{ "labelLang" : "hun", "responseDate" : "2024-03-28 22:14", "content" : { "otype" : "JournalArticle", "mtid" : 23603599, "status" : "ADMIN_APPROVED", "published" : true, "unhandledTickets" : 0, "oldTimestamp" : "2018-10-01T21:56:26.000+0000", "deleted" : false, "oldId" : 13603599, "lastRefresh" : "2022-08-01T19:41:51.871+0000", "lastModified" : "2018-10-01T21:56:26.000+0000", "created" : "2014-01-22T09:41:19.000+0000", "creator" : { "otype" : "Author", "mtid" : 10000100, "link" : "/api/author/10000100", "label" : "Sarang Zsolt (Programozott sejthalál, elhalt sejtek fagocitózisa)", "familyName" : "Sarang", "givenName" : "Zsolt", "published" : true, "oldId" : 10000100, "snippet" : true }, "lastDuplumOK" : "2018-10-20T20:09:17.919+0000", "lastDuplumSearch" : "2018-10-20T20:09:17.919+0000", "adminApproved" : "2017-01-09T08:22:40.000+0000", "adminApprover" : { "otype" : "Admin", "mtid" : 10055572, "link" : "/api/admin/10055572", "label" : "Szabó Orsolya (DE/ÁOK/BMBI, DE/ÁOK/BMBI/GenomMBSZL, DE/ÁOK/BMBI/KÁllatH, MTADEFKCS, MTADELGSZRKCS, MTADELIKCS, MTADEŐAGKCS, DE/ÁOK/BMBI/ProteoSzL admin 5)", "familyName" : "Szabó", "givenName" : "Orsolya", "published" : true, "oldId" : 10055572, "snippet" : true }, "core" : false, "citation" : true, "publicationPending" : false, "type" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "languages" : [ { "otype" : "Language", "mtid" : 10002, "link" : "/api/language/10002", "label" : "Angol", "name" : "Angol", "nameEng" : "English", "published" : true, "oldId" : 2, "snippet" : true } ], "firstAuthor" : "McFadyen, MC", "authorships" : [ { "otype" : "PersonAuthorship", "mtid" : 31830948, "link" : "/api/authorship/31830948", "label" : "McFadyen, MC", "listPosition" : 1, "share" : 0.0, "first" : true, "last" : false, "familyName" : "McFadyen", "givenName" : "MC", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 51220848, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 31830949, "link" : "/api/authorship/31830949", "label" : "Murray, GI", "listPosition" : 2, "share" : 0.0, "first" : false, "last" : true, "familyName" : "Murray", "givenName" : "GI", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 51220847, "snippet" : true } ], "title" : "Cytochrome P450 1B1: A novel anticancer therapeutic target", "identifiers" : [ { "otype" : "PublicationIdentifier", "mtid" : 7126595, "link" : "/api/publicationidentifier/7126595", "label" : "DOI: 10.1517/14796694.1.2.259", "source" : { "otype" : "PlainSource", "mtid" : 6, "link" : "/api/publicationsource/6", "label" : "DOI", "type" : { "otype" : "PublicationSourceType", "mtid" : 10001, "link" : "/api/publicationsourcetype/10001", "label" : "DOI", "mayHaveOa" : true, "published" : true, "snippet" : true }, "name" : "DOI", "nameEng" : "DOI", "linkPattern" : "https://doi.org/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 6, "snippet" : true }, "validState" : "NO", "idValue" : "10.1517/14796694.1.2.259", "realUrl" : "https://doi.org/10.1517%2F14796694.1.2.259", "published" : false, "oldId" : 4899120, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 7126596, "link" : "/api/publicationidentifier/7126596", "label" : "PubMed: 16555997", "source" : { "otype" : "PlainSource", "mtid" : 17, "link" : "/api/publicationsource/17", "label" : "PubMed", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "PubMed", "nameEng" : "PubMed", "linkPattern" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract", "publiclyVisible" : true, "published" : true, "oldId" : 17, "snippet" : true }, "validState" : "NO", "idValue" : "16555997", "realUrl" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16555997&dopt=Abstract", "published" : false, "oldId" : 4899121, "snippet" : true } ], "journal" : { "otype" : "Journal", "mtid" : 10012436, "link" : "/api/journal/10012436", "label" : "FUTURE ONCOLOGY 1479-6694 1744-8301", "pIssn" : "1479-6694", "eIssn" : "1744-8301", "reviewType" : "REVIEWED", "noIF" : false, "sciIndexed" : true, "scopusIndexed" : true, "lang" : "FOREIGN", "hungarian" : false, "published" : true, "oldId" : 10012436, "snippet" : true }, "volume" : "1", "issue" : "2", "firstPage" : "259", "lastPage" : "263", "firstPageOrInternalIdForSort" : "259", "pageLength" : 5, "publishedYear" : 2005, "digital" : null, "printed" : null, "sourceYear" : 2014, "packet" : "(Sarang Zsolt (Programozott sejthalál); 2014.01.22. 10:39:35)", "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : false, "conferencePublication" : null, "nationalOrigin" : null, "missingAuthor" : false, "oaType" : "NONE", "oaCheckDate" : "2022-08-01", "oaFree" : false, "citationCount" : 0, "citationCountUnpublished" : 0, "citationCountWoOther" : 0, "independentCitCountWoOther" : 0, "doiCitationCount" : 0, "wosCitationCount" : 0, "scopusCitationCount" : 0, "independentCitationCount" : 0, "unhandledCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "unhandledCitingPubCount" : 0, "citedPubCount" : 1, "citedCount" : 1, "referenceList" : "Murray, G.I., Taylor, M.C., McFadyen, M.C., Tumour specific expression of cytochrome P450 CYP1B1 (1997) Cancer Res., 57, pp. 3026-3031; \n\nMurray, G.I., Taylor, M.C., Burke, M.D., Melvin, W.T., Enhanced expression of cytochrome P450 in stomach cancer (1998) Br. J. Cancer, 77, pp. 1040-1004; \n\nMurray, G.I., The role of cytochrome P450 in tumour development and progression and its potential in therapy (2000) J. Pathol, 192, pp. 419-426; \n\nMcFadyen, M.C.E., McLeod, H.L., Jackson, F.C., Melvin, W.T., Doehmer, J., Murray, G.I., Cytochrome P450 CYP1B1 protein expression. A novel mechanism of anti-cancer drug resistance (2001) Biochem. Pharmacol, 62, pp. 207-212; \n\nMcFadyen, M.C.E., Breeman, S., Payne, S., Immunohistochemical localisation of cytochrome P450 CYP1B1 in breast cancer with monoclonal antibodies specific for CYP1B1 (1999) J. Histochem. Cytochem., 47, pp. 1457-1464; \n\nMurray, G.I., Melvin, W.T., Greenlee, W.F., Burke, M.D., Regulation, function and tissue-specific expression of cytochrome P450 CYP1B1 (2001) Annu. Rev. Pharmacol.Toxicol, 41, pp. 297-316; \n\nPatterson, L.H., Murray, G.I., Tumour cytochrome P450 and drug activation (2002) Curr. Pharm. des, 8, pp. 1335-1347; \n\nMcFadyen, M.C.E., Cruickshank, M.E., Miller, I.D., Cytochrome P450 CYP1B1 is overexpressed in primary and secondary ovarian cancer (2001) Br. J. Cancer, 85, pp. 242-246; \n\nChaib, H., Cockrell, E.K., Rubin, M.A., Macoska, J.A., Profiling and verification of gene expression patterns in normal and malignant human prostate tissues by cDNA microarray analysis (2001) Neoplasia, 3, pp. 43-52; \n\nHellmann, G.M., Fields, W.R., Doolittle, D.J., Gene expression profiling of cultured human bronchial epithelial and lung carcinoma cells (2000) Toxicol. Sci, 61, pp. 154-163; \n\nIslam, T.C., Lindvall, J., Wennborg, A., Branden, L.J., Rabbani, H., Smith, C.I., Expression profiling in transformed human B cells: Influence of Btk mutations and comparison to B cell lymphomas using filter and oligonucleotide arrays (2002) Eur. J. Immunol, 32, pp. 982-993; \n\nVondracek, M., Weaver, D.A., Sarang, Z., Transcript profiling of enzymes involved in detoxification of xenobiotics and reactive oxygen in human normal and simian virus 40 T antigen-immortalized oral keratinocytes (2002) Int. J. Cancer, 99, pp. 776-782; \n\nEdwards, R.J., Adams, D.A., Watts, P.S., Davies, D.S., Boobis, A.R., Development of a comprehensive panel of antibodies against the major xenobiotic metabolising forms of cytochrome P450 in humans (1998) Biochem. Pharmacol, 56, pp. 377-387; \n\nMcFadyen, M.C.E., Melvin, W.T., Murray, G.I., Cytochrome P450 CYP1B1 activity in renal cell carcinoma (2004) Br. J. Cancer, 91, pp. 966-971; \n\nMaecker, B., Sherr, D.H., Vonderheide, R.H., The shared tumor-associated antigen cytochrome P450 1B1 is recognized by specific cytotoxic T cells (2003) Blood, 102, pp. 3287-3294; \n\nLuby, T.M., Cole, G., Baker, L., Kornher, J.S., Ramstedt, U., Hedley, M.L., Repeated immunization with plasmid DNA formulated in poly(lactide-co- glycolide) microparticles is well tolerated and stimulates durable T cell responses to the tumorassociated antigen cytochrome P450 1B1 (2004) Clin. Immunol, 112, pp. 45-53; \n\nPotter, G.A., Patterson, L.H., Wanogho, E., The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1 (2002) Br. J. Cancer, 86, pp. 774-778; \n\nWardman, P., Free radicals and new prodrugs for cancer therapy (2002) CRC Scientific Yearbook 2001-2002, pp. 36-39. , UK; \n\nRochat, B., Morsman, J.M., Murray, G.I., Figg, W.D., McLeod, H.L.L., Human CYP1B1 and anti-cancer agent metabolism: Mechanism for tumor specific drug inactivation? (2001) J. Pharmacol. Exp. Ther., 296, pp. 537-541; \n\nBournique, B., Lemarie, A., Docetaxel (Taxotere) is not metabolized by recombinant human CYP1B1 in vitro, but acts as an effector of this isozyme (2003) Drug Metab. Dispos., 30, pp. 1149-1152; \n\nRoberts, D.W., Doerge, D.R., Churchwell, M.I., Inhibition of extrahepatic human cytochromes P450 1A1 and 1B1 by metabolism of isoflavones found in Trifolium pratense (red clover) (2004) Agric. Food Chem., 52, pp. 6623-6632; \n\nBai, J., Sata, N., Nagai, H., Genisteininduced changes in gene expression in Panc 1 cells at physiological concentrations of genistein (2004) Pancreas, 29, pp. 93-98; \n\nChang, T.K., Lee, W.B., Ko, H.H., Transresveratrol modulates the catalytic activity and mRNA expression of the procarcinogenactivating human cytochrome P450 1B1 (2000) Can. J. Physiol. Pharmacol, 78, pp. 874-881; \n\nChun, Y.J., Kim, S., Kim, D., Lee, S.K., Guengerich, F.P., A new selective and potent inhibitor of human cytochrome P450 1B1 and its application to antimutagenesis (2001) Cancer Res., 61, pp. 8164-8170; \n\nChun, Y.J., Kim, S., Discovery of cytochrome P450 1B1 inhibitors as new promising anticancer agents (2003) Med. Res. Rev., 23, pp. 657-668; \n\nInayat-Hussain, S.H., Thomas, N.F., Recent advances in the discovery and development of stilbenes and lactones in anticancer therapy (2004) Expert Opin. Ther. Patents, 14, pp. 1-17; \n\nArora, V., Cate, M.L., Ghosh, C., Iversen, P.L., Phosphorodiamidate morpholino antisense oligomers inhibit expression of human cytochrome P450 3A4 and alter selected drug metabolism (2002) Drug Metab. Dispos., 30, pp. 757-762; \n\nKumarakulasingham, M., Rooney, P.H., Dundas, S.R., Cytochrome P450 profile of colorectal cancer: Identification of markers of prognosis (2005) Clin. Cancer Res, , In press; \n\nMGI Pharmabiologics, , www.mgipharmabiologics.com, Previously Zycos Inc Accessed March 2005; \n\n(2005) Gray Cancer Institute Research Report 2001, , www.gci.ac.uk, Accessed March; \n\n(2005), www.avibio.com/home.html, AVI Biopharma Inc Accessed MarchUR - http://www.scopus.com/inward/record.url?eid=2-s2.0-33646463990&partnerID=40&md5=6ae1c313cf9eccd862d48f62e616e3cd", "hasCitationDuplums" : false, "userChangeableUntil" : "2017-01-09T08:22:40.000+0000", "publishDate" : "2014-01-22T09:41:58.000+0000", "directInstitutesForSort" : "", "ownerAuthorCount" : 1, "ownerInstituteCount" : 6, "directInstituteCount" : 0, "authorCount" : 2, "contributorCount" : 0, "hasQualityFactor" : false, "link" : "/api/publication/23603599", "label" : "McFadyen MC et al. Cytochrome P450 1B1: A novel anticancer therapeutic target. (2005) FUTURE ONCOLOGY 1479-6694 1744-8301 1 2 259-263", "template" : "