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NN 308578540.\\n\n\\n Department of Microbiology and Clinical Immunology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 13, 10-719 Olsztyn, Poland \\n Department of Experimental and Clinical Pharmacology, Medical University of Lublin, Poland \\n Cited By :5 \\n Export Date: 5 November 2018 \\n CODEN: CJIMF \\n Correspondence Address: Małaczewska, J.; Department of Microbiology and Clinical Immunology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 13, 10-719 Olsztyn, Poland; email: j.malaczewska7@wp.pl \\n Chemicals/CAS: kynurenic acid, 492-27-3\n\\n Department of Microbiology and Clinical Immunology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 13, 10-719 Olsztyn, Poland \\n Department of Experimental and Clinical Pharmacology, Medical University of Lublin, Poland \\n Cited By :5 \\n Export Date: 6 November 2018 \\n CODEN: CJIMF \\n Correspondence Address: Małaczewska, J.; Department of Microbiology and Clinical Immunology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 13, 10-719 Olsztyn, Poland; email: j.malaczewska7@wp.pl \\n Chemicals/CAS: kynurenic acid, 492-27-3\n\\n Department of Microbiology and Clinical Immunology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 13, 10-719 Olsztyn, Poland \\n Department of Experimental and Clinical Pharmacology, Medical University of Lublin, Poland \\n Cited By :5 \\n Export Date: 13 November 2018 \\n CODEN: CJIMF \\n Correspondence Address: Małaczewska, J.; Department of Microbiology and Clinical Immunology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 13, 10-719 Olsztyn, Poland; email: j.malaczewska7@wp.pl \\n Chemicals/CAS: kynurenic acid, 492-27-3\nDepartment of Microbiology and Clinical Immunology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 13, 10-719 Olsztyn, Poland \n Department of Experimental and Clinical Pharmacology, Medical University of Lublin, Poland \n Cited By :5 \n Export Date: 27 December 2018 \n CODEN: CJIMF \n Correspondence Address: Małaczewska, J.; Department of Microbiology and Clinical Immunology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 13, 10-719 Olsztyn, Poland; email: j.malaczewska7@wp.pl \n Chemicals/CAS: kynurenic acid, 492-27-3\nDepartment of Microbiology and Clinical Immunology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 13, 10-719 Olsztyn, Poland \n Department of Experimental and Clinical Pharmacology, Medical University of Lublin, Poland \n Cited By :6 \n Export Date: 25 March 2020 \n CODEN: CJIMF \n Correspondence Address: Małaczewska, J.; Department of Microbiology and Clinical Immunology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 13, 10-719 Olsztyn, Poland; email: j.malaczewska7@wp.pl \n Chemicals/CAS: kynurenic acid, 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In inflammatory conditions, by affecting this receptor, KYNA inhibits the synthesis of pro-inflammatory cytokines and probably protects tissues from oxidative damage. However, we lack data regarding the effect of exogenous KYNA on the activity of immune cells in healthy individuals. The objective of this study has been to determine the influence of kynurenic acid administered to mice in different doses (2.5, 25 or 250 mg/l) and for different time periods (3, 7, 14, 28 days) in drinking water, on the activity of their peripheral blood leukocytes. The determinations comprised the proliferative activity of lymphocytes (MTT assay) and the phagocytic activity as well as the respiratory burst activity of granulocytes and monocytes (Phagotest, Phagoburst). It was only the lowest KYNA dose that influenced the mitogenic response of lymphocytes, namely by increasing the proliferation of T cells. The impact on the phagocytic activity was varied with KYNA dose and administration time. However, all the KYNA doses significantly lowered the activity of oxidative burst in phagocytes, which was probably associated with its antioxidant properties. 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