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University of Szeged, Faculty of Pharmacy, Department of Pharmaceutical Technology, Eötvös u. 6, H-6720 Szeged, Hungary
Martin-Luther-University Halle-Wittenberg, FB Ingenieurwissenschaften, Institut für Verfahrenstechnik, D-06099 Halle (Saale), Germany
University of Veszprém, Department of Silicate and Materials Engineering, Egyetem u. 10, H-8200 Veszprém, Hungary
University of Veszprém, Department of Environmental Engineering and Chemical Technology, P.O. Box 158, H-8200 Veszprém, Hungary
Cited By :38
Export Date: 15 October 2020
CODEN: CENPE
Correspondence Address: Szabó-Révész, P.; University of Szeged, Faculty of Pharmacy, Department of Pharmaceutical Technology, Eötvös u. 6, H-6720 Szeged, Hungary; email: revesz@pharm.u-szeged.hu
Funding details: Deutscher Akademischer Austauschdienst, DAAD
Funding details: OTKA T-047166
Funding text 1: This study was supported by the German Academic Exchange Service and the Hungarian Scholarship Committee, and by the Hungarian National Research Foundation (OTKA T-047166), for which the authors express their thanks.
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The aim of the present study was to develop a fast-dissolving solid dosage form containing theophylline as active ingredient using the freeze-casting technique. The structure, the physical properties and mechanism of drug release from the freeze-casted units were investigated. The examined properties of the samples were compared with those of tablets compressed by an eccentric tableting machine using three different compression pressures. The freeze-casting technique proved to be an appropriate alternative for the development of porous solid drug delivery systems. The mechanical strength of the matrices could be improved by using water-soluble additives, which stabilized the solid bodies during recrystallization upon drying. As compared with the tablets, the freeze-casted units revealed a highly porous nature and a remarkable difference in pore volume size distribution. The results demonstrated that the drug-solvent interaction, enhanced by the structural properties, resulted in a rapid delivery of the theophylline from the solid units into artificial gastric juice. © 2006 Elsevier B.V. All rights reserved.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" > Szepes, A </span> <span class="author-type"> </span> ; <span class="author-name" > Ulrich, J </span> <span class="author-type"> </span> ; <span class="author-name" > Farkas, Z </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10028027"> <a href="/gui2/?type=authors&mode=browse&sel=10028027" target="_blank">Kovács, J</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10003610"> <a href="/gui2/?type=authors&mode=browse&sel=10003610" target="_blank">Szabó-Révész, P ✉</a> </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;1872173" mtid="1872173" target="_blank">Freeze-casting technique in the development of solid drug delivery systems</a></div> <div class="pub-info"> <span class="journal-title">CHEMICAL ENGINEERING AND PROCESSING</span> <span class="journal-volume">46</span> : <span class="journal-issue">3</span> <span class="page"> pp. 230-238. , 9 p. </span> <span class="year">(2007)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.cep.2006.06.004" target="_blank" href="https://doi.org/10.1016/j.cep.2006.06.004"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000243777800008" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000243777800008"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="33845200427" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-33845200427"> Scopus </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:1872173 </span> <span class="status-holder"><span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 38</span> | Független: 32 | Függő: 6 | Nem jelölt: 0 | WoS jelölt: 34 | Scopus jelölt: 23 | WoS/Scopus jelölt: 38 | DOI jelölt: 32 </div> </div> </div> </div><div class="JournalArticle Publication long-list">
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<div class="mtid"><span class="long-pub-mtid">Közlemény: 1872173</span>
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<div class="lastModified">Utolsó módosítás: 2020.12.22. 12:39 Szuper Admin (admin)
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<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Megjegyzés-21940563
Z9: 8
University of Szeged, Faculty of Pharmacy, Department of Pharmaceutical Technology, Eötvös u. 6, H-6720 Szeged, Hungary
Martin-Luther-University Halle-Wittenberg, FB Ingenieurwissenschaften, Institut für Verfahrenstechnik, D-06099 Halle (Saale), Germany
University of Veszprém, Department of Silicate and Materials Engineer...</pre>
</div></div>