https://m2.mtmt.hu/ hun 2026-05-04 10:12 JournalArticle 2502657 VALIDATED true Megjegyzés-23823594 Megjegyzés-23823728 Megjegyzés-23823755 Megjegyzés-23823799 Megjegyzés-23823938 Megjegyzés-24192952 Megjegyzés-24192958 Department of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary Center for Stem Cell Biology, Life Sciences Institute, University of Michigan, Ann Arbor, MI, United States IMP-Research Institute of Molecular Pathology, Vienna, Austria Cited By :49 Export Date: 4 May 2021 Correspondence Address: Juhász, G.; Department of Anatomy, , Budapest, Hungary; email: szmrt@elte.hu 0 2018-10-02T08:54:25.000+0000 false 2502657 2026-04-08T11:45:29.685+0000 2024-05-03T11:41:12.101+0000 2014-01-20T09:45:18.000+0000 true 10000590 Juhász Gábor /api/author/10000590 Author true 10000590 2026-02-09T11:42:46.328+0000 2016-10-27T10:45:55.000+0000 true 10021517 xVégh Judit /api/admin/10021517 Admin true 10021517 2021-03-22T17:09:27.472+0000 true 10075782 Ferbert Barbara /api/admin/10075782 Admin true Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true Admin 10080085 /api/admin/10080085 Fölkerné Csernyik Rita true true 2024-10-17T16:48:31.101+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Nagy, P Atg17/FIP200 localizes to perilysosomal Ref(2)P aggregates and promotes autophagy by activation of Atg1 in Drosophila true true /api/journal/10004714 REVIEWED true false 10004714 false 10004714 true 1554-8627 1554-8635 Journal FOREIGN 10 3 453 467 453 15 2014 Phagophore-derived autophagosomes deliver cytoplasmic material to lysosomes for degradation and reuse. Autophagy mediated by the incompletely characterized actions of Atg proteins is involved in numerous physiological and pathological settings including stress resistance, immunity, aging, cancer, and neurodegenerative diseases. Here we characterized Atg17/FIP200, the Drosophila ortholog of mammalian RB1CC1/FIP200, a proposed functional equivalent of yeast Atg17. Atg17 disruption inhibits basal, starvation-induced and developmental autophagy, and interferes with the programmed elimination of larval salivary glands and midgut during metamorphosis. Upon starvation, Atg17-positive structures appear at aggregates of the selective cargo Ref(2)P/p62 near lysosomes. This location may be similar to the perivacuolar PAS (phagophore assembly site) described in yeast. Drosophila Atg17 is a member of the Atg1 kinase complex as in mammals, and we showed that it binds to the other subunits including Atg1, Atg13 and Atg101 (C12orf44 in humans, 9430023L20Rik in mice and RGD1359310 in rats). Atg17 is required for the kinase activity of endogenous Atg1 in vivo, as loss of Atg17 prevents the Atg1-dependent shift of endogenous Atg13 to hyperphosphorylated forms, and also blocks punctate Atg1 localization during starvation. Finally, we found that Atg1 overexpression induces autophagy and reduces cell size in Atg17-null mutant fat body cells, and that overexpression of Atg17 promotes endogenous Atg13 phosphorylation and enhances autophagy in an Atg1-dependent manner in the fat body. We propose a model according to which the relative activity of Atg1, estimated by the ratio of hyper- to hypophosphorylated Atg13, contributes to setting low (basal) vs. high (starvation-induced) autophagy levels in Drosophila. Funding 2039844 /api/funding/2039844 false true 2014 732111 true true true false true false RESTRICTED 2026-04-08 false true 10018677 Berkes Kata /api/admin/10018677 Admin true 10018677 69 0 69 53 11 69 69 69 68 69 69 53 53 53 16 0 69 53 69 53 0 10 10 Folyóiratcikk Journal Article 24 68 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2014 0 9 5 9 5 2015 0 6 3 6 3 2016 0 8 7 8 7 2017 0 6 5 6 5 2018 0 3 2 3 2 2019 0 8 6 8 6 2020 0 7 7 7 7 2021 0 5 4 5 4 2022 0 4 4 4 4 2023 0 7 5 7 5 2024 0 3 2 3 2 2025 0 3 3 3 3 Q1 false false false false 2016-10-27T10:45:55.000+0000 2014-01-20T10:01:39.000+0000 Anatómiai, Sejt- és Fejlődésbiológiai Tanszék (ELTE / TTK / Bio_I) 9 21 1 10 0 true 10080085 10067876 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 4887011 /api/authorship/4887011 1 0.1 true false Author 10020368 /api/author/10020368 Nagy Péter true 10020368 true Nagy P true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 19261074 true PersonAuthorship 4887012 /api/authorship/4887012 2 0.1 true false Author 10040074 /api/author/10040074 Kárpáti Manuéla true 10040074 true Karpati M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 19261073 true PersonAuthorship 4887013 /api/authorship/4887013 3 0.1 false false Author 10020342 /api/author/10020342 Varga Ágnes true 10020342 true Varga A true 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/api/authorship/4887018 8 0.1 false false Author 10020016 /api/author/10020016 Érdi Balázs true 10020016 true Erdi B true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 19261067 true PersonAuthorship 4887019 /api/authorship/4887019 9 0.1 false false Author 10040519 /api/author/10040519 Hegedűs Krisztina true 10040519 true Hegedus K true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 19261066 true PersonAuthorship 4887020 /api/authorship/4887020 10 0.1 false true true Author 10000590 /api/author/10000590 Juhász Gábor true 10000590 true Juhasz G true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 19261065 true PublicationIdentifier 759814 /api/publicationidentifier/759814 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true false IDENTICAL 10.4161/auto.27442 https://doi.org/10.4161/auto.27442 false 688026 true 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https://www.scopus.com/inward/record.uri?eid=2-s2.0-84892805825&doi=10.4161%2Fauto.27442&partnerID=40&md5=67733167a8f2cc03386b81266f46490c false true Classification 10545 /api/classification/10545 true true SjrRating 11066098 /api/sjrrating/11066098 33 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1307 /api/classificationexternal/1307 true 1307 true Q1 DIRECT true true /api/publication/2502657 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10020368"><a href="/gui2/?type=authors&mode=browse&sel=10020368" target="_blank">Nagy P (<span class="authorship-author-name">Nagy Péter</span> <span class="authorAux-mtmt"> sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/Anatómiai, Sejt- és Fejlődésbiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040074"><a href="/gui2/?type=authors&mode=browse&sel=10040074" target="_blank">Karpati M<sup>*</sup> (<span class="authorship-author-name">Kárpáti Manuéla</span> <span class="authorAux-mtmt"> molekuláris sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/Anatómiai, Sejt- és Fejlődésbiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020342"><a href="/gui2/?type=authors&mode=browse&sel=10020342" target="_blank">Varga A (<span class="authorship-author-name">Varga Ágnes</span> <span class="authorAux-mtmt"> Sejt- és Fejlődésbiológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/Anatómiai, Sejt- és Fejlődésbiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020736"><a href="/gui2/?type=authors&mode=browse&sel=10020736" target="_blank">Pircs K (<span class="authorship-author-name">Pircs Karolina Milena</span> <span class="authorAux-mtmt"> biológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/Anatómiai, Sejt- és Fejlődésbiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Venkei Z </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040075"><a href="/gui2/?type=authors&mode=browse&sel=10040075" target="_blank">Takats S (<span class="authorship-author-name">Takáts Szabolcs</span> <span class="authorAux-mtmt"> Molekuláris sejtbiológia/genetika</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/Anatómiai, Sejt- és Fejlődésbiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10044615"><a href="/gui2/?type=authors&mode=browse&sel=10044615" target="_blank">Varga K (<span class="authorship-author-name">Varga Kata</span> <span class="authorAux-mtmt"> Sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/Anatómiai, Sejt- és Fejlődésbiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020016"><a href="/gui2/?type=authors&mode=browse&sel=10020016" target="_blank">Erdi B (<span class="authorship-author-name">Érdi Balázs</span> <span class="authorAux-mtmt"> Biológia, sejttan</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/Anatómiai, Sejt- és Fejlődésbiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040519"><a href="/gui2/?type=authors&mode=browse&sel=10040519" target="_blank">Hegedus K (<span class="authorship-author-name">Hegedűs Krisztina</span> <span class="authorAux-mtmt"> sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/Anatómiai, Sejt- és Fejlődésbiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000590"><a href="/gui2/?type=authors&mode=browse&sel=10000590" target="_blank">Juhasz G ✉ (<span class="authorship-author-name">Juhász Gábor</span> <span class="authorAux-mtmt"> Sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/Anatómiai, Sejt- és Fejlődésbiológiai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2502657" target="_blank">Atg17/FIP200 localizes to perilysosomal Ref(2)P aggregates and promotes autophagy by activation of Atg1 in Drosophila</a></div> <div> <span class="journal-title">AUTOPHAGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1554-8627">1554-8627</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1554-8635">1554-8635</a>)</span>: <span class="journal-volume">10</span> <span class="journal-issue">3</span> <span class="page"> pp 453-467 </span> <span class="year">(2014)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.4161/auto.27442" target="_blank" href="https://doi.org/10.4161/auto.27442"> DOI </a> </span> <span class="id identifier oa_RESTRICTED" title=" Korlátozott "> <a style="color:blue" title="15354" target="_blank" href="http://real.mtak.hu/15354"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000332164400007" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000332164400007"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84892805825" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84892805825"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="24419107" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=24419107&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_NONE" title=" Nincs "> <a style="color:blue" title="https://www.scopus.com/inward/record.uri?eid=2-s2.0-84892805825&doi=10.4161%2Fauto.27442&partnerID=40&md5=67733167a8f2cc03386b81266f46490c" target="_blank" href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-84892805825&doi=10.4161%2Fauto.27442&partnerID=40&md5=67733167a8f2cc03386b81266f46490c"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cell Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 69</span> | Független: 53 | Függő: 16 | Nem jelölt: 0 | WoS jelölt: 69 | Scopus jelölt:&nbsp;68 | WoS/Scopus jelölt:&nbsp;69 | DOI jelölt:&nbsp;69 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2502657&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 10 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 2502657</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> <span class="oldId">Régi azonosító: 2502657</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="funder"> K83509 Támogató: OTKA </div> <div class="lastModified">Utolsó módosítás: 2024.05.03. 13:41 Pintér Ibolya Katalin (SE_AOK_TranszlációsMedInt_Admin5_PI, admin) </div> <div class="lockedBy">Központi kezelésű 2024.10.17. 18:48 Ladányi Gusztáv (MTMT API user, admin) Fölkerné Csernyik Rita (MTMT ellenőrzés admin5) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Megjegyzés-23823594 Megjegyzés-23823728 Megjegyzés-23823755 Megjegyzés-23823799 Megjegyzés-23823938 Megjegyzés-24192952 Megjegyzés-24192958 Department of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary Center for Stem Cell Biology, Life Sciences Institute, University of Michigan, Ann Arbor, MI, United States IM...</pre> </div></div>