https://m2.mtmt.hu/ eng 2026-04-19 03:18 JournalArticle 1760809 ADMIN_APPROVED true 0 2017-06-26T08:46:38.000+0000 false 1760809 2025-12-21T07:47:56.090+0000 2025-03-27T08:42:16.346+0000 2011-11-14T14:55:39.000+0000 true 10017441 Hegedűs Tamás /api/admin/10017441 Admin true 10017441 2025-03-27T08:42:16.696+0000 2025-03-27T08:42:16.696+0000 2023-01-29T14:37:56.572+0000 true 10014568 Vándor Andrea /api/admin/10014568 Admin true 10014568 Admin 10014568 /api/admin/10014568 Vándor Andrea true 10014568 true 2023-01-24T18:18:57.045+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Apati, A Calcium signaling in pluripotent stem cells. true true /api/journal/3258 REVIEWED true false 3258 false 3258 true 0303-7207 1872-8057 Journal FOREIGN 353 1-2 57 67 57 11 2012 Pluripotent stem cells represent a new source of biological material allowing the exploration of signaling phenomena during normal cell development and differentiation. Still, the calcium signaling pathways and intracellular calcium responses to various ligands or stress conditions have not been sufficiently explored as yet in embryonic or induced pluripotent stem cells and in their differentiated offspring. This is partly due to the special culturing conditions of these cell types, the rapid morphological and functional changes in heterogeneous cell populations during early differentiation, and methodological problems in cellular calcium measurements. In this paper, we review the currently available data in the literature on calcium signaling in pluripotent stem cells and discuss the potential shortcomings of these studies. Various assay methods are surveyed for obtaining reliable data both in undifferentiated embryonic stem cells and in specific, stem cell-derived human tissues. In this paper, we present the modulation of calcium signaling in human embryonic stem cells (hESC) and in their derivates; mesenchymal stem cell like (MSCl) cells and cardiac tissues using the fluorescent calcium indicator Fluo-4 and confocal microscopy. LPA, trypsin and angiotensin II were effective in inducing calcium signals both in HUES9 and MSCl cells. Histamine and thrombin induced calcium signal exclusively in the MSCl cells, while ATP was effective only in HUES9 cells. There was no calcium signal evoked by GABA, even at relatively high concentrations. In stem cell-derived cardiomyocytes a rapid increase in the beating rate and an increase of the calcium signal peaks could be observed after the addition of adrenaline, while verapamil led to a strong decrease in cellular calcium and stopped spontaneous contractions in a relaxed state. 2011 (Hegedűs Tamás (MTA-OGYK Membránbiol KCs); 2011.11.14. 15:54:00) true true true false true false NONE 2025-12-21 false true 10014931 Farkas Andrea /api/admin/10014931 Admin true 10014931 27 0 27 22 5 27 27 26 27 27 27 22 22 22 5 0 27 22 27 22 0 5 5 Folyóiratcikk Journal Article 24 27 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2012 0 4 4 4 4 2013 0 4 3 4 3 2014 0 0 0 0 0 2015 0 5 5 5 5 2016 0 5 3 5 3 2017 0 3 3 3 3 2018 0 1 0 1 0 2019 0 1 0 1 0 2020 0 1 1 1 1 2021 0 3 3 3 3 Q1 false false false false 2012-09-16T15:55:04.000+0000 2012-06-18T15:55:04.000+0000 MTA-OGYK Membránbiológiai Kutatócsoport (SE / AOK / I / BSI); MTA-SE Molekuláris Biofizikai Kutatócsoport (SE / AOK / I / BSI); Molekuláris Farmakológiai Intézet (MTA TTK) 6 36 3 6 0 true 10014568 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 2089791 /api/authorship/2089791 1 0.167 true false Author 10027529 /api/author/10027529 Apáti Ágota true 10027529 true Apati A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 13755283 true PersonAuthorship 2089792 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src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10027529"><a href="/gui2/?type=authors&mode=browse&sel=10027529" target="_blank">Apati A (<span class="authorship-author-name">Apáti Ágota</span> <span class="authorAux-mtmt"> Őssejt kutatás</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015749"><a href="/gui2/?type=authors&mode=browse&sel=10015749" target="_blank">Paszty K (<span class="authorship-author-name">Pászty Katalin</span> <span class="authorAux-mtmt"> Biokémia, sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Departmnet of Biophysics and Radiation Biology">DBRB</span>/MTA-SE Molekuláris Biofizikai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10034299"><a href="/gui2/?type=authors&mode=browse&sel=10034299" target="_blank">Erdei Z (<span class="authorship-author-name">Erdei Zsuzsa</span> <span class="authorAux-mtmt"> fiatal kutató</span>) </a> </span> <span class="author-affil"><span title="MTA Research Centre for Natural Sciences">MTA TTK</span>/Institute of Molecular Pharmacology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10022032"><a href="/gui2/?type=authors&mode=browse&sel=10022032" target="_blank">Szebenyi K (<span class="authorship-author-name">Szebényi Kornélia</span> <span class="authorAux-mtmt"> Őssejtbiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010446"><a href="/gui2/?type=authors&mode=browse&sel=10010446" target="_blank">Homolya L (<span class="authorship-author-name">Homolya László</span> <span class="authorAux-mtmt"> Molekuláris sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Departmnet of Biophysics and Radiation Biology">DBRB</span>/MTA-OGYK Membránbiológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="1241938"><a href="/gui2/?type=authors&mode=browse&sel=1241938" target="_blank">Sarkadi B (<span class="authorship-author-name">Sarkadi Balázs</span> <span class="authorAux-mtmt"> biofizika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Departmnet of Biophysics and Radiation Biology">DBRB</span>/MTA-OGYK Membránbiológiai Kutatócsoport</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;1760809" target="_blank">Calcium signaling in pluripotent stem cells.</a></div> <div> <span class="journal-title">MOLECULAR AND CELLULAR ENDOCRINOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0303-7207">0303-7207</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1872-8057">1872-8057</a>)</span>: <span class="journal-volume">353</span> <span class="journal-issue">1-2</span> <span class="page"> pp 57-67 </span> <span class="year">(2012)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.mce.2011.08.038" target="_blank" href="https://doi.org/10.1016/j.mce.2011.08.038"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000302513300008" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000302513300008"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="84857789636" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84857789636"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="21945604" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21945604&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Biochemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Endocrinology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 27</span> | Independent citation: 22 | Self citation: 5 | Unknown citation: 0 | Number of citations in WoS: 26 | Number of citations in Scopus:&nbsp;27 | WoS/Scopus assigned:&nbsp;27 | Number of citations with DOI:&nbsp;27 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;1760809&sort=publishedYear,desc&sort=title"> Number of cited publications: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 1760809</span> | <span class="status-data status-ADMIN_APPROVED"> Admin approved </span> <span class="oldId">Old id: 1760809</span> | Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Last Modified: 2025.03.27. 09:42 Gusztáv Ladányi (MTMT API user, admin) </div> <div class="lockedBy">Centrally managed 2023.01.24. 19:18 Andrea Vándor (VA, admin) </div> </div></div>