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      <abstractText>BACKGROUND: Despite the extensive research approaches applied to characterise malignant melanoma, no specific molecular markers are available that are clearly related to the progression of this disease. In this study, our aims were to define a gene expression signature associated with the clinical outcome of melanoma patients and to provide an integrative interpretation of the gene expression -, copy number alterations -, and promoter methylation patterns that contribute to clinically relevant molecular functional alterations. METHODS: Gene expression profiles were determined using the Affymetrix U133 Plus2.0 array. The NimbleGen Human CGH Whole-Genome Tiling array was used to define CNAs, and the Illumina GoldenGate Methylation platform was applied to characterise the methylation patterns of overlapping genes. RESULTS: WE IDENTIFIED TWO SUBCLASSES OF PRIMARY MELANOMA: one representing patients with better prognoses and the other being characteristic of patients with unfavourable outcomes. We assigned 1,080 genes as being significantly correlated with ulceration, 987 genes were downregulated and significantly enriched in the p53, Nf-kappaB, and WNT/beta-catenin pathways. Through integrated genome analysis, we defined 150 downregulated genes whose expression correlated with copy number losses in ulcerated samples. These genes were significantly enriched on chromosome 6q and 10q, which contained a total of 36 genes. Ten of these genes were downregulated and involved in cell-cell and cell-matrix adhesion or apoptosis. The expression and methylation patterns of additional genes exhibited an inverse correlation, suggesting that transcriptional silencing of these genes is driven by epigenetic events. CONCLUSION: Using an integrative genomic approach, we were able to identify functionally relevant molecular hotspots characterised by copy number losses and promoter hypermethylation in distinct molecular subtypes of melanoma that contribute to specific transcriptomic silencing and might indicate a poor clinical outcome of melanoma.</abstractText>
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(2013) PLOS ONE 1932-6203 8 1</label><template>&lt;div class=&quot;JournalArticle Publication short-list&quot;&gt; &lt;div class=&quot;authors&quot;&gt; &lt;span class=&quot;author-name&quot; mtid=&quot;10019106&quot;&gt; &lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10019106&quot; target=&quot;_blank&quot;&gt;Rakosy, Z&lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; mtid=&quot;10020957&quot;&gt; &lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10020957&quot; target=&quot;_blank&quot;&gt;Ecsedi, S&lt;sup&gt;*&lt;/sup&gt;&lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; &gt; Toth, R &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; mtid=&quot;10034960&quot;&gt; &lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10034960&quot; target=&quot;_blank&quot;&gt;Vizkeleti, L&lt;/a&gt; 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; &lt;span class=&quot;author-name&quot; &gt; Herceg, Z &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; mtid=&quot;1131057&quot;&gt; &lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=1131057&quot; target=&quot;_blank&quot;&gt;Adany, R&lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; et al. &lt;/div &gt;&lt;div class=&quot;title&quot;&gt;&lt;a href=&quot;/gui2/?mode=browse&amp;params=publication;2206458&quot; mtid=&quot;2206458&quot; target=&quot;_blank&quot;&gt;Integrative genomics identifies gene signature associated with melanoma ulceration.&lt;/a&gt;&lt;/div&gt; &lt;div class=&quot;pub-info&quot;&gt; &lt;span class=&quot;journal-title&quot;&gt;PLOS ONE&lt;/span&gt; &lt;span class=&quot;journal-volume&quot;&gt;8&lt;/span&gt; : &lt;span class=&quot;journal-issue&quot;&gt;1&lt;/span&gt; &lt;span class=&quot;page&quot;&gt; Paper: e54958 , 14 p. &lt;/span&gt; &lt;span class=&quot;year&quot;&gt;(2013)&lt;/span&gt; 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																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10019106&quot; target=&quot;_blank&quot;&gt;Rakosy Z
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Rákosy Zsuzsa&lt;/span&gt;
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							&lt;span class=&quot;author-name&quot; mtid=&quot;10020957&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10020957&quot; target=&quot;_blank&quot;&gt;Ecsedi S&lt;sup&gt;*&lt;/sup&gt;
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Ecsedi Szilvia&lt;/span&gt;
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&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Debreceni Egyetem&quot;&gt;DE&lt;/span&gt;/&lt;span title=&quot;Népegészségügyi Kar&quot;&gt;NK&lt;/span&gt;/Megelőző Orvostani Intézet&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; &gt;Toth R
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;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10034960&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10034960&quot; target=&quot;_blank&quot;&gt;Vizkeleti L
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Vízkeleti Laura&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; molekuláris biológia, daganat (epi)genomika&lt;/span&gt;)
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&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Debreceni Egyetem&quot;&gt;DE&lt;/span&gt;/&lt;span title=&quot;Népegészségügyi Kar&quot;&gt;NK&lt;/span&gt;/Megelőző Orvostani Intézet&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; &gt;Herandez-Vargas H
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							&lt;span class=&quot;author-name&quot; mtid=&quot;10036222&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10036222&quot; target=&quot;_blank&quot;&gt;Lazar V
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Lázár Viktória&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Molekuláris biológia&lt;/span&gt;)
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							&lt;span class=&quot;author-name&quot; mtid=&quot;10029732&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10029732&quot; target=&quot;_blank&quot;&gt;Emri G
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Emri Gabriella&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Bőrgyógyászat&lt;/span&gt;)
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&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Debreceni Egyetem&quot;&gt;DE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;ÁOK&lt;/span&gt;/Bőrgyógyászati Tanszék&lt;/span&gt;
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							&lt;span class=&quot;author-name&quot; mtid=&quot;10018856&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10018856&quot; target=&quot;_blank&quot;&gt;Szatmari I
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Szatmári István&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Molekuláris biológia&lt;/span&gt;)
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&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Debreceni Egyetem&quot;&gt;DE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;ÁOK&lt;/span&gt;/Biokémiai és Molekuláris Biológiai Intézet&lt;/span&gt;
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							&lt;span class=&quot;author-name&quot; &gt;Herceg Z
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							&lt;span class=&quot;author-name&quot; mtid=&quot;1131057&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=1131057&quot; target=&quot;_blank&quot;&gt;Adany R
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Ádány Róza&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Népegészségügy, genetikai epidemiológia&lt;/span&gt;)
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;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10000801&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10000801&quot; target=&quot;_blank&quot;&gt;Balazs M ✉
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Balázs Margit&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; daganatos betegségek, genomika&lt;/span&gt;)
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&lt;div class=&quot;title&quot;&gt;&lt;a href=&quot;/gui2/?mode=browse&amp;params=publication;2206458&quot; target=&quot;_blank&quot;&gt;Integrative genomics identifies gene signature associated with melanoma ulceration.&lt;/a&gt;&lt;/div&gt;    &lt;div&gt;		&lt;span class=&quot;journal-title&quot;&gt;PLOS ONE&lt;/span&gt;

        &lt;span class=&quot;journal-issn&quot;&gt;( &lt;a target=&quot;_blank&quot; href=&quot;https://portal.issn.org/resource/ISSN/1932-6203&quot;&gt;1932-6203&lt;/a&gt;)&lt;/span&gt;:
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&lt;span class=&quot;page&quot;&gt;
		Paper e54958.
	 14 p. 
&lt;/span&gt;		 &lt;span class=&quot;year&quot;&gt;(2013)&lt;/span&gt;  
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&lt;div class=&quot;pub-footer&quot;&gt;
    

	&lt;span class=&quot;language&quot; xmlns=&quot;http://www.w3.org/1999/html&quot;&gt;Nyelv:
			Angol
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									DOI
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									DEA
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				&lt;div class=&quot;journal-subject&quot;&gt;Folyóirat szakterülete: Scopus - Agricultural and Biological Sciences (miscellaneous)&amp;nbsp;&amp;nbsp;&amp;nbsp;SJR indikátor:&amp;nbsp;D1&lt;/div&gt;
				&lt;div class=&quot;journal-subject&quot;&gt;Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&amp;nbsp;&amp;nbsp;&amp;nbsp;SJR indikátor:&amp;nbsp;D1&lt;/div&gt;
				&lt;div class=&quot;journal-subject&quot;&gt;Folyóirat szakterülete: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&amp;nbsp;&amp;nbsp;&amp;nbsp;SJR indikátor:&amp;nbsp;Q1&lt;/div&gt;
			&lt;div class=&quot;journal-subject&quot;&gt;Szociológiai Tudományos Bizottság IXGJO SZTB [1901-]&amp;nbsp;&amp;nbsp;&amp;nbsp;A nemzetközi&lt;/div&gt;
			&lt;div class=&quot;journal-subject&quot;&gt;Regionális Tudományok Bizottsága IXGJO RTB [1901-]&amp;nbsp;&amp;nbsp;&amp;nbsp;B nemzetközi&lt;/div&gt;
			&lt;div class=&quot;journal-subject&quot;&gt;Pedagógiai Tudományos Bizottság II. FTO PedTB [1901-]&amp;nbsp;&amp;nbsp;&amp;nbsp;A&lt;/div&gt;
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		| Független: 23
		| Függő: 8
		| Nem jelölt: 0
		| WoS jelölt: 26 
		|  Scopus jelölt:&amp;nbsp;31 
		|  WoS/Scopus jelölt:&amp;nbsp;31 
		|  DOI jelölt:&amp;nbsp;28 
		
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Forrás	 Idéző
	
	
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&lt;div class=&quot;lastModified&quot;&gt;Utolsó módosítás: 2026.01.15. 13:31 Milánkovics Róbert (PTE ÁOK admin 4)
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	&lt;pre class=&quot;comment&quot; style=&quot;margin-top: 0; margin-bottom: 0;&quot;&gt;&lt;u&gt;Megjegyzés&lt;/u&gt;: * Megosztott szerzőség&lt;/pre&gt;
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