https://m2.mtmt.hu/ eng 2026-10-24 09:00 JournalArticle 2498353 VALIDATED true 0 2017-04-25T07:03:25.000+0000 false 2498353 2026-10-16T07:34:56.418+0000 2025-01-02T15:22:15.104+0000 2014-01-15T08:34:32.000+0000 true 10039736 xRadó Nikolett /api/admin/10039736 Admin true 10039736 2025-04-10T09:59:26.896+0000 2025-04-10T09:59:26.896+0000 2025-01-02T15:22:15.329+0000 true 10003132 Balázs András /api/admin/10003132 Admin true 10003132 Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true Admin 10003132 /api/admin/10003132 Balázs András true 10003132 true 2024-10-17T16:47:09.541+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Haller, J Effects of the fatty acid amide hydrolase inhibitor URB597 on coping behavior under challenging conditions in mice true true /api/journal/3816 REVIEWED true false 3816 false 3816 true 0033-3158 1432-2072 Journal FOREIGN 231 3 593 601 593 9 2014 RATIONALE: Recent evidence suggests that in addition to controlling emotional behavior in general, endocannabinoid signaling is engaged in shaping behavioral responses to challenges. This important function of endocannabinoids is still poorly understood. OBJECTIVES: Here we investigated the impact of blockade of fatty acid amide hydrolase (FAAH), the degrading enzyme of anandamide on behavioral responses induced by challenges of different intensity. METHODS: Mice treated with FAAH inhibitor URB597 were either manually restrained on their backs (back test) or received foot-shocks. RESULTS: The behavior of mice showed bimodal distribution in the back test: they either predominantly showed escape attempts or equally distributed time between passivity and escape. URB597 increased escapes in animals with low escape scores. No effects were noticed in mice showing high escape scores, which is likely due to a ceiling effect. We hypothesized that stronger stressors would wash out individual differences in coping; therefore, we exposed mice to foot-shocks that decreased locomotion and increased freezing in all mice. URB597 ameliorated both responses. The re-exposure of mice to the shock cage 14 days later without delivering shocks or treatment was followed by reduced and fragmented sleep as shown by electrophysiological recordings. Surprisingly, sleep was more disturbed after the reminder than after shocks in rats receiving vehicle before foot-shocks. These reminder-induced disturbances were abolished by URB597 administered before shocks. CONCLUSIONS: These findings suggest that FAAH blockade has an important role in the selection of behavioral responses under challenging conditions and-judging from its long-term effects-that it influences the cognitive appraisal of the challenge. 2014 660227 true true true false true false GREEN GREEN 2026-10-16 true https://real.mtak.hu/10742 true 10030236 Molnár-Taga Márta /api/admin/10030236 Admin true 10030236 18 0 18 11 7 18 17 16 16 18 18 11 11 11 7 0 18 11 18 11 0 7 7 Folyóiratcikk Journal Article 24 16 Könyvrészlet Chapter in Book 25 2 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2014 0 1 1 1 1 2015 0 4 2 4 2 2016 0 1 0 1 0 2017 0 4 3 4 3 2018 0 3 2 3 2 2019 0 2 1 2 1 2020 0 0 0 0 0 2021 0 1 1 1 1 2022 0 1 1 1 1 2023 0 1 0 1 0 D1 false false false false 2017-03-01T12:38:14.000+0000 2014-01-15T08:44:12.000+0000 MTA Kísérleti Orvostudományi Kutatóintézet; Magatartásélettan és Stressz Kutatócsoport (KOKI / MO) 6 35 2 6 0 true 10003132 10067876 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 4875074 /api/authorship/4875074 1 0.167 true false true Author 10011498 /api/author/10011498 Haller József true 10011498 true Haller J true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 19236279 true PersonAuthorship 4875075 /api/authorship/4875075 2 0.16666667 false false Author 10020826 /api/author/10020826 Aliczki Manó true 10020826 true Aliczki M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 19236278 true PersonAuthorship 4875076 /api/authorship/4875076 3 0.16666667 false false Author 10038052 /api/author/10038052 Gyímesiné Pelczer Katalin true 10038052 true Pelczer KG true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 19236277 true PersonAuthorship 4875077 /api/authorship/4875077 4 0.16666667 false false Author 10062077 /api/author/10062077 Spitzer Klaudia true 10062077 true Spitzer K true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 19236276 true PersonAuthorship 4875078 /api/authorship/4875078 5 0.16666667 false false Author 10040723 /api/author/10040723 Balogh Zoltán true 10040723 true Balogh Z true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 19236275 true PersonAuthorship 4875079 /api/authorship/4875079 6 0.16666667 false true Author 10020387 /api/author/10020387 Kántor Sándor true 10020387 true Kantor S true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 19236274 true PublicationIdentifier 757415 /api/publicationidentifier/757415 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true PAY false IDENTICAL 10.1007/s00213-013-3273-8 https://doi.org/10.1007/s00213-013-3273-8 false 582047 true PublicationIdentifier 757417 /api/publicationidentifier/757417 SwordSource 36 /api/publicationsource/36 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true REAL REAL https://real.mtak.hu/@@@ true true 36 true GREEN false IDENTICAL 10742 https://real.mtak.hu/10742 false 643879 true PublicationIdentifier 757413 /api/publicationidentifier/757413 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000329673300014 https://www.webofscience.com/wos/woscc/full-record/000329673300014 false 616077 true PublicationIdentifier 757414 /api/publicationidentifier/757414 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 84892791333 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84892791333 false 1578386 true PublicationIdentifier 757416 /api/publicationidentifier/757416 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false NO 24037493 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=24037493&dopt=Abstract false 582048 true Classification 12125 /api/classification/12125 true true Classification 12215 /api/classification/12215 true true SjrRating 11101001 /api/sjrrating/11101001 30 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 3004 /api/classificationexternal/3004 true 3004 true D1 DIRECT true true /api/publication/2498353 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10011498"><a href="/gui2/?type=authors&mode=browse&sel=10011498" target="_blank">Haller J ✉ (<span class="authorship-author-name">Haller József</span> <span class="authorAux-mtmt"> Magatartás neurobiológiája, Kriminálpszichológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Deparment of Behavioural Neurobiology">DBN</span>/Laboratory of Behavioural and Stress Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020826"><a href="/gui2/?type=authors&mode=browse&sel=10020826" target="_blank">Aliczki M (<span class="authorship-author-name">Aliczki Manó</span> <span class="authorAux-mtmt"> Magatartásélettan</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Deparment of Behavioural Neurobiology">DBN</span>/Laboratory of Behavioural and Stress Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10038052"><a href="/gui2/?type=authors&mode=browse&sel=10038052" target="_blank">Pelczer KG (<span class="authorship-author-name">Gyímesiné Pelczer Katalin</span> <span class="authorAux-mtmt"> magatartáskutatás</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Deparment of Behavioural Neurobiology">DBN</span>/Laboratory of Behavioural and Stress Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10062077"><a href="/gui2/?type=authors&mode=browse&sel=10062077" target="_blank">Spitzer K (<span class="authorship-author-name">Spitzer Klaudia</span> <span class="authorAux-mtmt"> Neurobiologia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040723"><a href="/gui2/?type=authors&mode=browse&sel=10040723" target="_blank">Balogh Z (<span class="authorship-author-name">Balogh Zoltán</span> <span class="authorAux-mtmt"> Magatartásneurobiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Deparment of Behavioural Neurobiology">DBN</span>/Laboratory of Behavioural and Stress Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020387"><a href="/gui2/?type=authors&mode=browse&sel=10020387" target="_blank">Kantor S (<span class="authorship-author-name">Kántor Sándor</span> <span class="authorAux-mtmt"> Idegtudományok</span>) </a> </span> <span class="author-affil">MTA Kísérleti Orvostudományi Kutatóintézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2498353" target="_blank">Effects of the fatty acid amide hydrolase inhibitor URB597 on coping behavior under challenging conditions in mice</a></div> <div> <span class="journal-title">PSYCHOPHARMACOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0033-3158">0033-3158</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1432-2072">1432-2072</a>)</span>: <span class="journal-volume">231</span> <span class="journal-issue">3</span> <span class="page"> pp 593-601 </span> <span class="year">(2014)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_PAY" title=" Pay "> <a style="color:blue" title="10.1007/s00213-013-3273-8" target="_blank" href="https://doi.org/10.1007/s00213-013-3273-8"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="10742" target="_blank" href="https://real.mtak.hu/10742"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000329673300014" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000329673300014"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84892791333" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84892791333"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="24037493" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=24037493&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Pharmacology&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 18</span> | Independent citation: 11 | Self citation: 7 | Unknown citation: 0 | Number of citations in WoS: 16 | Number of citations in Scopus:&nbsp;16 | WoS/Scopus assigned:&nbsp;18 | Number of citations with DOI:&nbsp;17 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2498353&sort=publishedYear,desc&sort=title"> Number of cited publications: 7 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 2498353</span> | <span class="status-data status-VALIDATED"> Validated </span> <span class="oldId">Old id: 2498353</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Last Modified: 2025.01.02. 16:22 András Balázs (MTMT Központ, admin) </div> <div class="lockedBy">Centrally managed 2024.10.17. 18:47 Gusztáv Ladányi (MTMT API user, admin) András Balázs (MTMT Központ, admin) </div> </div></div>