Kidney tissue engineering

Krane, LS; Aboushwareb, T; Atala, A

Angol nyelvű Tudományos Könyvfejezet (Könyvrészlet)
    End-stage renal disease (ESRD) is a devastating condition, which involves multiple organ systems in affected individuals and requires renal replacement therapy. Currently, the gold standard treatment for this condition is renal transplantation, which can restore complete kidney function. However, renal transplantation is limited by the critical shortage of transplant organs as well as complications that can result from chronic immunosuppressive therapy and graft failure. Physicians and scientists are now turning to the fields of tissue engineering and regenerative medicine to develop alternative treatment modalities for ESRD. The kidney is a complex organ containing multiple cell types and an intricate functional anatomy that renders it one of the most difficult to reconstruct. Developmental approaches to kidney regeneration that are based on the embryology of the kidney are being studied and have shown promise. In addition, recent advances in cell technologies, including the identification of putative renal progenitor cell populations, have allowed for the development of novel cell-based approaches for kidney tissue regeneration. Efforts to identify reliable cell sources, develop ideal growth environments and innovative differentiation factors, and discover synthetic and naturally derived materials for use as an ideal support structure for tissue regeneration are ongoing. However, numerous challenges must still be overcome in order to translate these techniques into clinically relevant therapies.
    Hivatkozás stílusok: IEEEACMAPAChicagoHarvardCSLMásolásNyomtatás
    2021-05-17 05:32