https://m2.mtmt.hu/ eng 2026-10-25 09:48 JournalArticle 2210210 VALIDATED true 0 2016-12-06T10:01:02.000+0000 false 2210210 2026-10-20T10:22:34.052+0000 2026-08-27T07:41:38.327+0000 2012-09-07T12:48:41.000+0000 true 146 Makara Judit /api/author/146 Author true 146 2026-08-27T07:41:56.405+0000 2026-08-27T07:41:56.405+0000 2024-05-23T08:05:47.942+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin true 10015544 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Harnett, MT Synaptic amplification by dendritic spines enhances input cooperativity. true true /api/journal/3308 REVIEWED true false 3308 false 3308 true 0028-0836 1476-4687 Journal FOREIGN 491 7425 599 602 599 4 2012 Dendritic spines are the nearly ubiquitous site of excitatory synaptic input onto neurons and as such are critically positioned to influence diverse aspects of neuronal signalling. Decades of theoretical studies have proposed that spines may function as highly effective and modifiable chemical and electrical compartments that regulate synaptic efficacy, integration and plasticity. Experimental studies have confirmed activity-dependent structural dynamics and biochemical compartmentalization by spines. However, there is a longstanding debate over the influence of spines on the electrical aspects of synaptic transmission and dendritic operation. Here we measure the amplitude ratio of spine head to parent dendrite voltage across a range of dendritic compartments and calculate the associated spine neck resistance (R(neck)) for spines at apical trunk dendrites in rat hippocampal CA1 pyramidal neurons. We find that R(neck) is large enough (~500 MOmega) to amplify substantially the spine head depolarization associated with a unitary synaptic input by ~1.5- to ~45-fold, depending on parent dendritic impedance. A morphologically realistic compartmental model capable of reproducing the observed spatial profile of the amplitude ratio indicates that spines provide a consistently high-impedance input structure throughout the dendritic arborization. Finally, we demonstrate that the amplification produced by spines encourages electrical interaction among coactive inputs through an R(neck)-dependent increase in spine head voltage-gated conductance activation. We conclude that the electrical properties of spines promote nonlinear dendritic processing and associated forms of plasticity and storage, thus fundamentally enhancing the computational capabilities of neurons. Funding 2070322 /api/funding/2070322 false true Funding 2070323 /api/funding/2070323 false true Funding 2070324 /api/funding/2070324 false true true true 2013 789622 true true true false true false NONE 2026-10-20 false true 10003134 Wolf György /api/admin/10003134 Admin true 10003134 234 0 234 218 14 232 231 219 224 234 234 218 218 218 16 0 234 218 234 218 0 2 2 Folyóiratcikk Journal Article 24 221 Könyvrészlet Chapter in Book 25 10 Könyv Book 23 3 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2012 0 1 1 1 1 2013 0 15 13 15 13 2014 0 25 25 25 25 2015 0 26 24 26 24 2016 0 21 20 21 20 2017 0 22 21 22 21 2018 0 14 12 14 12 2019 0 11 10 11 10 2020 0 10 7 10 7 2021 0 16 15 16 15 2022 0 23 22 23 22 2023 0 16 16 16 16 2024 0 10 9 10 9 2025 0 11 11 11 11 2026 0 13 12 13 12 D1 A false 146 false false false 2013-02-15T09:11:21.000+0000 2013-02-14T20:52:02.000+0000 Lendület Idegi Jelátvitel Kutatócsoport (KOKI / CHO) 1 13 1 5 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 3704528 /api/authorship/3704528 1 0.2 true false Harnett MT true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 17068317 true PersonAuthorship 3704529 /api/authorship/3704529 2 0.2 true false Author 146 /api/author/146 Makara Judit true 146 true Makara JK true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 17068316 true PersonAuthorship 3704530 /api/authorship/3704530 3 0.2 false false Spruston N true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 17068315 true PersonAuthorship 3704531 /api/authorship/3704531 4 0.2 false false Kath WL true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 17068314 true PersonAuthorship 3704532 /api/authorship/3704532 5 0.2 false true true Magee JC true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 17068313 true PublicationIdentifier 634237 /api/publicationidentifier/634237 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true false IDENTICAL 10.1038/nature11554 https://doi.org/10.1038/nature11554 false 401556 true PublicationIdentifier 634235 /api/publicationidentifier/634235 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000311339800053 https://www.webofscience.com/wos/woscc/full-record/000311339800053 false 460060 true PublicationIdentifier 634236 /api/publicationidentifier/634236 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 84869866723 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84869866723 false 460061 true PublicationIdentifier 634238 /api/publicationidentifier/634238 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false NO 23103868 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23103868&dopt=Abstract false 401557 true Classification 10799 /api/classification/10799 true true Keyword 12 /api/keyword/12 true 12 true Keyword 62 /api/keyword/62 true 62 true Keyword 1547 /api/keyword/1547 true 1547 true Keyword 3423 /api/keyword/3423 true 3423 true Keyword 3471 /api/keyword/3471 true 3471 true Keyword 3494 /api/keyword/3494 true 3494 true Keyword 5878 /api/keyword/5878 true 5878 true Keyword 6915 /api/keyword/6915 true 6915 true Keyword 15438 /api/keyword/15438 true 15438 true Keyword 1006324 /api/keyword/1006324 true 1006324 true Keyword 1042479 /api/keyword/1042479 true 1042479 true MtaRating 11435135 /api/mtarating/11435135 RatingType 10031 /api/ratingtype/10031 X. FTO Institute 70 /api/institute/70 0 false false false X. Földtudományok Osztálya HAS Section of Earth Sciences (X.) true 70 true true true A true true MtaRating 11551101 /api/mtarating/11551101 RatingType 10010 /api/ratingtype/10010 RegTB Institute 14100 /api/institute/14100 0 false true false Regionális Tudományok Bizottsága Committee on Regional Studies true 14100 true true true A nemzetközi true true MtaRating 519065 /api/mtarating/519065 RatingType 10007 /api/ratingtype/10007 SZTB Institute 14102 /api/institute/14102 0 false true false Szociológiai Tudományos Bizottság Committee on Sociology true 14102 true true true A nemzetközi true 19065 true SjrRating 5671263 /api/sjrrating/5671263 1 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1000 /api/classificationexternal/1000 true 1000 true D1 DIRECT true 5671263 true /api/publication/2210210 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Harnett MT </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="146"><a href="/gui2/?type=authors&mode=browse&sel=146" target="_blank">Makara JK<sup>*</sup> (<span class="authorship-author-name">Makara Judit</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Neuronal Signaling</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Spruston N </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kath WL </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Magee JC ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2210210" target="_blank">Synaptic amplification by dendritic spines enhances input cooperativity.</a></div> <div> <span class="journal-title">NATURE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0028-0836">0028-0836</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1476-4687">1476-4687</a>)</span>: <span class="journal-volume">491</span> <span class="journal-issue">7425</span> <span class="page"> pp 599-602 </span> <span class="year">(2012)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1038/nature11554" target="_blank" href="https://doi.org/10.1038/nature11554"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000311339800053" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000311339800053"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84869866723" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84869866723"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="23103868" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23103868&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Multidisciplinary&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">HAS Section of Earth Sciences (X.) HASSESX&nbsp;&nbsp;&nbsp;A</div> <div class="journal-subject">Committee on Regional Studies HASSELIX RTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Committee on Sociology HASSELIX SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 234</span> | Independent citation: 218 | Self citation: 16 | Unknown citation: 0 | Number of citations in WoS: 219 | Number of citations in Scopus:&nbsp;224 | WoS/Scopus assigned:&nbsp;234 | Number of citations with DOI:&nbsp;231 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2210210&sort=publishedYear,desc&sort=title"> Number of cited publications: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 2210210</span> | <span class="status-data status-VALIDATED"> Validated </span> <span class="oldId">Old id: 2210210</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="funder"> Howard Hughes Medical Institute, the National Institutes of Health(NS-046064), Howard Hughes Medical Institute, the National Institutes of Health(NS-077601), Wellcome Trust (International Senior Research Fellowship(090915) </div> <div class="lastModified">Last Modified: 2026.08.27. 09:41 Márta Turek (KOKI admin 4) </div> </div></div>