{ "labelLang" : "hun", "responseDate" : "2024-03-29 13:01", "content" : { "otype" : "JournalArticle", "mtid" : 24184153, "status" : "APPROVED", "published" : true, "unhandledTickets" : 0, "oldTimestamp" : "2015-03-24T16:19:00.000+0000", "deleted" : false, "oldId" : 14184153, "lastRefresh" : "2021-09-28T22:18:51.275+0000", "lastModified" : "2015-03-24T16:19:00.000+0000", "created" : "2014-09-12T13:17:40.000+0000", "creator" : { "otype" : "Author", "mtid" : 10011674, "link" : "/api/author/10011674", "label" : "Bánhegyi Gábor (Biokémia, molekuláris biológia)", "familyName" : "Bánhegyi", "givenName" : "Gábor", "published" : true, "oldId" : 10011674, "snippet" : true }, "lastDuplumOK" : "2019-02-11T02:08:41.816+0000", "lastDuplumSearch" : "2019-02-11T02:08:41.816+0000", "core" : false, "citation" : true, "publicationPending" : false, "type" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "category" : { "otype" : "Category", "mtid" : 1, "link" : "/api/category/1", "label" : "Tudományos", "published" : true, "oldId" : 1, "snippet" : true }, "languages" : [ { "otype" : "Language", "mtid" : 10002, "link" : "/api/language/10002", "label" : "Angol", "name" : "Angol", "nameEng" : "English", "published" : true, "oldId" : 2, "snippet" : true } ], "firstAuthor" : "Vilela, VR", "authorships" : [ { "otype" : "PersonAuthorship", "mtid" : 34337774, "link" : "/api/authorship/34337774", "label" : "Vilela, VR", "listPosition" : 1, "share" : 0.0, "first" : true, "last" : false, "familyName" : "Vilela", "givenName" : "VR", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 56051856, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 34337775, "link" : "/api/authorship/34337775", "label" : "De Oliveira, AL", "listPosition" : 2, "share" : 0.0, "first" : false, "last" : false, "familyName" : "De Oliveira", "givenName" : "AL", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 56051855, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 34337776, "link" : "/api/authorship/34337776", "label" : "Comar, JF", "listPosition" : 3, "share" : 0.0, "first" : false, "last" : false, "familyName" : "Comar", "givenName" : "JF", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 56051854, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 34337777, "link" : "/api/authorship/34337777", "label" : "Peralta, RM", "listPosition" : 4, "share" : 0.0, "first" : false, "last" : false, "familyName" : "Peralta", "givenName" : "RM", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 56051853, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 34337778, "link" : "/api/authorship/34337778", "label" : "Bracht, A", "listPosition" : 5, "share" : 0.0, "first" : false, "last" : true, "familyName" : "Bracht", "givenName" : "A", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 56051852, "snippet" : true } ], "title" : "Tadalafil inhibits the cAMP stimulated glucose output in the rat liver", "identifiers" : [ { "otype" : "PublicationIdentifier", "mtid" : 8130483, "link" : "/api/publicationidentifier/8130483", "label" : "DOI: 10.1016/j.cbi.2014.05.020", "source" : { "otype" : "PlainSource", "mtid" : 6, "link" : "/api/publicationsource/6", "label" : "DOI", "type" : { "otype" : "PublicationSourceType", "mtid" : 10001, "link" : "/api/publicationsourcetype/10001", "label" : "DOI", "mayHaveOa" : true, "published" : true, "snippet" : true }, "name" : "DOI", "nameEng" : "DOI", "linkPattern" : "https://doi.org/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 6, "snippet" : true }, "validState" : "NO", "idValue" : "10.1016/j.cbi.2014.05.020", "realUrl" : "https://doi.org/10.1016%2Fj.cbi.2014.05.020", "published" : false, "oldId" : 7400311, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 8130481, "link" : "/api/publicationidentifier/8130481", "label" : "WoS: 000345638300001", "source" : { "otype" : "PlainSource", "mtid" : 1, "link" : "/api/publicationsource/1", "label" : "WoS", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "WoS", "nameEng" : "WoS", "linkPattern" : "http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=CustomerName&SrcApp=CustomerName&DestLinkType=FullRecord&KeyUT=@@@&DestApp=WOS", "publiclyVisible" : true, "published" : true, "oldId" : 1, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "000345638300001", "realUrl" : "http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=CustomerName&SrcApp=CustomerName&DestLinkType=FullRecord&KeyUT=000345638300001&DestApp=WOS", "published" : false, "oldId" : 14357414, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 8130482, "link" : "/api/publicationidentifier/8130482", "label" : "Scopus: 84903193307", "source" : { "otype" : "PlainSource", "mtid" : 3, "link" : "/api/publicationsource/3", "label" : "Scopus", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "Scopus", "linkPattern" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@", "publiclyVisible" : true, "published" : true, "oldId" : 3, "snippet" : true }, "validState" : "NO", "idValue" : "84903193307", "realUrl" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84903193307", "published" : false, "oldId" : 7400310, "snippet" : true } ], "journal" : { "otype" : "Journal", "mtid" : 995, "link" : "/api/journal/995", "label" : "CHEMICO-BIOLOGICAL INTERACTIONS 0009-2797", "pIssn" : "0009-2797", "reviewType" : "REVIEWED", "noIF" : false, "sciIndexed" : true, "scopusIndexed" : true, "lang" : "FOREIGN", "hungarian" : false, "published" : true, "oldId" : 995, "snippet" : true }, "volume" : "220", "firstPage" : "1", "lastPage" : "11", "firstPageOrInternalIdForSort" : "1", "pageLength" : 11, "publishedYear" : 2014, "digital" : null, "printed" : null, "sourceYear" : 2014, "packet" : "(Bánhegyi Gábor (Biokémia, molekuláris b...); 2014.09.12. 15:17:35)", "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : false, "conferencePublication" : null, "nationalOrigin" : null, "missingAuthor" : false, "oaType" : "NONE", "oaCheckDate" : "2021-09-29", "oaFree" : false, "citationCount" : 0, "citationCountUnpublished" : 0, "citationCountWoOther" : 0, "independentCitCountWoOther" : 0, "doiCitationCount" : 0, "wosCitationCount" : 0, "scopusCitationCount" : 0, "independentCitationCount" : 0, "unhandledCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "unhandledCitingPubCount" : 0, "citedPubCount" : 1, "citedCount" : 1, "referenceList" : "Rosen, R.C., McKenna, K.E., PDE-5 inhibition and sexual response: Pharmacological mechanisms and clinical outcomes (2002) Annu. Rev. Sex Res., 13, pp. 36-88; \n\nDaugan, A., Grondin, P., Ruault, C., Le Monnier De Gouville, A.C., Coste, H., Kirilovsky, J., Hyafil, F., Labaudinière, R., The discovery of tadalafil: A novel and highly selective PDE5 inhibitor (2003) J. Med. Chem., 46, pp. 4525-4532; \n\nLaumann, E.O., Paik, A., Rosen, R.C., Sexual dysfunction in United States: Prevalence and predictors (1999) JAMA, 281, pp. 537-544; \n\nDoggrell, S., Do vardenafil and tadalafil have advantages over sildenafil in the treatment of erectile dysfunction? (2007) Int. J. Impot. Res., 19, pp. 281-295; \n\nRabindra, G., Erectile dysfunction (2010) InnovAiT, 3, pp. 44-47; \n\nRosen, R.C., Lane, R.M., Menza, M., Effects of SSRIs on sexual function: A critical review (1999) J. Clin. Psychopharmacol., 19, pp. 67-85; \n\nGratzke, C., Angulo, J., Chitaley, K., Dai, Y.T., Kim, N.N., Paick, J.S., Simonsen, U., Stief, C.G., Anatomy, physiology, and pathophysiology of erectile dysfunction (2010) J. Sex. Med., 7, pp. 445-475; \n\nWright, P.J., Comparison of phosphodiesterase type 5 (PDE5) inhibitors (2006) Int. J. Clin. Pract., 60, pp. 967-975; \n\nDmochowski, R., Roehrborn, C., Klise, S., Xu, L., Kaminetsky, J., Kraus, S., Urodynamic effects of once daily tadalafil in men with lower urinary tract symptoms secondary to clinical benign prostatic hyperplasia: A randomized, placebo controlled 12-week clinical trial (2010) J. Urol., 183, pp. 1092-1097; \n\nGaliè, N., Brundage, B.H., Ghofrani, H.A., Oudiz, R.J., Simonneau, G., Safdar, Z., Shapiro, S., Barst, R.J., Tadalafil therapy for pulmonary arterial hypertension (2009) Circulation, 119, pp. 2894-2903; \n\nSalloum, F.N., Chau, V.Q., Hoke, N.N., Abbate, A., Varma, A., Ockaili, R.A., Toldo, S., Kukreja, R.C., Phosphodiesterase-5 inhibitor, tadalafila, protects against myocardial ischemia/reperfusion through protein-kinase g-dependent generation of hydrogen sulfide (2009) Circulation, 120, pp. 31-36; \n\nSesti, C., Florio, V., Johnson, E.G., Kloner, R.A., The phosphodiesterase-5 inhibitor tadalafil reduces myocardial infarct size (2007) Int. J. Impot. Res., 19, pp. 55-61; \n\nTakimoto, E., Champion, H.C., Li, M., Belardi, D., Ren, S., Rodriguez, E.R., Bedja, D., Kass, K.A., Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy (2005) Nat. Med., 11, pp. 214-222; \n\nJansson, P.A., Murdolo, G., Sjögren, L., Nyström, B., Sjöstrand, M., Strindberg, L., Lönnroth, P., Tadalafil increases muscle capillary recruitment and forearm glucose uptake in women with type 2 diabetes (2010) Diabetologia, 53, pp. 2205-2208; \n\nHill, K.D., Eckhauser, A.W., Marney, A., Brown, N.J., Phosphodiesterase 5 inhibition improves β-cell function in metabolic syndrome (2009) Diabetes Care, 32, pp. 857-859; \n\nBischoff, E., Potency, selectivity, and consequences of nonselectivity of PDE inhibition (2004) Int. J. Impot. Res., 16, pp. 11-S14; \n\nBeavo, J.A., Cyclic nucleotide phosphodiesterases: Functional implications of multiple isoforms (1995) Physiol. Rev., 75, pp. 725-748; \n\nFrancis, S.H., Turko, I.V., Corbin, J.D., Cyclic nucleotide phospho-diesterases: Relating structure and function (2001) Prog. Nucleic Acid Res. Mol. Biol., 65, pp. 1-52; \n\nHouslay, M.D., Adams, D.R., PDE4 cAMP phosphodiesterases: Modular enzymes that orchestrate signaling cross-talk, desensitization and compartmentalization (2003) Biochem. J., 370, pp. 1-18; \n\nUckert, S., Hedlund, P., Andersson, K.E., Truss, M.C., Jonas, U., Stief, C.G., Update on phosphodiesterase (PDE) isoenzymes as pharmacologic targets in urology: Present and future (2006) Eur. Urol., 50, pp. 1194-1207; \n\nBruzziches, R., Greco, E.A., Pili, M., Francomano, D., Spera, G., Aversa, A., Redefining the role of long-acting phosphodiesterase inhibitor tadalafil in the treatment of diabetic erectile dysfunction (2008) Curr. Diabetes Rev., 4, pp. 24-30; \n\nAbdollahi, M., Chan, T.S., Subrahmanyam, V., O'Brien, P.J., Effects of phosphodiesterase 3,4,5 inhibitors on hepatocyte cAMP levels, glycogenolysis, gluconeogenesis, and susceptibility to a mitochondrial toxin (2003) Mol. Cell. Biochem., 252, pp. 205-211; \n\nHoseini, S., Esmaily, H., Mohammadirad, A., Abdollahi, M., Effects of sildenafil a phosphodiesterase 5 inhibitor on rat liver cell key enzymes of gluconeogenesis and glycogenolysis (2006) Int. J. Pharmacol., 2, pp. 280-285; \n\nConstantin, J., Suzuki-Kemmelmeyer, F., Yamamoto, N.S., Bracht, A., Production, uptake and metabolic effects of cAMP in the bivascularly perfused rat liver (1997) Biochem. Pharmacol., 54, pp. 1115-1125; \n\nVicentini, G.E., Lopez, C.H., Constantin, J., Bracht, A., Modeling the transformation of exogenously supplied [3H]cAMP in the perfused rat liver (2000) Res. Comm. Mol. Pathol. Pharmacol., 107, pp. 297-309; \n\nVicentini, G.E., Constantin, J., Lopez, C.H., Bracht, A., Transport of cyclic AMP and synthetic analogs in the perfused rat liver (2000) Biochem. Pharmacol., 59, pp. 1187-1201; \n\nBracht, A., Ishii-Iwamoto, E.L., Kelmer-Bracht, A.M., O estudo do metabolismo no fígado em perfusão (2003) Métodos de Laboratório em Bioquímica, pp. 275-289. , A. Bracht, E.L. Ishii-Iwamoto, Editora Manole São Paulo; \n\nScholz, R., Bücher, T., Hemoglobin-free perfusion of rat liver (1965) Control of Energy Metabolism, pp. 393-414. , B. Chance, R.W. Estabrook, J.R. Williamson, Academic Press New York; \n\nYunoos, M., Sankar, D.G., Kumar, B.P., Hameed, S., UV spectrophotometric method for the estimation of tadalafil in bulk and tablet dosage form (2010) E-J. Chem., 7, pp. 833-836; \n\nBergmeyer, H.U., (1974) Methods of Enzymatic Analysis, , Academic Press New York; \n\nBrown, B.L., Albano, J.D.M., Ekins, R.P., Sgherzi, A.M., Tampion, W., A simple and sensitive saturation assay method for the measurement of adenosine 3′:5′-cyclic monophosphate (1971) Biochem. J., 121, pp. 561-562; \n\nLowry, O.H., Rosebrough, N.J., Farr, A.C., Randall, R.J., Protein measurement with the Folin phenol reagent (1955) J. Biol. Chem., 193, pp. 265-275; \n\nKuwajima, M., Newgard, C.B., Foster, D.W., McGarry, J.D., The glucose phosphorylating capacity of liver as measured by three independent assays (1986) J. Biol. Chem., 261, pp. 8849-8853; \n\nMoore, L., Chen, T., Knapp, R., London, E.J., Energy-dependent calcium se-questration activity in rat liver microsomes (1975) J. Biol. Chem., 250, pp. 4562-4568; \n\nBygrave, F.L., Properties of energy-dependent calcium transport by rat liver microsomal fractions as revealed by initial-rate measurements (1978) Biochem. J., 170, pp. 87-91; \n\nConstantin, R.P., Constantin, J., Salgueiro-Pagadigorria, C.L., Ishii-Iwamoto, E.L., Bracht, A., Ono, M.K.C., Yamamoto, N.S., The actions of fisetin on glucose metabolism in the rat liver (2010) Chem. Biol. Interact., 28, pp. 149-158; \n\nKelmer-Bracht, A.M., Santos, C.P.B., Ishii-Iwamoto, E.L., Broetto-Biazon, A.C., Bracht, A., Kinetic properties of the glucose 6-phosphatase of the liver from arthritic rats (2003) Biochim. Biophys. Acta, 1638, pp. 50-56; \n\nFiske, C.H., Subbarow, Y., The colorimetric determination of phosphorus (1925) J. Biol. Chem., 66, pp. 375-400; \n\nBergmeyer, H.U., Gawehn, K., Grassi, M., (1974) Methods of Enzymatic Analysis, pp. 509-510. , Bergmeyer Verlag Chemie-Academic Press Weinheim-London; \n\nLohr, G.W., Waller, H.D., Glucose-6-phosphate dehydrogenase (1974) Methods of Enzymatic Analysis, pp. 636-643. , H.U. Berg-meyer, Verlag Chemie-Academic Press Weinheim-London; \n\nDeaciuc, I.V., Spitzer, J.A., Rat liver free cytosolic Ca2+ and glycogen phosphorylase in endotoxicosis and sepsis (1986) Am. J. Physiol. Regul. Integr. Comp. Physiol., 251, pp. 984-R995; \n\nPutney, Jr.J.W., Calcium pools in saponin-permeabilized guinea pig hepa-tocytes (1983) J. Biol. Chem., 258, pp. 15336-15345; \n\nLang, G., Michal, G., D-Glucose 6-phosphate and d-fructose 6-phosphate (1974) Methods of Enzymatic Analysis, pp. 1794-1801. , H.U. Bergmeyer, Verlag Chemie-Academic Press Weinheim-London; \n\nMorangoni, A.J., (2003) Enzyme Kinetics, A Modern Approach, , John Wiley & Sons Inc. Hobokenm - NJ; \n\nAcco, A., Comar, J.F., Bracht, A., Metabolic effects of propofol in the isolated perfused rat liver (2004) Basic Clin. Pharmacol. Toxicol., 95, pp. 166-174; \n\nSaling, S.C., Comar, J.F., Mito, M.S., Peralta, R.M., Bracht, A., Actions of juglone on energy metabolism in the rat liver (2011) Toxicol. Appl. Pharmacol., 257, pp. 319-327; \n\nGroen, A.K., Van Roermund, C.W.T., Vervoorn, R.C., Tager, J.M., Control of gluconeogenesis in rat liver cells (1986) Biochem. J., 237, pp. 379-389; \n\nStanton, R.C., Glucose-6-phosphate dehydrogenase, NADPH, and cell survival (2012) IUBMB Life, 64, pp. 362-369; \n\nDe La Iglesia, N., Veiga-Da-Cunha, M., Van Schaftingen, E., Guinovart, J.J., Ferrer, J.C., Glucokinase regulatory protein is essential for the proper subcellular localization of liver glucokinase (1999) FEBS Lett., 456, pp. 332-338; \n\nArden, C., Baltrusch, S., Agius, L., Glucokinase regulatory protein is associated with mitochondria in hepatocytes (2006) FEBS Lett., 580, pp. 2065-2070; \n\nScholz, R., Hansen, W., Thurman, R.G., Interaction of mixed-function oxidation with biosynthetic processes 1. Inhibition of gluconeogenesis by aminopyrine in perfused rat liver (1973) Eur. J. Biochem., 38, pp. 64-72; \n\nBánhegyi, G., Garzó, T., Antoni, F., Mandl, J., Glycogenolysis - And not gluconeogenesis - Is the source of UDP-glucuronic acid for glucuronidation (1988) Biochim. Biophys. Acta, 967, pp. 429-435; \n\nForgue, S.T., Patterson, B.E., Bedding, A.W., Payne, C.D., Phillips, D.L., Wrishko, R.E., Mitchell, M.L., Tadalafil pharmacokinetics in healthy subjects (2006) Br. J. Clin. Pharmacol., 61, pp. 280-288; \n\nKaravadi, T., Challa, B.R., Determination of tadalafil in rat plasma by liquid chromatography tandem mass spectrometry: Application to a pharmaco-kinetic study (2012) Der Pharmacia Lettre, 4, pp. 1401-1413; \n\nYamano, K., Yamamoto, K., Katashima, M., Kotaki, H., Takedomi, S., Matsuo, H., Ohtani, H., Iga, T., Prediction of midazolam - Cyp3a inhibitors interaction in the human liver from in vivo/in vitro absorption, distribution, and metabolism data (2001) Drug Metab. Dispos., 29, pp. 443-452; \n\nSabatini, S., Sgrò, P., Duranti, G., Ceci, R., Luigi, L.D., Tadalafil alters energy metabolism in C2C12 skeletal muscle cells (2001) Acta Biochim. Pol., 58, pp. 237-241", "hasCitationDuplums" : false, "userChangeableUntil" : "2014-12-11T14:18:06.000+0000", "publishDate" : "2014-09-12T13:18:06.000+0000", "directInstitutesForSort" : "", "ownerAuthorCount" : 2, "ownerInstituteCount" : 9, "directInstituteCount" : 0, "authorCount" : 5, "contributorCount" : 0, "hasQualityFactor" : false, "link" : "/api/publication/24184153", "label" : "Vilela VR et al. Tadalafil inhibits the cAMP stimulated glucose output in the rat liver. (2014) CHEMICO-BIOLOGICAL INTERACTIONS 0009-2797 220 1-11", "template" : "