTICAL 24551115 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=24551115&dopt=Abstract false 635461 true Classification 10545 /api/classification/10545 Biological sciences true true Classification 12713 /api/classification/12713 Other agricultural sciences true true Classification 12548 /api/classification/12548 Other medical sciences true true Classification 10799 /api/classification/10799 Other natural sciences true true Classification 12215 /api/classification/12215 Clinical medicine true true MtaRating 10486385 /api/mtarating/10486385 II. 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Committee on Regional Studies RegTB Institute 14100 /api/institute/14100 Committee on Regional Studies HASSELIX RTB [1901-] 0 false true false Regionális Tudományok Bizottsága Committee on Regional Studies true 14100 true true true B nemzetközi false true SjrRating 11058740 /api/sjrrating/11058740 sjr:D1 (2014) Scopus - Agricultural and Biological Sciences (miscellaneous) PLOS ONE 1932-6203 24 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1101 /api/classificationexternal/1101 Scopus - Agricultural and Biological Sciences (miscellaneous) true 1101 true D1 DIRECT true true Reference 1793666 /api/reference/1793666 1. Buzsáki, G., Moser, E.I., Memory, navigation and theta rhythm in the hippocampal-entorhinal system (2013) Nat Neurosci, 16, pp. 130-138 1 false true Reference 1793667 /api/reference/1793667 2. 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(2014) PLOS ONE 1932-6203 9 2<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10014210"><a href="/gui2/?type=authors&mode=browse&sel=10014210" target="_blank">Sarvari M ✉ (<span class="authorship-author-name">Sárvári Miklós</span> <span class="authorAux-mtmt"> Endokrin neurobiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Endocrine Neurobiology">DEN</span>/Laboratory of Endocrine Neurobiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011501"><a href="/gui2/?type=authors&mode=browse&sel=10011501" target="_blank">Kallo I (<span class="authorship-author-name">Kalló Imre</span> <span class="authorAux-mtmt"> Neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Endocrine Neurobiology">DEN</span>/Laboratory of Endocrine Neurobiology; <span title="Pázmány Péter Catholic University">PPCU</span>/Faculty of Information Technology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011472"><a href="/gui2/?type=authors&mode=browse&sel=10011472" target="_blank">Hrabovszky E (<span class="authorship-author-name">Hrabovszky Erik</span> <span class="authorAux-mtmt"> Reproduktív endokrinológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Endocrine Neurobiology">DEN</span>/Laboratory of Endocrine Neurobiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10017846"><a href="/gui2/?type=authors&mode=browse&sel=10017846" target="_blank">Solymosi N (<span class="authorship-author-name">Solymosi Norbert</span> <span class="authorAux-mtmt"> bioinformatika, epidemiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002755"><a href="/gui2/?type=authors&mode=browse&sel=10002755" target="_blank">Liposits Z (<span class="authorship-author-name">Liposits Zsolt</span> <span class="authorAux-mtmt"> Neurobiológia, neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Endocrine Neurobiology">DEN</span>/Laboratory of Endocrine Neurobiology; <span title="Pázmány Péter Catholic University">PPCU</span>/Információs Technológiai és Bionikai Kar</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2539846" target="_blank">Ovariectomy and subsequent treatment with estrogen receptor agonists tune the innate immune system of the hippocampus in middle-aged female rats</a></div> <div> <span class="journal-title">PLOS ONE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1932-6203">1932-6203</a>)</span>: <span class="journal-volume">9</span> <span class="journal-issue">2</span> <span class="page"> Paper e88540. 12 p. </span> <span class="year">(2014)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1371/journal.pone.0088540" target="_blank" href="https://doi.org/10.1371/journal.pone.0088540"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="14321" target="_blank" href="https://real.mtak.hu/14321"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000331266000043" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000331266000043"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84895836218" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84895836218"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="24551115" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=24551115&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Agricultural and Biological Sciences (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Pedagógiai Tudományos Bizottság HASSPHSII PedTB [1901-]&nbsp;&nbsp;&nbsp;A</div> <div class="journal-subject">Committee on Sociology HASSELIX SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Committee on Regional Studies HASSELIX RTB [1901-]&nbsp;&nbsp;&nbsp;B nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 44</span> | Independent citation: 38 | Self citation: 6 | Unknown citation: 0 | Number of citations in WoS: 40 | Number of citations in Scopus:&nbsp;42 | WoS/Scopus assigned:&nbsp;43 | Number of citations with DOI:&nbsp;44 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2539846&sort=publishedYear,desc&sort=title"> Number of cited publications: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 2539846</span> | <span class="status-data status-VALIDATED"> Validated </span> <span class="oldId">Old id: 2539846</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Last Modified: 2025.11.20. 14:39 András Balázs (MTMT Központ, admin) </div> <div class="lockedBy">Centrally managed 2025.10.30. 08:42 Marcell Kovács (MTMT Közp., admin) </div> </div></div>