{ "labelLang" : "hun", "responseDate" : "2024-03-28 09:19", "content" : { "otype" : "JournalArticle", "mtid" : 23319950, "status" : "ADMIN_APPROVED", "published" : true, "comment" : "Megjegyzés-22352238\nChemicals/CAS: multidrug resistance protein, 149200-37-3, 208997-77-7; Flavonoids; Lipid Bilayers; Multidrug Resistance-Associated Proteins; P-Glycoprotein; Phenothiazines; Stilbenes; multidrug resistance-associated protein 1\nMegjegyzés-22406571\nN1 Source: Scopus\nN1 PubMed ID: 22187677\nN1 Language of Original Document: English\nN1 Chemicals/CAS: multidrug resistance protein, 149200-37-3, 208997-77-7; Flavonoids; Lipid Bilayers; Multidrug Resistance-Associated Proteins; P-Glycoprotein; Phenothiazines; Stilbenes; multidrug resistance-associated protein 1\nN1 References: Akiyama, S., Cornwell, M.M., Kuwano, M., Pastan, I., Gottesman, M.M., Most drugs that reverse multidrug resistance also inhibit photoaffinity labeling of P-glycoprotein by a vinblastine analog (1988) Mol Pharmacol, 33, pp. 144-147; \nAller, S.G., Yu, J., Ward, A., Weng, Y., Chittaboina, S., Zhuo, R., Harrell, P.M., Chang, G., Structure of Pglycoprotein reveals a molecular basis for poly-specific drug binding (2009) Science, 323, pp. 1718-1722; \nAlvarez, A.I., Real, R., Perez, M., Mendoza, G., Prieto, J.G., Merino, G., Modulation of the activity of ABC transporters (P-glycoprotein, MRP2, BCRP) by flavonoids and drug response (2010) J Pharm Sci, 99, pp. 598-617; \nAmbudkar, S.V., Dey, S., Hrycyna, C.A., Ramachandra, M., Pastan, I., Gottesman, M.M., Biochemical, cellular, and pharmacological aspects of the multidrug transporter (1999) Annu Rev Pharmacol Toxicol, 39, pp. 361-398; \nAmbudkar, S.V., Kim, I.W., Sauna, Z.E., The power of the pump: Mechanisms of action of P-glycoprotein (ABCB1) (2006) Eur J Pharm Sci, 27, pp. 392-400; \nAyesh, S., Shao, Y.M., Stein, W.D., Co-operative, competitive and non-competitive interactions between modulators of P-glycoprotein (1996) Biochim Biophys Acta, 1316, pp. 8-18; \nBarbieri, F., Alama, A., Tasso, B., Boido, V., Bruzzo, C., Sparatore, F., Quinolizidinyl derivatives of iminodibenzyl and phenothiazine as multidrug resistance modulators in ovarian cancer cells (2003) Invest New Drugs, 21, pp. 413-420; \nBaur, J.A., Sinclair, D.A., Therapeutic potential of resveratrol: the in vivo evidence (2006) Nat Rev Drug Discov, 5, pp. 493-506; \nBebawy, M., Morris, M.B., Roufogalis, B.D., Selective modulation of P-glycoprotein-mediated drug resistance (2001) Br J Cancer, 85, pp. 1998-2003; \nBeck, W.T., Cellular pharmacology of Vinca alkaloid resistance and its circumvention (1984) Adv Enzyme Regul, 22, pp. 207-227; \nBisi, A., Meli, M., Gobbi, S., Rampa, A., Tolomeo, M., Dusonchet, L., Multidrug resistance reverting activity and antitumor profile of new phenothiazine derivatives (2008) Bioorg Med Chem, 16, pp. 6474-6482; \nBobrowska-Hagerstrand, M., Wrobel, A., Mrowczynska, L., Soderstrom, T., Shirataki, Y., Motohashi, N., Molnar, J., Hagerstrand, H., Flavonoids as inhibitors of MRP1-like efflux activity in human erythrocytes. A structure-activity relationship study (2003) Oncol Res, 13, pp. 463-469; \nBobrowska-Hagerstrand, M., Lillas, M., Mrowczynska, L., Wrobel, A., Shirataki, Y., Motohashi, N., Hagerstrand, H., Resveratrol oligomers are potent MRP1 transport inhibitors (2006) Anticancer Res, 26, pp. 2081-2084; \nBoccard, J., Bajot, F., Di Pietro, A., Rudaz, S., Boumendjel, A., Nicolle, E., Carrupt, P.A., A 3D linear solvation energy model to quantify the affinity of flavonoid derivatives toward P-glycoprotein (2009) Eur J Pharm Sci, 36, pp. 254-264; \nBorst, P., Zelcer, N., van de Wetering, K., Poolman, B., On the putative co-transport of drugs by multidrug resistance proteins (2006) FEBS Lett, 580, pp. 1085-1093; \nBoumendjel, A., Di Pietro, A., Dumontet, C., Barron, D., Recent advances in the discovery of flavonoids and analogs with high-affinity binding to P-glycoprotein responsible for cancer cell multidrug resistance (2002) Med Res Rev, 22, pp. 512-529; \nBroccatelli, F., Carosati, E., Neri, A., Frosini, M., Goracci, L., Oprea, T.I., Cruciani, G., A novel approach for predicting P-glycoprotein (ABCB1) inhibition using molecular interaction fields (2011) J Med Chem, 54, pp. 1740-1751; \nCallaghan, R., Higgins, C.F., Interaction of tamoxifen with the multidrug resistance P-glycoprotein (1995) Br J Cancer, 71, pp. 294-299; \nCampbell, J.D., Koike, K., Moreau, C., Sansom, M.S., Deeley, R.G., Cole, S.P., Molecular modeling correctly predicts the functional importance of Phe594 in transmembrane helix 11 of the multidrug resistance protein. MRP1 (ABCC1) (2004) J Biol Chem, 279, pp. 463-468; \nCastro, A.F., Altenberg, G.A., Inhibition of drug transport by genistein in multidrug-resistant cells expressing P-glycoprotein (1997) Biochem Pharmacol, 53, pp. 89-93; \nChan, K.F., Zhao, Y., Burkett, B.A., Wong, I.L., Chow, L.M., Chan, T.H., Flavonoid dimers as bivalent modulators for P-glycoprotein-based multidrug resistance: synthetic apigenin homodimers linked with defined-length poly(ethylene glycol) spacers increase drug retention and enhance chemosensitivity in resistant cancer cells (2006) J Med Chem, 49, pp. 6742-6759; \nChieli, E., Romiti, N., Cervelli, F., Tongiani, R., Effects of flavonols on P-glycoprotein activity in cultured rat hepatocytes (1995) Life Sci, 57, pp. 1741-1751; \nChoi, C.H., Kim, J.H., Kim, S.H., Reversal of P-glycoprotein-mediated MDR by 5,7,3',4',5'-pentamethoxyflavone and SAR (2004) Biochem Biophys Res Commun, 320, pp. 672-679; \nChoi, J.S., Choi, B.C., Kang, K.W., Effect of resveratrol on the pharmacokinetics of oral and intravenous nicardipine in rats: possible role of P-glycoprotein inhibition by resveratrol (2009) Pharmazie, 64, pp. 49-52; \nChoudhuri, S., Klaassen, C.D., Structure, function, expression, genomic organization, and single nucleotide polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) efflux transporters (2006) Int J Toxicol, 25, pp. 231-259; \nChung, S.Y., Sung, M.K., Kim, N.H., Jang, J.O., Go, E.J., Lee, H.J., Inhibition of P-glycoprotein by natural products in human breast cancer cells (2005) Arch Pharm Res, 28, pp. 823-828; \nCole, S.P., Bhardwaj, G., Gerlach, J.H., Mackie, J.E., Grant, C.E., Almquist, K.C., Stewart, A.J., Deeley, R.G., Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line (1992) Science, 258, pp. 1650-1654; \nConseil, G., Baubichon-Cortay, H., Dayan, G., Jault, J.M., Barron, D., Di Pietro, A., Flavonoids: a class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse Pglycoprotein (1998) Proc Natl Acad Sci USA, 95, pp. 9831-9836; \nCritchfield, J.W., Welsh, C.J., Phang, J.M., Yeh, G.C., Modulation of adriamycin accumulation and efflux by flavonoids in HCT-15 colon cells. Activation of P-glycoprotein as a putative mechanism (1994) Biochem Pharmacol, 48, pp. 1437-1445; \nCrowley, E., Callaghan, R., Multidrug efflux pumps: drug binding - gates or cavity? (2010) FEBS J, 277, pp. 530-539; \nCrowley, E., McDevitt, C.A., Callaghan, R., Generating inhibitors of P-glycoprotein: where to, now? (2010) Methods Mol Biol, 596, pp. 405-432; \nDe Vincenzo, R., Scambia, G., Benedetti Panici, P., Fattorossi, A., Bonanno, G., Ferlini, C., Isola, G., Mancuso, S., Modulatory effect of tamoxifen and ICI, 182. 780 on adriamycin resistance in MCF-7 human breast-cancer cells (1996) Int J Cancer, 68, pp. 340-348; \nDean, M., The genetics of ATP-binding cassette transporters (2005) Methods Enzymol, 400, pp. 409-429; \nDearden, J.C., Al-Noobi, A., Scott, A.C., Thomson, S.A., QSAR studies on P-glycoprotein-regulated multidrug resistance and on its reversal by phenothiazines (2003) SAR QSAR Environ Res, 14, pp. 447-454; \nDeeley, R.G., Cole, S.P., Substrate recognition and transport by multidrug resistance protein 1 (ABCC1) (2006) FEBS Lett, 580, pp. 1103-1111; \nDey, S., Ramachandra, M., Pastan, I., Gottesman, M.M., Ambudkar, S.V., Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein (1997) Proc Natl Acad Sci USA, 94, pp. 10594-10599; \nDi Pietro, A., Conseil, G., Perez-Victoria, J.M., Dayan, G., Baubichon-Cortay, H., Trompier, D., Steinfels, E., Barron, D., Modulation by flavonoids of cell multidrug resistance mediated by P-glycoprotein and related ABC transporters (2002) Cell Mol Life Sci, 59, pp. 307-322; \nDoualla-Bell Kotto Maka, F., Breuiller, M., Leroy, M.J., Josserand, S., Ferre, F., Sensitivity of the human myometrial adenylate cyclase to calcium and calmodulin (1990) Gynecol Obstet Invest, 30, pp. 169-173; \nDzubak, P., Hajduch, M., Gazak, R., Svobodova, A., Psotova, J., Walterova, D., Sedmera, P., Kren, V., New derivatives of silybin and 2,3-dehydrosilybin and their cytotoxic and P-glycoprotein modulatory activity (2006) Bioorg Med Chem, 14, pp. 3793-3810; \nEvers, R., de Haas, M., Sparidans, R., Beijnen, J., Wielinga, P.R., Lankelma, J., Borst, P., Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export (2000) Br J Cancer, 83, pp. 375-383; \nEytan, G.D., Regev, R., Oren, G., Assaraf, Y.G., The role of passive transbilayer drug movement in multidrug resistance and its modulation (1996) J Biol Chem, 271, pp. 12897-12902; \nFabris, S., Momo, F., Ravagnan, G., Stevanato, R., Antioxidant properties of resveratrol and piceid on lipid peroxidation in micelles and monolamellar liposomes (2008) Biophys Chem, 135, pp. 76-83; \nFaustino, R.S., Sobrattee, S., Edel, A.L., Pierce, G.N., Comparative analysis of the phenolic content of selected Chilean. Canadian and American Merlot red wines (2003) Mol Cell Biochem, 249, pp. 11-19; \nFerreira, M.J., Duarte, N., Gyemant, N., Radics, R., Cherepnev, G., Varga, A., Molnar, J., Interaction between doxorubicin and the resistance modifier stilbene on multidrug resistant mouse lymphoma and human breast cancer cells (2006) Anticancer Res, 26, pp. 3541-3546; \nFojo, A., Hamilton, T.C., Young, R.C., Ozols, R.F., Multidrug resistance in ovarian cancer (1987) Cancer, 60, pp. 2075-2080; \nFont, J., Marino, A., Ravelingien, N., Dehaye, J.P., Trueba, M., Macarulla, J.M., Calcium-activated, phospholipid-dependent protein kinase activity in calf platelets (1990) Rev Esp Fisiol, 46, pp. 325-330; \nFord, J.M., Prozialeck, W.C., Hait, W.N., Structural features determining activity of phenothiazines and related drugs for inhibition of cell growth and reversal of multidrug resistance (1989) Mol Pharmacol, 35, pp. 105-115; \nFromm, M.F., P-glycoprotein: a defense mechanism limiting oral bioavailability and CNS accumulation of drugs (2000) Int J Clin Pharmacol Ther, 38, pp. 69-74; \nGanapathi, R., Grabowski, D., Rouse, W., Riegler, F., Differential effect of the calmodulin inhibitor trifluoperazine on cellular accumulation, retention, and cytotoxicity of anthracyclines in doxorubicin (adriamycin)-resistant P388 mouse leukemia cells (1984) Cancer Res, 44, pp. 5056-5061; \nGerrard, G., Payne, E., Baker, R.J., Jones, D.T., Potter, M., Prentice, H.G., Ethell, M., Ganeshaguru, K., Clinical effects and P-glycoprotein inhibition in patients with acute myeloid leukemia treated with zosuquidar trihydrochloride, daunorubicin and cytarabine (2004) Haematologica, 89, pp. 782-790; \nGottesman, M.M., Pastan, I., Biochemistry of multidrug resistance mediated by the multidrug transporter (1993) Annu Rev Biochem, 62, pp. 385-427; \nGottesman, M.M., Pastan, I., Ambudkar, S.V., P-glycoprotein and multidrug resistance (1996) Curr Opin Genet Devel, 6, pp. 610-617; \nGutmann, D.A., Ward, A., Urbatsch, I.L., Chang, G., van Veen, H.W., Understanding polyspecificity of multidrug ABC transporters: closing in on the gaps in ABCB1 (2010) Trends Biochem Sci, 35, pp. 36-42; \nGyemant, N., Tanaka, M., Antus, S., Hohmann, J., Csuka, O., Mandoky, L., Molnar, J., In vitro search for synergy between flavonoids and epirubicin on multidrug-resistant cancer cells (2005) In Vivo, 19, pp. 367-374; \nHarborne, J.B., Williams, C.A., Advances in flavonoid research since 1992 (2000) Phytochemistry, 55, pp. 481-504; \nHendrich, A.B., Wesolowska, O., Michalak, K., Trifluoperazine induces domain formation in zwitterionic phosphatidylcholine but not in charged phosphatidylglycerol bilayers (2001) Biochim Biophys Acta, 1510, pp. 414-425; \nHendrich, A.B., Michalak, K., Lipids as a target for drugs modulating multidrug resistance of cancer cells (2003) Curr Drug Targ, 4, pp. 23-30; \nHendrich, A.B., Wesolowska, O., Motohashi, N., Molnar, J., Michalak, K., New phenothiazine-type multidrug resistance modifiers: anti-MDR activity versus membrane perturbing potency (2003) Biochem Biophys Res Commun, 304, pp. 260-265; \nHendrich, A.B., Wesolowska, O., Pola, A., Motohashi, N., Molnar, J., Michalak, K., Neither lipophilicity nor membrane-perturbing potency of phenothiazine maleates correlate with the ability to inhibit P-glycoprotein transport activity (2003) Mol Membr Biol, 20, pp. 53-60; \nHiggins, C.F., Multiple molecular mechanisms for multidrug resistance transporters (2007) Nature, 446, pp. 749-757; \nHipfner, D.R., Deeley, R.G., Cole, S.P.C., Structural, mechanistic and clinical aspects of MRP1 (1999) Biochim Biophys Acta, 1461, pp. 359-376; \nHooijberg, J.H., Broxterman, H.J., Scheffer, G.L., Vrasdonk, C., Heijn, M., de Jong, M.C., Scheper, R.J., Pinedo, H.M., Potent interaction of flavopiridol with MRP1 (1999) Br J Cancer, 81, pp. 269-276; \nJodoin, J., Demeule, M., Beliveau, R., Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols (2002) Biochim Biophys Acta, 1542, pp. 149-159; \nJohnson, J.D., Wittenauer, L.A., A fluorescent calmodulin that reports the binding of hydrophobic inhibitory ligands (1983) Biochem J, 211, pp. 473-479; \nJuliano, R.L., Ling, V., A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants (1976) Biochim Biophys Acta, 455, pp. 152-162; \nKane, S.E., Multidrug resistance of cancer cells (1996) Adv Drug Res, 28, pp. 181-252; \nKatayama, K., Masuyama, K., Yoshioka, S., Hasegawa, H., Mitsuhashi, J., Sugimoto, Y., Flavonoids inhibit breast cancer resistance protein-mediated drug resistance: transporter specificity and structureactivity relationship (2007) Cancer Chemother Pharmacol, 60, pp. 789-797; \nKaye, S.B., The multidrug resistance phenotype (1988) Br J Cancer, 58, pp. 691-694; \nKeppler, D., Leier, I., Jedlitschky, G., Transport of glutathione conjugates and glucuronides by the multidrug resistance proteins MRP1 and MRP2 (1997) Biol Chem, 378, pp. 787-791; \nKitagawa, S., Nabekura, T., Takahashi, T., Nakamura, Y., Sakamoto, H., Tano, H., Hirai, M., Tsukahara, G., Structure-activity relationships of the inhibitory effects of flavonoids on P-glycoprotein-mediated transport in KB-C2 cells (2005) Biol Pharm Bull, 28, pp. 2274-2278; \nKitagawa, S., Inhibitory effects of polyphenols on P-glycoproteinmediated transport (2006) Biol Pharm Bull, 29, pp. 1-6; \nKonya, A., Andor, A., Satorhelyi, P., Nemeth, K., Kurucz, I., Inhibition of the MDR1 transporter by new phenothiazine derivatives (2006) Biochem Biophys Res Commun, 346, pp. 45-50; \nKothandan, G., Gadhe, C.G., Madhavan, T., Choi, C.H., Cho, S.J., Docking and 3D-QSAR (quantitative structure activity relationship) studies of flavones, the potent inhibitors of P-glycoprotein targeting the nucleotide binding domain (2011) Eur J Med Chem, 46, pp. 4078-4088; \nKweon, S.H., Song, J.H., Kim, T.S., Resveratrol-mediated reversal of doxorubicin resistance in acute myeloid leukemia cells via downregulation of MRP1 expression (2010) Biochem Biophys Res Commun, 395, pp. 104-110; \nLage, H., ABC-transporters: implications on drug resistance from microorganisms to human cancers (2003) Int J Antimicrob Agents, 22, pp. 188-199; \nLage, H., An overview of cancer multidrug resistance: a still unsolved problem (2008) Cell Mol Life Sci, 65, pp. 3145-3167; \nLania-Pietrzak, B., Michalak, K., Hendrich, A.B., Mosiadz, D., Grynkiewicz, G., Motohashi, N., Shirataki, Y., Modulation of MRP1 protein transport by plant, and synthetically modified flavonoids (2005) Life Sci, 77, pp. 1879-1891; \nLee, C.H., Reversing agents for ATP-binding cassette drug transporters (2010) Methods Mol Biol, 596, pp. 325-340; \nLeier, I., Jedlitschky, G., Buchholz, U., Cole, S.P., Deeley, R.G., Keppler, D., The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates (1994) J Biol Chem, 269, pp. 27807-27810; \nLeite, D.F., Echevarria-Lima, J., Salgado, L.T., Capella, M.A., Calixto, J.B., Rumjanek, V.M., In vivo and in vitro modulation of MDR molecules in murine thymocytes (2006) Int Immunopharmacol, 6, pp. 204-215; \nLeonard, G.D., Polgar, O., Bates, S.E., ABC transporters and inhibitors: new targets, new agents (2002) Curr Opin Investig Drugs, 3, pp. 1652-1659; \nLeslie, E.M., Mao, Q., Oleschuk, C.J., Deeley, R.G., Cole, S.P.C., Modulation of multidrug resistance protein 1 (MRP1/ABCC1) transport and ATPase activities by interaction with dietary flavonoids (2001) Mol Pharmacol, 59, pp. 1171-1180; \nLeslie, E.M., Deeley, R.G., Cole, S.P., Bioflavonoid stimulation of glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1) (2003) Drug Metab Dispos, 31, pp. 11-15; \nLeslie, E.M., Deeley, R.G., Cole, S.P., Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense (2005) Toxicol Appl Pharmacol, 204, pp. 216-237; \nLiu, R., Sharom, F.J., Site-directed fluorescence labeling of P-glycoprotein on cysteine residues in the nucleotide binding domains (1996) Biochemistry, 35, pp. 11865-11873; \nLiu, R., Siemiarczuk, A., Sharom, F.J., Intrinsic fluorescence of the P-glycoprotein multidrug transporter: sensitivity of tryptophan residues to binding of drugs and nucleotides (2000) Biochemistry, 38, pp. 14927-14938; \nLoe, D.W., Almquist, K.C., Deeley, R.G., Cole, S.P., Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles, Demonstration of glutathione-dependent vincristine transport (1996) J Biol Chem, 271, pp. 9675-9682; \nLoe, D.W., Deeley, R.G., Cole, S.P., Characterization of vincristine transport by the M(r), 190,000 multidrug resistance protein (MRP): evidence for cotransport with reduced glutathione (1998) Cancer Res, 58, pp. 5130-5136; \nLoe, D.W., Deeley, R.G., Cole, S.P., Verapamil stimulates glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1) (2000) J Pharmacol Exp Ther, 293, pp. 530-538; \nLoe, D.W., Oleschuk, C.J., Deeley, R.G., Cole, S.P., Structure-activity studies of verapamil analogs that modulate transport of leukotriene C 4 and reduced glutathione by multidrug resistance protein MRP1 (2000) Biochem Biophys Res Commun, 275, pp. 795-803; \nLoo, T.W., Bartlett, M.C., Clarke, D.M., Simultaneous binding of two different drugs in the binding pocket of the human multidrug resistance P-glycoprotein (2003) J Biol Chem, 278, pp. 39706-39710; \nLugo, M.R., Sharom, F.J., Interaction of LDS-751 with P-glycoprotein and mapping of the location of the R drug binding site (2005) Biochemistry, 44, pp. 643-655; \nMao, Q., Leslie, E.M., Deeley, R.G., Cole, S.P., ATPase activity of purified and reconstituted multidrug resistance protein MRP1 from drug-selected H69AR cells (1999) Biochim Biophys Acta, 1461, pp. 69-82; \nMarbeuf-Gueye, C., Ettori, D., Priebe, W., Kozlowski, H., Garnier-Suillerot, A., Correlation between the kinetics of anthracycline uptake and the resistance factor in cancer cells expressing the multidrug resistance protein or the P-glycoprotein (1999) Biochim Biophys Acta, 1450, pp. 374-384; \nMarques, L.O., Lima, M.S., Soares, B.G., Trifluoperazine for schizophrenia (2004) Cochrane Database Syst Rev, pp. CD003545; \nMartin, C., Berridge, G., Higgins, C.F., Mistry, P., Charlton, P., Callaghan, R., Communication between multiple drug binding sites on Pglycoprotein (2000) Mol Pharmacol, 58, pp. 624-632; \nMavel, S., Dikic, B., Palakas, S., Emond, P., Greguric, I., de Gracia, A.G., Mattner, F., Katsifis, A., Synthesis and biological evaluation of a series of flavone derivatives as potential radioligands for imaging the multidrug resistance-associated protein 1 (ABCC1/MRP1) (2006) Bioorg Med Chem, 14, pp. 1599-1607; \nMcDevitt, C.A., Callaghan, R., How can we best use structural information on P-glycoprotein to design inhibitors? (2007) Pharmacol Ther, 113, pp. 429-441; \nMichalak, K., Wesolowska, O., Motohashi, N., Molnar, J., Hendrich, A.B., Interactions of phenothiazines with lipid bilayer and their role in multidrug resistance reversal (2006) Curr Drug Targets, 7, pp. 1095-1105; \nMichalak, K., Wesolowska, O., Motohashi, N., Hendrich, A.B., The role of the membrane actions of phenothiazines and flavonoids as functional modulators (2007) Top Heterocycl Chem, 8, pp. 223-302; \nMolnar, J., Molnar, A., Mucsi, I., Pinter, O., Nagy, B., Varga, A., Motohashi, N., Reversal of multidrug resistance in mouse lymphoma cells by phenothiazines (2003) In Vivo, 17, pp. 145-149; \nMolnar, J., Engi, H., Hohmann, J., Molnar, P., Deli, J., Wesolowska, O., Michalak, K., Wang, Q., Reversal of multidrug resistance by natural substances from plants (2010) Curr Top Med Chem, 10, pp. 1757-1768; \nMorris, M.E., Zhang, S., Flavonoid-drug interactions: Effects of flavonoids on ABC transporters (2006) Life Sci, 78, pp. 2116-2130; \nMorschhauser, F., Zinzani, P.L., Burgess, M., Sloots, L., Bouafia, F., Dumontet, C., Phase I/II trial of a P-glycoprotein inhibitor, Zosuquidar.3HCl trihydrochloride (LY335979), given orally in combination with the CHOP regimen in patients with non-Hodgkin's lymphoma (2007) Leuk Lymphoma, 48, pp. 708-715; \nMotohashi, N., Kurihara, T., Kawase, M., Hever, A., Tanaka, M., Szabo, D., Nacsa, J., Molnar, J., Drug resistance reversal, anti-mutagenicity and antiretroviral effect of phthalimidoand chloroethyl-phenothiazines (1997) Anticancer Res, 17, pp. 3537-3543; \nNa, H.K., Surh, Y.J., Intracellular signaling network as a prime chemopreventive target of (-)-epigallocatechin gallate (2006) Mol Nutr Food Res, 50, pp. 152-159; \nNabekura, T., Kamiyama, S., Kitagawa, S., Effects of dietary chemopreventive phytochemicals on P-glycoprotein function (2005) Biochem Biophys Res Commun, 327, pp. 866-870; \nNabekura, T., Yamaki, T., Kitagawa, S., Effects of chemopreventive citrus phytochemicals on human P-glycoprotein and multidrug resistance protein 1 (2008) Eur J Pharmacol, 600, pp. 45-49; \nNguyen, H., Zhang, S., Morris, M.E., Effect of flavonoids on MRP1-mediated transport in Panc-1 cells (2003) J Pharm Sci, 92, pp. 250-257; \nOhtani, H., Ikegawa, T., Honda, Y., Kohyama, N., Morimoto, S., Shoyama, Y., Juichi, M., Sawada, Y., Effects of various methoxyflavones on vincristine uptake and multidrug resistance to vincristine in P-gp-overexpressing K562/ADM cells (2007) Pharm Res, 24, pp. 1936-1943; \nOkura, T., Ibe, M., Umegaki, K., Shinozuka, K., Yamada, S., Effects of dietary ingredients on function and expression of P-glycoprotein in human intestinal epithelial cells (2010) Biol Pharm Bull, 33, pp. 255-259; \nPajeva, I.K., Wiese, M., Cordes, H.P., Seydel, J.K., Membrane interactions of some catamphiphilic drugs and relation to their multidrugresistance-reversing ability (1996) J Cancer Res Clin Oncol, 122, pp. 27-40; \nPajeva, I.K., Wiese, M., Molecular modeling of phenothiazines and related drugs as multidrug resistance modifiers: a comparative molecular field analysis study (1998) J Med Chem, 41, pp. 1815-1826; \nPajeva, I.K., Globisch, C., Wiese, M., Combined pharmacophore modeling, docking, and 3D QSAR studies of ABCB1 and ABCC1 transporter inhibitors (2009) Chem Med Chem, 4, pp. 1883-1896; \nPatanasethanont, D., Nagai, J., Matsuura, C., Fukui, K., Sutthanut, K., Sripanidkulchai, B.O., Yumoto, R., Takano, M., Modulation of function of multidrug resistance associated-proteins by Kaempferia parviflora extracts and their components (2007) Eur J Pharmacol, 566, pp. 67-74; \nPatanasethanont, D., Nagai, J., Yumoto, R., Murakami, T., Sutthanut, K., Sripanidkulchai, B.O., Yenjai, C., Takano, M., Effects of Kaempferia parviflora extracts and their flavone constituents on P-glycoprotein function (2007) J Pharm Sci, 96, pp. 223-233; \nPayen, L.F., Gao, M., Westlake, C.J., Cole, S.P., Deeley, R.G., Role of carboxylate residues adjacent to the conserved core Walker B motifs in the catalytic cycle of multidrug resistance protein 1 (ABCC1) (2003) J Biol Chem, 278, pp. 38537-38547; \nPeroutka, S.J., Synder, S.H., Relationship of neuroleptic drug effects at brain dopamine, serotonin, alpha-adrenergic, and histamine receptors to clinical potency (1980) Am J Psychiatry, 137, pp. 1518-1522; \nPhang, J.M., Poore, C.M., Lopaczynska, J., Yeh, G.C., Flavonol-stimulated efflux of 7,12-dimethylbenz(a)anthracene in multidrug-resistant breast cancer cells (1993) Cancer Res, 53, pp. 5977-5981; \nPirola, L., Frojdo, S., Resveratrol: one molecule, many targets (2008) IUBMB Life, 60, pp. 323-332; \nPotter, G.A., Patterson, L.H., Wanogho, E., Perry, P.J., Butler, P.C., Ijaz, T., Ruparelia, K.C., Burke, M.D., The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1 (2002) Br J Cancer, 86, pp. 774-778; \nPulaski, L., Jedlitschky, G., Leier, I., Buchholz, U., Keppler, D., Identification of the multidrug-resistance protein (MRP) as the glutathione-S-conjugate export pump of erythrocytes (1996) Eur J Biochem, 241, pp. 644-648; \nQuan, F., Pan, C., Ma, Q., Zhang, S., Yan, L., Reversal effect of resveratrol on multidrug resistance in KBv200 cell line (2008) Biomed Pharmacother, 62, pp. 622-629; \nRaderer, M., Scheithauer, W., Clinical trials of agents that reverse multidrug resistance. A literature review (1993) Cancer, 72, pp. 3553-3563; \nRamu, A., Ramu, N., Reversal of multidrug resistance by phenothiazines and structurally related compounds (1992) Cancer Chemother Pharmacol, 30, pp. 165-173; \nRaviv, Y., Pollard, H.B., Bruggemann, E.P., Pastan, I., Gottesman, M.M., Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells (1990) J Biol Chem, 265, pp. 3975-3980; \nRosenberg, M.F., Oleschuk, C.J., Wu, P., Mao, Q., Deeley, R.G., Cole, S.P., Ford, R.C., Structure of a human multidrug transporter in an inward-facing conformation (2010) J Struct Biol, 170, pp. 540-547; \nRoupe, K.A., Remsberg, C.M., Yanez, J.A., Davies, N.M., Pharmacometrics of stilbenes: seguing towards the clinic (2006) Curr Clin Pharmacol, 1, pp. 81-101; \nRychlik, B., Balcerczyk, A., Klimczak, A., Bartosz, G., The role of multidrug resistance protein 1 (MRP1) in transport of fluorescent anions across the human erythrocyte membrane (2003) J Membr Biol, 193, pp. 79-90; \nSafa, A.R., Agresti, M., Bryk, D., Tamai, I., N-(p-azido-3-[125I]iodophenethyl) spiperone binds to specific regions of P-glycoprotein and another multidrug binding protein, spiperophilin, in human neuroblastoma cells (1994) Biochemistry, 33, pp. 256-265; \nSafa, A.R., Photoaffinity labels for characterizing drug interaction sites of P-glycoprotein (1998) Methods Enzymol, 292, pp. 289-307; \nSauna, Z.E., Ambudkar, S.V., Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoprotein (2000) Proc Natl Sci USA, 97, pp. 2515-2520; \nScalbert, A., Williamson, G., Dietary intake and bioavailability of polyphenols (2000) J Nutr, 130, pp. 2073S-2285S; \nSchinkel, A.H., The physiological function of drug-transporting Pglycoproteins (1997) Semin Cancer Biol, 8, pp. 161-170; \nSchmidt, M., Teitge, M., Castillo, M.E., Brandt, T., Dobner, B., Langner, A., Synthesis and biochemical characterization of new phenothiazines and related drugs as MDR reversal agents (2008) Arch Pharm, 341, pp. 624-638; \nSeelig, A., A general pattern for substrate recognition by P-glycoprotein (1998) Eur J Biochem, 251, pp. 252-261; \nSeelig, A., Blatter, X.L., Wohnsland, F., Substrate recognition by Pglycoprotein and the multidrug resistance-associated protein MRP1: a comparison (2000) Int J Clin Pharmacol Ther, 38, pp. 111-121; \nSenior, A.E., Al-Shawi, M.K., Urbatsch, I.L., The catalytic cycle of P-glycoprotein (1995) FEBS Lett, 377, pp. 285-289; \nShapiro, A.B., Ling, V., Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities (1997) Eur J Biochem, 250, pp. 130-137; \nShapiro, A.B., Fox, K., Lam, P., Ling, V., Stimulation of P-glycoprotein-mediated drug transport by prazosin and progesterone. Evidence for a third drug-binding site (1999) Eur J Biochem, 259, pp. 841-850; \nSharom, F.J., ABC multidrug transporters: structure, function and role in chemoresistance (2008) Pharmacogenomics, 9, pp. 105-127; \nShepard, R.L., Winter, M.A., Hsaio, S.C., Pearce, H.L., Beck, W.T., Dantzig, A.H., Effect of modulators on the ATPase activity and vanadate nucleotide trapping of human P-glycoprotein (1998) Biochem Pharmacol, 56, pp. 719-727; \nSheu, M.T., Liou, Y.B., Kao, Y.H., Lin, Y.K., Ho, H.O., A quantitative structure-activity relationship for the modulation effects of flavonoids on P-glycoprotein-mediated transport (2010) Chem Pharm Bull, 58, pp. 1187-1194; \nSignorelli, P., Ghidoni, R., Resveratrol as an anticancer nutrient: molecular basis, open questions and promises (2005) J Nutr Biochem, 16, pp. 449-466; \nSkovsgaard, T., Nielsen, D., Maare, C., Wassermann, K., Cellular resistance to cancer chemotherapy (1994) Int Rev Cytol, 156, pp. 77-157; \nStouch, T.R., Gudmundsson, O., Progress in understanding the structure-activity relationships of P-glycoprotein (2002) Adv Drug Deliv Rev, 54, pp. 315-328; \nSyed, S.K., Christopherson, R.I., Roufogalis, B.D., Reversal of vinblastine transport by chlorpromazine in membrane vesicles from multidrug-resistant human CCRF-CEM leukaemia cells (1998) Br J Cancer, 78, pp. 321-327; \nSzabo, D., Szabo, G.J., Ocsovszki, I., Aszalos, A., Molnar, J., Antipsychotic drugs reverse multidrug resistance of tumor cell lines and human AML cells ex-vivo (1999) Cancer Lett, 139, pp. 115-119; \nTawari, N.R., Bag, S., Degani, M.S., Pharmacophore mapping of a series of pyrrolopyrimidines, indolopyrimidines and their congeners as multidrug-resistance-associated protein (MRP1) modulators (2008) J Mol Model, 14, pp. 911-921; \nTeodori, E., Dei, S., Martelli, C., Scapecchi, S., Gualtieri, F., The functions and structure of ABC transporters: implications for the design of new inhibitors of Pgp and MRP1 to control multidrug resistance (MDR) (2006) Curr Drug Targets, 7, pp. 893-909; \nTian, X., Yang, X., Wang, K., The efflux of flavonoids morin, isorhamnetin-3-O-rutinoside and diosmetin-7-O-beta-D-xylopyranosyl-(1-6)-beta-D-glucopyranoside in the human intestinal cell line caco-2 (2006) Pharm Res, 23, pp. 1721-1728; \nTrompier, D., Baubichon-Cortay, H., Chang, X.B., Maitrejean, M., Barron, D., Riordon, J.R., Di Pietro, A., Multiple flavonoid-binding sites within multidrug resistance protein MRP1 (2003) Cell Mol Life Sci, 60, pp. 2164-2177; \nTsakovska, I.M., QSAR and 3D-QSAR of phenothiazine type multidrug resistance modulators in P388/ADR cells (2003) Bioorg Med Chem, 11, pp. 2889-2899; \nTsakovska, I., Pajeva, I., Phenothiazines and structurally related compounds as modulators of cancer multidrug resistance (2006) Curr Drug Targets, 7, pp. 1123-1134; \nTsuruo, T., Iida, H., Tsukagoshi, S., Sakurai, Y., Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors (1982) Cancer Res, 42, pp. 4730-4733; \nvan Zanden, J.J., Geraets, L., Wortelboer, H.M., van Bladeren, P.J., Rietjens, I.M., Cnubben, N.H., Structural requirements for the flavonoidmediated modulation of glutathione S-transferase P1-1 and GS-X pump activity in MCF7 breast cancer cells (2004) Biochem Pharmacol, 67, pp. 1607-1617; \nvan Zanden, J.J., Wortelboer, H.M., Bijlsma, S., Punt, A., Usta, M., Bladeren, P.J., Rietjens, I.M., Cnubben, N.H., Quantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance proteins 1 and 2 (2005) Biochem Pharmacol, 69, pp. 699-708; \nVersantvoort, C.H., Schuurhuis, G.J., Pinedo, H.M., Eekman, C.A., Kuiper, C.M., Lankelma, J., Broxterman, H.J., Genistein modulates the decreased drug accumulation in non-P-glycoprotein mediated multidrug resistant tumour cells (1993) Br J Cancer, 68, pp. 939-946; \nVersantvoort, C.H., Rhodes, T., Twentyman, P.R., Acceleration of MRP-associated efflux of rhodamine 123 by genistein and related compounds (1996) Br J Cancer, 74, pp. 1949-1954; \nWang, E.J., Barecki-Roach, M., Johnson, W.W., Elevation of P-glycoprotein function by a catechin in green tea (2002) Biochem Biophys Res Commun, 297, pp. 412-418; \nWang, R.B., Kuo, C.L., Lien, L.L., Lien, E.J., Structure-activity relationship: analyses of P-glycoprotein substrates and inhibitors (2003) J Clin Pharm Ther, 28, pp. 203-228; \nWang, Y., Cao, J., Zeng, S., Involvement of P-glycoprotein in regulating cellular levels of Ginkgo flavonols: quercetin, kaempferol, and isorhamnetin (2005) J Pharm Pharmacol, 57, pp. 751-758; \nWang, J.S., Zhu, H.J., Markowitz, J.S., Donovan, J.L., Devane, C.L., Evaluation of antipsychotic drugs as inhibitors of multidrug resistance transporter P-glycoprotein (2006) Psychopharmacology, 187, pp. 415-423; \nWesolowska, O., Molnar, J., Motohashi, N., Michalak, K., Inhibition of P-glycoprotein transport function by N-acylphenothiazines (2002) Anticancer Res, 22, pp. 2863-2867; \nWesolowska, O., Mosiadz, D., Motohashi, N., Kawase, M., Michalak, K., Phenothiazine maleates stimulate MRP1 transport activity in human erythrocytes (2005) Biochim Biophys Acta, 1720, pp. 52-58; \nWesolowska, O., Paprocka, M., Kozlak, J., Motohashi, N., Dus, D., Michalak, K., Human sarcoma cell lines MES-SA and MES-SA/Dx5 as a model for multidrug resistance modulators screening (2005) Anticancer Res, 25, pp. 383-389; \nWesolowska, O., Wisniewski, J., Duarte, N., Ferreira, M.J., Michalak, K., Inhibition of MRP1 transport activity by phenolic and terpenic compounds isolated from Euphorbia species (2007) Anticancer Res, 27, pp. 4127-4133; \nWesolowska, O., Molnar, J., Ocsovszki, I., Michalak, K., Differential effect of phenothiazines on MRP1 and P-glycoprotein activity (2009) In Vivo, 23, pp. 943-947; \nWesolowska, O., Hendrich, A.B., Lania-Pietrzak, B., Wisniewski, J., Molnar, J., Ocsovszki, I., Michalak, K., Perturbation of the lipid phase of a membrane is not involved in the modulation of MRP1 transport activity by flavonoids (2009) Cell Mol Biol Lett, 14, pp. 199-221; \nWesolowska, O., Kuzdzal, M., Strancar, J., Michalak, K., Interaction of the chemopreventive agent resveratrol and its metabolite, piceatannol, with model membranes (2009) Biochim Biophys Acta, 1788, pp. 1851-1860; \nWesolowska, O., Wisniewski, J., Sroda, K., Krawczenko, A., Bielawska-Pohl, A., Paprocka, M., Dus, D., Michalak, K., 8-Prenylnaringenin is an inhibitor of multidrug resistance-associated transporters. P-glycoprotein and MRP1 (2010) Eur J Pharmacol, 644, pp. 32-40; \nWesolowska, O., Wisniewski, J., Bielawska-Pohl, A., Paprocka, M., Duarte, N., Ferreira, M.J., Dus, D., Michalak, K., Stilbenes as multidrug resistance modulators and apoptosis inducers in human adenocarcinoma cells (2010) Anticancer Res, 30, pp. 4587-4593; \nWesolowska, O., Michalak, K., Hendrich, A.B., Direct visualization of phase separation induced by phenothiazine-type antipsychotic drugs in model lipid membranes (2011) Mol Membr Biol, 28, pp. 103-114; \nWong, I.L., Chan, K.F., Tsang, K.H., Lam, C.Y., Zhao, Y., Chan, T.H., Chow, L.M., Modulation of multidrug resistance protein 1 (MRP1/ABCC1)-mediated multidrug resistance by bivalent apigenin homodimers and their derivatives (2009) J Med Chem, 52, pp. 5311-5322; \nWu, C.P., Calcagno, A.M., Hladky, S.B., Ambudkar, S.V., Barrand, M.A., Modulatory effects of plant phenols on human multidrug-resistance proteins 1, 4 and 5 (ABCC1, 4 and 5) (2005) FEBS J, 272, pp. 4725-4740; \nYang, R., Cui, L., Hou, Y., Riordan, J.R., Chang, X., ATP binding to the first nucleotide binding domain of multidrug resistance-associated protein plays a regulatory role at low nucleotide concentration, whereas ATP hydrolysis at the second plays a dominant role in ATP-dependent leukotriene C4 transport (2003) J Biol Chem, 278, pp. 30764-30771; \nYang, R., McBride, A., Hou, Y., Goldberg, A., Chang, X., Nucleotide dissociation from NBD1 promotes solute transport by MRP1 (2005) Biochim Biophys Acta, 1668, pp. 248-261; \nYu, R., Jiao, J.J., Duh, J.L., Gudehithlu, K., Tan, T.H., Kong, A.N., Activation of mitogen-activated protein kinases by green tea polyphenols: potential signaling pathways in the regulation of antioxidantresponsive element-mediated phase II enzyme gene expression (1997) Carcinogenesis, 18, pp. 451-456; \nZamora, J.M., Pearce, H.L., Beck, W.T., Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells (1988) Mol Pharmacol, 33, pp. 454-462; \nZhang, S., Morris, M.E., Effects of the flavonoids biochanin A, morin, phloretin, and silymarin on P-glycoprotein-mediated transport (2003) J Pharmacol Exp Ther, 304, pp. 1258-1267; \nZhang, S., Sagawa, K., Arnold, R.D., Tseng, E., Wang, X., Morris, M.E., Interactions between the flavonoid biochanin A and P-glycoprotein substrates in rats: in vitro and in vivo (2010) J Pharm Sci, 99, pp. 430-441", "unhandledTickets" : 0, "oldTimestamp" : "2018-10-01T21:51:26.000+0000", "deleted" : false, "oldId" : 13319950, "lastRefresh" : "2023-02-14T10:11:32.474+0000", "lastModified" : "2019-01-29T10:35:45.058+0000", "created" : "2013-09-18T13:06:37.000+0000", "creator" : { "otype" : "Author", "mtid" : 10007780, "link" : "/api/author/10007780", "label" : "Szabó Gábor (Sejtbiológia)", "familyName" : "Szabó", "givenName" : "Gábor", "published" : true, "oldId" : 10007780, "snippet" : true }, "lastDuplumSearch" : "2023-02-14T10:10:04.130+0000", "adminApproved" : 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