https://m2.mtmt.hu/ eng 2026-10-25 07:52 JournalArticle 2511551 APPROVED true Magyar Tudomanyos Akademia, Department of Endocrine Neurobiology, Budapest, Hungary Tufts Medical Center, Department of Medicine, Boston, United States Tufts University School of Medicine, Department of Neuroscience, Boston, United States Export Date: 11 November 2025; Cited By: 281; CODEN: ERVID 0 2018-02-28T20:09:27.000+0000 false 2511551 2026-10-16T08:25:48.336+0000 2025-11-11T09:13:07.238+0000 2014-01-27T13:14:50.000+0000 true 10012354 Fekete Csaba /api/author/10012354 Author true 10012354 2026-02-05T13:51:19.865+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Fekete, C Central Regulation of Pituitary-Thyroid Axis Under Physiological and Pathophysiological Conditions. true true /api/journal/1408 REVIEWED true false 1408 false 1408 true 0163-769X 1945-7189 Journal FOREIGN 35 2 159 194 159 36 2014 TRH is a tripeptide amide that functions as a neurotransmitter but also serves as a neurohormone that has a critical role in the central regulation of the hypothalamic-pituitary-thyroid axis. Hypophysiotropic TRH neurons involved in this neuroendocrine process are located in the hypothalamic paraventricular nucleus and secrete TRH into the pericapillary space of the external zone of the median eminence for conveyance to anterior pituitary thyrotrophs. Under basal conditions, the activity of hypophysiotropic TRH neurons is regulated by the negative feedback effects of thyroid hormone to ensure stable, circulating, thyroid hormone concentrations, a mechanism that involves complex interactions between hypophysiotropic TRH neurons and the vascular system, cerebrospinal fluid, and specialized glial cells called tanycytes. Hypophysiotropic TRH neurons also integrate other humoral and neuronal inputs that can alter the setpoint for negative feedback regulation by thyroid hormone. This mechanism facilitates adaptation of the organism to changing environmental conditions, including the shortage of food and a cold environment. The thyroid axis is also affected by other adverse conditions such as infection, but the central mechanisms mediating suppression of hypophysiotropic TRH may be pathophysiological. In this review, we discuss current knowledge about the mechanisms that contribute to the regulation of hypophysiotropic TRH neurons under physiological and pathophysiological conditions. true true 2014 876861 true true true false true false GOLD 2026-10-16 true https://real.mtak.hu/18207 true 10030885 Bálint Eszter /api/admin/10030885 Admin true 10030885 307 0 307 289 21 300 298 269 283 306 306 288 288 289 18 0 307 289 307 289 0 55 55 Folyóiratcikk Journal Article 24 282 Könyvrészlet Chapter in Book 25 24 Könyv Book 23 1 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2014 0 4 4 4 4 2015 0 18 17 18 17 2016 0 20 18 20 18 2017 0 26 24 26 24 2018 0 25 23 25 23 2019 0 23 22 23 22 2020 0 22 21 22 21 2021 0 44 43 44 43 2022 0 21 19 21 19 2023 0 26 23 26 23 2024 0 22 20 22 20 2025 0 30 30 30 30 2026 0 26 25 26 25 D1 false 10012354 false false false 2014-04-27T12:18:20.000+0000 2014-01-27T13:18:20.000+0000 Lendület Integratív Neuroendokrinológiai Kutató... (KOKI / ENO) 1 14 1 2 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 4929248 /api/authorship/4929248 1 0.5 true false true Author 10012354 /api/author/10012354 Fekete Csaba true 10012354 true Fekete C true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 19314061 true PersonAuthorship 4929249 /api/authorship/4929249 2 0.5 false true Lechan RM true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 19314060 true PublicationIdentifier 765794 /api/publicationidentifier/765794 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true PAY false IDENTICAL 10.1210/er.2013-1087 https://doi.org/10.1210/er.2013-1087 false 599745 true PublicationIdentifier 765796 /api/publicationidentifier/765796 SwordSource 36 /api/publicationsource/36 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true REAL REAL https://real.mtak.hu/@@@ true true 36 true GOLD true NO 18207 https://real.mtak.hu/18207 false 985772 true PublicationIdentifier 765792 /api/publicationidentifier/765792 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000335446000001 https://www.webofscience.com/wos/woscc/full-record/000335446000001 false 1165812 true PublicationIdentifier 765793 /api/publicationidentifier/765793 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 84897395869 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84897395869 false 1731460 true PublicationIdentifier 765795 /api/publicationidentifier/765795 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false IDENTICAL 24423980 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=24423980&dopt=Abstract false 599746 true PublicationIdentifier 14960130 /api/publicationidentifier/14960130 PlainSource 40 /api/publicationsource/40 PublicationSourceType 10006 /api/publicationsourcetype/10006 true true true Egyéb URL Other URL @@@ true true 40 true NO http://www.scopus.com/inward/record.url?eid=2-s2.0-84897395869&partnerID=40&md5=e35d91c99a1992d02fa37e63253dfda4 http://www.scopus.com/inward/record.url?eid=2-s2.0-84897395869&partnerID=40&md5=e35d91c99a1992d02fa37e63253dfda4 false 5694474 true Classification 10545 /api/classification/10545 true true Classification 12215 /api/classification/12215 true true SjrRating 11077244 /api/sjrrating/11077244 1 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1310 /api/classificationexternal/1310 true 1310 true D1 DIRECT true true /api/publication/2511551 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10012354"><a href="/gui2/?type=authors&mode=browse&sel=10012354" target="_blank">Fekete C ✉ (<span class="authorship-author-name">Fekete Csaba</span> <span class="authorAux-mtmt"> Neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Endocrine Neurobiology">DEN</span>/Laboratory of Integrative Neuroendocrinology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lechan RM </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2511551" target="_blank">Central Regulation of Pituitary-Thyroid Axis Under Physiological and Pathophysiological Conditions.</a></div> <div> <span class="journal-title">ENDOCRINE REVIEWS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0163-769X">0163-769X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1945-7189">1945-7189</a>)</span>: <span class="journal-volume">35</span> <span class="journal-issue">2</span> <span class="page"> pp 159-194 </span> <span class="year">(2014)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_PAY" title=" Pay "> <a style="color:blue" title="10.1210/er.2013-1087" target="_blank" href="https://doi.org/10.1210/er.2013-1087"> DOI </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="18207" target="_blank" href="https://real.mtak.hu/18207"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000335446000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000335446000001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84897395869" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84897395869"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="24423980" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=24423980&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="http://www.scopus.com/inward/record.url?eid=2-s2.0-84897395869&partnerID=40&md5=e35d91c99a1992d02fa37e63253dfda4" target="_blank" href="http://www.scopus.com/inward/record.url?eid=2-s2.0-84897395869&partnerID=40&md5=e35d91c99a1992d02fa37e63253dfda4"> Other URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Endocrinology&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Endocrinology, Diabetes and Metabolism&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 307</span> | Independent citation: 289 | Self citation: 18 | Unknown citation: 0 | Number of citations in WoS: 269 | Number of citations in Scopus:&nbsp;283 | WoS/Scopus assigned:&nbsp;306 | Number of citations with DOI:&nbsp;298 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2511551&sort=publishedYear,desc&sort=title"> Number of cited publications: 55 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 2511551</span> | <span class="status-data status-APPROVED"> Published </span> <span class="oldId">Old id: 2511551</span> | Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Last Modified: 2025.11.11. 10:13 Márta Turek (KOKI admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Magyar Tudomanyos Akademia, Department of Endocrine Neurobiology, Budapest, Hungary Tufts Medical Center, Department of Medicine, Boston, United States Tufts University School of Medicine, Department of Neuroscience, Boston, United States Export Date: 11 November 2025; Cited By: 281; CODEN: ERVID</pre> </div></div>