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Normal activation, premature intrapancreatic activation, protective mechanisms against inappropriate activation (1986) Dig Dis Sci, 31, pp. 314-321; \n\nVárallyay, É., Two mutations in the rat trypsin confer resistance against autolysis (1998) Biochem Biophys Res Commun, 243, pp. 56-60; \n\nFérec, C., Raguénès, O., Salomon, R., Mutations in the cationic trypsinogen gene and evidence for genetic heterogeneity in hereditary pancreatitis (1999) J Med Genet, 36, pp. 228-232; \n\nSahin-Tóth, M., Gráf, L., Tóth, M., Trypsinogen stabilization by mutation arg117-to-his: An unifying pathomechanism for hereditary pancreatitis? 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