https://m2.mtmt.hu/ hun 2026-08-24 01:17 JournalArticle 2015355 ADMIN_APPROVED true 0 2014-10-16T10:58:24.000+0000 false 2015355 2026-08-14T19:42:38.101+0000 2025-04-02T18:17:38.565+0000 2012-07-10T07:01:40.000+0000 true 10015165 Veresné Dékány Mária /api/admin/10015165 Admin Veresné Dékány Mária (SZBK admin - INAKTÍV) true 10015165 2024-02-29T21:04:20.670+0000 2020-01-21T12:58:20.641+0000 true 10018677 Berkes Kata /api/admin/10018677 Admin Berkes Kata (SZBK 5admin) true 10018677 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Nelson, KS true true /api/journal/25047 REVIEWED NATURE CELL BIOLOGY 1465-7392 1476-4679 true false 25047 false 25047 true 1465-7392 1476-4679 Journal FOREIGN 14 5 518 525 518 8 2012 Networks of epithelial and endothelial tubes are essential for the function of organs such as the lung, kidney and vascular system. The sizes and shapes of these tubes are highly regulated to match their individual functions. Defects in tube size can cause debilitating diseases such as polycystic kidney disease and ischaemia(1,2). It is therefore critical to understand how tube dimensions are regulated. Here we identify the tyrosine kinase Src as an instructive regulator of epithelial-tube length in the Drosophila tracheal system. Loss-of-function Src42 mutations shorten tracheal tubes, whereas Src42 overexpression elongates them. Surprisingly, Src42 acts distinctly from known tube-size pathways and regulates both the amount of apical surface growth and, with the conserved formin dDaam, the direction of growth. Quantitative three-dimensional image analysis reveals that Src42- and dDaam-mutant tracheal cells expand more in the circumferential than the axial dimension, resulting in tubes that are shorter in length-but larger in diameter-than wild-type tubes. Thus, Src42 and dDaam control tube dimensions by regulating the direction of anisotropic growth, a mechanism that has not previously been described. 2012 98994 true true true false true false NONE 2026-08-14 false 56 0 56 52 0 55 56 53 20 56 56 52 52 52 4 0 56 52 56 52 0 2 2 Folyóiratcikk Journal Article 24 55 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2012 0 2 2 2 2 2013 0 6 5 6 5 2014 0 9 7 9 7 2015 0 6 6 6 6 2016 0 3 3 3 3 2017 0 2 2 2 2 2018 0 8 8 8 8 2019 0 8 7 8 7 2020 0 0 0 0 0 2021 0 5 5 5 5 2022 0 1 1 1 1 2023 0 4 4 4 4 2024 0 1 1 1 1 2025 0 1 1 1 1 D1 false false false false 2012-07-10T08:00:50.000+0000 2012-07-10T07:59:58.000+0000 Genetikai Intézet (HRN SZBK) 2 11 1 6 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 2962132 /api/authorship/2962132 Nelson, KS 1 0.16666667 true false Nelson KS true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 15408946 true PersonAuthorship 2962133 /api/authorship/2962133 Khan, Z 2 0.16666667 false false Khan Z true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 15408945 true PersonAuthorship 2962134 /api/authorship/2962134 Molnar, I [Molnár, Imre Árpád (genetika), szerző] Genetikai Intézet (HRN SZBK) 3 0.16666667 false false Author 10027877 /api/author/10027877 Molnár Imre Árpád (genetika) Molnár Imre Árpád true 10027877 true Molnar I true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 15408944 true PersonAuthorship 2962135 /api/authorship/2962135 Mihaly, J [Mihály, József (genetika), szerző] Genetikai Intézet (HRN SZBK) 4 0.16666667 false false Author 10010519 /api/author/10010519 Mihály József (genetika) Mihály József true 10010519 true Mihaly J true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 15408943 true PersonAuthorship 2962136 /api/authorship/2962136 Kaschube, M 5 0.16666667 false false Kaschube M true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 15408942 true PersonAuthorship 2962137 /api/authorship/2962137 Beitel, GJ 6 0.16666667 false true Beitel GJ true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 15408941 true PublicationIdentifier 548668 /api/publicationidentifier/548668 DOI: 10.1038/ncb2467 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true false IDENTICAL 10.1038/ncb2467 https://doi.org/10.1038/ncb2467 false 336477 true PublicationIdentifier 548667 /api/publicationidentifier/548667 WoS: 000303598300012 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000303598300012 https://www.webofscience.com/wos/woscc/full-record/000303598300012 false 336478 true PublicationIdentifier 25792484 /api/publicationidentifier/25792484 Scopus: 84860536901 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 84860536901 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84860536901 false true PublicationIdentifier 548669 /api/publicationidentifier/548669 Teljes dokumentum: http://www.nature.com/ncb/journal/v14/n5/pdf/ncb2467.pdf PlainSource 39 /api/publicationsource/39 Teljes dokumentum PublicationSourceType 10006 /api/publicationsourcetype/10006 Link true true true Teljes dokumentum Full text @@@ true true 39 true false NO http://www.nature.com/ncb/journal/v14/n5/pdf/ncb2467.pdf http://www.nature.com/ncb/journal/v14/n5/pdf/ncb2467.pdf false 336479 true Classification 10545 /api/classification/10545 Biológiai tudományok true true SjrRating 5640792 /api/sjrrating/5640792 sjr:D1 (2012) Scopus - Cell Biology NATURE CELL BIOLOGY 1465-7392 1476-4679 5 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1307 /api/classificationexternal/1307 Scopus - Cell Biology true 1307 true D1 DIRECT true 5640792 true Reference 1504917 /api/reference/1504917 1. 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(2012) NATURE CELL BIOLOGY 1465-7392 1476-4679 14 5 518-525<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Nelson KS </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Khan Z </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027877"><a href="/gui2/?type=authors&mode=browse&sel=10027877" target="_blank">Molnar I (<span class="authorship-author-name">Molnár Imre Árpád</span> <span class="authorAux-mtmt"> genetika</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Kutatóközpont">MTA SZBK</span>/Genetikai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010519"><a href="/gui2/?type=authors&mode=browse&sel=10010519" target="_blank">Mihaly J (<span class="authorship-author-name">Mihály József</span> <span class="authorAux-mtmt"> genetika</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Kutatóközpont">MTA SZBK</span>/Genetikai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kaschube M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Beitel GJ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2015355" target="_blank">Drosophila Src regulates anisotropic apical surface growth to control epithelial tube size</a></div> <div> <span class="journal-title">NATURE CELL BIOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1465-7392">1465-7392</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1476-4679">1476-4679</a>)</span>: <span class="journal-volume">14</span> <span class="journal-issue">5</span> <span class="page"> pp 518-525 </span> <span class="year">(2012)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1038/ncb2467" target="_blank" href="https://doi.org/10.1038/ncb2467"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000303598300012" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000303598300012"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84860536901" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84860536901"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="http://www.nature.com/ncb/journal/v14/n5/pdf/ncb2467.pdf" target="_blank" href="http://www.nature.com/ncb/journal/v14/n5/pdf/ncb2467.pdf"> Teljes dokumentum </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cell Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 56</span> | Független: 52 | Függő: 4 | Nem jelölt: 0 | WoS jelölt: 53 | Scopus jelölt:&nbsp;20 | WoS/Scopus jelölt:&nbsp;56 | DOI jelölt:&nbsp;56 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2015355&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 2015355</span> | <span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span> <span class="oldId">Régi azonosító: 2015355</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS</span> </div> <div class="lastModified">Utolsó módosítás: 2025.04.02. 20:17 Pécsi Éva (MTMT Közp 2,3, admin) </div> </div></div>