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Gen. Physiol., 103, pp. 153-179; \n\nAguilar-Bryan, L., Nichols, C., Wechsler, S., Clement, J., Boyd, A., González, G., Herrera-Sosa, H., Nelson, D., Cloning of the β cell high-affinity sulfonylurea receptor: A regulator of insulin secretion (1995) Science, 268, pp. 423-429; \n\nAkiyama, T., Ishida, J., Nakagawa, S., Ogawara, H., Watanabe, S., Itoh, N., Shibuya, M., Fukami, Y., Genistein, a specific inhibitor of tyrosine-specific protein kinases (1987) J. Biol. Chem., 262, pp. 5592-5595; \n\nAkiyama, T., Ogawara, H., Use and specificity of genistein as inhibitor of protein-tyrosine kinases (1991) Methods Enzymol., 201, pp. 362-370; \n\nAl-Nakkash, L., Cotton, C.U., Bovine pancreatic duct cells express cAMP- and Ca2+-activated apical membrane Cl- conductances (1997) Am. J. Physiol. 273 (Gastrointest. Liver Physiol. 36), 273, pp. G204-G216; \n\nAlper, S.L., The band 3-related anion exchanger (AE) gene family (1991) Annu. Rev. Physiol., 53, pp. 549-564; \n\nAlper, S.L., Kopito, R.R., Libresco, S.M., Lodish, H.F., Cloning and characterization of a murine band 3-related cDNA from kidney and from a lymphoid cell line (1988) J. Biol. Chem., 263, pp. 17092-17099; \n\nAlton, E.W., Manning, S.D., Schlatter, P.J., Geddes, D.M., Williams, A.J., Characterization of a Ca2+-dependent anion channel from sheep tracheal epithelium incorporated into planar bilayers (1991) J. Physiol. (Lond.), 443, pp. 137-159; \n\nAlton, E.W., Williams, A.J., Modification of gating of an airway epithelial chloride channel by 5-nitro-2-(3-phenylpropylamino)benzoic acid (NPPB) (1992) J. Membr. Biol., 128, pp. 141-151; \n\nAnderson, M.P., Berger, H.A., Rich, D.P., Gregory, R.J., Smith, A.E., Welsh, M.J., Nucleotide triphosphates are required to open the CFTR chloride channel (1991) Cell, 67, pp. 775-784; \n\nAnderson, M.P., Rich, D.P., Gregory, R.J., Smith, A.E., Welsh, M.J., Generation of cAMP-activated chloride currents by expression of CFTR (1991) Science, 251, pp. 679-682; \n\nAnderson, M.P., Welsh, M.J., Regulation by ATP and ADP of CFTR chloride channels that contain mutant nucleotide-binding domains (1992) Science, 251, pp. 1701-1704; \n\nPopulation variation of common cystic fibrosis mutations. The Cystic Fibrosis Genetic Analysis Consortium (1994) Hum. Mutat., 4, pp. 167-177; \n\nAshcroft, S.J.H., Ashcroft, F.M., The sulfonylurea receptor (1992) Biochim. Biophys. Acta, 1175, pp. 45-59; \n\nBachmann, K., Sarver, J.G., Chlorzoxazone as a single sample probe of hepatic CYP2E1 activity in humans (1996) Pharmacology, 52, pp. 169-177; \n\nBaker, A., Cotten, M., Delivery of bacterial artificial chromosomes into mammalian cells with psoralen-inactivated adenovirus carrier (1997) Nucleic Acids Res., 25, pp. 1950-1956; \n\nBakhramov, A., Fenech, C., Bolton, T.B., Chloride current activated by hypotonicity in cultured human astrocytoma cells (1995) Exp. Physiol., 80, pp. 373-389; \n\nBallatori, N., Simmons, T.W., Boyer, J.L., A volume-activated taurine channel in skate hepatocytes: Membrane polarity and role of intracellular ATP (1994) Am. J. Physiol. 267 (Gastrointest. Liver Physiol. 30), 267, pp. G285-G291; \n\nBallatori, N., Truong, A.T., Jackson, P.S., Strange, K., Boyer, J.L., ATP depletion and inactivation of an ATP-sensitive taurine channel by classic ion channel blockers (1995) Mol. Pharmacol., 48, pp. 472-476; \n\nBarford, D., Molecular mechanisms of the protein serine/threonine phosphatases (1996) Trends Biochem. Sci., 21, pp. 407-412; \n\nBarnes, S., Effect of genistein on in vitro and in vivo models of cancer (1995) J. Nutr., 125 (SUPPL.), pp. 777S-783S; \n\nBarnes, S., Peterson, T.G., Biochemical targets of the isoflavone genistein in tumor cell lines (1995) Proc. Soc. Exp. Biol. Med., 208, pp. 103-108; \n\nBarrett, K.E., Positive and negative regulation of chloride secretion in T84 cells (1993) Am. J. Physiol. 265 (Cell Physiol. 34), 265, pp. C859-C868; \n\nBarrett, K.E., Dharmsathaphorn, K., (1990) Mechanisms of Chloride Secretion in a Colonic Epithelial Cell Line, Edited by E. Lebenthal and M. Duffey, pp. 59-66. , New York: Raven; \n\nBarzilay, M., Cabantchik, Z.I., Anion transport in red blood cells. III. Sites and sidedness of inhibition by high-affinity reversible binding probes (1979) Membr. Biochem., 2, pp. 297-322; \n\nBarzilay, M., Ship, S., Cabantchik, Z.I., Anion transport in red blood cells. I. Chemical properties of anion recognition sites as revealed by structure-activity relationships of aromatic sulfonic acids (1979) Membr. Biochem., 2, pp. 227-254; \n\nBaukrowitz, T., Hwang, T.C., Nairn, A.C., Gadsby, D.C., Coupling of CFTR Cl- channel gating to an ATP hydrolysis cycle (1994) Neuron, 12, pp. 473-482; \n\nBeavo, J.A., Cyclic nucleotide phosphodiesterases: Functional implications of multiple isoforms (1995) Physiol. Rev., 75, pp. 725-748; \n\nBecq, F., Fanjul, M., Merten, M., Figarella, C., Hollande, E., Gola, M., Possible regulation of CFTR-chloride channels by membrane-bound phosphatases in pancreatic duct cells (1993) FEBS Lett., 327, pp. 337-342; \n\nBecq, F., Jensen, T.J., Chang, X., Savoia, A., Rommens, J.M., Tsui, L., Buchwald, M., Hanrahan, J.W., Phosphatase inhibitors activate normal and defective CFTR chloride channels (1994) Proc. Natl. Acad. Sci. Usa, 91, pp. 9160-9164; \n\nBecq, F., Verrier, B., Chang, X.B., Riordan, J.R., Hanrahan, J.W., cAMP- and Ca2+-independent activation of cystic fibrosis transmembrane conductance regulator channels by phenylimidazothiazole drugs (1996) J. Biol. Chem., 271, pp. 16171-16179; \n\nBeech, D.J., Zhang, H., Nakao, K., Bolton, T.B., Single channel and whole-cell K-currents evoked by levcromakalim in smooth muscle cells from the rabbit portal vein (1993) Br. J. Pharmacol., 110, pp. 583-590; \n\nBell, C.J., Gall, D.G., Wallace, J.L., Disruption of colonic electrolyte transport in experimental colitis (1995) Am. J. Physiol., 268, pp. G622-G630. , Gastrointest. Liver Physiol. 31; \n\nBenharouga, M., Fritsch, J., Banting, G., Edelman, A., Properties of chloride-conductive pathways in rat kidney cortical and outer-medulla brush-border membranes: inhibition by anti-(cystic fibrosis transmembrane regulator) Mabs (1997) Eur. J. Biochem., 246, pp. 367-372; \n\nBennets, H.W., Underwood, E.J., Shier, F.L., A specific breeding problem of sheep on subterranean clover pastures in western Australia (1946) Aust. Vet. J., 22, pp. 2-12; \n\nBerger, H.A., Travis, S.M., Welsh, M.J., Regulation of the cystic fibrosis transmembrane conductance regulator Cl- channel by specific protein kinases and protein phosphatases (1993) J. Biol. Chem., 268, pp. 2037-2047; \n\nBerger, H.A., Travis, S.M., Welsh, M.J., Fluoride stimulates cystic fibrosis transmembrane conductance regulator Cl- channel activity (1998) Am. J. Physiol. 274 (Lung Cell. Mol. Physiol. 18), 274, pp. L305-L312; \n\nBest, L., Sheader, E.A., Brown, P.D., A volume-activated anion conductance in insulin-secreting cells (1996) Pflügers Arch., 431, pp. 363-370; \n\nBijman, J., Dalemans, W., Kansen, M., Keuleman, J., Verbeek, E., Hoogeveen, A., De Jonge, H., Scholte, B., Low-conductance chloride channels in IEC-6 and CF nasal cells expressing CFTR (1993) Am. J. Physiol. 264 (Lung Cell Mol. Physiol. 8), 264, pp. L229-L235; \n\nBischof, G., Illek, B., Reenstra, W.W., Machen, T.E., Role for tyrosine kinases in carbachol-regulated Ca entry into colonic epithelial cells (1995) Am. J. Physiol. 268 (Cell Physiol. 37), 268, pp. C154-C161; \n\nBlack, J., Diazoxide and the treatment of hypoglycemia: An historical review (1968) Ann. NY Acad. Sci., 150, pp. 194-203; \n\nBoese, S.H., Wehner, F., Kinne, R.K., Taurine permeation through swelling-activated anion conductance in rat IMCD cells in primary culture (1996) Am. J. Physiol. 271 (Renal Fluid Electrolyte Physiol. 40), 271, pp. F498-F507; \n\nBotchkin, L.M., Matthews, G., Chloride current activated by swelling in retinal pigment epithelium cells (1993) Am. J. Physiol. 265 (Cell Physiol. 34), 265, pp. C1037-C1045; \n\nBoucher, R.C., Human airway ion transport (1994) Am. J. Respir. Crit. Care Med., 150, pp. 581-593; \n\nBradbury, N.A., Weixel, K., Jackson, T., Gangopadhyay, N., Devor, D.C., Expression and characterization of an epithelial Ca2+ activated K channel, hIK1 (1998) Pediatr. Pulmonol. Suppl., 17, p. 234; \n\nBradbury, R.B., White, D.E., The chemistry of subterranean clover. Part I. Isolation of formonetin and genistein (1951) J. Chem. Soc., 12, pp. 3447-3449; \n\nBraun, A.P., Schulman, H., Distinct voltage-dependent gating behaviours of a swelling-activated chloride current in human epithelial cells (1996) J. Physiol. (Lond.), 495, pp. 743-753; \n\nBrayden, D.J., Krouse, M.E., Law, T., Wine, J.J., Stilbenes stimulate T84 Cl secretion by elevating Ca2+ (1993) Am. J. Physiol. 264 (Gastrointest. Liver Physiol. 27), 264, pp. G325-G333; \n\nBridges, R.J., Worrell, R.T., Frizzell, R.A., Benos, D.J., Stilbene disulfonate blockade of colonic secretory Cl- channels in planar lipid bilayers (1989) Am. J. Physiol. 256 (Cell Physiol. 25), 256, pp. C902-C912; \n\nBrochiero, E., Banderali, U., Lindenthal, S., Raschi, C., Ehrenfeld, J., Basolateral membrane chloride permeability of A6 cells: Implication in cell volume regulation (1995) Eur. J. Physiol., 431, pp. 32-45; \n\nBrodin, B., Rytved, K.A., Nielsen, R., An increase in [Ca2+]i activates basolateral chloride channels and inhibits apical sodium channels in frog skin epithelium (1996) Pflügers Arch., 433, pp. 16-25; \n\nBrzuszczak, I.M., Zhao, J., Bell, C., Stiel, D., Fielding, I., Percy, J., Smith, R., O'Loughlin, E.V., Cyclic AMP-dependent anion secretion in human small and large intestine (1996) J. Gastroenterol. Hepatol., 11, pp. 804-810; \n\nBultmann, R., Starke, K., Blockade by 4,4′-diisothiocyanatostilbene-2,2′-disulphonate (DIDS) of P2X-purinoceptors in rat vas deferens (1994) Br. J. Pharmacol., 112, pp. 690-694; \n\nBultmann, R., Starke, K., Reactive red 2: A P2y-selective purinoceptor antagonist and an inhibitor of ecto-nucleotidase (1995) Naunyn-schmiedebergs Arch. Pharmacol., 352, pp. 477-482; \n\nBusch, A.E., Herzer, T., Wagner, C.A., Schmidt, F., Raber, G., Waldegger, S., Lang, F., Positive regulation by chloride channel blockers of IsK channels expressed in Xenopus oocytes (1994) Mol. Pharmacol., 46, pp. 750-753; \n\nButlen, D., Bernard, C., Ammar, A., Ferrary, E., Purine and pyrimidine nucleotide-sensitive phosphoinositidase C in ampulla from frog semicircular canal (1997) Am. J. Physiol. 272 (Regulatory Integrative Comp. Physiol. 41), 272, pp. R51-R58; \n\nCabantchik, Z.I., Greger, R., Chemical probes for anion transporters of mammalian cell membranes (1992) Am. J. Physiol. 262 (Cell Physiol. 31), 262, pp. C803-C827; \n\nCabantchik, Z.I., Rothstein, A., The nature of the membrane sites controlling anion permeability of human red blood cells as determined by studies with disulfonic stilbene derivatives (1972) J. Membr. Biol., 10, pp. 311-330; \n\nCabantchik, Z.I., Rothstein, A., Membrane proteins related to anion permeability of human red blood cells. I. Localization of disulfonic stilbene binding sites in proteins involved in permeation (1974) J. Membr. Biol., 15, pp. 207-226; \n\nCabantchik, Z.I., Rothstein, A., Membrane proteins related to anion permeability of human red blood cells. II. Effects of proteolytic enzymes on disulfonic stilbene sites of surface proteins (1974) J. Membr. Biol., 15, pp. 227-248; \n\nCantiello, H.F., Role of the actin cytoskeleton in the regulation of the cystic fibrosis transmembrane conductance regulator (1996) Exp. Physiol., 81, pp. 505-514; \n\nCaro, J.F., Effects of glyburide on carbohydrate metabolism and insulin action in the liver (1990) Am. J. Med., 89 (SUPPL.), pp. 17S-25S; \n\nCarson, M.R., Travis, S.M., Welsh, M.J., The two nucleotide-binding domains of cystic fibrosis transmembrane conductance regulator (CFTR) have distinct functions in controlling channel activity (1995) J. Biol. Chem., 270, pp. 1711-1717; \n\nCarson, M.R., Travis, S.M., Winter, M.C., Sheppard, D.N., Welsh, M.J., Phosphate stimulates CFTR Cl- channels (1994) Biophys. J., 67, pp. 1867-1875; \n\nCarter, M.W., Matrone, G., Smart, W.W.G., Effect of genistein on reproduction in the mouse (1955) J. Nutr., 55, pp. 639-645; \n\nCarter, M.W., Smart, W.W.G., Matrone, G., Estimation of the estrogenic activity of genistein obtained from soybean meal (1953) Proc. Soc. Exp. Biol. Med., 84, pp. 506-507; \n\nCasavola, V., Guerra, L., Reshkin, S.J., Jacobson, K.A., Verrey, F., Murer, H., Effect of adenosine on Na+ and Cl- currents in A6 monolayers. Receptor localization and messenger involvement (1996) J. Membr. Biol., 15, pp. 237-245; \n\nCasnellie, J.E., Protein kinase inhibitors: Probes for the functions of protein phosphorylation (1991) Adv. Pharmacol., 22, pp. 167-205; \n\nChallinor-Rogers, J.L., Kong, D.C., Iskander, M.N., McPherson, G.A., Structure-activity relationship of glibenclamide analogs: A comparison of potency as levcromakalim antagonists in rat aorta vs. Affinity for [3H]glibenclamide binding to membranes from rat cerebral cortex (1995) J. Pharmacol. Exp. Ther., 273, pp. 778-786; \n\nChampigny, G., Imler, J.L., Puchelle, E., Dalemans, W., Gribkoff, V., Hinnrasky, J., Dott, K., Lazdunski, M., A change in gating mode leading to increased intrinsic Cl- channel activity compensates for defective processing in a cystic fibrosis mutant corresponding to a mild form of the disease (1995) EMBO J., 14, pp. 2417-2423; \n\nChan, H.C., Fu, W.O., Chung, Y.W., Huang, S.J., Chan, P.S., Wong, P.Y., Swelling-induced anion and cation conductances in human epididymal cells (1994) J. Physiol. (Lond.), 478, pp. 449-460; \n\nChan, H.C., Goldstein, J., Nelson, D.J., Alternate pathways for chloride conductance activation in normal and cystic fibrosis airway epithelial cells (1992) Am. J. Physiol. 262 (Cell Physiol. 31), 262, pp. C1273-C1283; \n\nChan, H.C., Zhou, W.L., Fu, W.O., Ko, W.H., Wong, P.Y., Different regulatory pathways involved in ATP-stimulated chloride secretion in rat epididymal epithelium (1995) J. Cell. Physiol., 164, pp. 271-276; \n\nChen, L., Yang, C.S., Effects of cytochrome P-450 2E1 modulators on the pharmacokinetics of chlorzoxazone and 6-hydroxychlorzoxazone in rats (1996) Life Sci., 58, pp. 1575-1585; \n\nChen, S., Inoue, R., Ito, Y., Pharmacological characterization of muscarinic receptor-activated cation channels in guinea-pig ileum (1993) Br. J. Pharmacol., 109, pp. 793-801; \n\nChiang, C.E., Chen, S.A., Chang, M.S., Lin, C.I., Luk, H.N., Genistein directly induces cardiac CFTR chloride current by a tyrosine kinase-independent and protein kinase A-independent pathway in guinea pig ventricular myocytes (1997) Biochem. Biophys. Res. Commun., 235, pp. 74-78; \n\nCliff, W.H., Schoumacher, R.A., Frizzell, R.A., cAMP-activated Cl channels in CFTR-transfected cystic fibrosis pancreatic epithelial cells (1992) Am. J. Physiol. 262 (Cell Physiol. 31), 262, pp. C1154-C1160; \n\nCochet, C., Feige, J.J., Pirollet, F., Keramidas, M., Chambaz, E.M., Selective inhibition of a cyclic nucleotide independent protein kinase (G type casein kinase) by quercetin and related polyphenols (1982) Biochem. Pharmacol., 31, pp. 1357-1361; \n\nCotten, M., Saltik, M., Kursa, M., Wagner, E., Maass, G., Birnstiel, M.L., Psoralen treatment of adenovirus particles eliminates virus replication and transcription while maintaining the endosomolytic activity of the virus capsid (1994) Virology, 205, pp. 254-261; \n\nCristofolini, M., Recchia, G., Boi, S., Al, E., 6-Methylangelicins: New nonfunctional photochemotherapeutic agents for psoriasis (1990) Br. J. Dermatol., 122, pp. 513-524; \n\nCroce, M.A., Kramer, G.L., Garbers, D.L., Inhibition of alkaline phosphatase by substituted xanthines. Biochem (1979) Pharmacol., 28, pp. 1227-1231; \n\nCropp, G.J., Effectiveness of bronchodilators in cystic fibrosis (1996) Am. J. Med., 100 (SUPPL.), pp. 19S-29S; \n\nCunningham, S.A., Worrell, R.T., Benos, D.J., Frizzell, R.A., cAMP-stimulated ion currents in Xenopus oocytes expressing CFTR cRNA (1992) Am. J. Physiol. 262 (Cell Physiol. 31), 262, pp. C783-C788; \n\nCutting, G.R., Lu, L., Bf, O.H., Kasch, L.M., Montrose-Rafizadeh, C., Donovan, D.M., Shimada, S., Uhl, G.R., Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: A GABA receptor subunit highly expressed in the retina (1991) Proc. Natl. Acad. Sci. USA, 88, pp. 2673-2677; \n\nDalemans, W., Barbry, P., Champigny, G., Jallat, S., Dott, K., Dreyer, D., Crystal, R.G., Lazdunski, M., Altered chloride ion channel kinetics associated with the ΔF508 cystic fibrosis mutation (1991) Nature, 354, pp. 526-528; \n\nDavidow, C.J., Maser, R.L., Rome, L.A., Calvet, J.P., Grantham, J.J., The cystic fibrosis transmembrane conductance regulator mediates transepithelial fluid secretion by human autosomal dominant polycystic kidney disease epithelium in vitro (1996) Kidney Int., 50, pp. 208-218; \n\nDemuth, D.R., Showe, L.C., Ballantine, M., Palumbo, A., Fraser, P.J., Cioe, L., Rovera, G., Curtis, P.J., Cloning and structural characterization of a human non-erythroid band 3-like protein (1986) EMBO J., 5, pp. 1205-1214; \n\nDenning, C.R., Sommers, S.C., Quigley H.J., Jr., Infertility in male patients with cystic fibrosis (1968) Pediatrics, 41, pp. 7-17; \n\nDenning, G.M., Anderson, M.P., Amara, J.F., Marshall, J., Smith, A.E., Welsh, M.J., Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive (1992) Nature, 358, pp. 761-764; \n\nDevor, D.C., Forrest, J.N., Suggs, W.K., Frizzell, R.A., cAMP-activated Cl- channels in primary cultures of spiny dogfish (Squalus acanthias) rectal gland (1995) Am. J. Physiol. 268 (Cell Physiol. 37), 268, pp. C70-C79; \n\nDevor, D.C., Frizzell, R.A., Calcium-mediated agonists activate an inwardly rectified K+ channel in colonic secretory cells (1993) Am. J. Physiol. 265 (Cell Physiol. 34), 265, pp. C1271-C1280; \n\nDevor, D.C., Pilewski, J.M., Effect of 1-EBIO, NS004 and genistein on ion transport across human bronchial epithelium expressing wild type and ΔF508 CFTR (1998) Pediatr. Pulmonol. Suppl., 17, p. 219; \n\nDevor, D.C., Singh, A.K., Bridges, R.J., Frizzell, R.A., Modulation of Cl- secretion by benzimidazolones. II. Coordinate regulation of apical GCl and basolateral GK (1996) Am. J. Physiol. 271 (Lung Cell. Mol. Physiol. 15), 271, pp. L785-L795; \n\nDevor, D.C., Singh, A.K., Bridges, R.J., Frizzell, R.A., Psoralens: Novel modulators of Cl- secretion (1997) Am. J. Physiol. 272 (Cell Physiol. 41), 272, pp. C976-C988; \n\nDevor, D.C., Singh, A.K., Frizzell, R.A., Bridges, R.J., Modulation of Cl- secretion by benzimidazolones. I. Direct activation of a Ca2+-dependent K+ channel (1996) Am. J. Physiol. 271 (Lung Cell. Mol. Physiol. 15), 271, pp. L775-L784; \n\nDiaz, M., Valverde, M.A., Higgins, C.F., Rucareanu, C., Sepulveda, F.V., Volume-activated chloride channels in HeLa cells are blocked by verapamil and dideoxyforskolin (1993) Pflügers Arch., 422, pp. 347-353; \n\nDiener, M., Hug, F., Modulation of Cl- secretion in rat distal colon by genistein, a protein tyrosine kinase inhibitor (1996) Eur. J. Pharmacol., 299, pp. 161-170; \n\nDils, F., A placebo controlled, double-blind evaluation of levamisole in the reduction of the frequency, duration and severity of attacks in children suffering from recurrent upper respiratory tract infections (1979) J. Int. Med. Res., 7, pp. 302-304; \n\nDinudom, A., Komwatana, P., Young, J.A., Cook, D.I., A forskolin-activated Cl current in mouse mandibular duct cells (1995) Am. J. Physiol. 268 (Gastrointest. Liver Physiol. 31), 268, pp. G806-G812; \n\nStefano, D.I., A, M.W., Schlatter, E., Lang, H.J., Englert, H., Greger, R., Diphenylamine-2-carboxylate, a blocker of the Cl--conductive pathway in Cl--transporting epithelia (1985) Pflügers Arch., 405 (SUPPL. 1), pp. 95-100; \n\nDoroshenko, P., Neher, E., Volume-sensitive chloride conductance in bovine chromaffin cell membrane (1992) J. Physiol. (Lond.), 449, pp. 197-218; \n\nDreinhofer, J., Gogelein, H., Greger, R., Blocking kinetics of Cl- channels in colonic carcinoma cells (HT29) as revealed by 5-nitro-2-(3-phenylpropylamino)benzoic acid (NPPB) (1988) Biochim. Biophys. Acta, 946, pp. 135-142; \n\nDrumm, M.L., Wilkinson, D.J., Smit, L.S., Worrell, R.T., Strong, T.V., Frizzell, R.A., Dawson, D.C., Collins, F.S., Chloride conductance expressed by ΔF508 and other mutant CFTRs in Xenopus oocytes (1991) Science, 254, pp. 1797-1799; \n\nDubyak, G.R., El-Moatassim, C., Signal transduction via P2-purinergic receptors for extracellular ATP and other nucleotides (1993) Am. J. Physiol. 265 (Cell Physiol. 34), 265, pp. C577-C606; \n\nDudeck, O., Bultmann, R., Starke, K., Two relaxation-mediating P2-purinoceptors in guinea-pig taenia caeci (1995) Naunyn-schmiedebergs Arch. Pharmacol., 351, pp. 107-110; \n\nDunne, M.J., Petersen, O.H., Intracellular ADP activates K+ channels that are inhibited by ATP in an insulin-secreting cell line (1986) FEBS Lett., 208, pp. 59-62; \n\nDworetzky, S.I., Boissard, C.G., Lum-Ragan, J.T., McKay, M.C., Post-Munson, D.J., Trojnacki, J.T., Chang, C.P., Gribkoff, V.K., Phenotypic alteration of a human BK (hSlo) channel by hSloβ subunit coexpression: Changes in blocker sensitivity, activation/relaxation and inactivation kinetics, and protein kinase A modulation (1996) J. Neurosci., 16, pp. 4543-4550; \n\nDworetzky, S.I., Trojnacki, J.T., Gribkoff, V.K., Cloning and expression of a human large-conductance calcium-activated potassium channel (1994) Brain Res., 27, pp. 189-193; \n\nEdwards, G., Niederste-Hollenberg, A., Schneider, J., Noack, T., Weston, A.H., Ion channel modulation by NS 1619, the putative BKCa channel opener, in vascular smooth muscle (1994) Br. J. Pharmacol., 113, pp. 1538-1547; \n\nEdwards, G., Weston, A.H., Induction of a glibenclamide-sensitive K+ current by modification of a delayed rectifier channel in rat portal vein and insulinoma cells (1993) Br. J. Pharmacol., 110, pp. 1280-1281; \n\nEidelman, O., Cabantchik, Z.I., The mechanism of anion transport across human red blood cell membranes as revealed with a fluorescent substrate. II. Kinetic properties of NBD-taurine transfer in asymmetric conditions (1983) J. Membr. Biol., 71, pp. 149-161; \n\nEidelman, O., Guay-Broder, C., Van Galen, P.J.M., Jacobson, K.A., Fox, C., Turner, R.J., Cabantchik, Z.I., Pollard, H.B., A1 adenosine-receptor antagonists activate chloride efflux from cystic fibrosis cells (1992) Proc. Natl. Acad. Sci. USA, 89, pp. 5562-5566; \n\nElenbaas, J.K., Centrally acting oral skeleton muscle relaxants (1980) Am. J. Hosp. Pharm., 37, pp. 1313-1323; \n\nEl-Mofty, A.M., (1968) Vitiligo and Psoralens, pp. 1-5. , Oxford, UK: Pergamon; \n\nEndo, M., Calcium release from the sarcoplasmic reticulum (1977) Physiol. Rev., 57, pp. 71-108; \n\nEvans, R.J., Lewis, C., Buell, G., Valera, S., North, R.A., Surprenant, A., Pharmacological characterization of heterologously expressed ATP-gated cation channels (P2x purinoceptors) (1995) Mol. Pharmacol., 48, pp. 178-183; \n\nFalke, J.J., Pace, R.J., Chan, S.I., Chloride binding to the anion transport binding sites of band 3. A 35Cl NMR study (1984) J. Biol. Chem., 259, pp. 6472-6480; \n\nFarley, J.R., Ivey, J.L., Baylink, D.J., Human skeletal alkaline phosphatase (1980) J. Biol. Chem., 255, pp. 4680-4686; \n\nFauman, E.B., Saper, M.A., Structure and function of the protein tyrosine phosphatases (1996) Trends Biochem. Sci., 21, pp. 413-417; \n\nFindlay, I., Effects of ADP upon the ATP-sensitive K+ channel in rat ventricular myocytes (1988) J. Membr. Biol., 101, pp. 83-92; \n\nFotsis, T., Pepper, M., Adlercreutz, H., Hase, T., Montesano, R., Schweigerer, L., Genistein, a dietary ingested isoflavonoid, inhibits cell proliferation and in vitro angiogenesis (1995) J. Nutr., 125 (SUPPL.), pp. 790S-797S; \n\nH, M.T., Descatoire, V., Letteron, P., Larrey, D., Geneve, J., Pessayre, D., Inactivation of cytochrome P-450 by the drug methoxsalen (1986) J. Pharmacol. Exp. Ther., 236, pp. 237-247; \n\nFrancia, E., Marin, A., Verdejo, F., Sanchez, M.S., Morell, J., New oral antidiabetic drugs. Synthesis and structure-activity relationships (1975) Boll. Chim. Farm., 114, pp. 379-392; \n\nFrench, P.J., Bijman, J., Bot, A.G., Boomaars, W.E.M., Scholte, B.J., De Jonge, H.R., Genistein activates CFTR Cl- channels via a tyrosine kinase- and protein phosphatase-independent mechanism (1997) Am. J. Physiol. 273 (Cell Physiol. 42), 273, pp. C747-C753; \n\nFrench, P.J., Bijman, J., Edixhoven, M., Vaandrager, A.B., Scholte, B.J., Lohmann, S.M., Nairn, A.C., De Jonge, H.R., Isotype-specific activation of cystic fibrosis transmembrane conductance regulator-chloride channels by cGMP-dependent protein kinase II (1995) J. Biol. Chem., 270, pp. 26626-26631; \n\nFrohlich, O., The external anion binding site of the human erythrocyte anion transporter: DNDS binding and competition with chloride (1982) J. Membr. Biol., 65, pp. 111-123; \n\nFurukawa, M., Ikeda, K., Yamaya, M., Oshima, T., Sasaki, H., Takasaka, T., Effects of extracellular ATP on ion transport and [Ca2+]i in Mongolian gerbil middle ear epithelium (1997) Am. J. Physiol. 272 (Cell Physiol. 41), 272, pp. C827-C836; \n\nFurukawa, T., Virag, L., Sawanobori, T., Hiraoka, M., Stilbene disulfonates block ATP-sensitive K+ channels in guinea pig ventricular myocytes (1993) J. Membr. Biol., 136, pp. 289-302; \n\nGadsby, D.C., Hwang, T.C., Baukrowitz, T., Nagel, G., Horie, M., Nairn, A.C., Regulation of CFTR channel gating (1994) Jpn. J. Physiol., 44 (SUPPL. 2), pp. S183-S192; \n\nGadsby, D.C., Nairn, A.C., Control of CFTR channel gating by phosphorylation and nucleotide hydrolysis (1999) Physiol. Rev., 79 (SUPPL.), pp. S77-S107; \n\nGalanter, W.L., Labotka, R.J., The binding of nitrate to the human anion exchange protein (AE1) studied with 14N nuclear magnetic resonance (1991) Biochim. Biophys. Acta, 1079, pp. 146-151; \n\nGillis, K., Gee, W., Hammoud, A., McDaniel, M., Falke, L., Misler, S., Effects of sulfonamides on a metabolite-regulated ATPi-sensitive K+ channel in rat pancreatic β-cells (1989) Am. J. Physiol. 257 (Cell Physiol. 26), 257, pp. C1119-C1127; \n\nGogelein, H., Greger, R., A voltage-dependent ionic channel in the basolateral membrane of late proximal tubules of the rabbit kidney (1986) Pflügers Arch., 407 (SUPPL. 2), pp. S142-S148; \n\nGogelein, H., Pfannmuller, B., The nonselective cation channel in the basolateral membrane of rat exocrine pancreas. Inhibition by 3′,5-dichlorodiphenylamine-2-carboxylic acid (DCDPC) and activation by stilbene disulfonates (1989) Pflügers Arch., 413, pp. 287-298; \n\nGombar, C.T., Burak, E., Harper, N., Smith, B.R., Pulmonary clearance of vasoactive drugs: N-oxidation of SK&F 86466 in the isolated perfused rat lung (1988) J. Pharmacol. Exp. Ther., 245, pp. 402-406; \n\nGonzalez, E., Puva for psoriasis (1995) Dermatol. Clin., 13, pp. 851-866; \n\nGonzalez, E., Sanchez-Olea, R., Pasantes-Morales, H., Inhibition by Cl- channel blockers of the volume-activated, diffusional mechanism of inositol transport in primary astrocytes in culture (1995) Neurochem. Res., 20, pp. 895-900; \n\nGorski, J.C., Jones, D.R., Wrighton, S.A., Hall, S.D., Contribution of human CYP3A subfamily members to the 6-hydroxylation of chlorzoxazone (1997) Xenobiotica, 27, pp. 243-256; \n\nGosling, M., Smith, J.W., Poyner, D.R., Characterization of a volume-sensitive chloride current in rat osteoblast-like (ROS 17/2.8) cells (1995) J. Physiol. (Lond.), 485, pp. 671-682; \n\nGray, M.A., Plant, S., Argent, B.E., cAMP-regulated whole cell chloride currents in pancreatic duct cells (1993) Am. J. Physiol. 264 (Cell Physiol. 33), 264, pp. C591-C602; \n\nGray, M.A., Pollard, C.E., Harris, A., Coleman, L., Greenwell, J.R., Argent, B.E., Anion selectivity and block of the small-conductance chloride channel on pancreatic duct cells (1990) Am. J. Physiol., 259, pp. C752-C761. , Cell Physiol. 28; \n\nGraziani, Y., Erikson, E., Erikson, R.L., The effect of quercetin on the phosphorylation activity of the Rous sarcoma virus transforming gene product in vitro and in vivo (1983) Eur. J. Biochem., 135, pp. 583-589; \n\nGreger, R., Nitschke, R.B., Lohrmann, E., Burhoff, I., Hropot, M., Englert, H.C., Lang, H.J., Effects of arylaminobenzoate-type chloride channel blockers on equivalent short-circuit current in rabbit colon (1991) Pflügers Arch., 419, pp. 190-196; \n\nGreger, R., Schlatter, E., Mechanism of NaCl secretion in the rectal gland of spiny dogfish (Squalus acanthias). I. Experiments in isolated in vitro perfused rectal gland tubules (1984) Pflügers Arch., 402, pp. 63-75; \n\nGreger, R., Schlatter, E., Mechanism of NaCl secretion in rectal gland tubules of spiny dogfish (Squalus acanthias). II. Effects of inhibitors (1984) Pflügers Arch., 402, pp. 364-375; \n\nGreger, R., Schlatter, E., Gogelein, H., Chloride channels in the luminal membrane of the rectal gland of the dogfish (Squalus acanthias). Properties of the \"larger\" conductance channel (1987) Pflügers Arch., 409, pp. 114-121; \n\nGribble, F.M., Tucker, S.J., Ashcroft, F.M., The interaction of nucleotides with the tolbutamide block of cloned ATP-sensitive K+ channel currents expressed in Xenopus oocytes: A reinterpretation (1997) J. Physiol. (Lond.), 504, pp. 35-45; \n\nGribkoff, V.K., Champigny, G., Barbry, P., Dworetzky, S.I., Meanwell, N.A., Lazdunski, M., The substituted benzimidazolone NS004 is an opener of the cystic fibrosis chloride channel (1994) J. Biol. Chem., 269, pp. 10983-10986; \n\nGrubb, B., Lazarowski, E., Knowles, M., Boucher, R., Isobutylmethylxanthine fails to stimulate chloride secretion in cystic fibrosis airway epithelia (1993) Am. J. Respir. Cell Mol. Biol., 8, pp. 454-460; \n\nGschwendt, M., Horn, F., Kittstein, W., Marks, F., Inhibition of the calcium- and phospholipid-dependent protein kinase activity from mouse brain cytosol by quercetin (1983) Biochem. Biophys. Res. Commun., 117, pp. 444-447; \n\nGu, H., Smith, M.W., Phelps, P.C., Berezesky, I.K., Merriman, R.L., Boder, G.B., Trump, B.F., H-ras transfection of the rat kidney cell line NRK-52E results in increased induction of c-fos, c-jun and hsp70 following sulofenur treatment (1996) Cancer Lett., 106, pp. 199-205; \n\nGuay-Broder, C., Jacobson, K.A., Barnoy, S., Cabantchik, Z.I., Guggino, W.B., Zeitlin, P.L., Turner, R.J., Pollard, H.B., A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine selectively activates chloride efflux from human epithelial and mouse fibroblast cell lines expressing the cystic fibrosis transmembrane regulator ΔF508 mutation (1995) Biochemistry, 34, pp. 9079-9087; \n\nGunderson, K.L., Kopito, R.R., Effects of pyrophosphate and nucleotide analogs suggest a role for ATP hydrolysis in cystic fibrosis transmembrane regulator channel gating (1994) J. Biol. Chem., 269, pp. 19349-19353; \n\nGunderson, K.L., Kopito, R.R., Conformational states of CFTR associated with channel gating: The role of ATP binding and hydrolysis (1995) Cell., 85, pp. 231-239; \n\nHalm, D.R., Frizzell, R.A., (1990) Intestinal Chloride Secretion, Edited by E. Lebenthal and M. Duffey, pp. 47-58. , New York: Raven; \n\nHanaoka, K., Devuyst, O., Schwiebert, E.M., Wilson, P.D., Guggino, W.B., A role for CFTR in human autosomal dominant polycystic kidney disease (1996) Am. J. Physiol. 270 (Cell Physiol. 39), 270, pp. C389-C399; \n\nHanazawa, S., Kawata, Y., Murakami, Y., Naganuma, K., Amano, S., Miyata, Y., Kitano, S., Porphyromonas gingivalis fimbria-stimulated bone resorption in vitro is inhibited by a tyrosine kinase inhibitor (1995) Infect. Immun., 63, pp. 2374-2377; \n\nHannafin, J., Kinne-Saffran, E., Friedman, D., Kinne, R., Presence of a sodium-potassium chloride cotransport system in the rectal gland of Squalus acanthias (1983) J. Membr. Biol., 75, pp. 73-83; \n\nHaws, C., Krouse, M.E., Xia, Y., Gruenert, D.C., Wine, J.C., CFTR channels in immortalized human airway cells (1992) Am. J. Physiol. 263 (Lung Cell. Mol. Physiol. 7), 263, pp. L692-L707; \n\nHaws, C.M., Nepomuceno, I.B., Krouse, M.E., Wakelee, H., Law, T., Xia, Y., Nguyen, H., Wine, J.J., ΔF508-CFTR channels: Kinetics, activation by forskolin, and potentiation by xanthines (1996) Am. J. Physiol. 270 (Cell Physiol. 39), 270, pp. C1544-C1555; \n\nHaynes, J.K., Goldstein, L., Volume-regulatory amino acid transport in erythrocytes of the little skate, Raja erinacea (1993) Am. J. Physiol. 265 (Regulatory Integrative Comp. Physiol. 34), 265, pp. R173-R179; \n\nHayslett, J.P., Gogelein, H., Kunzelmann, K., Greger, R., Characteristics of apical chloride channels in human colon cells (HT29) (1987) Pflügers Arch., 410, pp. 487-494; \n\nHazato, T., Naganawa, H., Kumagai, M., Aoyagi, T., Umeqawa, H., β-Galactosidase-inhibiting new isoflavonoids produced by actinomycetes (1979) J. Antibiotics, 32, pp. 217-222; \n\nHebert, S.C., Andreoli, T.E., Control of NaCl transport in the thick ascending limb (1984) Am. J. Physiol. 246 (Renal Fluid Electrolyte Physiol. 15), 246, pp. F745-F756; \n\nHebert, S.C., Andreoli, T.E., Effects of antidiuretic hormone on cellular conductive pathways in mouse medullary thick ascending limbs of Henle. II. Determinants of the ADH-mediated increases in transepithetial voltage and in net Cl- absorption (1984) J. Membr. Biol., 80, pp. 221-233; \n\nHeinemann, S.H., Rettig, J., Graack, H.R., Pongs, O., Functional characterization of Kv channel β-subuntis from rat brain (1996) J. Physiol. (Lond.), 493, pp. 625-633; \n\nHeisler, S., Antagonists of epithelial chloride channels inhibit cAMP synthesis (1991) Can. J. Physiol. Pharmacol., 69, pp. 501-506; \n\nHogg, R.C., Wang, Q., Large, W.A., Effects of Cl channel blockers on Ca-activated chloride and potassium currents in smooth muscle cells from rabbit portal vein (1994) Br. J. Pharmacol., 111, pp. 1333-1341; \n\nHolland, M., Langton, P.D., Standen, N.B., Boyle, J.P., Effects of the BKCa channel activator, NS1619, on rat cerebral artery smooth muscle (1996) Br. J. Pharmacol., 117, pp. 119-129; \n\nHonig, B., Morison, W.L., Karp, D., Photochemotherapy beyond psoriasis (1994) J. Am. Acad. Dermatol., 31, pp. 775-790; \n\nHowbert, J., Sulofenur: LY186641 (1991) Drugs of the Future, 16, pp. 517-520; \n\nHowbert, J.J., Grossman, C.S., Crowell, T.A., Rieder, B.J., Harper, R.W., Kramer, K.E., Tao, E.V., Todd, G.C., Novel agents against solid tumors: The diarylsulfonylureas. Synthesis, activities, and analysis of quantitative structure-activity relationships (1990) J. Med. Chem., 33, pp. 2393-2407; \n\nHu, S., Kim, H.S., On the mechanism of the differential effects of NS004 and NS1608 in smooth muscle cells from guinea pig bladder (1996) Eur. J. Pharmacol., 318, pp. 461-468; \n\nHu, S., Kim, H.S., Fink, C.A., Differential effects of the BKCa channel openers NS004 and NS1608 in porcine coronary arterial cells (1995) Eur. J. Pharmacol, 294, pp. 357-360; \n\nHughes, B.A., Segawa, Y., cAMP-activated chloride currents in amphibian retinal pigment epithelial cells (1993) J. Physiol. (Lond.), 466, pp. 749-766; \n\nHusted, R.F., Volk, K.A., Sigmund, R.D., Stokes, J.B., Anion secretion by the inner medullary collecting duct. Evidence for involvement of the cystic fibrosis transmembrane conductance regulator (1995) J. Clin. Invest., 95, pp. 644-650; \n\nHwang, G.S., Kim, J.K., Choi, B.S., The solution structure of a psoralen cross-linked DNA duplex by NMR and relaxation matrix refinement (1996) Biochem. Biophys. Res. Commun., 219, pp. 191-197; \n\nHwang, T.C., Horie, M., Gadsby, D.C., Functionally distinct phospho-forms underlie incremental activation of protein kinase-regulated Cl- conductance in mammalian heart (1993) J. Gen. Physiol., 101, pp. 629-650; \n\nHwang, T.-C., Wang, F., Yang, I.C.-H., Reenstra, W.W., Genistein potentiates wild-type and ΔF508-CFTR channel activity (1997) Am. J. Physiol., 273, pp. C988-C998. , Cell Physiol. 42; \n\nHwang, T.H., Schwiebert, E.M., Guggino, W.B., Apical and basolateral ATP stimulates tracheal epithelial chloride secretion via multiple purinergic receptors (1996) Am. J. Physiol. 270 (Cell Physiol. 39), 270, pp. C1611-C1623; \n\nIllek, B., Fischer, H., Kreusel, K.M., Hegel, U., Clauss, W., Volume-sensitive basolateral K+ channels in HT-29/B6 cells: Block by lidocaine, quinidine, NPPB, and Ba2+ (1992) Am. J. Physiol. 263 (Cell Physiol. 32), 263, pp. C674-C683; \n\nIllek, B., Fischer, H., Machen, T.E., Alternate stimulation of apical CFTR by genistein in epithelia (1996) Am. J. Physiol. 270 (Cell Physiol. 39), 270, pp. C265-C275; \n\nIllek, B., Fischer, H., Santos, G.F., Widdicombe, J.H., Machen, T.E., Reenstra, W.W., cAMP-independent activation of CFTR Cl channels by the tyrosine kinase inhibitor genistein (1995) Am. J. Physiol. 268 (Cell Physiol. 37), 268, pp. C886-C893; \n\nIllek, B., Yankaskas, J.R., Machen, T.E., cAMP and genistein stimulate HCO- 3 conductance through CFTR in human airway epithelia (1997) Am. J. Physiol. 272 (Lung Cell. Mol. Physiol. 16), 272, pp. L752-L761; \n\nInagaki, N., Gonoi, T., Clement J.P. IV, Namba, N., Inazawa, J., Gonzalez, G., Aguilar-Bryan, L., Bryan, J., Reconstitution of IKATP: An inward rectifier subunit plus the sulfonylurea receptor (1995) Science, 270, pp. 1166-1170; \n\nInagaki, N., Gonoi, T., Clement, J.P., Wang, C.Z., Aguilar-Bryan, L., Bryan, J., Seino, S., A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels (1996) Neuron, 16, pp. 1011-1017; \n\nIngebritsen, T.S., Cohen, P., The protein phosphatases involved in cellular regulation. I. Classification and substrate specificities (1983) Eur. J. Biochem., 132, pp. 255-261; \n\nIngebritsen, T.S., Cohen, P., Protein phosphatases: Properties and role in cellular regulation (1983) Science, 221, pp. 331-1238; \n\nIshii, T.M., Silvia, C., Hirschberg, B., Bond, C.T., Adelman, J.P., Maylie, J., A human intermediate conductance calcium-activated potassium channel (1997) Prof. Natl. Acad. Sci. USA, 94, pp. 11651-11656; \n\nIwase, N., Sasaki, T., Shimura, S., Yamamoto, M., Suzuki, S., Shirato, K., ATP-induced Cl- secretion with suppressed Na+ absorption in rabbit tracheal epithelium (1997) Respir. Physiol., 107, pp. 173-180; \n\nJackson, P.S., Churchwell, K., Ballatori, N., Bover, J.L., Strange, K., Swelling-activated anion conductance in skate hepatocytes: Regulation by cell Cl- and ATP (1996) Am. J. Physiol. 270 (Cell Physiol. 39), 270, pp. C57-C66; \n\nJackson, P.S., Strange, K., Volume-sensitive anion channels mediate swelling-activated inositol and taurine efflux (1993) Am. J. Physiol. 265 (Cell Physiol. 34), 265, pp. C1489-C1500; \n\nJacobson, K.A., Guay-Broder, C., Van Galen, P.J.M., Gallo-Rodriguez, C., Melman, N., Jacobson, M.A., Eidelman, O., Pollard, H.B., Stimulation by alkylxanthines of chloride efflux in CFPAC-1 cells does not involve A1 adenosine receptors (1995) Biochemistry, 34, pp. 9088-9094; \n\nJentsch, T.J., Gunther, W., Chloride channels: An emerging molecular picture (1997) Bioessays, 19, pp. 117-126; \n\nJi, X.D., Melman, N., Jacobson, K.A., Interactions of flavonoids and other phytochemicals with adenosine receptors (1996) J. Med. Chem., 39, pp. 781-788; \n\nJoiner, W.J., Wang, L.Y., Tang, M.D., Kaczmarek, L.K., hSK4, a member of a novel subfamily of calcium-activated potassium channels (1997) Proc. Natl. Acad. Sci. USA, 94, pp. 11013-11018; \n\nKamthan, A., Scarffe, J.H., Walling, J., Hatty, S., Peters, B., Coleman, R., Smyth, J.F., A phase II study of sulofenur (LY186641) in gastric cancer (1992) Anti-cancer Drugs, 3, pp. 331-335; \n\nKelley, T.J., Al-Nakkash, L., Cotton, C.U., Drumm, M.L., Activation of endogenous ΔF508 cystic fibrosis transmembrane conductance regulator by phosphodiesterase inhibition (1996) J. Clin. Invest., 98, pp. 513-520; \n\nKelley, T.J., Al-Nakkash, L., Drumm, M.L., CFTR-mediated chloride permeability is regulated by type III phosphodiesterases in airway epithelial cells (1995) Am. J. Respir. Cell Mol. Biol., 13, pp. 657-664; \n\nKelley, T.J., Thomas, K., Milgram, L.J.H., Drumm, M.L., In vivo activation of the cystic fibrosis transmembrane conductance regulator mutant ΔF508 in murine nasal epithelium (1997) Proc. Natl. Acad. Sci. USA, 94, pp. 2604-2608; \n\nKelly, M.E., Dixon, S.J., Sims, S.M., Outwardly rectifying chloride current in rabbit osteoclasts is activated by hyposmotic stimulation (1994) J. Physiol. (Lond.), 475, pp. 377-389; \n\nKerem, B.-S., Rommens, J.M., Buchanan, J.A., Al, E., Identification of the cystic fibrosis gene: Gene analysis (1989) Science, 245, pp. 1073-1080; \n\nKibble, J.D., Trezise, A.E., Brown, P.D., Properties of the cAMP-activated Cl- current in choroid plexus epithelial cells isolated from the rat (1996) J. Physiol. (Lond.), 496, pp. 69-80; \n\nKim, C., Mackellar, W.C., N, C.H.O., Byrn, S.R., Morre, D.J., Impermeant antitumor sulfonylurea conjugates that inhibit plasma membrane NADH oxidase and growth of HeLa cells in culture. Identification of binding proteins from sera of cancer patients (1997) Biochim. Biophys. Acta, 1324, pp. 171-181; \n\nKinard, T.A., Satin, L.S., An ATP-sensitive Cl- channel current that is activated by cell swelling, cAMP, and glyburide in insulin-secreting cells (1995) Diabetes, 44, pp. 1461-1466; \n\nKirk, K., Ellory, J.C., Young, J.D., Transport of organic substrates via a volume-activated channel (1992) J. Biol. Chem., 267, pp. 23475-23478; \n\nKnauf, P.A., Rothstein, A., Chemical modification of membranes. I. Effects of sulfhydryl and amino reactive reagents on anion and cation permeability of the human red blood cell (1971) J. Gen. Physiol., 58, pp. 190-210; \n\nKnaus, H.G., Folander, K., Garcia-Calvo, M., Garcia, M.L., Kaaczorowski, G.J., Smith, M., Swanson, R., Primary sequence and immunological characterization of β-subunit of high conductance of Ca2+-activated K+ channel from smooth muscle (1994) J. Biol. Chem., 269, pp. 17274-17278; \n\nKnowles, M.R., Clarke, L.L., Boucher, R.C., Activation by extracellular nucleotides of chloride secretion in the airway epithelia of patients with cystic fibrosis (1991) N. Engl. J. Med., 325, pp. 533-538; \n\nKo, W.H., Chan, H.C., Chew, S.B., Wong, P.Y., Ionic mechanisms of Ca2+-dependent electrolyte transport across equine sweat gland epithelium (1996) J. Physiol. (Lond.), 493, pp. 885-894; \n\nKohler, M., Hirschberg, B., Bond, C.T., Kinzie, J.M., Marrion, N.V., Maylie, J., Adelman, J.P., Small-conductance, calcium-activated potassium channels from mammalian brain (1996) Science, 273, pp. 1709-1714; \n\nKokko, K.E., Matsumoto, P.S., Zhang, Z.R., Ling, B.N., Eaton, D.C., Prostaglandin E2 increases 7-pS Cl- channel density in the apical membrane of A6 distal nephron (1997) Am. J. Physiol. 273 (Cell Physiol. 42), pp. C548-C557; \n\nKomwatana, P., Dinudom, A., Young, J.A., Cook, D.I., Characterizatinon of the Cl- conductance in the granular duct cells of mouse mandibular glands (1994) Pflügers Arch., 428, pp. 641-647; \n\nKopito, R.R., Lee, B.S., Simmons, D.M., Lindsey, A.E., Morgans, C.W., Schneider, K., Regulation of intracellular pH by a neuronal homolog of the erythrocyte anion exchanger (1989) Cell, 59, pp. 927-937; \n\nKreusel, K.M., Fromm, M., Schulzke, J.D., Hegel, U., Cl- secretion in epithelial monolayers of mucus-forming human colon cells (HT-29/B6) (1991) Am. J. Physiol. 261 (Cell Physiol. 30), 261, pp. C574-C582; \n\nKubo, M., Okada, Y., Volume-regulatory Cl- channel currents in cultured human epithelial cells (1992) J. Physiol. (Lond.), 456, pp. 351-371; \n\nKudrycki, K.E., Newman, P.R., Shull, G.E., cDNA cloning and tissue distribution of mRNAs for two proteins that are related to the band 3 Cl-/HCO3 exchanger (1990) J. Biol. Chem., 265, pp. 462-471; \n\nKunzelmann, K., Pavenstadt, H., Greger, R., Cells, N.A., Properties and regulation of chloride channels in cystic fibrosis and (1989) Pflügers Arch., 415, pp. 172-182; \n\nLabbe, G., Descatoire, V., Letteron, P., Degott, C., Tinel, M., Larrey, D., Carrion-Pavlov, Y., Pessayre, D., The drug methoxsalen, a suicide substrate for cytochrome P-450, decreases the metabolic activation, and prevents the hepatotoxicity, of carbon tetrachloride in mice (1987) Biochem. Pharmacol., 36, pp. 907-914; \n\nLazdunski, M., Ion channel effects of antidiabetic sulfonylureas (1996) Horm. Metab. Res., 28, pp. 488-495; \n\nLee, K.-M., Toscas, K., Villereal, M.L., Inhibition of bradykinin- and thapsigargin-induced Ca2+ entry by tyrosine kinase inhibitors (1993) J. Biol. Chem., 268, pp. 9945-9948; \n\nLehrich, R.W., Forrest J.N., Jr., Tyrosine phosphorylation is a novel pathway for regulation of chloride secretion in shark rectal gland (1995) Am. J. Physiol. 269 (Renal Fluid Electrolyte Physiol. 38), 269, pp. F594-F600; \n\nLepke, S.H.F., Pring, M., Passow, H., A study of the relationship between inhibition of anion exchange and binding to the red blood cell membrane of 4,4′-diisothiocyanostilbene-2,2′-disulfonic acid (DIDS) and its dihydro derivative (H2DIDS) (1976) J. Membr. Biol., 29, pp. 147-177; \n\nLetteron, P., Descatoire, V., Larrey, D., Tinel, M., Geneve, J., Pessayre, D., Inactivation and induction of cytochrome P-450 by various psoralen derivatives in rats (1986) J. Pharmacol. Exp. Ther., 238, pp. 685-692; \n\nLewis, R.A., Bursell, J.D., Kirk, K., Anion-selectivity of the swelling-activated osmolyte channel in eel erythrocytes (1996) J. Membr. Biol., 149, pp. 103-111; \n\nLewis, R.S., Ross, P.E., Cahalan, M.D., Chloride channels activated by osmotic stress in T lymphocytes (1993) J. Gen. Physiol., 101, pp. 801-826; \n\nLindsey, A.E., Schneider, K., Simmons, D.M., Baron, R., Lee, B.S., Kopito, R.R., Functional expression and subcellular localization of an anion exchanger cloned from choroid plexus (1990) Proc. Natl. Acad. Sci. USA, 87, pp. 5278-5282; \n\nLinsdell, P., Hanrahan, J.W., Disulphonic stilbene block 0 of cystic fibrosis transmembrane conductance regulator Cl- channels expressed in a mammalian cell line and its regulation by a critical pore residue (1996) J. Physiol. (Lond.), 496, pp. 687-693; \n\nLinsdell, P., Hanrahan, J.W., Flickery block of single CFTR chloride channels by intracellular anions and osmolytes (1996) Am. J. Physiol. 271 (Cell Physiol. 40), 271, pp. C628-C634; \n\nLomax, R.B., Warhurst, G., Sandle, G.I., Characteristics of two basolateral potassium channel populations in human colonic crypts (1996) Gut, 38, pp. 243-247; \n\nLoo, T.W., Clarke, D.M., Correction of defective protein kinesis of human P-glycoprotein mutants by substrates and modulators (1997) J. Biol. Chem., 272, pp. 709-712; \n\nLoubatieres, A., History and development of the oral treatment of diabetes. Oral hypoglycaemic agents: Pharmacology and therapeutics (1969) Medicinal Chemistry, a Series of Monographs, 9, pp. 1-14. , edited by G. DeSteves. London: Academic; \n\nLucas, D., Berthou, F., Girre, C., Poitrenaud, F., Menez, J.F., High-performance liquid chromatographic determination of chlorzoxazone and 6-hydroxychlorzoxazone in serum: A tool for indirect evaluation of cytochrome P-4502E1 activity in humans (1993) J. Chromatogr., 622, pp. 79-86; \n\nMacnaughton, W.K., Gall, D.G., Electrolyte transport responses to secretagogues in neonatal versus adult rabbit jejunum (1994) Biol. Neonate, 65, pp. 51-59; \n\nMaddy, A.H., A fluorescent label for the outer components of the plasma membrane (1964) Biochim. Biophys. Acta, 88, pp. 390-399; \n\nMajumder, K., Debiasi, M., Wang, Z., Wible, B.A., Molecular cloning and functional expression of a novel potassium channel β-subunit from human atrium (1995) Federation Eur. Biochem. Soc. Lett., 361, pp. 13-16; \n\nMalinowska, D.H., Kupert, E.Y., Bahinski, A., Sherry, A.M., Cuppoletti, J., Cloning, functional expression, and characterization of a PKA-activated gastric Cl- channel (1995) Am. J. Physiol. 268 (Cell Physiol. 37), 268, pp. C191-C200; \n\nMardini, I.A., Higgins, N.C., Zhou, S., Benovic, J.L., Kelsen, S.G., Functional behavior of the beta-adrenergic receptor-adenylyl cyclase system in rabbit airway epithelium (1994) Am. J. Respir. Cell Mol. Biol., 11, pp. 287-295; \n\nMarkovits, J., Linassier, C., Fosse, P., Couprie, J., Pierre, J., Jacquemin-Sablon, A., Saucier, J.-M., Larsen, A.K., Inhibitory effects of the tyrosine kinase inhibitor genisein on mammalian DNA topoisomerase II (1989) Cancer Res., 49, pp. 5111-5117; \n\nMathews, J.M., Dostal, L.A., Bend, J.R., Inactivation of rabbit pulmonary cytochrome P-450 in microsomes and isolated perfused lungs by the suicide substrate 1-aminobenzotriazole (1985) J. Pharmacol. Exp. Ther., 235, pp. 186-190; \n\nMatthews, R.T., McMillen, B.A., Speciale, S.G., Jarrah, H., Shore, P.A., Sanghera, M.K., Shepard, P.D., German, D.C., Effects of zoxazolamine and related centrally acting muscle relaxants on nigrostriatal dopaminergic neurons (1984) Brain Res. Bull., 12, pp. 479-486; \n\nMayorga-Ward, O., Dubinsky, W.P., Schultz, S.G., Reversal of glibenclamide and voltage block of an epithelial KATP channel (1996) Am. J. Physiol. 271 (Cell Physiol. 40), 271, pp. C1122-C1130; \n\nMcCann, J.D., M, L.I., Welsh, M.J., Identification and regulation of whole-cell chloride currents in airway epithelium (1989) J. Gen. Physiol., 94, pp. 1015-1036; \n\nMcCarty, N.A., McDonough, S., Cohen, B.N., Riordan, J.R., Davidson, N., Lester, H.A., Voltage-dependent block of the cystic fibrosis transmembrane conductance regulator Cl- channel by two closely related arylaminobenzoates (1993) J. Gen. Physiol., 102, pp. 1-23; \n\nMcCray P.B., Jr., Bettencourt, J.D., Bastacky, J., Denning, G.M., Welsh, M.J., Expression of CFTR and a cAMP-stimulated chloride secretory current in cultured human fetal alveolar epithelial cells (1993) Am. J. Respir. Cell Mol. Biol., 9, pp. 578-585; \n\nMcDonough, S., Davidson, N., Lester, H.A., McCarty, N.A., Novel pore-lining residues in CFTR that govern permeation and open-channel block (1994) Neuron, 13, pp. 623-634; \n\nMcKay, M.C., Dworetzky, S.I., Meanwell, N.A., Olesen, S.P., Reinhart, P.H., Levitan, I.B., Adelman, J.P., Gribkoff, V.K., Opening of large-conductance calcium-activated potassium channels by the substituted benzimidazolone NS004 (1994) J. Neurophysiol., 71, pp. 1873-1882; \n\nMcManus, O.B., Helms, L.M.H., Pallanck, L., Ganetzky, B., Swanson, R., Leonard, R.J., Functional role of the β subunit of high conductance calcium-activated potassium channels (1995) Neuron, 14, pp. 645-650; \n\nMcMillen, B.A., Williams, H.L., Lehmann, H., Shepard, P.D., On central muscle relaxants, strychnine-insensitive glycine receptors and two old drugs: Zoxazolamine and HA-966 (1992) J. Neural Transm., 89, pp. 11-25; \n\nMcMillian, M.K., Soltoff, S.P., Lechleiter, J.D., Cantley, L.C., Talamo, B.R., Extracellular ATP increases free cytosolic calcium in rat parotid acinar cells. Differences from phospholipase C-linked receptor agonists (1988) Biochem. J., 255, pp. 291-300; \n\nMcNicholas, C.M., Guggino, W.B., Schwiebert, E.M., Hebert, S.C., Giebisch, G., Egan, M.E., Sensitivity of a renal K+ channel (ROMK2) to the inhibitory sulfonylurea compound glibenclamide is enhanced by coexpression with the ATP-binding cassette transporter cystic fibrosis transmembrane regulator (1996) Proc. Natl. Acad. Sci. USA, 93, pp. 8083-8088; \n\nMcPherson, M.A., Dormer, R.L., Bradbury, N.A., Dodge, J.A., Goodchild, M.C., Defective β-adrenergic secretory responses in submandibular acinar cells from cystic fibrosis patients (1986) Lancet, 2, pp. 1007-1008; \n\nMehnert, H., Karg, E., Glibenclamid (HB419): Ein neues orales antidiabetikum der sulfonylharnstoff-reihe (1969) Deutsche Med. Wochen., 94, pp. 819-824; \n\nMessina, M.J., Persky, V., Setchell, K.D.R., Barnes, S., Soy intake and cancer risk: A review of the in vitro and in vivo data (1994) Nutr. Cancer, 21, pp. 113-131; \n\nMetaye, T., Millet, C., Kraimps, J.L., Saunier, B., Barbier, J., Begon, F., Effect of bromolevamisole and other imidazo [2,1-β]thiazole derivatives on adenylate cyclase activity (1992) Biochem. Pharmacol., 43, pp. 1507-1511; \n\nMeyer, K., Korbmacher, C., Cell swelling activates ATP-dependent voltage-gated chloride channels in M-1 mouse cortical collecting duct cells (1996) J. Gen. Physiol., 108, pp. 177-193; \n\nMichel, A.D., Grahames, C.B., Humphrey, P.P., Functional characterisation of P2 purinoceptors in PC12 cells by measurement of radiolabelled calcium influx (1996) Naunyn-schmiedebergs Arch. Pharmacol., 354, pp. 562-571; \n\nMintenig, G.M., Valverde, M.A., Sepulveda, F.V., Gill, D.R., Hyde, S.C., Kirk, J., Higgins, C.F., Specific inhibitors distinguish the chloride channel and drug transporter functions associated with the human multidrug resistance P-glycoprotein (1993) Receptors Channels, 1, pp. 305-313; \n\nMitchell, C.H., Zhang, J.J., Wang, L., Jacob, T.J., Volume-sensitive chloride current in pigmented ciliary epithelial cells: Role of phospholipases (1997) Am. J. Physiol. 272 (Cell Physiol. 41), 272, pp. C212-C222; \n\nMohamadi, F., Spees, M., Grindey, G., Sulfonylureas: A new class of cancer chemotherapeutic agents (1992) J. Med. Chem., 35, pp. 3012-3016; \n\nMohamed, A., Ferguson, D., Seibert, F.S., Cai, H.M., Kartner, N., Grinstein, S., Riordan, J.R., Lukacs, G.L., Functional expression and apical localization of the cystic fibrosis transmembrane conductance regulator in MDCK I cells (1997) Biochem. J., 322, pp. 259-265; \n\nMountian, I., Chou, K.Y., Van Driessche, W., Electrolyte transport mechanisms involved in regulatory volume increase in C6 glioma cells (1996) Am. J. Physiol. 271 (Cell Physiol. 40), 271, pp. C1041-C1048; \n\nMumby, M.C., Walter, G., Protein serine/threonine phosphatases: Structure, regulation, and functions in cell growth (1993) Physiol. Rev., 73, pp. 673-699; \n\nNguyen, T.D., Canada, A.T., Heintz, G.G., Gettys, T.W., Cohn, J.A., Stimulation of secretion by the T84 colonic epithelial cell line with dietary flavonols (1991) Biochem. Pharmacol., 41, pp. 1879-1886; \n\nNguyen, T.D., Koh, D.S., Moody, M.W., Fox, N.R., Savard, C.E., Kuver, R., Hille, B., Lee, S.P., Characterization of two distinct chloride channels in cultured dog pancreatic duct epithelial cells (1997) Am. J. Physiol. 272 (Gastrointest. Liver Physiol. 35), 272, pp. G172-G180; \n\nNiisato, N., Marunaka, Y., Regulation of Cl- transport by IBMX in renal A6 epithelium (1997) Eur. J. Physiol., 434, pp. 227-233; \n\nNilius, B., Oike, M., Zahradnik, I., Droogmans, G., Activation of a Cl- current by hypotonic volume increase in human endothelial cells (1994) J. Gen. Physiol., 103, pp. 787-805; \n\nNilius, B., Sehrer, J., Desmet, P., Van Driessche, W., Droogmans, G., Volume regulation in a toad epithelial cell line: Role of coactivation of K+ and Cl- channels (1995) J. Physiol. (Lond.), 487, pp. 367-378; \n\nNilius, B., Sehrer, J., Viana, F., Degreef, C., Raeymaekers, L., Eggermont, J., Droogmans, G., Volume-activated Cl currents in different mammalian non-excitable cell types (1994) Eur. J. Physiol., 428, pp. 364-371; \n\nOates, R.D., Amos, J.A., The genetic basis of congenital bilateral absence of the vas deferens and cystic fibrosis (1994) J. Androl., 15, pp. 1-8; \n\nO'Brien, M.E., Hardy, J., Tan, S., Walling, J., Peters, B., Hatty, S., Wiltshaw, E., A phase II study of sulofenur, a novel sulfonylurea, in recurrent epithelial ovarian cancer (1992) Cancer Chemother. Pharmacol., 30, pp. 245-248; \n\nOgawara, H., Akiyama, T., Ishida, J., Watanabe, S., Suzuki, K., A specific inhibitor for tyrosine protein kinase from Pseudomonas (1986) J. Antibiot., 39, pp. 606-608; \n\nOgawara, H., Akiyama, T., Watanabe, S., Ito, N., Kobori, M., Seoda, Y., Inhibition of tyrosine protein kinase activity by synthetic isoflavones and flavones (1989) J. Antibiot., 42, pp. 340-343; \n\nOkajima, F., Akbar, M., Majid, M.A., Sho, K., Tomura, H., Kondo, Y., Genistein, an inhibitor of protein tyrosine kinase, is also a competitive antagonist for P1-purinergic (adenosine) receptor in FRTL-5 thyroid cells (1994) Biochem. Biophys. Res. Commun., 203, pp. 1488-1495; \n\nOkuno, S., Inaba, M., Nishizawa, Y., Inoue, A., Morii, H., Effect of glyburide and tolbutamide on cAMP-dependent protein kinase activity in rat liver cytosol (1988) Diabetes, 37, pp. 857-861; \n\nOlesen, S.P., Munch, E., Moldt, P., Drejer, J., Selective activation of Ca2+-dependent K+ channels by novel benzimidazolone (1994) Eur. J. Pharmacol., 251, pp. 53-59; \n\nOlesen, S.P., Munch, E., Watjen, F., Drejer, J., NS 004 -an activator of Ca2+-dependent K+ channels in cerebellar granule cells (1994) Neuroreport, 5, pp. 1001-1004; \n\nOsheroff, N., Corbett, A.H., Elsea, S.H., Westergaard, M., Defining functional drug-interaction domains on topoisomerase II by exploiting mechanistic differences between drug classes (1994) Cancer Chemother. Pharmacol., 34 (SUPPL.), pp. S19-S25; \n\nOz, M.C., Sorota, S., Forskolin stimulates swelling-induced chloride current, not cardiac cystic fibrosis transmembrane-conductance regulator current, in human cardiac myocytes (1995) Circ. Res., 76, pp. 1063-1070; \n\nParrish, J.A., Fitzpatrick, T.B., Tanenbaum, L., Al, E., Photochemotherapy of psoriasis with oral methoxsalen and long-wave ultraviolet light (1974) N. Engl. J. Med., 291, pp. 1207-1211; \n\nPathak, M.A., Kramer, D.M., Fitzpatrick, T.B., (1974) Photobiology and Photochemistry of Furocoumarins (Psoralens), , Tokyo: Univ. of Tokyo Press; \n\nPaul, S., Belinsky, M.G., Shen, H.X., Kruh, G.D., Structure and in vitro substrate specificity of the murine multidrug resistance-associated protein (1996) Biochemistry, 35, pp. 13647-13655; \n\nPearce, S.F., Zadunaisky, J.A., Fluorescent stilbene (BADS) binding proteins in anion-transporting epithelia (1990) Am. J. Physiol. 259 (Cell Physiol. 28), 259, pp. C439-C449; \n\nPeterson, G., Evaluation of the biochemical targets of genistein in tumor cells (1995) J. Nutr., 125 (SUPPL.), pp. 784S-789S; \n\nPhelps, P.C., Best, C.J., Berezesky, I.K., Merriman, R.L., Tanzer, L.R., Boder, G.B., Trump, B.F., Studies on the mechanism of sulofenur and LY295501 toxicity: Effect on the regulation of cytosolic calcium in relation to cytotoxicity in normal and tumorigenic rat kidney cell lines (1995) Cancer Lett., 97, pp. 7-15; \n\nPhelps, P.C., Jain, P.T., Berezesky, I.K., Boder, G.B., Trump, B.F., Sulofenur cytotoxicity and changes in cytosolic calcium and mitochondrial membrane potential in human colon adenocarcinoma cell lines (1995) Cancer Lett., 88, pp. 27-35; \n\nPhilipson, L., Steiner, D., Pas de Deux or More: The sulfonylurea receptor and K+ channels (1995) Science, 268, pp. 372-373; \n\nPiontek, M., Hengels, K.J., Porschen, R., Strohmeyer, G., Antiproliferative effect of tyrosine kinase inhibitors in epidermal growth factor-stimulated growth of human gastric cancer cells (1993) Anticancer Res., 13, pp. 2119-2123; \n\nPollard, C.E., A volume-sensitive Cl- conductance in a mouse neuroblastoma X rat dorsal root ganglion cell line (F11) (1993) Brain Res., 614, pp. 178-184; \n\nPopp, R., Englert, H.C., Lang, H.J., Gogelein, H., Inhibitors of nonselective cation channels in cells of the blood-brain barrier (1993) Exs, 66, pp. 213-218; \n\nPoulsen, J.H., Machen, T.E., HCO3-dependent pHi regulation in tracheal epithelial cells (1996) Pflügers Arch., 432, pp. 546-554; \n\nPowell, D.W., Neuroimmunophysiology of the gastrointestinal mucosa: Implications for inflammatory diseases (1994) Trans. Am. Clin. Climatol. Assoc., 106, pp. 124-140; \n\nRabe, A., Disser, J., Fromter, E., Cl- channel inhibition by glibenclamide is not specific for the CFTR-type Cl- channel (1995) Pflügers Arch., 429, pp. 659-662; \n\nRacker, E., (1985) Transporters of Plasma Membranes, , Orlando, FL: Academic; \n\nRampton, D.S., Sladen, G.E., Relationship between rectal mucosal prostaglandin production and water and electrolyte transport in ulcerative colitis (1984) Digestion, 30, pp. 13-22; \n\nReddy, M.M., Quinton, P.M., Effects of bumetanide on chloride transport in human eccrine sweat ducts: Implications for cystic fibrosis (1987) Israel J. Med. Sci., 23, pp. 1210-1213; \n\nReddy, M.M., Quinton, P.M., Deactivation of CFTR-Cl conductance by endogenous phosphatases in the native sweat duct (1996) Am. J. Physiol. 270 (Cell Physiol. 39), 270, pp. C474-C480; \n\nReenstra, W.W., Yurko-Mauro, K., Dam, A., Raman, S., Shorten, S., CFTR chloride channel activation by genistein: The role of serine/threonine protein phosphatases (1996) Am. J. Physiol. 271 (Cell Physiol. 40), 271, pp. C650-C657; \n\nRettig, J., Heinemann, S.H., Wunder, F., Lorra, C., Parcej, D.N., Dolly, J.O., Pongs, O., Inactivation properties of voltage-gated K+ channels altered by presence of β-subunit (1994) Nature, 369, pp. 289-294; \n\nRich, D.P., Anderson, M.P., Gregory, R.J., Cheng, S.H., Paul, S., Jefferson, D.M., McCann, J.D., Welsh, M.J., Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cells (1990) Nature, 347, pp. 358-363; \n\nRichards, N.W., Dawson, D.C., Selective block of specific K+-conducting channels by diphenylamine-2-carboxylate in turtle colon epithelial cells (1993) J. Physiol. (Lond.), 462, pp. 715-734; \n\nRiordan, J.R., Rommens, J.M., Kerem, B.-S., E, A.L., Identification of the cystic fibrosis gene: Cloning and characterization of complementary DNA (1989) Science, 245, pp. 1066-1073; \n\nRitchie, J.M., (1970) Central Nervous System Stimulants: Xanthines (4th Ed.), , Toronto: MacMillan; \n\nRobson, L., Hunter, M., Role of cell volume and protein kinase C in regulation of a Cl- conductance in single proximal tubule cells of Rana temporaria (1994) J. Physiol. (Lond.), 480, pp. 1-7; \n\nRoman, R.M., Wang, Y., Fitz, J.G., Regulation of cell volume in a human biliary cell line: Activation of K+ and Cl- currents (1996) Am. J. Physiol., 271, pp. G239-G248. , Gastrointest. Liver Physiol. 34; \n\nRommens, J.M., Iannuzzi, M.C., Kerem, B.-S., Al, E., Identification of the cystic fibrosis gene: Chromosome walking and jumping (1989) Science, 245, pp. 1059-1065; \n\nRosenstein, B., (1998) Making the Confirming Diagnosis, pp. 1-42. , edited by D. Orenstein and R. Stern. New York: Dekker; \n\nRoy, G., Malo, C., Activation of amino acid diffusion by a volume increase in cultured kidney (MDCK) cells (1992) J. Membr. Biol., 130, pp. 83-90; \n\nRubera, I., Tauc, M., Michel, F., Poujeol, C., Poujeol, P., Simultaneous functional expression of swelling and forskolin-activated chloride currents in primary cultures of rabbit distal convoluted tubule (1997) C. R. Acad. Sci. Ser. Iii Sci. Vie, 320, pp. 223-232; \n\nRufer, C., Biere, H., Ahrens, H., Loge, O., Schroder, E., Blood glucose lowering sulfonamides with asymmetric carbon atoms (1974) J. Med. Chem., 17, pp. 708-715; \n\nRush, G.F., Rinzel, S., Boder, G., Heim, R.A., Toth, J.E., Ponsler, G.D., Effects of diarylsulfonylurea antitumor agents on the function of mitochondria isolated from rat liver and GC3/c1 cells (1992) Biochem. Pharmacol., 44, pp. 2387-2394; \n\nSahi, J., Goldstein, J.L., Layden, T.J., Rao, M.C., Cyclic AMP- and phorbol ester-regulated Cl permeabilities in primary cultures of human and rabbit colonocytes (1994) Am. J. Physiol. 266 (Gastrointest. Liver Physiol. 29), 266, pp. G846-G855; \n\nSahi, J., Wiggins, M.P., Gibori, G.B., Layden, T.J., Rao, M.C., Calcium regulated chloride permeabilities in primary cultures of rabbit colonocytes (1996) J. Cell. Physiol., 168, pp. 276-283; \n\nSalter, H., On some points in the treatment and clinical history of asthma (1859) Edinburgh Med. J., 4, pp. 1109-1115; \n\nSanchez-Olea, R., Fuller, C., Benos, D., Pasantes-Morales, H., Volume-associated osmolyte fluxes in cell lines with or without the anion exchanger (1995) Am. J. Physiol. 269 (Cell Physiol. 38), 269, pp. C1280-C1286; \n\nSanchez-Olea, R., Pasantes-Morales, H., Lazaro, A., Cereijido, M., Osmolarity-sensitive release of free amino acids from cultured kidney cells (MDCK) (1991) J. Membr. Biol., 121, pp. 1-9; \n\nSanchez-Olea, R., Pena, C., Moran, J., Pasantes-Morales, H., Inhibition of volume regulation and efflux of osmoregulatory amino acids by blockers of Cl transport in cultured astrocytes (1993) Neurosci. Lett., 156, pp. 141-144; \n\nSantell, R.C., Chang, Y.C., Nair, M.G., Helferich, W.G., Dietary genistein exerts estrogenic effects upon the uterus1 mammary gland and the hypothalamic/pituitary axis in rats (1997) J. Nutr., 127, pp. 263-269; \n\nSargent, C.A., Grover, G.J., Antonaccio, M.J., McCullough, J.R., The cardioprotective, vasorelaxant and electrophysiological profile of the large conductance calcium-activated potassium channel opener NS-004 (1993) J. Pharmacol. Exp. Ther., 266, pp. 1422-1429; \n\nSchmid-Antomarchi, H., De Weille, J., Fosset, M., Lazdunski, M., The antidiabetic sulfonylurea glibenclamide is a potent blocker of the ATP-modulated K+ channel in insulin secreting cells (1987) Biochem. Biophys. Res. Commun., 146, pp. 21-25; \n\nSchmid-Antomarchi, H., De Weille, J., Fosset, M., Lazdunski, M., The receptor for antidiabetic sulfonylureas controls the activity of the ATP-modulated K+ channel in insulin-secreting cells (1987) J. Biol. Chem., 262, pp. 15840-15844; \n\nSchultz, B.D., Bridges, R.J., Frizzell, R.A., IBMX-induced fast block of CFTR can explain stimulation of ΔF508-CFTR (1994) Pediatr. Pulmonol. Suppl., 10, p. 205; \n\nSchultz, B.D., Bridges, R.J., Frizzell, R.A., Lack of conventional ATPase properties in CFTR chloride channel gating (1996) J. Membr. Biol., 151, pp. 63-75; \n\nSchultz, B.D., Deroos, A.D., Venglarik, C.J., Singh, A.K., Frizzell, R.A., Bridges, R.J., Glibenclamide blockade of CFTR chloride channels (1996) Am. J. Physiol. 271 (Lung Cell. Mol. Physiol. 15), 271, pp. L192-L200; \n\nSchultz, B.D., Frizzell, R.A., Bridges, R.J., IBMX stabilizes the ATP-bound state of ΔF508-CFTR (1994) J. Gen. Physiol., 104, p. 35; \n\nSchultz, B.D., Liu, C., Devor, D.C., Balombiny, H.L., Frizzell, R.A., Bridges, R.J., Maximizing G551D CFTR Cl- currents with IBMX, genistein and NS004 (1997) Pediatr. Pulmonol. Suppl, 14, p. 235; \n\nSchultz, B.D., Singh, A.K., Aguilar-Bryan, L., Frizzell, R.A., Bridg", "hasCitationDuplums" : false, "userChangeableUntil" : "2014-06-13T16:57:49.000+0000", "publishDate" : "2014-03-15T17:57:49.000+0000", "directInstitutesForSort" : "", "ownerAuthorCount" : 3, "ownerInstituteCount" : 24, "directInstituteCount" : 0, "authorCount" : 4, "contributorCount" : 0, "hasQualityFactor" : false, "link" : "/api/publication/23688114", "label" : "Schultz BD et al. Pharmacology of CFTR chloride channel activity. (1999) PHYSIOLOGICAL REVIEWS 0031-9333 1522-1210 79 1 SUPPL. 1 S109-S144", "template" : "