https://m2.mtmt.hu/ eng 2026-05-01 08:07 JournalArticle 1792132 VALIDATED true PMID: 22109281 0 2018-10-02T08:54:25.000+0000 false 1792132 2026-04-22T18:09:31.239+0000 2026-01-26T16:38:19.479+0000 2011-12-21T15:09:00.000+0000 true 10009579 Dinya Elek /api/author/10009579 Author true 10009579 2026-01-26T16:38:03.648+0000 2026-01-26T16:38:03.648+0000 2026-01-26T16:38:19.653+0000 true 10023268 Házkötő Béláné /api/admin/10023268 Admin true 10023268 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 18 Note, Short, Rapid communications true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/18 Rövid közlemény SubType 103 true 18 true 1 /api/category/1 Category true 1 Lukacs, K The type 2 diabetes-associated variant in TCF7L2 is associated with latent autoimmune diabetes in adult Europeans and the gene effect is modified by obesity: a meta-analysis and an individual study. true true /api/journal/1310 REVIEWED true false 1310 false 1310 true 0012-186X 1432-0428 Journal FOREIGN 55 3 689 693 689 5 2012 AIMS/HYPOTHESIS: The variants of transcription factor 7-like 2 (TCF7L2) gene have been proposed to be associated with latent autoimmune diabetes in adults (LADA). We sought to confirm the possible association in Europeans and to examine the interaction between one gene variant and clinical data. METHODS: The TCF7L2 rs7903146 C-to-T polymorphism was genotyped in 211 LADA, 1,297 type 2 diabetic, 545 type 1 diabetic and 1,497 control individuals from Hungary. A meta-analysis of our and previously published studies was performed to evaluate the size and the heterogeneity of the gene effect. RESULTS: The meta-analysis yielded a significant effect of TCF7L2 T allele (OR 1.28; p < 0.0001) on LADA risk without heterogeneity among Europeans. The T allele conferred equally strong susceptibility to LADA and type 2 diabetes. In the Hungarian dataset, the T allele was associated with LADA and type 2 diabetes, but not with type 1 diabetes. T allele carriers had significantly lower BMI than patients with the CC genotype in the LADA and type 2 diabetes groups (p = 0.0021 and p = 0.0013, respectively). In both diseases, the diabetes risk was significantly higher in the non-overweight than in the overweight BMI category (p = 0.0013 and p < 0.0001, respectively); susceptibility to LADA was increased by 2.84-fold in non-overweight individuals compared with overweight ones. CONCLUSIONS/INTERPRETATION: The meta-analysis demonstrates that TCF7L2 rs7903146 polymorphism is a population-independent susceptibility locus for LADA in Europeans. The effect size is similar for LADA and type 2 diabetes. The gene effect on diabetes risk may be modulated by BMI, such that the lower the BMI, the higher the gene effect. true true 2011 (Csávics Adrienn (SE_EKK_Adm5_EüInf); 2011.12.21. 16:08:55) true true true false true false RESTRICTED 2026-04-22 false true 10030236 Molnár-Taga Márta /api/admin/10030236 Admin true 10030236 72 0 72 71 1 70 65 66 64 72 72 71 71 71 1 0 72 71 72 71 0 1 1 Folyóiratcikk Journal Article 24 69 Könyvrészlet Chapter in Book 25 3 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2012 0 1 1 1 1 2013 0 13 13 13 13 2014 0 8 8 8 8 2015 0 0 0 0 0 2016 0 8 8 8 8 2017 0 6 5 6 5 2018 0 5 5 5 5 2019 0 10 10 10 10 2020 0 4 4 4 4 2021 0 4 4 4 4 2022 0 4 4 4 4 2023 0 2 2 2 2 2024 0 4 4 4 4 2025 0 2 2 2 2 2026 0 1 1 1 1 D1 false 10020065 false false false 2014-01-17T11:21:31.000+0000 2012-10-27T06:42:14.000+0000 Egészségügyi Informatikai Fejlesztő és Továbbké... (SE / EKK); I. Sz. Gyermekgyógyászati Klinika (SE / AOK / K); III. Sz. Belgyógyászati Klinika (SE / AOK / K) 5 19 3 6 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 2194746 /api/authorship/2194746 1 0.167 true false true Author 10026759 /api/author/10026759 Lukács Krisztina true 10026759 true Lukacs K true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 13945702 true PersonAuthorship 2194747 /api/authorship/2194747 2 0.16666667 false false Author 10020065 /api/author/10020065 Hosszúfalusi Nóra true 10020065 true Hosszufalusi N true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 13945701 true PersonAuthorship 2194748 /api/authorship/2194748 3 0.16666667 false false Author 10009579 /api/author/10009579 Dinya Elek true 10009579 true Dinya E true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 13945700 true PersonAuthorship 2194749 /api/authorship/2194749 4 0.16666667 false false Bakacs M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 13945699 true PersonAuthorship 2194750 /api/authorship/2194750 5 0.16666667 false false Author 10004559 /api/author/10004559 Madácsy László true 10004559 true Madacsy L true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 13945698 true PersonAuthorship 2194751 /api/authorship/2194751 6 0.16666667 false true Author 10003710 /api/author/10003710 Pánczél Pál true 10003710 true Panczel P true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 13945697 true PublicationIdentifier 454882 /api/publicationidentifier/454882 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true false IDENTICAL 10.1007/s00125-011-2378-z https://doi.org/10.1007/s00125-011-2378-z false 269797 true PublicationIdentifier 454884 /api/publicationidentifier/454884 SwordSource 84 /api/publicationsource/84 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true SE Repozitórium SE Repozitórium https://repo.lib.semmelweis.hu/handle/123456789/@@@ true true 84 true RESTRICTED false IDENTICAL 3919 https://repo.lib.semmelweis.hu/handle/123456789/3919 false 1503552 true PublicationIdentifier 454880 /api/publicationidentifier/454880 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000299921200019 https://www.webofscience.com/wos/woscc/full-record/000299921200019 false 269798 true PublicationIdentifier 454881 /api/publicationidentifier/454881 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 84856697168 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84856697168 false 269799 true PublicationIdentifier 454883 /api/publicationidentifier/454883 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false IDENTICAL 22109281 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22109281&dopt=Abstract false 269800 true Classification 12215 /api/classification/12215 true true Keyword 4560 /api/keyword/4560 true 4560 true Keyword 13575 /api/keyword/13575 true 13575 true Keyword 1044596 /api/keyword/1044596 true 1044596 true Keyword 1062311 /api/keyword/1062311 true 1062311 true Keyword 1099221 /api/keyword/1099221 true 1099221 true Keyword 1099222 /api/keyword/1099222 true 1099222 true SjrRating 5662255 /api/sjrrating/5662255 7 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2712 /api/classificationexternal/2712 true 2712 true D1 DIRECT true 5662255 true /api/publication/1792132 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10026759"><a href="/gui2/?type=authors&mode=browse&sel=10026759" target="_blank">Lukacs K ✉ (<span class="authorship-author-name">Lukács Krisztina</span> <span class="authorAux-mtmt"> Belgyógyászat, diabetológia, obesitológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/III. Department of Internal Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020065"><a href="/gui2/?type=authors&mode=browse&sel=10020065" target="_blank">Hosszufalusi N (<span class="authorship-author-name">Hosszúfalusi Nóra</span> <span class="authorAux-mtmt"> Belgyógyászat, Diabetológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/III. Department of Internal Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009579"><a href="/gui2/?type=authors&mode=browse&sel=10009579" target="_blank">Dinya E (<span class="authorship-author-name">Dinya Elek</span> <span class="authorAux-mtmt"> Orvosi biometria</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Department of Hygienic Service">DHS</span>/Institute of Department and Higher Education in the Field of Health Informatics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bakacs M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10004559"><a href="/gui2/?type=authors&mode=browse&sel=10004559" target="_blank">Madacsy L (<span class="authorship-author-name">Madácsy László</span> <span class="authorAux-mtmt"> Élettudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/I. Department of Pediatrics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003710"><a href="/gui2/?type=authors&mode=browse&sel=10003710" target="_blank">Panczel P (<span class="authorship-author-name">Pánczél Pál</span> <span class="authorAux-mtmt"> Belgyógyászat, diabetológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/III. Department of Internal Medicine</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;1792132" target="_blank">The type 2 diabetes-associated variant in TCF7L2 is associated with latent autoimmune diabetes in adult Europeans and the gene effect is modified by obesity: a meta-analysis and an individual study.</a></div> <div> <span class="journal-title">DIABETOLOGIA</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0012-186X">0012-186X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1432-0428">1432-0428</a>)</span>: <span class="journal-volume">55</span> <span class="journal-issue">3</span> <span class="page"> pp 689-693 </span> <span class="year">(2012)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1007/s00125-011-2378-z" target="_blank" href="https://doi.org/10.1007/s00125-011-2378-z"> DOI </a> </span> <span class="id identifier oa_RESTRICTED" title=" Restricted "> <a style="color:blue" title="3919" target="_blank" href="https://repo.lib.semmelweis.hu/handle/123456789/3919"> SE Repozitórium </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000299921200019" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000299921200019"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84856697168" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84856697168"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="22109281" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22109281&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Endocrinology, Diabetes and Metabolism&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Internal Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 72</span> | Independent citation: 71 | Self citation: 1 | Unknown citation: 0 | Number of citations in WoS: 66 | Number of citations in Scopus:&nbsp;64 | WoS/Scopus assigned:&nbsp;72 | Number of citations with DOI:&nbsp;65 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;1792132&sort=publishedYear,desc&sort=title"> Number of cited publications: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 1792132</span> | <span class="status-data status-VALIDATED"> Validated </span> <span class="oldId">Old id: 1792132</span> | Core Citing | <span class="type-subtype">Journal Article ( Note, Short, Rapid communications ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Last Modified: 2026.01.26. 17:38 Béláné Házkötő (SE_AOK_3Bel_Admin5_Hani, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: PMID: 22109281</pre> </div></div>