https://m2.mtmt.hu/ eng 2026-04-17 08:10 JournalArticle 1925102 APPROVED true Megjegyzés-23017121 N1 Molecular Sequence Numbers: GENBANK: AAB42015, AAF52567, AAF55261, AAF56856, AAN14116, AAS65100, AAZ66587, ACL83530, CAA99203, DAA07245, NP_010093, NP_010958, NP_033384, NP_055739, NP_058587, NP_062284, NP_068753, NP_659129, P31383; Megjegyzés-23021495 N1 Molecular Sequence Numbers: GENBANK: AAB42015, AAF52567, AAF55261, AAF56856, AAN14116, AAS65100, AAZ66587, ACL83530, CAA99203, DAA07245, NP_010093, NP_010958, NP_033384, NP_055739, NP_058587, NP_062284, NP_068753, NP_659129, P31383; 0 2014-10-16T10:57:58.000+0000 false 1925102 2026-02-10T09:10:09.421+0000 2023-09-19T12:05:43.104+0000 2012-03-30T15:34:18.000+0000 true 10028989 Bánréti Ágnes Regina /api/author/10028989 Author true 10028989 2023-09-19T12:05:43.422+0000 2023-09-19T12:05:43.422+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Banreti, A PP2A regulates autophagy in two alternative ways in Drosophila. true true /api/journal/10004714 REVIEWED true false 10004714 false 10004714 true 1554-8627 1554-8635 Journal FOREIGN 8 4 623 636 623 14 2012 Protein phosphatase 2A (PP2A) holoenzyme is a heterotrimeric complex, consisting of A, B and C subunits. The catalytic subunit PP2A-C (microtubule star/mts) binds to the C-terminal part of the scaffold protein PP2A-A (PP2A-29B). In Drosophila, there are three different forms of B subunits (widerborst/wdb, twins/tws and PP2A-B'), which determine the subcellular localization and substrate specificity of the holoenzyme. Previous studies demonstrated that PP2A is involved in the control of TOR-dependent autophagy both in yeast and mammals. Furthermore, in Drosophila, wdb genetically interacts with the PtdIns3K/PTEN/Akt signaling cascade, which is a main upstream regulatory system of dTOR. Here we demonstrate that in Drosophila, two different PP2A complexes (containing B' or wdb subunit) play essential roles in the regulation of starvation-induced autophagy. The PP2A-A/wdb/C complex acts upstream of dTOR, whereas the PP2A-A/B'/C complex functions as a target of dTOR and may regulate the elongation of autophagosomes and their subsequent fusion with lysosomes. We also identified three Drosophila Atg orthologs (Atg14, Atg17 and Atg101), which represent potential targets of the PP2A-A/B'/C complex during autophagy. 2012 (Bánréti Ágnes Regina (Molekuláris Sejt- és Ne...); 2012.03.30. 17:34:07) true true true false true false NONE 2026-02-10 false 50 0 50 49 1 50 49 49 47 50 50 49 49 49 1 0 50 49 50 49 0 4 4 Folyóiratcikk Journal Article 24 49 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2013 0 3 3 3 3 2014 0 12 11 12 11 2015 0 5 5 5 5 2016 0 4 4 4 4 2017 0 4 4 4 4 2018 0 3 3 3 3 2019 0 5 5 5 5 2020 0 2 2 2 2 2021 0 2 2 2 2 2022 0 3 3 3 3 2023 0 1 1 1 1 2024 0 2 2 2 2 2025 0 4 4 4 4 Q1 false false false false 2013-09-12T12:36:41.000+0000 2012-11-06T10:24:59.000+0000 Anatómiai, Sejt- és Fejlődésbiológiai Tanszék (ELTE / TTK / Bio_I); Genetikai Intézet (HRN SZBK) 4 19 2 5 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 2668866 /api/authorship/2668866 1 0.2 true false Author 10028989 /api/author/10028989 Bánréti Ágnes Regina true 10028989 true Banreti A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 14811103 true PersonAuthorship 2668867 /api/authorship/2668867 2 0.2 false false Lukacsovich T true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 14811102 true PersonAuthorship 2668868 /api/authorship/2668868 3 0.2 false false Author 10020323 /api/author/10020323 Csikós György true 10020323 true Csikos G true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 14811101 true PersonAuthorship 2668869 /api/authorship/2668869 4 0.2 false false Author 10009410 /api/author/10009410 Erdélyi Miklós true 10009410 true Erdelyi M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 14811100 true PersonAuthorship 2668870 /api/authorship/2668870 5 0.2 false true Author 10009420 /api/author/10009420 Sass Miklós true 10009420 true Sass M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 14811099 true PublicationIdentifier 514897 /api/publicationidentifier/514897 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true false IDENTICAL 10.4161/auto.19081 https://doi.org/10.4161/auto.19081 false 312124 true PublicationIdentifier 514895 /api/publicationidentifier/514895 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000305403400008 https://www.webofscience.com/wos/woscc/full-record/000305403400008 false 312125 true PublicationIdentifier 514896 /api/publicationidentifier/514896 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 84862297232 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84862297232 false 312126 true PublicationIdentifier 514898 /api/publicationidentifier/514898 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false IDENTICAL 22330894 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22330894&dopt=Abstract false 312127 true Classification 10545 /api/classification/10545 true true Keyword 2732 /api/keyword/2732 true 2732 true Keyword 1027167 /api/keyword/1027167 true 1027167 true Keyword 1096530 /api/keyword/1096530 true 1096530 true Keyword 1150679 /api/keyword/1150679 true 1150679 true Keyword 1177646 /api/keyword/1177646 true 1177646 true Keyword 1177647 /api/keyword/1177647 true 1177647 true Keyword 1177648 /api/keyword/1177648 true 1177648 true Keyword 1177649 /api/keyword/1177649 true 1177649 true SjrRating 5640831 /api/sjrrating/5640831 42 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1307 /api/classificationexternal/1307 true 1307 true Q1 DIRECT true 5640831 true /api/publication/1925102 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10028989"><a href="/gui2/?type=authors&mode=browse&sel=10028989" target="_blank">Banreti A (<span class="authorship-author-name">Bánréti Ágnes Regina</span> <span class="authorAux-mtmt"> Molekuláris Sejt- és Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd University">ELTE</span>/<span title="Faculty of Science">ELU FoS</span>/<span title="Institute of Biology">Bio_I</span>/Department of Anatomy, Cell and Developmental Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lukacsovich T </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020323"><a href="/gui2/?type=authors&mode=browse&sel=10020323" target="_blank">Csikos G (<span class="authorship-author-name">Csikós György</span> <span class="authorAux-mtmt"> Fejlődésbiológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd University">ELTE</span>/<span title="Faculty of Science">ELU FoS</span>/<span title="Institute of Biology">Bio_I</span>/Department of Anatomy, Cell and Developmental Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009410"><a href="/gui2/?type=authors&mode=browse&sel=10009410" target="_blank">Erdelyi M (<span class="authorship-author-name">Erdélyi Miklós</span> <span class="authorAux-mtmt"> genetika</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Központ">MTA SZBK</span>/Institute of Genetics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009420"><a href="/gui2/?type=authors&mode=browse&sel=10009420" target="_blank">Sass M (<span class="authorship-author-name">Sass Miklós</span> <span class="authorAux-mtmt"> Biológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd University">ELTE</span>/<span title="Faculty of Science">ELU FoS</span>/<span title="Institute of Biology">Bio_I</span>/Department of Anatomy, Cell and Developmental Biology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;1925102" target="_blank">PP2A regulates autophagy in two alternative ways in Drosophila.</a></div> <div> <span class="journal-title">AUTOPHAGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1554-8627">1554-8627</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1554-8635">1554-8635</a>)</span>: <span class="journal-volume">8</span> <span class="journal-issue">4</span> <span class="page"> pp 623-636 </span> <span class="year">(2012)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.4161/auto.19081" target="_blank" href="https://doi.org/10.4161/auto.19081"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000305403400008" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000305403400008"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84862297232" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84862297232"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="22330894" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22330894&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Cell Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 50</span> | Independent citation: 49 | Self citation: 1 | Unknown citation: 0 | Number of citations in WoS: 49 | Number of citations in Scopus:&nbsp;47 | WoS/Scopus assigned:&nbsp;50 | Number of citations with DOI:&nbsp;49 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;1925102&sort=publishedYear,desc&sort=title"> Number of cited publications: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 1925102</span> | <span class="status-data status-APPROVED"> Published </span> <span class="oldId">Old id: 1925102</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Last Modified: 2023.09.19. 14:05 Gusztáv Ladányi (MTMT API user, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Megjegyzés-23017121 N1 Molecular Sequence Numbers: GENBANK: AAB42015, AAF52567, AAF55261, AAF56856, AAN14116, AAS65100, AAZ66587, ACL83530, CAA99203, DAA07245, NP_010093, NP_010958, NP_033384, NP_055739, NP_058587, NP_062284, NP_068753, NP_659129, P31383; Megjegyzés-23021495 N1 Molecular Sequence Numbers: GENBANK: AAB42015, AAF52567, AAF55261, AAF56856, AAN14116, AAS65100, AAZ66587, ACL83530, C...</pre> </div></div>