https://m2.mtmt.hu/ hun 2026-05-02 12:56 JournalArticle 2445273 VALIDATED true 0 2015-06-01T22:20:58.000+0000 false 2445273 2026-01-27T18:58:37.942+0000 2022-07-18T16:31:28.972+0000 2013-10-29T13:43:12.000+0000 true 10020065 Hosszúfalusi Nóra /api/author/10020065 Author true 10020065 2023-02-06T17:40:15.346+0000 2014-05-06T06:22:46.000+0000 true 10025654 Mátyás Melinda /api/admin/10025654 Admin true 10025654 2014-05-06T06:22:46.000+0000 true 10025654 Mátyás Melinda /api/admin/10025654 Admin true 10025654 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Barker, A Age-dependent decline of beta cell function in type 1 diabetes after diagnosis: a multi-centre longitudinal study. true true /api/journal/28050 REVIEWED true false 28050 false 28050 true 1462-8902 1463-1326 Journal FOREIGN 16 3 262 267 262 6 2014 AIMS: C-peptide secretion is currently the only available clinical biomarker to measure residual beta-cell function in type 1 diabetes. However, the natural history of C-peptide decline after diagnosis can vary considerably dependent upon several variables. We investigated the shape of C-peptide decline over time from type 1 diabetes onset in relation to age at diagnosis, HbA1c levels and insulin dose. MATERIALS AND METHODS: We analysed data from 3,929 type 1 diabetes patients recruited from 7 European centres representing all age groups at disease onset (childhood, adolescence, adulthood). The influence of the age at onset on beta-cell function was investigated in a longitudinal analysis at diagnosis and up to 5-years follow-up. RESULTS: Fasting C-peptide data at diagnosis were available in 3,668 patients stratified according to age at diagnosis in four groups (<5 yrs, n=344; >5 yrs< 10 yrs, n=668; >10 yrs<18yrs, n=991; >18 yrs, n=1655). Fasting C-peptide levels were positively correlated with age (p<0.001); the subsequent decline in fasting C-peptide over time was log-linear with a greater decline rate in younger age groups (p<0.0001). CONCLUSIONS: This study reveals a positive correlation between age at diagnosis of type 1 diabetes and fasting C-peptide with a more rapid decline of beta-cell function in the very young patients. These data can inform the design of clinical trials using C-peptide values as an end-point for the effect of a given treatment. 2013 (Farkas Henriette (klinikai immunológus, a...); 2013.10.29. 14:43:06) true true true false true false NONE 2026-01-27 false 93 0 93 74 1 93 90 87 87 93 93 74 74 74 19 0 93 74 93 74 0 1 1 Folyóiratcikk Journal Article 24 92 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2014 0 2 1 2 1 2015 0 9 7 9 7 2016 0 8 6 8 6 2017 0 6 6 6 6 2018 0 11 7 11 7 2019 0 8 7 8 7 2020 0 9 9 9 9 2021 0 10 10 10 10 2022 0 11 8 11 8 2023 0 4 4 4 4 2024 0 8 5 8 5 2025 0 7 4 7 4 D1 false 10020065 false false false 2014-05-06T06:22:46.000+0000 2013-10-29T13:50:51.000+0000 III. 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Belgyógyászati Klinika (SE / AOK / K) 1 7 1 16 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 4512098 /api/authorship/4512098 1 0.0625 true false Barker A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 18953518 true PersonAuthorship 4512099 /api/authorship/4512099 2 0.0625 false false Lauria A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 18953517 true PersonAuthorship 4512100 /api/authorship/4512100 3 0.0625 false false Schloot N true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 18953516 true PersonAuthorship 4512101 /api/authorship/4512101 4 0.0625 false false Author 10020065 /api/author/10020065 Hosszúfalusi Nóra true 10020065 true Hosszufalusi N true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 18953515 true PersonAuthorship 4512102 /api/authorship/4512102 5 0.0625 false false Ludvigsson J true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 18953514 true PersonAuthorship 4512103 /api/authorship/4512103 6 0.0625 false false Mathieu C true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 18953513 true PersonAuthorship 4512104 /api/authorship/4512104 7 0.0625 false false Mauricio D true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 18953512 true PersonAuthorship 4512105 /api/authorship/4512105 8 0.0625 false false Nordwall M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 18953511 true PersonAuthorship 4512106 /api/authorship/4512106 9 0.0625 false false Van der Schueren B true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 18953510 true PersonAuthorship 4512107 /api/authorship/4512107 10 0.0625 false false Mandrup-Poulsen T true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 18953509 true PersonAuthorship 4512108 /api/authorship/4512108 11 0.0625 false false Scherbaum W true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 18953508 true PersonAuthorship 4512109 /api/authorship/4512109 12 0.0625 false false Weets I true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 18953507 true PersonAuthorship 4512110 /api/authorship/4512110 13 0.0625 false false Gorus F true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 18953506 true PersonAuthorship 4512111 /api/authorship/4512111 14 0.0625 false false Wareham N true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 18953505 true PersonAuthorship 4512112 /api/authorship/4512112 15 0.0625 false false Leslie R true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 18953504 true PersonAuthorship 4512113 /api/authorship/4512113 16 0.0625 false true Pozzilli P true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 18953503 true PublicationIdentifier 730105 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style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Barker A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lauria A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schloot N </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020065"><a href="/gui2/?type=authors&mode=browse&sel=10020065" target="_blank">Hosszufalusi N (<span class="authorship-author-name">Hosszúfalusi Nóra</span> <span class="authorAux-mtmt"> Belgyógyászat, Diabetológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/III. 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Belgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ludvigsson J </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mathieu C </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mauricio D </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Nordwall M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Van der Schueren B </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mandrup-Poulsen T </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Scherbaum W </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Weets I </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gorus F </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Wareham N </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Leslie R </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pozzilli P </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2445273" target="_blank">Age-dependent decline of beta cell function in type 1 diabetes after diagnosis: a multi-centre longitudinal study.</a></div> <div> <span class="journal-title">DIABETES OBESITY & METABOLISM</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1462-8902">1462-8902</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1463-1326">1463-1326</a>)</span>: <span class="journal-volume">16</span> <span class="journal-issue">3</span> <span class="page"> pp 262-267 </span> <span class="year">(2014)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1111/dom.12216" target="_blank" href="https://doi.org/10.1111/dom.12216"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000330564800009" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000330564800009"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="84893798821" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84893798821"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="24118704" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=24118704&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Endocrinology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Endocrinology, Diabetes and Metabolism&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Internal Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 93</span> | Független: 74 | Függő: 19 | Nem jelölt: 0 | WoS jelölt: 87 | Scopus jelölt:&nbsp;87 | WoS/Scopus jelölt:&nbsp;93 | DOI jelölt:&nbsp;90 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2445273&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 2445273</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> <span class="oldId">Régi azonosító: 2445273</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Utolsó módosítás: 2022.07.18. 18:31 Áts József (admin) </div> </div></div>