https://m2.mtmt.hu/ hun 2026-10-23 11:43 JournalArticle 1792015 VALIDATED true 0 2018-10-02T08:54:25.000+0000 false 1792015 2026-10-18T07:11:53.615+0000 2020-05-27T10:07:37.775+0000 2011-12-21T11:58:47.000+0000 true 10026695 Radács Marianna /api/author/10026695 Author true 10026695 2026-03-25T17:03:10.787+0000 2026-03-25T17:03:10.787+0000 2020-05-27T10:07:37.794+0000 true 10026258 Nemesvári Zoltánné /api/admin/10026258 Admin true 10026258 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Nagyeri, G Behavioral and endocrine effects of chronic exposure to low doses of chlorobenzenes in Wistar rats true true /api/journal/3376 REVIEWED true false 3376 false 3376 true 0892-0362 1872-9738 Journal FOREIGN 34 1 9 19 9 11 2012 Chlorobenzenes have often been applied to study persistent organic pollutants with endocrine disruptor effects (POP/EDCs), but with the focus mainly on physiological aspects. Few data exist on the effects of chlorobenzenes and most POP/EDCs on anxiety or other arginine-vasopressin (AVP)- and oxytocin (OXT)-mediated behavior, albeit exposure to POP/EDCs or their ambient mixtures, even in low doses, may pose health risks for subjects living in contaminated areas and/or consuming polluted food. Our primary aim was therefore to demonstrate behavioral effects of longterm exposure to a discrete dose of a chlorobenzene mixture, and to draw attention to the results of subtoxic oral exposure on anxiety-related elements and the possible underlying endocrine processes. Adult male Wistar rats were treated daily with a mixture (ClB) of 1mug/kg each of hexachlorobenzene and 1,2,4-trichlorobenzene via a gastric tube for 30, 60 or 90days. After exposure, anxiety-related behavioral elements were determined in open-field and elevated plus maze tests. At euthanasia, the plasma levels of AVP, OXT and adrenocorticotrophic hormone (ACTH) were measured. Simultaneously, pituicytes from subjects were cultured to study the levels of basal and serotonin- or norepinephrinestimulated AVP and OXT secretion. Various anxiety-related behavioral elements were observed to be increased in both tests. The plasma AVP, OXT and ACTH concentrations were increased, to extents depending on the duration of exposure. The basal and monoamine-stimulated levels of AVP and OXT secretion of pituicytes prepared from the ClB-exposed rats were also elevated. Thus, certain anxietyrelated behavioral and endocrine elements were modulated by long-term exposure to ClB. As adult subjects were involved, which are generally less susceptible to toxic agents, it may be concluded that discrete doses of POP/EDC chlorobenzenes that are low enough to fall below the range of legal regulation may exert anxiogenic effects, which suggests that certain anxiogenic disorders may be induced environmentally in exposed human populations. 2011 (Radács Marianna (biológia, környezetbiol...); 2011.12.21. 12:55:58) true true true false true false PAY 2026-10-18 false true 10018695 Bernátskyné Babus Csilla /api/admin/10018695 Admin true 10018695 12 0 12 7 5 11 10 10 10 11 11 6 6 7 5 0 12 7 12 7 0 7 7 Folyóiratcikk Journal Article 24 11 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2013 0 1 1 1 1 2014 0 1 1 1 1 2015 0 0 0 0 0 2016 0 2 2 2 2 2017 0 2 2 2 2 2018 0 1 0 1 0 2019 0 1 0 1 0 2020 0 0 0 0 0 2021 0 0 0 0 0 2022 0 1 0 1 0 2023 0 1 1 1 1 2024 0 0 0 0 0 2025 0 2 0 2 0 Q1 false 10029231,10054048,10010671,10026695 false false false 2018-06-08T15:11:26.000+0000 2012-09-07T12:21:29.000+0000 Biológia Doktori Iskola (SZTE / DI); I. sz. Belgyógyászati Klinika (SZTE / SZAOK / BK); Környezet-biológia és Környezeti Nevelés Tanszék (SZTE / JGYPK / AEKNI); Pszichiátriai Klinika (SZTE / SZAOK); Élettani, Szervezettani és Idegtudományi Tanszék (SZTE / TTIK / BTCS) 8 30 5 10 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 2194558 /api/authorship/2194558 1 0.1 true false true Author 10030188 /api/author/10030188 Nagyéri György true 10030188 true Nagyeri G true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 13945372 true PersonAuthorship 2194559 /api/authorship/2194559 2 0.1 false false Author 10029231 /api/author/10029231 Valkusz Zsuzsanna true 10029231 true Valkusz Z true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 13945371 true PersonAuthorship 2194560 /api/authorship/2194560 3 0.1 false false Author 10026695 /api/author/10026695 Radács Marianna true 10026695 true Radacs M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 13945370 true PersonAuthorship 2194561 /api/authorship/2194561 4 0.1 false false Author 10028114 /api/author/10028114 Ocskó Tímea true 10028114 true Ocsko T true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 13945369 true PersonAuthorship 2194562 /api/authorship/2194562 5 0.1 false false Author 10054048 /api/author/10054048 Hausinger Péter true 10054048 true Hausinger P true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 13945368 true PersonAuthorship 2194563 /api/authorship/2194563 6 0.1 false false Laszlo M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 13945367 true PersonAuthorship 2194564 /api/authorship/2194564 7 0.1 false false Laszlo FA true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 13945366 true PersonAuthorship 2194565 /api/authorship/2194565 8 0.1 false false Author 10029191 /api/author/10029191 Juhász Anna true 10029191 true Juhasz A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 13945365 true PersonAuthorship 2194566 /api/authorship/2194566 9 0.1 false false Author 10010118 /api/author/10010118 Julesz János true 10010118 true Julesz J true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 13945364 true PersonAuthorship 2194567 /api/authorship/2194567 10 0.1 false true Author 10010671 /api/author/10010671 Gálfi Márta true 10010671 true Galfi M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 13945363 true PublicationIdentifier 454835 /api/publicationidentifier/454835 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true PAY false IDENTICAL 10.1016/j.ntt.2011.09.011 https://doi.org/10.1016/j.ntt.2011.09.011 false 1786646 true PublicationIdentifier 454833 /api/publicationidentifier/454833 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22024238&dopt=Abstract false 269780 true Classification 12125 /api/classification/12125 true true Classification 10545 /api/classification/10545 true true Classification 12284 /api/classification/12284 true true SjrRating 5673564 /api/sjrrating/5673564 29 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 3005 /api/classificationexternal/3005 true 3005 true Q1 DIRECT true 5673564 true /api/publication/1792015 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10030188"><a href="/gui2/?type=authors&mode=browse&sel=10030188" target="_blank">Nagyeri G ✉ (<span class="authorship-author-name">Nagyéri György</span> <span class="authorAux-mtmt"> biotechnológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/I. sz. Belgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10029231"><a href="/gui2/?type=authors&mode=browse&sel=10029231" target="_blank">Valkusz Z (<span class="authorship-author-name">Valkusz Zsuzsanna</span> <span class="authorAux-mtmt"> belgyógyászat, endokrinológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/I. sz. Belgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10026695"><a href="/gui2/?type=authors&mode=browse&sel=10026695" target="_blank">Radacs M (<span class="authorship-author-name">Radács Marianna</span> <span class="authorAux-mtmt"> környezetbiológia, környezeti nevelés</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Juhász Gyula Pedagógusképző Kar">JGYPK</span>/<span title="Alkalmazott Természettudományi Intézet">ATTI</span>/Környezet-biológia és Környezeti Nevelés Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028114"><a href="/gui2/?type=authors&mode=browse&sel=10028114" target="_blank">Ocsko T (<span class="authorship-author-name">Ocskó Tímea</span> <span class="authorAux-mtmt"> Neuroendokrin rendszer</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Juhász Gyula Pedagógusképző Kar">JGYPK</span>/<span title="Alkalmazott Természettudományi Intézet">ATTI</span>/Környezet-biológia és Környezeti Nevelés Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10054048"><a href="/gui2/?type=authors&mode=browse&sel=10054048" target="_blank">Hausinger P (<span class="authorship-author-name">Hausinger Péter</span> <span class="authorAux-mtmt"> invazív kardiológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Természettudományi és Informatikai Kar">TTIK</span>/<span title="Biológus Tanszékcsoport">BTCS</span>/Élettani, Szervezettani és Idegtudományi Tanszék; <span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Doktori Iskolák">DI</span>/Biológia Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Laszlo M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Laszlo FA </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10029191"><a href="/gui2/?type=authors&mode=browse&sel=10029191" target="_blank">Juhasz A (<span class="authorship-author-name">Juhász Anna</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Pszichiátriai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010118"><a href="/gui2/?type=authors&mode=browse&sel=10010118" target="_blank">Julesz J (<span class="authorship-author-name">Julesz János</span> <span class="authorAux-mtmt"> Endokrinológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/I. sz. Belgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010671"><a href="/gui2/?type=authors&mode=browse&sel=10010671" target="_blank">Galfi M (<span class="authorship-author-name">Gálfi Márta</span> <span class="authorAux-mtmt"> Környezetbiológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Juhász Gyula Pedagógusképző Kar">JGYPK</span>/<span title="Alkalmazott Természettudományi Intézet">ATTI</span>/Környezet-biológia és Környezeti Nevelés Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;1792015" target="_blank">Behavioral and endocrine effects of chronic exposure to low doses of chlorobenzenes in Wistar rats</a></div> <div> <span class="journal-title">NEUROTOXICOLOGY AND TERATOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0892-0362">0892-0362</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1872-9738">1872-9738</a>)</span>: <span class="journal-volume">34</span> <span class="journal-issue">1</span> <span class="page"> pp 9-19 </span> <span class="year">(2012)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_PAY" title=" Fizetős "> <a style="color:blue" title="10.1016/j.ntt.2011.09.011" target="_blank" href="https://doi.org/10.1016/j.ntt.2011.09.011"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000301037100002" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000301037100002"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="82655178520" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-82655178520"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="22024238" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22024238&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Toxicology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Developmental Neuroscience&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cellular and Molecular Neuroscience&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q3</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 12</span> | Független: 7 | Függő: 5 | Nem jelölt: 0 | WoS jelölt: 10 | Scopus jelölt:&nbsp;10 | WoS/Scopus jelölt:&nbsp;11 | DOI jelölt:&nbsp;10 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;1792015&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 7 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 1792015</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> <span class="oldId">Régi azonosító: 1792015</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Utolsó módosítás: 2020.05.27. 12:07 Nemesvári Zoltánné (SZTE admin5 SZAOK Radiológiai Klinika) </div> </div></div>