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DAOM 175924 was found on the Hungary oyster mushroom farm (Hatvani et al., 2007) and the study showed that two different, although genetically closely related species, Trichoderma pleurotum (the correct name Trichoderma\npleuroti, see Atanasova et al., in press ) and T. pleuroticola together with T. aggressivum were the causing agents of green mold disease in Hungary, Poland, Romania, Italy, South Korea and Taiwan (Park et al., 2004; Hatvani et al., 2007; Komon-Zelazowska et al., 2007).\n...\nThis clade contains also species known as green mold disease agents on mushroom farms from all north temperate regions (T. aggressivum, T. pleurotum and T. pleuroticola; Samuels et al., 2002; Park et al., 2006; Komon-Zelazowska et al., 2007).\n...\nThe study revealed general metabolic characteristic of the genus and confirmed the applicability\nof this method as a supplement in species identification and later it became a useful tool in delimitation of novel species (Kraus et al., 2004; Komon-Zelazowska et al., 2007; Druzhinina et al., 2010a; Atanasova et al., 2010; Hoyos-Carvajal et al., 2009).\nMegjegyzés-23356631\nAll over the World in the last three decades severe damages have been caused by Trichoderma\nspp. what led to the extensive studies to identify the green mold disease agents (Muthumeenakshi et al., 1994; Castle et al., 1998; Park et al., 2004, 2006; Hatvani\net al., 2007; Komon-Zelazowska et al., 2007). A survey based on the molecular identification and diagnostic test for Trichoderma aggressivum, showed that seven species, T. aggressivum f. europaeum, T. asperellum, T. atroviride, Trichoderma ghanense, T. harzianum sensu lato, T. longibrachiatum and new undescribed phylogenetic species Trichoderma sp. DAOM 175924 co-occur in the infected mushroom substrates (Hatvani et al., 2007), but aggressive colonization was claimed to be exclusively due to two formae speciales of a new Trichoderma species, viz.\nT. aggressivum f. europaeum in Europe and T. aggressivum f. aggressivum in North America (Samuels et al., 2002). The same ITS1 and 2 allele as known for T. sp. DAOM 175924 was found on the Hungary oyster mushroom farm (Hatvani et al., 2007) and the study showed that two different, although genetically closely related species, Trichoderma pleurotum (the correct name Trichoderma pleuroti, see Atanasova et al., in press ) and T. pleuroticola together with T. aggressivum were the causing agents of green mold disease in Hungary, Poland, Romania, Italy,\nSouth Korea and Taiwan (Park et al., 2004; Hatvani et al., 2007; Komon-Zelazowska et al., 2007).\nMegjegyzés-23356655\nFurthermore, biotrophic interactions were observed also with other organisms such as immunocompromised humans (Kredics et al., 2003; Druzhinina et al., 2008) or nematodes (Casas-Flores and Herrera-Estrella, 2007) (Fig. 20.1).\n...\n\nTrichoderma spp. can cause invasive mycosis in immunocompromised mammals including humans. Such\ninvasions are up to date known only from H. orientalis, clonal T. longibrachiatum, and possibly T. cf. harzianum (Guarro et al., 1999; Kredics et al., 2003; Druzhinina et al., 2008; Kantarcioğlu et al., 2009) though there are several species that can grow at 37 °C such as T. reesei or T. citrinoviride.\nMegjegyzés-23356621\n...\nSimilar coexistence was also shown for T. longibrachiatum and Hypocrea orientalis isolated from terrestrial (Druzhinina et al., 2008; Kredics et al., 2008) and marine environments (Gal-Hamed et al., 2010).\n...\nClinical Trichoderma species were typically isolated from the peritoneal effluent of dialysis patients, infections of immunocompromised transplant recipients, and patients suffering\nfrom leukemia, brain abscesses and HIV (Druzhinina et al., 2008).\nIt has been shown that the lung cell cultures infected with T. longibrachiatum stated to rapidly sediment and lose their adhesive properties compared to those infected with T. reesei, implying that 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