Freeze-casting technique in the development of solid drug delivery systems

Szepes, A; Ulrich, J; Farkas, Z; Kovács, J [Kovács, József (Környezetmérnökség), szerző] Környezetmérnöki Intézeti Tanszék (PE / MK / KMI); Szabó-Révész, P ✉ [Révész, Piroska (Gyógyszerformák é...), szerző] Gyógyszertechnológiai Intézet (SZTE / GYTK)

Angol nyelvű Tudományos Szakcikk (Folyóiratcikk)
Megjelent: CHEMICAL ENGINEERING AND PROCESSING 0255-2701 46 (3) pp. 230-238 2007
  • SJR Scopus - Energy Engineering and Power Technology: D1
Azonosítók
Szakterületek:
    The aim of the present study was to develop a fast-dissolving solid dosage form containing theophylline as active ingredient using the freeze-casting technique. The structure, the physical properties and mechanism of drug release from the freeze-casted units were investigated. The examined properties of the samples were compared with those of tablets compressed by an eccentric tableting machine using three different compression pressures. The freeze-casting technique proved to be an appropriate alternative for the development of porous solid drug delivery systems. The mechanical strength of the matrices could be improved by using water-soluble additives, which stabilized the solid bodies during recrystallization upon drying. As compared with the tablets, the freeze-casted units revealed a highly porous nature and a remarkable difference in pore volume size distribution. The results demonstrated that the drug-solvent interaction, enhanced by the structural properties, resulted in a rapid delivery of the theophylline from the solid units into artificial gastric juice. © 2006 Elsevier B.V. All rights reserved.
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    2021-05-15 18:30