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The purpose of our study was to investigate the applicability of isostatic ultra high pressure (IUHP) for the aim of drug formulation. Aqueous suspensions of potato and maize starches containing theophylline as a model drug were subjected to IUHP. The changes in the structure and morphology of potato and maize starches were investigated. The release profile of theophylline from the pressurized samples was also studied. The aqueous suspensions subjected to WHIP turned into highly viscous gels. The crystalline structure of maize starch was changed, while PS pressurized in aqueous medium retained its original X-ray pattern. The sample containing potato starch as a gel-forming polymer exhibited faster drug dissolution compared to an aqueous theophylline suspension used as a reference, while the pressurization of maize starch resulted in a get exhibiting sustained drug release. The results of the dissolution study can be explained with the changes in structure and morphology of the starches caused by IUHP processing and with the different pressure sensitivities of PS and MS. (c) 2007 Elsevier Ltd. All rights reserved.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" > Szepes, A </span> <span class="author-type"> </span> ; <span class="author-name" > Makai, Z </span> <span class="author-type"> </span> ; <span class="author-name" > Blumer, C </span> <span class="author-type"> </span> ; <span class="author-name" > Mader, K </span> <span class="author-type"> </span> ; <span class="author-name" > Kasa, P </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10003610"> <a href="/gui2/?type=authors&mode=browse&sel=10003610" target="_blank">Szabo-Revesz, P ✉</a> </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;2187212" mtid="2187212" target="_blank">Characterization and drug delivery behaviour of starch-based hydrogels prepared via isostatic ultrahigh pressure</a></div> <div class="pub-info"> <span class="journal-title">CARBOHYDRATE POLYMERS</span> <span class="journal-volume">72</span> : <span class="journal-issue">4</span> <span class="page"> pp. 571-578. , 8 p. </span> <span class="year">(2008)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.carbpol.2007.09.028" target="_blank" href="https://doi.org/10.1016/j.carbpol.2007.09.028"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000255082700001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000255082700001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40049108721" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-40049108721"> Scopus </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:2187212 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 36</span> | Független: 36 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 33 | Scopus jelölt: 19 | WoS/Scopus jelölt: 36 | DOI jelölt: 33 </div> </div> </div> </div><div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Szepes A </span> ; <span class="author-name" >Makai Z </span> ; <span class="author-name" >Blumer C </span> ; <span class="author-name" >Mader K </span> ; <span class="author-name" >Kasa P </span> ; <span class="author-name" mtid="10003610"><a href="/gui2/?type=authors&mode=browse&sel=10003610" target="_blank">Szabo-Revesz P ✉ (<span class="authorship-author-name">Révész Piroska</span> <span class="authorAux-mtmt"> Gyógyszerformák és galenuszi készítmények techn...</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszertechnológiai Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse¶ms=publication;2187212" target="_blank">Characterization and drug delivery behaviour of starch-based hydrogels prepared via isostatic ultrahigh pressure</a></div> <div> <span class="journal-title">CARBOHYDRATE POLYMERS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0144-8617">0144-8617</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1879-1344">1879-1344</a>)</span>: <span class="journal-volume">72</span> <span class="journal-issue">4</span> <span class="page"> pp 571-578 </span> <span class="year">(2008)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.carbpol.2007.09.028" target="_blank" href="https://doi.org/10.1016/j.carbpol.2007.09.028"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000255082700001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000255082700001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40049108721" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-40049108721"> Scopus </a> </span> </span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 36</span> | Független: 36 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 33 | Scopus jelölt: 19 | WoS/Scopus jelölt: 36 | DOI jelölt: 33 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2187212&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 2187212</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> <span class="oldId">Régi azonosító: 2187212</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS</span> </div> <div class="lastModified">Utolsó módosítás: 2021.02.17. 12:48 Haefflerné Greilich Anikó (SZTE admin5-INAKTÍV) </div> </div></div>