Lateralization of observational fear learning at the cortical but not thalamic level in mice

https://m2.mtmt.hu/ eng 2026-05-10 13:22 JournalArticle 2193253 VALIDATED true 0 2015-10-27T08:56:14.000+0000 false 2193253 2026-02-17T12:42:22.477+0000 2024-11-23T19:52:05.262+0000 2013-01-31T19:58:00.000+0000 true 10009548 Acsády László /api/author/10009548 Author László Acsády (Neurobiológia) true 10009548 2025-03-22T18:42:09.219+0000 2025-03-22T18:42:09.219+0000 2024-11-23T19:52:05.458+0000 true 10003134 Wolf György /api/admin/10003134 Admin György Wolf (MTMT Központi admin) true 10003134 Admin 10003134 /api/admin/10003134 György Wolf (MTMT Központi admin) Wolf György true 10003134 true Admin 10067876 /api/admin/10067876 Gusztáv Ladányi (MTMT API user, admin) Ladányi Gusztáv true true 2024-10-17T16:42:14.442+0000 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Kim, S Lateralization of observational fear learning at the cortical but not thalamic level in mice true true /api/journal/3547 REVIEWED PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 0027-8424 1091-6490 true false 3547 false 3547 true 0027-8424 1091-6490 Journal FOREIGN 109 38 15497 15501 15497 5 2012 Major cognitive and emotional faculties are dominantly lateralized in the human cerebral cortex. The mechanism of this lateralization has remained elusive owing to the inaccessibility of human brains to many experimental manipulations. In this study we demonstrate the hemispheric lateralization of observational fear learning in mice. Using unilateral inactivation as well as electrical stimulation of the anterior cingulate cortex (ACC), we show that observational fear learning is controlled by the right but not the left ACC. In contrast to the cortex, inactivation of either left or right thalamic nuclei, both of which are in reciprocal connection to ACC, induced similar impairment of this behavior. The data suggest that lateralization of negative emotions is an evolutionarily conserved trait and mainly involves cortical operations. Lateralization of the observational fear learning behavior in a rodentmodelwill allow detailed analysis of cortical asymmetry in cognitive functions. true true 2013 (Bilicsi Erika (MTMT admin); 2013.01.31. 20:57:56) true true true false true false NONE 2026-02-17 false true 10014562 Temesvári Katalin /api/admin/10014562 Admin Katalin Temesvári (GKEM admin) true 10014562 83 0 83 71 2 83 82 75 79 83 83 71 71 71 12 0 83 71 83 71 0 1 1 Folyóiratcikk Journal Article 24 76 Könyvrészlet Chapter in Book 25 7 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection 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(2012) PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 0027-8424 1091-6490 109 38 15497-15501<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Kim S </span> ;    <span class="author-name" mtid="163"><a href="/gui2/?type=authors&mode=browse&sel=163" target="_blank">Matyas F (<span class="authorship-author-name">Mátyás Ferenc</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Thalamus Research</span> ;    <span class="author-name" >Lee S </span> ;    <span class="author-name" mtid="10009548"><a href="/gui2/?type=authors&mode=browse&sel=10009548" target="_blank">Acsady L (<span class="authorship-author-name">Acsády László</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Thalamus Research</span> ;    <span class="author-name" >Shin HS </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2193253" target="_blank">Lateralization of observational fear learning at the cortical but not thalamic level in mice</a></div> <div> <span class="journal-title">PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0027-8424">0027-8424</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1091-6490">1091-6490</a>)</span>: <span class="journal-volume">109</span> <span class="journal-issue">38</span> <span class="page"> pp 15497-15501 </span> <span class="year">(2012)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1073/pnas.1213903109" target="_blank" href="https://doi.org/10.1073/pnas.1213903109"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000309211000084" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000309211000084"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84866530723" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84866530723"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="22949656" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22949656&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Multidisciplinary   Rank: D1</div> <div class="journal-subject">HAS Section of Earth Sciences (X.) HASSESX   A</div> <div class="journal-subject">Committee on Regional Studies HASSELIX RTB [1901-]   A nemzetközi</div> <div class="journal-subject">Committee on Sociology HASSELIX SZTB [1901-]   A nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 83</span> | Independent citation: 71 | Self citation: 12 | Unknown citation: 0 | Number of citations in WoS: 75 | Number of citations in Scopus: 79 | WoS/Scopus assigned: 83 | Number of citations with DOI: 82 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2193253&sort=publishedYear,desc&sort=title"> Number of cited publications: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 2193253</span> | <span class="status-data status-VALIDATED"> Validated </span> <span class="oldId">Old id: 2193253</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">WOS</span> </div> <div class="lastModified">Last Modified: 2024.11.23. 20:52 György Wolf (MTMT Központi admin) </div> <div class="lockedBy">Centrally managed 2024.10.17. 18:42 György Wolf (MTMT Központi admin) Gusztáv Ladányi (MTMT API user, admin) </div> </div></div>