https://m2.mtmt.hu/ eng 2026-05-01 18:55 JournalArticle 2483302 ADMIN_APPROVED true Funding Agency and Grant Number: Hungarian Scientific Research FundsOrszagos Tudomanyos Kutatasi Alapprogramok (OTKA) [NK78012]; European UnionEuropean Commission [TAMOP 4.2.1./B-09/KMR-2010-0003]; European Social FundEuropean Social Fund (ESF) [TAMOP 4.2.1./B-09/KMR-2010-0003]; Hungarian Academy of SciencesHungarian Academy of Sciences [F01/031] Funding text: This work was supported by a grant from the Hungarian Scientific Research Funds (NK78012) provided to M.S. The European Union and the European Social Fund have provided financial support to this project under grant agreement no. TAMOP 4.2.1./B-09/KMR-2010-0003. T.F. was supported by the Hungarian Academy of Sciences (F01/031). We address special thanks to Helmut Kramer for the indicated antibodies, stocks, and constructs. We are thankful to Janos Elek for the colocalization analysis script in Matlab software. 0 2017-09-13T12:57:46.000+0000 false 2483302 2026-04-29T10:53:22.731+0000 2018-10-11T07:23:46.460+0000 2013-12-23T09:51:06.000+0000 true 10020030 Faragó Tamás /api/author/10020030 Author true 10020030 2021-10-12T12:35:45.423+0000 2021-10-12T12:35:45.423+0000 2017-09-13T12:57:46.000+0000 true 10019782 Csámer Iván /api/admin/10019782 Admin true 10019782 Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true Admin 10080085 /api/admin/10080085 Fölkerné Csernyik Rita true true 2024-10-17T16:48:31.101+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Szatmari, Z Rab11 facilitates crosstalk between autophagy and endosomal pathway through regulation of Hook localization. true true /api/journal/3249 REVIEWED true false 3249 false 3249 true 1059-1524 1939-4586 Journal FOREIGN 25 4 522 531 522 10 2014 During autophagy, double-membrane autophagosomes deliver sequestered cytoplasmic content to late endosomes and lysosomes for degradation. The molecular mechanism of autophagosome maturation is still poorly characterized. The small GTPase Rab11 regulates endosomal traffic, and is thought to function at the level of recycling endosomes. Here we show that loss of Rab11 leads to accumulation of autophagosomes and late endosomes in Drosophila melanogaster. Rab11 translocates from recycling endosomes to autophagosomes in response to autophagy induction, and physically interacts with Hook, a negative regulator of endosome maturation. Hook anchors endosomes to microtubules, and we show that Rab11 facilitates the fusion of endosomes and autophagosomes by removing Hook from mature late endosomes and inhibiting its homodimerization. Thus, induction of autophagy appears to promote autophagic flux by increased convergence with the endosomal pathway. 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/api/classificationexternal/1307 true 1307 true Q1 DIRECT true true /api/publication/2483302 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10020058"><a href="/gui2/?type=authors&mode=browse&sel=10020058" target="_blank">Szatmari Z ✉ (<span class="authorship-author-name">Szatmári Zsuzsanna</span> <span class="authorAux-mtmt"> biológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd University">ELTE</span>/<span title="Faculty of Science">ELU FoS</span>/<span title="Institute of Biology">Bio_I</span>/Department of Anatomy, Cell and Developmental Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020459"><a href="/gui2/?type=authors&mode=browse&sel=10020459" target="_blank">Kis V (<span class="authorship-author-name">Kis Viktor</span> <span class="authorAux-mtmt"> Sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd University">ELTE</span>/<span title="Faculty of Science">ELU FoS</span>/<span title="Institute of Biology">Bio_I</span>/Department of Anatomy, Cell and Developmental Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011058"><a href="/gui2/?type=authors&mode=browse&sel=10011058" target="_blank">Lippai M (<span class="authorship-author-name">Lippai Mónika</span> <span class="authorAux-mtmt"> Molekuláris genetika</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd University">ELTE</span>/<span title="Faculty of Science">ELU FoS</span>/<span title="Institute of Biology">Bio_I</span>/Department of Anatomy, Cell and Developmental Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040519"><a href="/gui2/?type=authors&mode=browse&sel=10040519" target="_blank">Hegedus K (<span class="authorship-author-name">Hegedűs Krisztina</span> <span class="authorAux-mtmt"> sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd University">ELTE</span>/<span title="Faculty of Science">ELU FoS</span>/<span title="Institute of Biology">Bio_I</span>/Department of Anatomy, Cell and Developmental Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020030"><a href="/gui2/?type=authors&mode=browse&sel=10020030" target="_blank">Farago T (<span class="authorship-author-name">Faragó Tamás</span> <span class="authorAux-mtmt"> Biológia, etológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd University">ELTE</span>/<span title="Faculty of Science">ELU FoS</span>/<span title="Institute of Biology">Bio_I</span>/MTA-ELTE Comparative Ethology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020615"><a href="/gui2/?type=authors&mode=browse&sel=10020615" target="_blank">Lorincz P (<span class="authorship-author-name">Lőrincz Péter</span> <span class="authorAux-mtmt"> Sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd University">ELTE</span>/<span title="Faculty of Science">ELU FoS</span>/<span title="Institute of Biology">Bio_I</span>/Department of Anatomy, Cell and Developmental Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tanaka T </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000590"><a href="/gui2/?type=authors&mode=browse&sel=10000590" target="_blank">Juhasz G (<span class="authorship-author-name">Juhász Gábor</span> <span class="authorAux-mtmt"> Sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd University">ELTE</span>/<span title="Faculty of Science">ELU FoS</span>/<span title="Institute of Biology">Bio_I</span>/Department of Anatomy, Cell and Developmental Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009420"><a href="/gui2/?type=authors&mode=browse&sel=10009420" target="_blank">Sass M (<span class="authorship-author-name">Sass Miklós</span> <span class="authorAux-mtmt"> Biológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd University">ELTE</span>/<span title="Faculty of Science">ELU FoS</span>/<span title="Institute of Biology">Bio_I</span>/Department of Anatomy, Cell and Developmental Biology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2483302" target="_blank">Rab11 facilitates crosstalk between autophagy and endosomal pathway through regulation of Hook localization.</a></div> <div> <span class="journal-title">MOLECULAR BIOLOGY OF THE CELL</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1059-1524">1059-1524</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1939-4586">1939-4586</a>)</span>: <span class="journal-volume">25</span> <span class="journal-issue">4</span> <span class="page"> pp 522-531 </span> <span class="year">(2014)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1091/mbc.E13-10-0574" target="_blank" href="https://doi.org/10.1091/mbc.E13-10-0574"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="9869" target="_blank" href="http://real.mtak.hu/9869"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000339628700010" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000339628700010"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" 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119 | Self citation: 8 | Unknown citation: 0 | Number of citations in WoS: 103 | Number of citations in Scopus:&nbsp;109 | WoS/Scopus assigned:&nbsp;113 | Number of citations with DOI:&nbsp;115 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2483302&sort=publishedYear,desc&sort=title"> Number of cited publications: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 2483302</span> | <span class="status-data status-ADMIN_APPROVED"> Admin approved </span> <span class="oldId">Old id: 2483302</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="funder"> (F01/031) Funder: MTA Lendület </div> <div class="lastModified">Last Modified: 2018.10.11. 09:23 import WoS (admin) </div> <div class="lockedBy">Centrally managed 2024.10.17. 18:48 Gusztáv Ladányi (MTMT API user, admin) Rita Fölkerné Csernyik (MTMT ellenőrzés admin5) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Funding Agency and Grant Number: Hungarian Scientific Research FundsOrszagos Tudomanyos Kutatasi Alapprogramok (OTKA) [NK78012]; European UnionEuropean Commission [TAMOP 4.2.1./B-09/KMR-2010-0003]; European Social FundEuropean Social Fund (ESF) [TAMOP 4.2.1./B-09/KMR-2010-0003]; Hungarian Academy of SciencesHungarian Academy of Sciences [F01/031] Funding text: This work was supporte...</pre> </div></div>