https://m2.mtmt.hu/ eng 2026-05-26 08:03 JournalArticle 2206458 VALIDATED true * Megosztott szerzőség 0 2015-07-23T06:59:33.000+0000 false 2206458 2026-05-15T13:23:59.416+0000 2026-01-15T12:31:22.596+0000 2013-02-11T12:04:02.000+0000 true 10019106 Rákosy Zsuzsa /api/author/10019106 Author true 10019106 2026-04-24T05:39:51.801+0000 2026-04-24T05:39:51.801+0000 2026-01-15T12:27:00.486+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Rakosy, Z Integrative genomics identifies gene signature associated with melanoma ulceration. true true /api/journal/10007440 REVIEWED true false 10007440 false 10007440 true 1932-6203 Journal FOREIGN 8 1 e54958 e54958 14 2013 BACKGROUND: Despite the extensive research approaches applied to characterise malignant melanoma, no specific molecular markers are available that are clearly related to the progression of this disease. In this study, our aims were to define a gene expression signature associated with the clinical outcome of melanoma patients and to provide an integrative interpretation of the gene expression -, copy number alterations -, and promoter methylation patterns that contribute to clinically relevant molecular functional alterations. METHODS: Gene expression profiles were determined using the Affymetrix U133 Plus2.0 array. The NimbleGen Human CGH Whole-Genome Tiling array was used to define CNAs, and the Illumina GoldenGate Methylation platform was applied to characterise the methylation patterns of overlapping genes. RESULTS: WE IDENTIFIED TWO SUBCLASSES OF PRIMARY MELANOMA: one representing patients with better prognoses and the other being characteristic of patients with unfavourable outcomes. We assigned 1,080 genes as being significantly correlated with ulceration, 987 genes were downregulated and significantly enriched in the p53, Nf-kappaB, and WNT/beta-catenin pathways. Through integrated genome analysis, we defined 150 downregulated genes whose expression correlated with copy number losses in ulcerated samples. These genes were significantly enriched on chromosome 6q and 10q, which contained a total of 36 genes. Ten of these genes were downregulated and involved in cell-cell and cell-matrix adhesion or apoptosis. The expression and methylation patterns of additional genes exhibited an inverse correlation, suggesting that transcriptional silencing of these genes is driven by epigenetic events. CONCLUSION: Using an integrative genomic approach, we were able to identify functionally relevant molecular hotspots characterised by copy number losses and promoter hypermethylation in distinct molecular subtypes of melanoma that contribute to specific transcriptomic silencing and might indicate a poor clinical outcome of melanoma. 2013 880646 true true true false true false GOLD 2026-05-15 true https://doi.org/10.1371/journal.pone.0054958 true 10045349 Fekete Rita /api/admin/10045349 Admin true 10045349 32 0 32 24 8 30 29 27 32 32 32 24 24 24 8 0 32 24 32 24 0 3 3 Folyóiratcikk Journal Article 24 31 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 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Rakosy Z true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 17052682 true PersonAuthorship 3694362 /api/authorship/3694362 2 0.091 true false Author 10020957 /api/author/10020957 Ecsedi Szilvia true 10020957 true Ecsedi S true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 17052681 true PersonAuthorship 3694363 /api/authorship/3694363 3 0.09090909 false false Toth R true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 17052680 true PersonAuthorship 3694364 /api/authorship/3694364 4 0.09090909 false false Author 10034960 /api/author/10034960 Vízkeleti Laura true 10034960 true Vizkeleti L true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 17052679 true PersonAuthorship 3694365 /api/authorship/3694365 5 0.09090909 false false Herandez-Vargas H true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 17052678 true PersonAuthorship 3694366 /api/authorship/3694366 6 0.09090909 false false Author 10036222 /api/author/10036222 Lázár Viktória true 10036222 true Lazar V true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 17052677 true PersonAuthorship 3694367 /api/authorship/3694367 7 0.09090909 false false Author 10029732 /api/author/10029732 Emri Gabriella true 10029732 true Emri G true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 17052676 true PersonAuthorship 3694368 /api/authorship/3694368 8 0.09090909 false false Author 10018856 /api/author/10018856 Szatmári István true 10018856 true Szatmari I true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 17052675 true PersonAuthorship 3694369 /api/authorship/3694369 9 0.09090909 false false Herceg Z true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 17052674 true PersonAuthorship 3694370 /api/authorship/3694370 10 0.09090909 false false Author 1131057 /api/author/1131057 Ádány Róza true 1131057 true Adany R true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 17052673 true PersonAuthorship 3694371 /api/authorship/3694371 11 0.091 false true true Author 10000801 /api/author/10000801 Balázs Margit true 10000801 true Balazs M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 17052672 true PublicationIdentifier 632696 /api/publicationidentifier/632696 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1371/journal.pone.0054958 https://doi.org/10.1371/journal.pone.0054958 false 400615 true PublicationIdentifier 632698 /api/publicationidentifier/632698 PlainSource 38 /api/publicationsource/38 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true DEA http://hdl.handle.net/2437/@@@ true true 38 true GREEN true IDENTICAL 171793 http://hdl.handle.net/2437/171793 false 618610 true PublicationIdentifier 632694 /api/publicationidentifier/632694 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000315563800090 https://www.webofscience.com/wos/woscc/full-record/000315563800090 false 594453 true PublicationIdentifier 632695 /api/publicationidentifier/632695 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 84873881608 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84873881608 false 400616 true PublicationIdentifier 632697 /api/publicationidentifier/632697 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed 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/api/classificationexternal/1101 true 1101 true D1 DIRECT true true /api/publication/2206458 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10019106"><a href="/gui2/?type=authors&mode=browse&sel=10019106" target="_blank">Rakosy Z (<span class="authorship-author-name">Rákosy Zsuzsa</span> <span class="authorAux-mtmt"> Népegészségügy</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020957"><a href="/gui2/?type=authors&mode=browse&sel=10020957" target="_blank">Ecsedi S<sup>*</sup> (<span class="authorship-author-name">Ecsedi Szilvia</span> <span class="authorAux-mtmt"> népegészségügy</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Public Health">FPH</span>/Department of Preventive Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Toth R </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10034960"><a href="/gui2/?type=authors&mode=browse&sel=10034960" target="_blank">Vizkeleti L (<span class="authorship-author-name">Vízkeleti Laura</span> <span class="authorAux-mtmt"> molekuláris biológia, daganat (epi)genomika</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Public Health">FPH</span>/Department of Preventive Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Herandez-Vargas H </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10036222"><a href="/gui2/?type=authors&mode=browse&sel=10036222" target="_blank">Lazar V (<span class="authorship-author-name">Lázár Viktória</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10029732"><a href="/gui2/?type=authors&mode=browse&sel=10029732" target="_blank">Emri G (<span class="authorship-author-name">Emri Gabriella</span> <span class="authorAux-mtmt"> Bőrgyógyászat</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/Department of Dermatology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10018856"><a href="/gui2/?type=authors&mode=browse&sel=10018856" target="_blank">Szatmari I (<span class="authorship-author-name">Szatmári István</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/Department of Biochemistry and Molecular Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Herceg Z </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="1131057"><a href="/gui2/?type=authors&mode=browse&sel=1131057" target="_blank">Adany R (<span class="authorship-author-name">Ádány Róza</span> <span class="authorAux-mtmt"> Népegészségügy, genetikai epidemiológia</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/<span title="Népegészség- és Járványtani Intézet">NegJtI</span>/MTA-DE Public Health Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000801"><a href="/gui2/?type=authors&mode=browse&sel=10000801" target="_blank">Balazs M ✉ (<span class="authorship-author-name">Balázs Margit</span> <span class="authorAux-mtmt"> daganatos betegségek, genomika</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Public Health">FPH</span>/Department of Preventive Medicine</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2206458" target="_blank">Integrative genomics identifies gene signature associated with melanoma ulceration.</a></div> <div> <span class="journal-title">PLOS ONE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1932-6203">1932-6203</a>)</span>: <span class="journal-volume">8</span> <span class="journal-issue">1</span> <span class="page"> Paper e54958. 14 p. </span> <span class="year">(2013)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1371/journal.pone.0054958" target="_blank" href="https://doi.org/10.1371/journal.pone.0054958"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="171793" target="_blank" href="http://hdl.handle.net/2437/171793"> DEA </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000315563800090" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000315563800090"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84873881608" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84873881608"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="23383013" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23383013&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Agricultural and Biological Sciences (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Pedagógiai Tudományos Bizottság HASSPHSII PedTB [1901-]&nbsp;&nbsp;&nbsp;A</div> <div class="journal-subject">Committee on Sociology HASSELIX SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Committee on Regional Studies HASSELIX RTB [1901-]&nbsp;&nbsp;&nbsp;B nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 32</span> | Independent citation: 24 | Self citation: 8 | Unknown citation: 0 | Number of citations in WoS: 27 | Number of citations in Scopus:&nbsp;32 | WoS/Scopus assigned:&nbsp;32 | Number of citations with DOI:&nbsp;29 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2206458&sort=publishedYear,desc&sort=title"> Number of cited publications: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 2206458</span> | <span class="status-data status-VALIDATED"> Validated </span> <span class="oldId">Old id: 2206458</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Last Modified: 2026.01.15. 13:31 Róbert Milánkovics (PTE ÁOK admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: * Megosztott szerzőség</pre> </div></div>