Carboxylated magnetic nanoparticles as MRI contrast agents:Relaxation measurements at different field strengths

Jedlovszky-Hajdú, A ✉ [Jedlovszky-Hajdú, Angéla (Kolloidkémia), szerző] Biofizikai és Sugárbiológiai Intézet (SE / AOK / I); Tombácz, E [Csákiné Tombácz, Etelka (Kolloidkémia), szerző] Fizikai Kémiai és Anyagtudományi Tanszék (SZTE / TTIK / KTCS); Bányai, I [Bányai, István (Fizikai kémia), szerző] Kolloid- és Környezetkémiai Tanszék (DE / TTK / KemI); Babos, M ✉; Palkó, A [Palkó, András (Radiológia), szerző] Radiológiai Klinika (SZTE / ÁOK)

Angol nyelvű Tudományos Szakcikk (Folyóiratcikk)
Megjelent: JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS 0304-8853 324 (19) pp. 3173-3180 2012
  • SJR Scopus - Condensed Matter Physics: Q1
Azonosítók
Szakterületek:
    At the moment the biomedical applications of magnetic fluids are the subject of intensive scientific interest. In the present work, magnetite nanoparticles (MNPs) were synthesized and stabilized in aqueous medium with different carboxylic compounds (citric acid (CA), polyacrylic acid (PAA), and sodium oleate (NaOA)), in order to prepare well stabilized magnetic fluids (MFs). The magnetic nanoparticles can be used in the magnetic resonance imaging (MRI) as contrast agents. Magnetic resonance relaxation measurements of the above MFs were performed at different field strengths (i.e., 0.47, 1.5 and 9.4 T) to reveal the field strength dependence of their magnetic responses, and to compare them with that of ferucarbotran, a well-known superparamagnetic contrast agent. The measurements showed characteristic differences between the tested magnetic fluids stabilized by carboxylic compounds and ferucarbotran. It is worthy of note that our magnetic fluids have the highest r2 relaxivities at the field strength of 1.5 T, where the most of the MRI works in worldwide.
    Hivatkozás stílusok: IEEEACMAPAChicagoHarvardCSLMásolásNyomtatás
    2021-04-17 22:56