https://m2.mtmt.hu/ eng 2026-10-23 17:46 JournalArticle 2498752 ADMIN_APPROVED true Laboratory of Cerebral Cortex, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Janos Szentagothai PhD Program of Semmelweis University, Budapest, Hungary Institute of Psychology, Hungarian Academy of Sciences, Budapest, Hungary Faculty of Information Technology, Péter Pázmány Catholic University, Budapest, Hungary Laboratory of Molecular Biology and Genetics, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Cited By :44 Export Date: 31 March 2021 CODEN: BRAIA Correspondence Address: Gulyás, A.I.; Institute of Experimental Medicine, Szigony utca 43, H-1083 Budapest, Hungary; email: gulyas@koki.hu Chemicals/CAS: 3 amino 2 (3 carboxypropyl) 6 (4 methoxyphenyl)pyridazinium bromide, 104104-50-9; magnesium, 7439-95-4; parvalbumin, 56094-12-3, 83667-75-8; potassium, 7440-09-7 Funding details: Seventh Framework Programme, FP7, 294313 Funding details: European Research Council, ERC Funding details: Hungarian Scientific Research Fund, OTKA, K83251, OTKA 81357 Funding text 1: This work was supported by:, Hungarian Scientific Research Fund (OTKA K83251 and OTKA 81357), European Research Council Advanced grant for T.F.F. (ERC-2011-ADG-294313) (SERRACO), National Office for Research and Technology NKTH-ANR, Neurogen and Multisca, European Union Seventh Framework Program (NeuroSeker) and TÁMOP-4.2.1.B-11/2/KMR-2011-0002 Laboratory of Cerebral Cortex, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Janos Szentagothai PhD Program of Semmelweis University, Budapest, Hungary Institute of Psychology, Hungarian Academy of Sciences, Budapest, Hungary Faculty of Information Technology, Péter Pázmány Catholic University, Budapest, Hungary Laboratory of Molecular Biology and Genetics, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Cited By :44 Export Date: 6 April 2021 CODEN: BRAIA Correspondence Address: Gulyás, A.I.; Institute of Experimental Medicine, Szigony utca 43, H-1083 Budapest, Hungary; email: gulyas@koki.hu Chemicals/CAS: 3 amino 2 (3 carboxypropyl) 6 (4 methoxyphenyl)pyridazinium bromide, 104104-50-9; magnesium, 7439-95-4; parvalbumin, 56094-12-3, 83667-75-8; potassium, 7440-09-7 Funding details: Seventh Framework Programme, FP7, 294313 Funding details: European Research Council, ERC Funding details: Hungarian Scientific Research Fund, OTKA, K83251, OTKA 81357 Funding text 1: This work was supported by:, Hungarian Scientific Research Fund (OTKA K83251 and OTKA 81357), European Research Council Advanced grant for T.F.F. (ERC-2011-ADG-294313) (SERRACO), National Office for Research and Technology NKTH-ANR, Neurogen and Multisca, European Union Seventh Framework Program (NeuroSeker) and TÁMOP-4.2.1.B-11/2/KMR-2011-0002 Laboratory of Cerebral Cortex, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Janos Szentagothai PhD Program of Semmelweis University, Budapest, Hungary Institute of Psychology, Hungarian Academy of Sciences, Budapest, Hungary Faculty of Information Technology, Péter Pázmány Catholic University, Budapest, Hungary Laboratory of Molecular Biology and Genetics, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Cited By :44 Export Date: 13 April 2021 CODEN: BRAIA Correspondence Address: Gulyás, A.I.; Institute of Experimental Medicine, Szigony utca 43, H-1083 Budapest, Hungary; email: gulyas@koki.hu Chemicals/CAS: 3 amino 2 (3 carboxypropyl) 6 (4 methoxyphenyl)pyridazinium bromide, 104104-50-9; magnesium, 7439-95-4; parvalbumin, 56094-12-3, 83667-75-8; potassium, 7440-09-7 Funding details: Seventh Framework Programme, FP7, 294313 Funding details: European Research Council, ERC Funding details: Hungarian Scientific Research Fund, OTKA, K83251, OTKA 81357 Funding text 1: This work was supported by:, Hungarian Scientific Research Fund (OTKA K83251 and OTKA 81357), European Research Council Advanced grant for T.F.F. (ERC-2011-ADG-294313) (SERRACO), National Office for Research and Technology NKTH-ANR, Neurogen and Multisca, European Union Seventh Framework Program (NeuroSeker) and TÁMOP-4.2.1.B-11/2/KMR-2011-0002 0 2017-02-15T10:28:19.000+0000 false 2498752 2026-10-16T10:31:51.709+0000 2023-09-23T09:07:53.051+0000 2014-01-15T12:22:13.000+0000 true 10014208 Karlócai Rita /api/author/10014208 Author true 10014208 2025-04-10T09:38:22.504+0000 2025-04-10T09:38:22.504+0000 2021-10-29T09:28:58.586+0000 true 10080067 Patkósné Hanesz Andrea /api/admin/10080067 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Karlocai, MR Physiological sharp wave-ripples and interictal events in vitro: what's the difference? true true /api/journal/788 REVIEWED true false 788 false 788 true 0006-8950 1460-2156 Journal FOREIGN 137 2 (Feb) 463 485 463 23 2014 Sharp wave-ripples and interictal events are physiological and pathological forms of transient high activity in the hippocampus with similar features. Sharp wave-ripples have been shown to be essential in memory consolidation, whereas epileptiform (interictal) events are thought to be damaging. It is essential to grasp the difference between physiological sharp wave-ripples and pathological interictal events to understand the failure of control mechanisms in the latter case. We investigated the dynamics of activity generated intrinsically in the Cornu Ammonis region 3 of the mouse hippocampus in vitro, using four different types of intervention to induce epileptiform activity. As a result, sharp wave-ripples spontaneously occurring in Cornu Ammonis region 3 disappeared, and following an asynchronous transitory phase, activity reorganized into a new form of pathological synchrony. During epileptiform events, all neurons increased their firing rate compared to sharp wave-ripples. Different cell types showed complementary firing: parvalbumin-positive basket cells and some axo-axonic cells stopped firing as a result of a depolarization block at the climax of the events in high potassium, 4-aminopyridine and zero magnesium models, but not in the gabazine model. In contrast, pyramidal cells began firing maximally at this stage. To understand the underlying mechanism we measured changes of intrinsic neuronal and transmission parameters in the high potassium model. We found that the cellular excitability increased and excitatory transmission was enhanced, whereas inhibitory transmission was compromised. We observed a strong short-term depression in parvalbumin-positive basket cell to pyramidal cell transmission. Thus, the collapse of pyramidal cell perisomatic inhibition appears to be a crucial factor in the emergence of epileptiform events. 2014 797941 true true true false true false GREEN GREEN 2026-10-16 true https://real.mtak.hu/7028 true 10039736 xRadó Nikolett /api/admin/10039736 Admin true 10039736 80 0 80 70 12 80 80 79 75 80 80 70 70 70 10 0 80 70 80 70 0 23 23 Folyóiratcikk Journal Article 24 79 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 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class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10014208"><a href="/gui2/?type=authors&mode=browse&sel=10014208" target="_blank">Karlocai MR (<span class="authorship-author-name">Karlócai Rita</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Cerebral Cortex Research</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10057445"><a href="/gui2/?type=authors&mode=browse&sel=10057445" target="_blank">Kohus Z (<span class="authorship-author-name">Kohus Zsolt</span> <span class="authorAux-mtmt"> Tudománymetria</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Cerebral Cortex Research; <span title="Semmelweis University">SU</span>/School of Ph. D. Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011500"><a href="/gui2/?type=authors&mode=browse&sel=10011500" target="_blank">Kali S (<span class="authorship-author-name">Káli Szabolcs</span> <span class="authorAux-mtmt"> Elméleti neurobiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Cerebral Cortex Research</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001193"><a href="/gui2/?type=authors&mode=browse&sel=10001193" target="_blank">Ulbert I (<span class="authorship-author-name">Ulbert István</span> <span class="authorAux-mtmt"> Idegtudományok</span>) </a> </span> <span class="author-affil"><span title="MTA Research Centre for Natural Sciences">MTA TTK</span>/Institute of Cognitive Neuroscience and Psychology; <span title="Pázmány Péter Catholic University">PPCU</span>/Információs Technológiai és Bionikai Kar</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009842"><a href="/gui2/?type=authors&mode=browse&sel=10009842" target="_blank">Szabo G (<span class="authorship-author-name">Szabó Gábor</span> <span class="authorAux-mtmt"> Molekuláris és sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Gene Technology and Developmental Neurobiology">DGTDN</span>/Laboratory of Molecular Biology and Genetics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="198"><a href="/gui2/?type=authors&mode=browse&sel=198" target="_blank">Mate Z (<span class="authorship-author-name">Máté Zoltán</span> <span class="authorAux-mtmt"> Molekuláris biológia, genetika</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Gene Technology and Developmental Neurobiology">DGTDN</span>/Laboratory of Molecular Biology and Genetics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000275"><a href="/gui2/?type=authors&mode=browse&sel=10000275" target="_blank">Freund TF (<span class="authorship-author-name">Freund Tamás</span> <span class="authorAux-mtmt"> Neurobiológia, idegtudomány</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Cerebral Cortex Research</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009114"><a href="/gui2/?type=authors&mode=browse&sel=10009114" target="_blank">Gulyas AI (<span class="authorship-author-name">Gulyás Attila</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Cerebral Cortex Research</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2498752" target="_blank">Physiological sharp wave-ripples and interictal events in vitro: what's the difference?</a></div> <div> <span class="journal-title">BRAIN</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0006-8950">0006-8950</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1460-2156">1460-2156</a>)</span>: <span class="journal-volume">137</span> <span class="journal-issue">2 (Feb)</span> <span class="page"> pp 463-485 </span> <span class="year">(2014)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_PAY" title=" Pay "> <a style="color:blue" title="10.1093/brain/awt348" target="_blank" href="https://doi.org/10.1093/brain/awt348"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="7028" target="_blank" href="https://real.mtak.hu/7028"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000331290900016" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000331290900016"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84893824784" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84893824784"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="24390441" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=24390441&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Neurology (clinical)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 80</span> | Independent citation: 70 | Self citation: 10 | Unknown citation: 0 | Number of citations in WoS: 79 | Number of citations in Scopus:&nbsp;75 | WoS/Scopus assigned:&nbsp;80 | Number of citations with DOI:&nbsp;80 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2498752&sort=publishedYear,desc&sort=title"> Number of cited publications: 23 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 2498752</span> | <span class="status-data status-ADMIN_APPROVED"> Admin approved </span> <span class="oldId">Old id: 2498752</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Last Modified: 2023.09.23. 11:07 Gusztáv Ladányi (MTMT API user, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Laboratory of Cerebral Cortex, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Janos Szentagothai PhD Program of Semmelweis University, Budapest, Hungary Institute of Psychology, Hungarian Academy of Sciences, Budapest, Hungary Faculty of Information Technology, Péter Pázmány Catholic Un...</pre> </div></div>