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Within this \"mini-organ\", the sebaceous gland has been neglected by the researchers of the field for several decades. Actually, it was labeled as a reminiscence of human development (\"a living fossil with a past but no future\"), and was thought to solely act as a producer of sebum, a lipid-enriched oily substance which protects our skin (and hence the body) against various insults. However, due to emerging research activities of the past two decades, it has now become evident that the sebaceous gland is not only a \"passive\" cutaneous \"relic\" to establish the physico-chemical barrier function of the skin against constant environmental challenges, but it rather functions as an \"active\" neuro-immuno-endocrine cutaneous organ. 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