This paper presents an analysis of classical and modern control methods for blood
glucose control of diabetic patients under intensive care. Employing a modified two-
compartment model proposed by Bergman, et al. (1979), linear feedback control law
leads to a fully symbolic solution. In case of nonlinear approach, considering glucose
injection as the only control variable and using Pontryagin's maximum principle, a
symbolic-numeric solution has been achieved. As modern control strategy, optimal glucose-insulin
control in the H2/H∞-space is presented using LQ and disturbance rejection LQ methods,
which result in a numerical solution to the control problem.