{ "labelLang" : "hun", "responseDate" : "2024-03-29 13:32", "content" : { "otype" : "JournalArticle", "mtid" : 2482465, "status" : "APPROVED", "published" : true, "comment" : "Megjegyzés-24539738\nSU 1\nMegjegyzés-24469911\nSU 1\nMegjegyzés-24442314\nSU 1\nBayer Technology Services GmbH, 51368 Leverkusen, Germany \n Department of Molecular Biology, University of Salzburg, Salzburg, Austria \n Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary \n Catalan Institute of Nanotechnology (ICN), Campus UAB, Edifici CIN2, Bellaterra, Barcelona, Spain \n Cited By :19 \n Export Date: 24 July 2019 \n Correspondence Address: Izak-Nau, E.; Bayer Technology Services GmbH, 51368 Leverkusen, Germany; email: izak.e@hotmail.com \n Chemicals/CAS: lactate dehydrogenase, 9001-60-9; povidone, 9003-39-8; silicon dioxide, 10279-57-9, 14464-46-1, 14808-60-7, 15468-32-3, 60676-86-0, 7631-86-9; Fluorescent Dyes; Silicon Dioxide \n Funding details: PITN-GA-2010-264506 \n Funding details: Seventh Framework Programme \n Funding text 1: The authors report no conflict of interest. The authors alone are responsible for the content and writing of this article. This study was supported by the EU seventh framework program, Marie Curie Actions, Network for Initial Training NanoTOES (PITN-GA-2010-264506), www.nanotoes.eu.\nBayer Technology Services GmbH, 51368 Leverkusen, Germany \n Department of Molecular Biology, University of Salzburg, Salzburg, Austria \n Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary \n Catalan Institute of Nanotechnology (ICN), Campus UAB, Edifici CIN2, Bellaterra, Barcelona, Spain \n Cited By :19 \n Export Date: 27 August 2019 \n Correspondence Address: Izak-Nau, E.; Bayer Technology Services GmbH, 51368 Leverkusen, Germany; email: izak.e@hotmail.com \n Chemicals/CAS: lactate dehydrogenase, 9001-60-9; povidone, 9003-39-8; silicon dioxide, 10279-57-9, 14464-46-1, 14808-60-7, 15468-32-3, 60676-86-0, 7631-86-9; Fluorescent Dyes; Silicon Dioxide \n Funding details: PITN-GA-2010-264506 \n Funding details: Seventh Framework Programme \n Funding text 1: The authors report no conflict of interest. The authors alone are responsible for the content and writing of this article. This study was supported by the EU seventh framework program, Marie Curie Actions, Network for Initial Training NanoTOES (PITN-GA-2010-264506), www.nanotoes.eu.\nBayer Technology Services GmbH, 51368 Leverkusen, Germany \n Department of Molecular Biology, University of Salzburg, Salzburg, Austria \n Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary \n Catalan Institute of Nanotechnology (ICN), Campus UAB, Edifici CIN2, Bellaterra, Barcelona, Spain \n Cited By :21 \n Export Date: 24 May 2020 \n Correspondence Address: Izak-Nau, E.; Bayer Technology Services GmbH, 51368 Leverkusen, Germany; email: izak.e@hotmail.com \n Chemicals/CAS: lactate dehydrogenase, 9001-60-9; povidone, 9003-39-8; silicon dioxide, 10279-57-9, 14464-46-1, 14808-60-7, 15468-32-3, 60676-86-0, 7631-86-9; Fluorescent Dyes; Silicon Dioxide \n Funding details: PITN-GA-2010-264506 \n Funding text 1: The authors report no conflict of interest. The authors alone are responsible for the content and writing of this article. This study was supported by the EU seventh framework program, Marie Curie Actions, Network for Initial Training NanoTOES (PITN-GA-2010-264506), www.nanotoes.eu.\nBayer Technology Services GmbH, 51368 Leverkusen, Germany \n Department of Molecular Biology, University of Salzburg, Salzburg, Austria \n Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary \n Catalan Institute of Nanotechnology (ICN), Campus UAB, Edifici CIN2, Bellaterra, Barcelona, Spain \n Cited By :21 \n Export Date: 29 May 2020 \n Correspondence Address: Izak-Nau, E.; Bayer Technology Services GmbH, 51368 Leverkusen, Germany; email: izak.e@hotmail.com \n Chemicals/CAS: lactate dehydrogenase, 9001-60-9; povidone, 9003-39-8; silicon dioxide, 10279-57-9, 14464-46-1, 14808-60-7, 15468-32-3, 60676-86-0, 7631-86-9; Fluorescent Dyes; Silicon Dioxide \n Funding details: PITN-GA-2010-264506 \n Funding text 1: The authors report no conflict of interest. The authors alone are responsible for the content and writing of this article. This study was supported by the EU seventh framework program, Marie Curie Actions, Network for Initial Training NanoTOES (PITN-GA-2010-264506), www.nanotoes.eu.\nBayer Technology Services GmbH, 51368 Leverkusen, Germany \n Department of Molecular Biology, University of Salzburg, Salzburg, Austria \n Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary \n Catalan Institute of Nanotechnology (ICN), Campus UAB, Edifici CIN2, Bellaterra, Barcelona, Spain \n Cited By :21 \n Export Date: 2 June 2020 \n Correspondence Address: Izak-Nau, E.; Bayer Technology Services GmbH, 51368 Leverkusen, Germany; email: izak.e@hotmail.com \n Chemicals/CAS: lactate dehydrogenase, 9001-60-9; povidone, 9003-39-8; silicon dioxide, 10279-57-9, 14464-46-1, 14808-60-7, 15468-32-3, 60676-86-0, 7631-86-9; Fluorescent Dyes; Silicon Dioxide \n Funding details: PITN-GA-2010-264506 \n Funding text 1: The authors report no conflict of interest. The authors alone are responsible for the content and writing of this article. This study was supported by the EU seventh framework program, Marie Curie Actions, Network for Initial Training NanoTOES (PITN-GA-2010-264506), www.nanotoes.eu.\nBayer Technology Services GmbH, 51368 Leverkusen, Germany \n Department of Molecular Biology, University of Salzburg, Salzburg, Austria \n Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary \n Catalan Institute of Nanotechnology (ICN), Campus UAB, Edifici CIN2, Bellaterra, Barcelona, Spain \n Cited By :24 \n Export Date: 24 March 2021 \n Correspondence Address: Izak-Nau, E.; Bayer Technology Services GmbH, 51368 Leverkusen, Germany; email: izak.e@hotmail.com \n Chemicals/CAS: lactate dehydrogenase, 9001-60-9; povidone, 9003-39-8; silicon dioxide, 10279-57-9, 14464-46-1, 14808-60-7, 15468-32-3, 60676-86-0, 7631-86-9; Fluorescent Dyes; Silicon Dioxide \n Funding details: PITN-GA-2010-264506 \n Funding details: Seventh Framework Programme, FP7, 264506 \n Funding text 1: The authors report no conflict of interest. The authors alone are responsible for the content and writing of this article. This study was supported by the EU seventh framework program, Marie Curie Actions, Network for Initial Training NanoTOES (PITN-GA-2010-264506), www.nanotoes.eu.\nBayer Technology Services GmbH, 51368 Leverkusen, Germany \n Department of Molecular Biology, University of Salzburg, Salzburg, Austria \n Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary \n Catalan Institute of Nanotechnology (ICN), Campus UAB, Edifici CIN2, Bellaterra, Barcelona, Spain \n Cited By :24 \n Export Date: 21 April 2021 \n Correspondence Address: Izak-Nau, E.; Bayer Technology Services GmbH, 51368 Leverkusen, Germany; email: izak.e@hotmail.com \n Chemicals/CAS: lactate dehydrogenase, 9001-60-9; povidone, 9003-39-8; silicon dioxide, 10279-57-9, 14464-46-1, 14808-60-7, 15468-32-3, 60676-86-0, 7631-86-9; Fluorescent Dyes; Silicon Dioxide \n Funding details: PITN-GA-2010-264506 \n Funding details: Seventh Framework Programme, FP7, 264506 \n Funding text 1: The authors report no conflict of interest. The authors alone are responsible for the content and writing of this article. 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Despite the potential benefits, there is a concern that exposure to certain types of SiO2 NPs may lead to adverse health effects. As some NPs can cross the blood--brain barrier and may, in addition, reach the central nervous system through the nasal epithelium, this study addresses the responses of different neural tissue-type cells including neural stem cells, neurons, astrocytes and microglia cells to increasing doses of 50 nm fluorescent core/shell SiO2 NPs with different [-NH2, -SH and polyvinylpyrrolidone (PVP)] surface chemistry. The SiO2 NPs are characterized using a variety of physicochemical methods. Assays of cytotoxicity and cellular metabolism indicates that SiO2 NPs cause cell death only at high particle doses, except PVP-coated SiO2 NPs which do not harm cells even at very high concentrations. All SiO2 NPs, except those coated with PVP, form large agglomerates in physiological solutions and adsorb a variety of proteins. Except PVP-NPs, all SiO2 NPs adhere strongly to cell surfaces, but internalization differs depending on neural cell type. Neural stem cells and astrocytes internalize plain SiO2, SiO2-NH2 and SiO2-SH NPs, while neurons do not take up any NPs. 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