Effect of vitamin D3 loading and thyroid hormone replacement therapy on the decreased serum 25-hydroxyvitamin D level in patients with hypothyroidism

Barsony, J; Lakatos, P [Lakatos, Péter (Osteológia, endok...), szerző] I. Sz. Belgyógyászati Klinika (SE / AOK / K); Foldes, J [Földes, János (Pajzsmirígy beteg...), szerző]; Feher, T

Angol nyelvű Tudományos Szakcikk (Folyóiratcikk)
Megjelent: ACTA ENDOCRINOLOGICA 0001-5598 113 (3) pp. 329-334 1986
    Azonosítók
    Twelve hypothyroid subjects, 13 healthy and 12 healthy women with a slight deficiency of vitamin D were studied to distinguish seasonal changes from the thyroxine-dependent ones. Serum 25-hydroxyvitamin D levels of hypothyroid patients were lower than those of healthy individuals when the sera were obtained in the autumn. In hypothyroid patients a single oral dose of 100,000 IU vitamin D3 resulted in a smaller increase in 25-hydroxyvitamin D concentration than in controls having subclinical exogenous vitamin D deficiency. Substitution therapy with thyroid hormone, started in our study always in autumn, increased the 25-hydroxyvitamin D concentration in hypothyroid patients, which was opposite to the autumn-to-spring variation of this hormone observed in healthy controls. The increase of 25-hydroxyvitamin D, dehydroepiandrosterone and its sulphate values following substitution therapy in the hypothyroid patients may indicate that thyroid hormone(s) is (are) involved in the regulation of steroid hormone synthesis.
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    2021-05-16 05:02