https://m2.mtmt.hu/ hun 2026-04-30 11:02 JournalArticle 2480038 ADMIN_APPROVED true 0 2018-03-07T09:28:00.000+0000 false 2480038 2026-04-29T10:45:02.820+0000 2024-09-23T11:39:52.683+0000 2013-12-17T11:23:38.000+0000 true 220 Hangya Balázs /api/author/220 Author true 220 2025-04-10T10:06:41.584+0000 2025-04-10T10:06:41.584+0000 2024-09-20T09:09:23.755+0000 true 10003133 Boros Annamária /api/admin/10003133 Admin true 10003133 Admin 10003133 /api/admin/10003133 Boros Annamária true 10003133 true 2024-09-13T11:56:08.998+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Pi, HJ Cortical interneurons that specialize in disinhibitory control. true true /api/journal/3308 REVIEWED true false 3308 false 3308 true 0028-0836 1476-4687 Journal FOREIGN 503 7477 521 524 521 4 2013 In the mammalian cerebral cortex the diversity of interneuronal subtypes underlies a division of labour subserving distinct modes of inhibitory control. A unique mode of inhibitory control may be provided by inhibitory neurons that specifically suppress the firing of other inhibitory neurons. Such disinhibition could lead to the selective amplification of local processing and serve the important computational functions of gating and gain modulation. Although several interneuron populations are known to target other interneurons to varying degrees, little is known about interneurons specializing in disinhibition and their in vivo function. Here we show that a class of interneurons that express vasoactive intestinal polypeptide (VIP) mediates disinhibitory control in multiple areas of neocortex and is recruited by reinforcement signals. By combining optogenetic activation with single-cell recordings, we examined the functional role of VIP interneurons in awake mice, and investigated the underlying circuit mechanisms in vitro in auditory and medial prefrontal cortices. We identified a basic disinhibitory circuit module in which activation of VIP interneurons transiently suppresses primarily somatostatin- and a fraction of parvalbumin-expressing inhibitory interneurons that specialize in the control of the input and output of principal cells, respectively. During the performance of an auditory discrimination task, reinforcement signals (reward and punishment) strongly and uniformly activated VIP neurons in auditory cortex, and in turn VIP recruitment increased the gain of a functional subpopulation of principal neurons. These results reveal a specific cell type and microcircuit underlying disinhibitory control in cortex and demonstrate that it is activated under specific behavioural conditions. Funding 1991369 /api/funding/1991369 false true true true 2013 722114 true true true false true false NONE 2026-04-29 false true 10030885 Bálint Eszter /api/admin/10030885 Admin true 10030885 838 0 838 812 20 838 836 808 784 838 838 812 812 812 26 0 838 812 838 812 0 10 10 Folyóiratcikk Journal Article 24 824 Könyvrészlet Chapter in Book 25 14 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2013 0 3 3 3 3 2014 0 44 39 44 39 2015 0 74 71 74 71 2016 0 72 70 72 70 2017 0 75 73 75 73 2018 0 82 79 82 79 2019 0 85 83 85 83 2020 0 75 71 75 71 2021 0 75 75 75 75 2022 0 81 78 81 78 2023 0 61 60 61 60 2024 0 40 39 40 39 2025 0 69 69 69 69 2026 0 2 2 2 2 D1 A false false false false 2014-03-17T11:25:21.000+0000 2013-12-17T11:25:21.000+0000 Agykéreg Kutatócsoport (KOKI / CHO) 1 14 1 6 0 true 10003133 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 4803531 /api/authorship/4803531 1 0.16666667 true false Pi HJ true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 19132431 true PersonAuthorship 4803532 /api/authorship/4803532 2 0.16666667 false false Author 220 /api/author/220 Hangya Balázs true 220 true Hangya B true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 19132430 true PersonAuthorship 4803533 /api/authorship/4803533 3 0.16666667 false false Kvitsiani D true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 19132429 true PersonAuthorship 4803534 /api/authorship/4803534 4 0.16666667 false false Sanders JI true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 19132428 true PersonAuthorship 4803535 /api/authorship/4803535 5 0.16666667 false false Huang ZJ true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 19132427 true PersonAuthorship 4803536 /api/authorship/4803536 6 0.167 false true true Kepecs A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 19132426 true PublicationIdentifier 747295 /api/publicationidentifier/747295 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true false IDENTICAL 10.1038/nature12676 https://doi.org/10.1038/nature12676 false 563649 true PublicationIdentifier 747293 /api/publicationidentifier/747293 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000327464200042 https://www.webofscience.com/wos/woscc/full-record/000327464200042 false 613797 true PublicationIdentifier 747294 /api/publicationidentifier/747294 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 84888639169 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84888639169 false 1736147 true PublicationIdentifier 747296 /api/publicationidentifier/747296 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false IDENTICAL 24097352 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=24097352&dopt=Abstract false 563650 true Classification 10799 /api/classification/10799 true true MtaRating 11435135 /api/mtarating/11435135 RatingType 10031 /api/ratingtype/10031 X. 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Földtudományok Osztálya HAS Section of Earth Sciences (X.) true 70 true true true A true true MtaRating 11551101 /api/mtarating/11551101 RatingType 10010 /api/ratingtype/10010 RegTB Institute 14100 /api/institute/14100 0 false true false Regionális Tudományok Bizottsága Committee on Regional Studies true 14100 true true true A nemzetközi false true MtaRating 519065 /api/mtarating/519065 RatingType 10007 /api/ratingtype/10007 SZTB Institute 14102 /api/institute/14102 0 false true false Szociológiai Tudományos Bizottság Committee on Sociology true 14102 true true true A nemzetközi true 19065 true SjrRating 11150537 /api/sjrrating/11150537 1 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1000 /api/classificationexternal/1000 true 1000 true D1 DIRECT true true /api/publication/2480038 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Pi HJ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="220"><a href="/gui2/?type=authors&mode=browse&sel=220" target="_blank">Hangya B (<span class="authorship-author-name">Hangya Balázs</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">MTAKOKI</span>/<span title="Celluláris és Hálózat-neurobiológiai Osztály">CHO</span>/Agykéreg Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kvitsiani D </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sanders JI </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Huang ZJ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kepecs A ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2480038" target="_blank">Cortical interneurons that specialize in disinhibitory control.</a></div> <div> <span class="journal-title">NATURE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0028-0836">0028-0836</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1476-4687">1476-4687</a>)</span>: <span class="journal-volume">503</span> <span class="journal-issue">7477</span> <span class="page"> pp 521-524 </span> <span class="year">(2013)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1038/nature12676" target="_blank" href="https://doi.org/10.1038/nature12676"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000327464200042" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000327464200042"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84888639169" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84888639169"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="24097352" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=24097352&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Multidisciplinary&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">X. 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