https://m2.mtmt.hu/hun2024-03-28 11:18JournalArticle1802374VALIDATEDtrueÖsszes idézések száma a WoS-ban: 0
Cited By :44
Export Date: 14 March 2020
Correspondence Address: Stern, P.H.; Department of Pharmacology, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, Illinois, 60611, United States
Chemicals/CAS: 3,3',5' triiodothyronine, 5817-39-0, 70-39-3; 3,5 dibromo 3' (2,3 dihydro 3 oxo 6 pyridazinylmethyl)thyronine, 105211-23-2; diiodotyrosine, 66-02-4; liothyronine, 6138-47-2, 6893-02-3; protein, 67254-75-5; somatomedin C, 67763-96-6; thyroxine, 7488-70-2; tiratricol, 51-24-1; 3,3',5-triiodothyroacetic acid, 51-24-1; Culture Media; Insulin-Like Growth Factor I, 67763-96-6; SK&F 94901; Thyroid Hormones; Thyronines; Thyroxine, 7488-70-2; Triiodothyronine, 6893-02-3; Triiodothyronine, Reverse, 5817-39-0; Tumor Necrosis Factor
Funding Agency and Grant Number: NIDDK NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) [R01 DK-45269]
Cited By :44
Export Date: 15 March 2020
Correspondence Address: Stern, P.H.; Department of Pharmacology, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, Illinois, 60611, United States
Chemicals/CAS: 3,3',5' triiodothyronine, 5817-39-0, 70-39-3; 3,5 dibromo 3' (2,3 dihydro 3 oxo 6 pyridazinylmethyl)thyronine, 105211-23-2; diiodotyrosine, 66-02-4; liothyronine, 6138-47-2, 6893-02-3; protein, 67254-75-5; somatomedin C, 67763-96-6; thyroxine, 7488-70-2; tiratricol, 51-24-1; 3,3',5-triiodothyroacetic acid, 51-24-1; Culture Media; Insulin-Like Growth Factor I, 67763-96-6; SK&F 94901; Thyroid Hormones; Thyronines; Thyroxine, 7488-70-2; Triiodothyronine, 6893-02-3; Triiodothyronine, Reverse, 5817-39-0; Tumor Necrosis Factor02018-10-02T08:54:25.000+0000false18023742024-02-16T03:48:25.174+00002018-10-09T09:59:41.618+00002012-01-05T12:46:08.000+0000true10012016LakatosPéter
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REVIEWEDtruefalse2311false2311true0884-04311523-4681JournalFOREIGN81214751481147571993The mechanism of action of thyroid hormones on bone is still not clear. At low concentrations, they stimulate bone formation; at high concentrations, they elicit bone resorption in vitro and in vivo. In the present study we investigated the effect of T3 and T4 as well as their active and inactive analogs (TRIAC, SKF L-94901, rT3, and DIT) on the IGF-I and TNF-α content in the medium of UMR-106 rat osteoblastic cells and fetal rat limb bones. In the dose-response studies, a biphasic increase in medium IGF-I was observed in both cells and limb bones, with peak stimulatory concentrations of 10-8 M for T3 and 10-7 M for T4 in both systems. At higher concentrations, at which thyroid hormones elicit bone resorption, the stimulatory effect diminished and finally was no longer detectable. The active analogs TRIAC and SKF L-94901 also enhanced IGF-I release in UMR-106 cells. The inactive compounds rT3 and DIT failed to increase IGF-I in these cultures. The protein content of the cell culture wells exposed to high concentrations of thyroid hormones was similar to those containing low concentrations, indicating that the decrease in IGF-I content at high doses was not due to toxic effects. This was also confirmed by trypan blue exclusion. Time course studies with UMR-106 cells revealed a significant increase in medium IGF-I after 2 days of incubation. No significant further increase was observed after this up to 5 days of culture. In contrast, the medium of limb bone cultures showed a linear increase in IGF-I content up to 7 days of culture. No TNF-α production was observed in either UMR-106 cells or fetal limb bones. Also, no increase in medium TNF-α levels was seen in response to thyroid hormones. Based on our results, we conclude that IGF-I may be responsible for some of the anabolic effects of thyroid hormones in bone tissue, but TNF-α, at least in the models we used, does not play a role in the mediation of thyroid hormone action.2012421819truetruetruefalsefalsePAY2024-02-16falsetrue10015546BerhidiAnna
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10012016"> <a href="/gui2/?type=authors&mode=browse&sel=10012016" target="_blank">Lakatos, P</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Caplice, M D </span> <span class="author-type"> </span> ; <span class="author-name" > Khanna, V </span> <span class="author-type"> </span> ; <span class="author-name" > Stern, P H </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;1802374" mtid="1802374" target="_blank">Thyroid hormones increase insulin-like growth factor I content in the medium of rat bone tissue</a></div> <div class="pub-info"> <span class="journal-title">JOURNAL OF BONE AND MINERAL RESEARCH</span> <span class="journal-volume">8</span> : <span class="journal-issue">12</span> <span class="page"> pp. 1475-1481. , 7 p. </span> <span class="year">(1993)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_PAY" title=" Fizetős "> <a style="color:blue" title="10.1002/jbmr.5650081210" target="_blank" href="https://doi.org/10.1002/jbmr.5650081210"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="A1993MH55200009" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/A1993MH55200009"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="0027428036" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-0027428036"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="8304049" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8304049&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:1802374 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 49</span> | Független: 37 | Függő: 12 | Nem jelölt: 0 | WoS jelölt: 42 | Scopus jelölt: 47 | WoS/Scopus jelölt: 49 | DOI jelölt: 44 </div> </div> </div> </div><div class="JournalArticle Publication long-list">
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<div class="autype autype0"> <span class="author-name" mtid="10012016"><a
href="/gui2/?type=authors&mode=browse&sel=10012016" target="_blank">Lakatos P
(<span class="authorship-author-name">Lakatos Péter</span>
<span class="authorAux-mtmt"> Osteológia, endokrinológia, molekuláris biológia</span>)
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<span class="author-name" >Caplice M D
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;
<span class="author-name" >Khanna V
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<span class="author-name" >Stern P H
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<div class="title"><a href="/gui2/?mode=browse¶ms=publication;1802374" target="_blank">Thyroid hormones increase insulin-like growth factor I content in the medium of rat bone tissue</a></div> <div> <span class="journal-title">JOURNAL OF BONE AND MINERAL RESEARCH</span>
<span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0884-0431">0884-0431</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1523-4681">1523-4681</a>)</span>:
<span class="journal-volume">8</span> <span class="journal-issue">12</span>
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<span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 49</span>
| Független: 37
| Függő: 12
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<div class="mtid"><span class="long-pub-mtid">Közlemény: 1802374</span>
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Forrás Idéző
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( Szakcikk
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<div class="lastModified">Utolsó módosítás: 2018.10.09. 11:59 Szuper Admin (admin)
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<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Összes idézések száma a WoS-ban: 0
Cited By :44
Export Date: 14 March 2020
Correspondence Address: Stern, P.H.; Department of Pharmacology, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, Illinois, 60611, United States
Chemicals/CAS: 3,3',5' triiodothyronine, 5817-39-0, 70-39-3; 3,5 dibromo 3' (2,3...</pre>
</div></div>