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Brodszky, Valentin
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Prostanoids (alprostadil and iloprost) are used for the treatment of patients with critical limb ischemia in whom revascularization procedure is inadequate or proved to be unsuccessful. According to a Cochrane analysis (CD006544) prostanoids differ in their effects on rest-pain relief and ulcer healing. Objectives: To study the efficacy and safety of prostanoids for critical limb ischemia. Methods: Systematic literature search and meta-analysis (mixed treatment comparison) was performed. Results: Seven randomized controlled trials including 964 patients were analyzed. Compared to placebo, both alprostadil (OR: 3.2 95% CI: 1.7-5.5 and OR: 1.8 95% CI: 0.6-4.3) and iloprost (OR: 2.7 95% CI: 1.7-4.2 and OR: 2.5 95% CI: 1.0-5.4) were more efficacious with regard to rest-pain relief and ulcer healing and the difference between the two prostanoids was not significant (OR: 1.2 95% CI: 0.7-1.9 and OR: 0.74 95% CI: 0.3-1.5). Adverse events occurred significantly more often with both drugs compared to placebo, however, they were less frequent with alprostadil than with iloprost (OR 0.2 95% CI: 0.1-0.3). Conclusions: Prostanoids have favorable effect on rest-pain relief and ulcer healing in critical limb ischemia, without statistically significant difference between the two available drugs. The Cochrane study (CD006544) reported mistaken results due to defaults in the analysis.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10020545"> <a href="/gui2/?type=authors&mode=browse&sel=10020545" target="_blank">Brodszky, Valentin</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10049490"> <a href="/gui2/?type=authors&mode=browse&sel=10049490" target="_blank">Farkas, K</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10014929"> <a href="/gui2/?type=authors&mode=browse&sel=10014929" target="_blank">Járai, Z</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Landi, A </span> <span class="author-type"> </span> ; <span class="author-name" > Pécsvárady, Z </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10033563"> <a href="/gui2/?type=authors&mode=browse&sel=10033563" target="_blank">Baji, P</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10039957"> <a href="/gui2/?type=authors&mode=browse&sel=10039957" target="_blank">Balogh, O</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10003170"> <a href="/gui2/?type=authors&mode=browse&sel=10003170" target="_blank">Gulácsi, L</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10002852"> <a href="/gui2/?type=authors&mode=browse&sel=10002852" target="_blank">Péntek, M</a> </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;2068490" mtid="2068490" target="_blank">Prosztanoidok hatásossága kritikus végtagischaemiában</a></div> <div class="pub-info"> <span class="journal-title">ORVOSI HETILAP</span> <span class="journal-volume">152</span> : <span class="journal-issue">51</span> <span class="page"> pp. 2047-2055. , 9 p. </span> <span class="year">(2011)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:black" title="10.1556/OH.2011.29277" target="_blank" href="https://doi.org/10.1556/OH.2011.29277"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="82955243798" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-82955243798"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="22130202" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22130202&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="1710795" target="_blank" href="http://www.matarka.hu/egy-kozlemeny-oldala.php?MatarkaID=1710795"> Matarka </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="deleted-record">Zárolt</span> <span class="short-pub-mtid"> Közlemény:2068490 </span> <span class="status-holder"><span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span></span> <span class="pub-core">Forrás </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 2</span> | Független: 2 | Függő: 0 | Nem jelölt: 0 | Scopus jelölt: 2 | WoS/Scopus jelölt: 2 </div> </div> </div> </div><div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10020545"><a href="/gui2/?type=authors&mode=browse&sel=10020545" target="_blank">Brodszky Valentin (<span class="authorship-author-name">Brodszky Valentin</span> <span class="authorAux-mtmt"> Egészségügyi közgazdaságtan</span>) </a> </span> <span class="author-affil"><span title="Budapesti Corvinus Egyetem">BCE</span>/<span title="Közgazdaságtudományi Kar">KK</span>/<span title="Közszolgálati Tanszék">KSZT</span>/Egészség-gazdaságtani és Egészségügyi Technológiaelemzési Kutatóközpont</span> ; <span class="author-name" mtid="10049490"><a href="/gui2/?type=authors&mode=browse&sel=10049490" target="_blank">Farkas K (<span class="authorship-author-name">Farkas Katalin</span> <span class="authorAux-mtmt"> Belgyógyászat</span>) </a> </span> ; <span class="author-name" mtid="10014929"><a href="/gui2/?type=authors&mode=browse&sel=10014929" target="_blank">Járai Z (<span class="authorship-author-name">Járai Zoltán</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> ; <span class="author-name" >Landi A </span> ; <span class="author-name" >Pécsvárady Z </span> ; <span class="author-name" mtid="10033563"><a href="/gui2/?type=authors&mode=browse&sel=10033563" target="_blank">Baji P (<span class="authorship-author-name">Baji Petra</span> <span class="authorAux-mtmt"> Közgazdaságtan</span>) </a> </span> <span class="author-affil"><span title="Budapesti Corvinus Egyetem">BCE</span>/<span title="Közgazdaságtudományi Kar">KK</span>/<span title="Közszolgálati Tanszék">KSZT</span>/Egészség-gazdaságtani és Egészségügyi Technológiaelemzési Kutatóközpont</span> ; <span class="author-name" mtid="10039957"><a href="/gui2/?type=authors&mode=browse&sel=10039957" target="_blank">Balogh O (<span class="authorship-author-name">Balogh Orsolya</span> <span class="authorAux-mtmt"> egészség-gazdaságtan</span>) </a> </span> <span class="author-affil"><span title="Budapesti Corvinus Egyetem">BCE</span>/<span title="Közgazdaságtudományi Kar">KK</span>/<span title="Közszolgálati Tanszék">KSZT</span>/Egészség-gazdaságtani és Egészségügyi Technológiaelemzési Kutatóközpont</span> ; <span class="author-name" mtid="10003170"><a href="/gui2/?type=authors&mode=browse&sel=10003170" target="_blank">Gulácsi L (<span class="authorship-author-name">Gulácsi László</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Budapesti Corvinus Egyetem">BCE</span>/<span title="Közgazdaságtudományi Kar">KK</span>/<span title="Közszolgálati Tanszék">KSZT</span>/Egészség-gazdaságtani és Egészségügyi Technológiaelemzési Kutatóközpont</span> ; <span class="author-name" mtid="10002852"><a href="/gui2/?type=authors&mode=browse&sel=10002852" target="_blank">Péntek M (<span class="authorship-author-name">Péntek Márta</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Budapesti Corvinus Egyetem">BCE</span>/<span title="Közgazdaságtudományi Kar">KK</span>/<span title="Közszolgálati Tanszék">KSZT</span>/Egészség-gazdaságtani és Egészségügyi Technológiaelemzési Kutatóközpont</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse¶ms=publication;2068490" target="_blank">Prosztanoidok hatásossága kritikus végtagischaemiában</a></div> <div> <span class="journal-title">ORVOSI HETILAP</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0030-6002">0030-6002</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1788-6120">1788-6120</a>)</span>: <span class="journal-volume">152</span> <span class="journal-issue">51</span> <span class="page"> pp 2047-2055 </span> <span class="year">(2011)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Magyar | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:black" title="10.1556/OH.2011.29277" target="_blank" href="https://doi.org/10.1556/OH.2011.29277"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="82955243798" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-82955243798"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="22130202" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22130202&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="1710795" target="_blank" href="http://www.matarka.hu/egy-kozlemeny-oldala.php?MatarkaID=1710795"> Matarka </a> </span> </span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 2</span> | Független: 2 | Függő: 0 | Nem jelölt: 0 | Scopus jelölt: 2 | WoS/Scopus jelölt: 2 </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 2068490</span> | <span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span> <span class="oldId">Régi azonosító: 2068490</span> | Forrás | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="lastModified">Utolsó módosítás: 2022.10.24. 18:15 Szuper Admin (admin) </div> <div class="lockedBy">Ideiglenesen zárolva 2021.02.08. 07:03 Tomcsányi Zsuzsanna (MTMT_KP_admin) </div> </div></div>