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disorders in patients with diabetes mellitus", "altTitles" : "Роль эндотелиальной дисфункции в развитии цереброваскулярного поражения у пациентов с сахарным диабетомRol' endotelial'noi disfunktsii v razvitii tserebrovaskulyarnogo porazheniya u patsientov s sakharnym diabetom", "identifiers" : [ { "otype" : "PublicationIdentifier", "mtid" : 14894796, "link" : "/api/publicationidentifier/14894796", "label" : "DOI: 10.14341/2072-0351-5978", "source" : { "otype" : "PlainSource", "mtid" : 6, "link" : "/api/publicationsource/6", "label" : "DOI", "type" : { "otype" : "PublicationSourceType", "mtid" : 10001, "link" : "/api/publicationsourcetype/10001", "label" : "DOI", "mayHaveOa" : true, "published" : true, "snippet" : true }, "name" : "DOI", "nameEng" : "DOI", "linkPattern" : "https://doi.org/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 6, "snippet" : true }, "validState" : "NO", "idValue" : "10.14341/2072-0351-5978", "realUrl" : "https://doi.org/10.14341/2072-0351-5978", 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: true, "oldId" : 10037499, "snippet" : true }, "volume" : "15", "issue" : "1", "firstPage" : "42", "lastPage" : "48", "firstPageOrInternalIdForSort" : "42", "pageLength" : 7, "publishedYear" : 2012, "abstractText" : "В возникновении цереброваскулярного поражения у пациентов с сахарным диабетом важнейшую роль играют эндо- телиальная дисфункция и нарушение гемостаза в сосудах головного мозга. На развитие и прогрессирование нарушения микроциркуляции, ишемизации ткани головного мозга оказывают влияние такие факторы, как гипер- и гипогликемия, гиперинсулинемия, инсулинорезистентность, избыточный вес. Для неинвазивной оценки гемодинамических изменений успешно используется транскраниальная допплерография.Endothelial dysfunction and aberrations of haemostasis play an important part in development of cerebrovascular disorders in patients with diabetes mellitus. Such factors as hyper- and hypoglycemia, hyperinsulinism, insulin resistance and excessive weight affect progression of microcirculation deficiency and cerebral ischemia. 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