{ "labelLang" : "hun", "responseDate" : "2024-03-28 12:09", "content" : { "otype" : "JournalArticle", "mtid" : 1680292, "status" : "VALIDATED", "published" : true, "unhandledTickets" : 0, "oldTimestamp" : "2015-02-10T14:39:44.000+0000", "deleted" : false, "oldId" : 1680292, "lastRefresh" : "2024-02-10T12:45:23.352+0000", "lastModified" : "2020-12-17T19:31:11.204+0000", "created" : "2011-08-23T12:02:15.000+0000", "creator" : { "otype" : "Author", "mtid" : 10015697, "link" : "/api/author/10015697", "label" : "Zsembery Ákos (Élettan)", "familyName" : "Zsembery", "givenName" : "Ákos", "published" : true, "oldId" : 10015697, "snippet" : true }, "lastDuplumOK" : "2020-02-29T14:30:07.571+0000", "lastDuplumSearch" : "2020-02-29T14:30:07.571+0000", "adminApproved" : "2015-02-10T14:39:44.000+0000", "adminApprover" : { "otype" : "Admin", "mtid" : 10033956, "link" : "/api/admin/10033956", "label" : "Ruttkay Szilvia (INAKTÍV_SE_KK_Admin5_RSz, admin)", "familyName" : "Ruttkay", "givenName" : "Szilvia", "published" : true, "oldId" : 10033956, "snippet" : true }, "validated" : "2015-02-10T14:39:44.000+0000", "validator" : { "otype" : "Admin", "mtid" : 10033956, "link" : "/api/admin/10033956", "label" : "Ruttkay Szilvia (INAKTÍV_SE_KK_Admin5_RSz, admin)", "familyName" : "Ruttkay", "givenName" : "Szilvia", "published" : true, "oldId" : 10033956, "snippet" : true }, "core" : true, "citation" : true, "publicationPending" : false, "type" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "subType" : { "otype" : "SubType", "mtid" : 10000059, "link" : "/api/subtype/10000059", "label" : "Szakcikk (Folyóiratcikk)", "name" : "Szakcikk", "nameEng" : "Article", "docType" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "listPosition" : 101, "published" : true, "oldId" : 10000059, "snippet" : true }, "category" : { "otype" : "Category", "mtid" : 1, "link" : "/api/category/1", "label" : "Tudományos", "published" : true, "oldId" : 1, "snippet" : true }, "languages" : [ { "otype" : "Language", "mtid" : 10002, "link" : "/api/language/10002", "label" : "Angol", "name" : "Angol", "nameEng" : "English", "published" : true, "oldId" : 2, "snippet" : true } ], "firstAuthor" : "Spirlì, C", "authorships" : [ { "otype" : "PersonAuthorship", "mtid" : 1875622, "link" : "/api/authorship/1875622", "label" : "Spirlì, C", "listPosition" : 1, "share" : 0.125, "first" : true, "last" : false, "familyName" : "Spirlì", "givenName" : "C", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 13331443, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 1875623, "link" : "/api/authorship/1875623", "label" : "Granato, A", "listPosition" : 2, "share" : 0.125, "first" : false, "last" : false, "familyName" : "Granato", "givenName" : "A", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 13331442, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 1875624, "link" : "/api/authorship/1875624", "label" : "Zsembery, À [Zsembery, Ákos (Élettan), szerző]", "listPosition" : 3, "share" : 0.125, "first" : false, "last" : false, "author" : { "otype" : "Author", "mtid" : 10015697, "link" : "/api/author/10015697", "label" : "Zsembery Ákos (Élettan)", "familyName" : "Zsembery", "givenName" : "Ákos", "published" : true, "oldId" : 10015697, "snippet" : true }, "familyName" : "Zsembery", "givenName" : "À", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 13331441, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 1875625, "link" : "/api/authorship/1875625", "label" : "Anglani, F", "listPosition" : 4, "share" : 0.125, "first" : false, "last" : false, "familyName" : "Anglani", "givenName" : "F", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 13331440, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 1875626, "link" : "/api/authorship/1875626", "label" : "Okolicsànyi, L", "listPosition" : 5, "share" : 0.125, "first" : false, "last" : false, "familyName" : "Okolicsànyi", "givenName" : "L", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 13331439, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 1875627, "link" : "/api/authorship/1875627", "label" : "LaRusso, N F", "listPosition" : 6, "share" : 0.125, "first" : false, "last" : false, "familyName" : "LaRusso", "givenName" : "N F", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 13331438, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 1875628, "link" : "/api/authorship/1875628", "label" : "Crepaldi, G", "listPosition" : 7, "share" : 0.125, "first" : false, "last" : false, "familyName" : "Crepaldi", "givenName" : "G", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 13331437, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 1875629, "link" : "/api/authorship/1875629", "label" : "Strazzabosco, M", "listPosition" : 8, "share" : 0.125, "first" : false, "last" : true, "familyName" : "Strazzabosco", "givenName" : "M", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 13331436, "snippet" : true } ], "title" : "Functional polarity of Na+/H+ and Cl-/HCO3/- exchangers in a rat cholangiocyte cell line", "identifiers" : [ { "otype" : "PublicationIdentifier", "mtid" : 10600953, "link" : "/api/publicationidentifier/10600953", "label" : "WoS: 000077746400004", "source" : { "otype" : "PlainSource", "mtid" : 1, "link" : "/api/publicationsource/1", "label" : "WoS", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "WoS", "nameEng" : "WoS", "linkPattern" : "https://www.webofscience.com/wos/woscc/full-record/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 1, "snippet" : true }, "validState" : "NO", "idValue" : "000077746400004", "realUrl" : "https://www.webofscience.com/wos/woscc/full-record/000077746400004", "published" : false, "oldId" : 18209193, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 412971, "link" : "/api/publicationidentifier/412971", "label" : "Scopus: 0032416170", "source" : { "otype" : "PlainSource", "mtid" : 3, "link" : "/api/publicationsource/3", "label" : "Scopus", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "Scopus", "linkPattern" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@", "publiclyVisible" : true, "published" : true, "oldId" : 3, "snippet" : true }, "oaFree" : false, "validState" : "IDENTICAL", "idValue" : "0032416170", "realUrl" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-0032416170", "published" : false, "oldId" : 243344, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 412972, "link" : "/api/publicationidentifier/412972", "label" : "PubMed: 9843758", "source" : { "otype" : "PlainSource", "mtid" : 17, "link" : "/api/publicationsource/17", "label" : "PubMed", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "PubMed", "nameEng" : "PubMed", "linkPattern" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract", "publiclyVisible" : true, "published" : true, "oldId" : 17, "snippet" : true }, "oaFree" : false, "validState" : "IDENTICAL", "idValue" : "9843758", "realUrl" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9843758&dopt=Abstract", "published" : false, "oldId" : 243345, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 412973, "link" : "/api/publicationidentifier/412973", "label" : "Teljes dokumentum: http://ajpgi.physiology.org/content/ajpgi/275/6/G1236.full.pdf", "source" : { "otype" : "PlainSource", "mtid" : 39, "link" : "/api/publicationsource/39", "label" : "Teljes dokumentum", "type" : { "otype" : "PublicationSourceType", "mtid" : 10006, "link" : "/api/publicationsourcetype/10006", "label" : "Link", "mayHaveOa" : true, "published" : true, "snippet" : true }, "name" : "Teljes dokumentum", "nameEng" : "Teljes dokumentum", "linkPattern" : "@@@", "publiclyVisible" : true, "published" : true, "oldId" : 39, "snippet" : true }, "oaFree" : false, "validState" : "IDENTICAL", "idValue" : "http://ajpgi.physiology.org/content/ajpgi/275/6/G1236.full.pdf", "realUrl" : "http://ajpgi.physiology.org/content/ajpgi/275/6/G1236.full.pdf", "published" : false, "oldId" : 1069886, "snippet" : true } ], "journal" : { "otype" : "Journal", "mtid" : 21226, "link" : "/api/journal/21226", "label" : "AMERICAN JOURNAL OF PHYSIOLOGY: GASTROINTESTINAL AND LIVER PHYSIOLOGY 0193-1857 1522-1547", "pIssn" : "0193-1857", "eIssn" : "1522-1547", "reviewType" : "REVIEWED", "noIF" : false, "sciIndexed" : true, "scopusIndexed" : true, "lang" : "FOREIGN", "hungarian" : false, "published" : true, "oldId" : 21226, "snippet" : true }, "volume" : "275", "issue" : "6", "firstPage" : "G1236", "lastPage" : "G1245", "firstPageOrInternalIdForSort" : "G1236", "publishedYear" : 1998, "abstractText" : "Intrahepatic bile duct cells (cholangiocytes) play an important role in the secretion and alkalinization of bile. Both Na+/H+ exchange (NHE) and Cl-/HCO3/- exchange (AE) contribute to these functions, but their functional distribution between the apical and basolateral membrane domains remains speculative. We have addressed this issue in a normal rat cholangiocyte cell line (NRC-1), which maintains a polarized distribution of membrane markers. Gene expression of AE and NHE isoforms was studied by RT- PCR. For functional studies, cells were placed in a chamber that allowed separate perfusion of the apical and basolateral aspect of the epithelial sheet; intracellular pH (pH(i)) was measured by 2',7'-bis(2-carboxyethyl)- 5(6)-carboxyfluorescein microfluorometry. In HCO3-/CO2 free medium and in the presence of apical amiloride, pHi recovery from an acid load was Na+ dependent and was inhibited by basolateral amiloride and by HOE-642 (10 μM), consistent with basolateral localization of the NHE1 isoform, which had clearly expressed mRNA. Apical Na+ readmission induced a slow pHi recovery that was inhibited by apical administration of 1 mM HOE-642 or amiloride. Among the apical NHE isoforms, NHE2 but not NHE3 gene expression was detected. The AE1 gene was not expressed, but two different variants of AE2 mRNAs (AE2a and AE2b) were detected; pH(i) experiments disclosed AE activities at both sides of the membrane, but only apical AE was activated by cAMP. In conclusion, these studies provide the first functional description of acid-base transporters in a polarized cholangiocyte cell line. NHE1, NHE2, AE2a, and AE2b isoforms are expressed and show different membrane polarity, functional properties, and sensitivity to inhibitors. These observations add a considerable level of complexity to current models of electrolyte transport in cholangiocytes.", "subjects" : [ { "otype" : "Classification", "mtid" : 12125, "link" : "/api/classification/12125", "label" : "Általános orvostudomány", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 10545, "link" : "/api/classification/10545", "label" : "Biológiai tudományok", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 12215, "link" : "/api/classification/12215", "label" : "Klinikai orvostan", "published" : true, "snippet" : true } ], "keywords" : [ { "otype" : "Keyword", "mtid" : 12, "link" : "/api/keyword/12", "label" : "Animals", "published" : true, "oldId" : 12, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1547, "link" : "/api/keyword/1547", "label" : "RATS", "published" : true, "oldId" : 1547, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1699, "link" : "/api/keyword/1699", "label" : "ARTICLE", "published" : true, "oldId" : 1699, "snippet" : true }, { "otype" : "Keyword", "mtid" : 2066, "link" : "/api/keyword/2066", "label" : "SODIUM", "published" : true, "oldId" : 2066, "snippet" : true }, { "otype" : "Keyword", "mtid" : 2183, "link" : "/api/keyword/2183", "label" : "INTRACELLULAR PH", "published" : true, "oldId" : 2183, "snippet" : true }, { "otype" : "Keyword", "mtid" : 4559, "link" : "/api/keyword/4559", "label" : "reverse transcription polymerase chain reaction", "published" : true, "oldId" : 4559, "snippet" : true }, { "otype" : "Keyword", "mtid" : 4600, "link" : "/api/keyword/4600", "label" : "priority journal", "published" : true, "oldId" : 4600, "snippet" : true }, { "otype" : "Keyword", "mtid" : 4608, "link" : "/api/keyword/4608", "label" : "controlled study", "published" : true, "oldId" : 4608, "snippet" : true }, { "otype" : "Keyword", "mtid" : 5079, "link" : "/api/keyword/5079", "label" : "nonhuman", "published" : true, "oldId" : 5079, "snippet" : true }, { "otype" : "Keyword", "mtid" : 5088, "link" : "/api/keyword/5088", "label" : "animal cell", "published" : true, "oldId" : 5088, "snippet" : true }, { "otype" : "Keyword", "mtid" : 5347, "link" : "/api/keyword/5347", "label" : "epithelium cell", "published" : true, "oldId" : 5347, "snippet" : true }, { "otype" : "Keyword", "mtid" : 7055, "link" : "/api/keyword/7055", "label" : "PROTON", "published" : true, "oldId" : 7055, "snippet" : true }, { "otype" : "Keyword", "mtid" : 7975, "link" : "/api/keyword/7975", "label" : "Gene Expression", "published" : true, "oldId" : 7975, "snippet" : true }, { "otype" : "Keyword", "mtid" : 8051, "link" : "/api/keyword/8051", "label" : "reverse transcriptase polymerase chain reaction", "published" : true, "oldId" : 8051, "snippet" : true }, { "otype" : "Keyword", "mtid" : 8067, "link" : "/api/keyword/8067", "label" : "Cell Line", "published" : true, "oldId" : 8067, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1005182, "link" : "/api/keyword/1005182", "label" : "BICARBONATE", "published" : true, "oldId" : 1005182, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1007766, "link" : "/api/keyword/1007766", "label" : "Isomerism", "published" : true, "oldId" : 1007766, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1013423, "link" : "/api/keyword/1013423", "label" : "cell polarity", "published" : true, "oldId" : 1013423, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1022306, "link" : "/api/keyword/1022306", "label" : "basolateral membrane", "published" : true, "oldId" : 1022306, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1022663, "link" : "/api/keyword/1022663", "label" : "cell pH", "published" : true, "oldId" : 1022663, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1022671, "link" : "/api/keyword/1022671", "label" : "Sodium-Hydrogen Antiporter", "published" : true, "oldId" : 1022671, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1022676, "link" : "/api/keyword/1022676", "label" : "Chloride-Bicarbonate Antiporters", "published" : true, "oldId" : 1022676, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1022678, "link" : "/api/keyword/1022678", "label" : "Antiporters", "published" : true, "oldId" : 1022678, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1032289, "link" : "/api/keyword/1032289", "label" : "apical membrane", "published" : true, "oldId" : 1032289, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1034005, "link" : "/api/keyword/1034005", "label" : "chloride ion", "published" : true, "oldId" : 1034005, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1047154, "link" : "/api/keyword/1047154", "label" : "Bile Ducts", "published" : true, "oldId" : 1047154, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1047254, "link" : "/api/keyword/1047254", "label" : "intrahepatic bile duct", "published" : true, "oldId" : 1047254, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1057043, "link" : "/api/keyword/1057043", "label" : "anion exchange", "published" : true, "oldId" : 1057043, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1070840, "link" : "/api/keyword/1070840", "label" : "Reverse transcription-polymerase chain reaction", "published" : true, "oldId" : 1070840, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1070849, "link" : "/api/keyword/1070849", "label" : "proton sodium exchange", "published" : true, "oldId" : 1070849, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1554523, "link" : "/api/keyword/1554523", "label" : "rat", "published" : true, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2011, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : null, "missingAuthor" : false, "oaType" : "NONE", "oaCheckDate" : "2024-02-10", "oaFree" : false, "oaByAuthor" : { "otype" : "Admin", "mtid" : 10033956, "link" : "/api/admin/10033956", "label" : "Ruttkay Szilvia (INAKTÍV_SE_KK_Admin5_RSz, admin)", "familyName" : "Ruttkay", "givenName" : "Szilvia", "published" : true, "oldId" : 10033956, "snippet" : true }, "citationCount" : 50, "citationCountUnpublished" : 0, "citationCountWoOther" : 50, "independentCitCountWoOther" : 36, "nationalOriginCitationCount" : 0, "foreignEditionCitationCount" : 49, "doiCitationCount" : 48, "wosCitationCount" : 44, "scopusCitationCount" : 44, "wosScopusCitationCount" : 49, "wosScopusCitationCountWoOther" : 49, "wosScopusIndependentCitationCount" : 35, "wosScopusIndependentCitationCountWoOther" : 35, "independentCitationCount" : 36, "selfCitationCount" : 14, "unhandledCitationCount" : 0, "citingPubCount" : 50, "independentCitingPubCount" : 36, "citingPubCountWoOther" : 50, "independentCitingPubCountWoOther" : 36, "unhandledCitingPubCount" : 0, "citedPubCount" : 1, "citedCount" : 1, "pubStats" : { "types" : [ { "type" : "Folyóiratcikk", "typeEng" : "Journal Article", "code" : 24, "count" : 43 }, { "type" : "Könyvrészlet", "typeEng" : "Chapter in Book", "code" : 25, "count" : 7 }, { "type" : "Könyv", "typeEng" : "Book", "code" : 23, "count" : 0 }, { "type" : "Egyéb konferenciaközlemény", "typeEng" : "Conference paper", "code" : 31, "count" : 0 }, { "type" : "Egyéb konferenciakötet", "typeEng" : "Conference proceedings", "code" : 32, "count" : 0 }, { "type" : "Oltalmi formák", "typeEng" : "Protection forms", "code" : 26, "count" : 0 }, { "type" : "Disszertáció", "typeEng" : "Thesis", "code" : 28, "count" : 0 }, { "type" : "Egyéb", "typeEng" : "Miscellaneous", "code" : 29, "count" : 0 }, { "type" : "Alkotás", "typeEng" : "Achievement", "code" : 22, "count" : 0 }, { "type" : "Kutatási adat", "typeEng" : "Research data", "code" : 33, "count" : 0 } ], "citationTypes" : [ { "type" : "Folyóiratcikk", "typeEng" : "Journal Article", "code" : 24, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Könyvrészlet", "typeEng" : "Chapter in Book", "code" : 25, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Könyv", "typeEng" : "Book", "code" : 23, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Egyéb konferenciaközlemény", "typeEng" : "Conference paper", "code" : 31, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Egyéb konferenciakötet", "typeEng" : "Conference proceedings", "code" : 32, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Oltalmi formák", "typeEng" : "Protection forms", "code" : 26, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Disszertáció", "typeEng" : "Thesis", "code" : 28, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Egyéb", "typeEng" : "Miscellaneous", "code" : 29, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Alkotás", "typeEng" : "Achievement", "code" : 22, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Kutatási adat", "typeEng" : "Research data", "code" : 33, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 } ], "years" : [ { "year" : 1999, "publicationCount" : 0, "citationCount" : 1, "independentCitationCount" : 0, "citingPubCount" : 1, "independentCitingPubCount" : 0, "oaStats" : null, "oaStats2" : null }, { "year" : 2000, "publicationCount" : 0, "citationCount" : 3, "independentCitationCount" : 1, "citingPubCount" : 3, "independentCitingPubCount" : 1, "oaStats" : null, "oaStats2" : null }, { "year" : 2001, "publicationCount" : 0, "citationCount" : 4, "independentCitationCount" : 3, "citingPubCount" : 4, "independentCitingPubCount" : 3, "oaStats" : null, "oaStats2" : null }, { "year" : 2002, "publicationCount" : 0, "citationCount" : 4, "independentCitationCount" : 3, "citingPubCount" : 4, "independentCitingPubCount" : 3, "oaStats" : null, "oaStats2" : null }, { "year" : 2003, "publicationCount" : 0, "citationCount" : 3, "independentCitationCount" : 2, "citingPubCount" : 3, "independentCitingPubCount" : 2, "oaStats" : null, "oaStats2" : null }, { "year" : 2004, "publicationCount" : 0, "citationCount" : 3, "independentCitationCount" : 3, "citingPubCount" : 3, "independentCitingPubCount" : 3, "oaStats" : null, "oaStats2" : null }, { "year" : 2005, "publicationCount" : 0, "citationCount" : 3, "independentCitationCount" : 2, "citingPubCount" : 3, "independentCitingPubCount" : 2, "oaStats" : null, "oaStats2" : null }, { "year" : 2006, "publicationCount" : 0, "citationCount" : 4, "independentCitationCount" : 3, "citingPubCount" : 4, "independentCitingPubCount" : 3, "oaStats" : null, "oaStats2" : null }, { "year" : 2007, "publicationCount" : 0, "citationCount" : 0, "independentCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "oaStats" : null, "oaStats2" : null }, { "year" : 2008, "publicationCount" : 0, "citationCount" : 2, "independentCitationCount" : 2, "citingPubCount" : 2, "independentCitingPubCount" : 2, "oaStats" : null, "oaStats2" : null }, { "year" : 2009, "publicationCount" : 0, "citationCount" : 2, "independentCitationCount" : 1, "citingPubCount" : 2, "independentCitingPubCount" : 1, "oaStats" : null, "oaStats2" : null }, { "year" : 2010, "publicationCount" : 0, "citationCount" : 3, "independentCitationCount" : 2, "citingPubCount" : 3, "independentCitingPubCount" : 2, "oaStats" : null, "oaStats2" : null }, { "year" : 2011, "publicationCount" : 0, "citationCount" : 1, "independentCitationCount" : 1, "citingPubCount" : 1, "independentCitingPubCount" : 1, "oaStats" : null, "oaStats2" : null }, { "year" : 2012, "publicationCount" : 0, "citationCount" : 1, "independentCitationCount" : 0, "citingPubCount" : 1, "independentCitingPubCount" : 0, "oaStats" : null, "oaStats2" : null }, { "year" : 2013, "publicationCount" : 0, "citationCount" : 2, "independentCitationCount" : 1, "citingPubCount" : 2, "independentCitingPubCount" : 1, "oaStats" : null, "oaStats2" : null }, { "year" : 2014, "publicationCount" : 0, "citationCount" : 1, "independentCitationCount" : 1, "citingPubCount" : 1, "independentCitingPubCount" : 1, "oaStats" : null, "oaStats2" : null }, { "year" : 2015, "publicationCount" : 0, "citationCount" : 0, "independentCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "oaStats" : null, "oaStats2" : null }, { "year" : 2016, "publicationCount" : 0, "citationCount" : 1, "independentCitationCount" : 1, "citingPubCount" : 1, "independentCitingPubCount" : 1, "oaStats" : null, "oaStats2" : null }, { "year" : 2017, "publicationCount" : 0, "citationCount" : 0, "independentCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "oaStats" : null, "oaStats2" : null }, { "year" : 2018, "publicationCount" : 0, "citationCount" : 3, "independentCitationCount" : 2, "citingPubCount" : 3, "independentCitingPubCount" : 2, "oaStats" : null, "oaStats2" : null }, { "year" : 2019, "publicationCount" : 0, "citationCount" : 5, "independentCitationCount" : 4, "citingPubCount" : 5, "independentCitingPubCount" : 4, "oaStats" : null, "oaStats2" : null }, { "year" : 2020, "publicationCount" : 0, "citationCount" : 1, "independentCitationCount" : 1, "citingPubCount" : 1, "independentCitingPubCount" : 1, "oaStats" : null, "oaStats2" : null }, { "year" : 2021, "publicationCount" : 0, "citationCount" : 2, "independentCitationCount" : 2, "citingPubCount" : 2, "independentCitingPubCount" : 2, "oaStats" : null, "oaStats2" : null }, { "year" : 2022, "publicationCount" : 0, "citationCount" : 1, "independentCitationCount" : 1, "citingPubCount" : 1, "independentCitingPubCount" : 1, "oaStats" : null, "oaStats2" : null } ] }, "references" : [ { "otype" : "Reference", "mtid" : 1297636, "link" : "/api/reference/1297636", "label" : "1. Alper, S.L., Stuart-Tilley, A.K., Biemesderfer, D., Shmukler, B.E., Brown, D., Immunolocalization of AE2 anion exchanger in rat kidney (1997) Am. J. Physiol., 273, pp. F601-F614. , (Renal Physiol. 42)", "listPosition" : 1, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 1297637, "link" : "/api/reference/1297637", "label" : "2. Alpini, G., Roberts, S., Kuntz, S.M., Ueno, Y., Gubba, S., Podila, P.V., Lesage, G.D., Larusso, N.F., Morphological, molecular and functional heterogeneity of cholangiocytes from normal rat liver (1996) Gastroenterology, 110, pp. 1636-1643", "listPosition" : 2, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 1297638, "link" : "/api/reference/1297638", "label" : "3. Alvaro, D., Cho, W.K., Mennone, A., Boyer, J.L., Effect of secretin on pHi regulation in isolated rat bile duct epithelial cells (1993) J. Clin. Invest., 92, pp. 1314-1325", "listPosition" : 3, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 1297639, "link" : "/api/reference/1297639", "label" : "4. Argent, B.E., Gray, M.A., Regulation and formation of fluid and electrolyte secretion by pancreatic ductal epithelium (1997) Biliary and Pancreatic Ductal Epithelia, , edited by A. E. Sirica and D. S. Longnecker. New York: Marcel Dekker", "listPosition" : 4, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 1297640, "link" : "/api/reference/1297640", "label" : "5. Benedetti, A., Strazzabosco, M., Ng, O.C., Boyer, J.L., Regulation of activity and apical targeting Cl-/HCO3- exchanger in rat hepatocytes (1994) Proc. Natl. Acad. Sci. USA, 91, pp. 792-796", "listPosition" : 5, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 1297641, "link" : "/api/reference/1297641", "label" : "6. Boron, W.F., Control of intracellular pH (1992) The Kidney in Physiology and Pathophysiology (2nd Ed.), pp. 219-263. , edited by D. W. Seldin and G. Giebish. New York: Raven", "listPosition" : 6, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 1297642, "link" : "/api/reference/1297642", "label" : "7. Boyarsky, G., Ganz, M.B., Sterzel, R.B., Boron, W.F., PH regulation in single glomerular mesangial cells. I. Acid extrusion in absence and presence of HCO3- (1988) Am. J. Physiol., 255, pp. C844-C856. , (Cell Physiol. 24)", "listPosition" : 7, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 1297643, "link" : "/api/reference/1297643", "label" : "8. Chomczynski, P., Sacchi, N., Single step method of RNA isolation by guanidinium thiocyanate phenol chloroform extraction (1987) Anal. Biochem., 162, pp. 156-159", "listPosition" : 8, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 1297644, "link" : "/api/reference/1297644", "label" : "9. Clarke, L.L., Harline, M.C., Dual role of CFTR in cAMP-stimulated HCO3- secretion across murine duodenum (1998) Am. J. Physiol., 274, pp. G718-G726. , (Gastrointest. Liver Physiol. 37)", "listPosition" : 9, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 1297645, "link" : "/api/reference/1297645", "label" : "10. Collins, J.F., Honda, T., Knobel, S., Bulus, N.M., Conary, J., Dubois, R., Ghishan, F.K., Molecular cloning sequencing, tissue distribution, and functional expression of Na+/H+ exchanger (NHE2) (1993) Proc. Natl. Acad. Sci. USA, 90, pp. 3938-3942", "listPosition" : 10, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 1297646, "link" : "/api/reference/1297646", "label" : "11. Colombani, V., Silviani, V., Marteau, C., Lerique, B., Cartouzou, G., Gerolami, A., Presence of the NHE3 isoform of the Na+/H+ exchanger in human gallbladder (1996) Clin. Sci. (Colch.), 91, pp. 209-212", "listPosition" : 11, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 1297647, "link" : "/api/reference/1297647", "label" : "12. Emmons, C., Kurtz, I., Functional characterization of three intercalated cell subtypes in the rabbit outer cortical collecting duct (1994) J. Clin. Invest., 93, pp. 417-423", "listPosition" : 12, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 1297648, "link" : "/api/reference/1297648", "label" : "13. Fish, E.M., Molitoris, B.A., Alterations in epithelial polarity and the pathogenesis of disease states (1994) N. Engl. J. Med., 330, pp. 1580-1588", "listPosition" : 13, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 1297649, "link" : "/api/reference/1297649", "label" : "14. Gray, M.A., Plant, S., Argent, B.E., CAMP regulated whole cell chloride currents in pancreatic ducts cells (1993) Am. J. Physiol., 264, pp. C591-C602. , (Cell Physiol. 33)", "listPosition" : 14, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 1297650, "link" : "/api/reference/1297650", "label" : "15. Grinstein, S., Rotin, D., Mason, J.M., Na+/H+ exchange and growth factor-induced cytosolic pH changes: Role in cellular proliferation (1989) Biochim. Biophys. Acta, 988, pp. 73-97", "listPosition" : 15, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 1297651, "link" : "/api/reference/1297651", "label" : "16. Honda, T., Knobel, S.M., Bulus, N.M., Ghishan, F.K., Kinetic characterization of a stably expressed novel Na+/H+ exchanger (NHE2) (1993) Biochim. Biophys. Acta, 1150, pp. 199-202", "listPosition" : 16, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 1297652, "link" : "/api/reference/1297652", "label" : "17. Kudrycki, K.E., Newman, P.R., Shull, G.E., CDNA cloning and tissue distribution of mRNA for two protein that are related to the band 3 Cl-/HCO3- exchanger (1990) J. Biol. Chem., 265, pp. 462-471", "listPosition" : 17, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 1297653, "link" : "/api/reference/1297653", "label" : "18. Kudrycki, K.E., Shull, G.E., Primary structure of the rat kidney band 3 anion exchange protein deduced from a cDNA (1989) J. Biol. Chem., 264, pp. 8185-8192", "listPosition" : 18, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 1297654, "link" : "/api/reference/1297654", "label" : "19. Lazaridis, K.N., Pham, L., Tietz, P., Marinelli, R.A., De Groen, P.C., Levine, S., Dawson, P.A., Larusso, N.F., Rat cholangiocytes absorb bile acids at their apical domain via the ileal sodium-dependent bile acid transporter (1997) J. Clin. Invest., 100, pp. 2714-2721", "listPosition" : 19, "published" : false, "snippet" : true }, { "otype" : "Reference", "mtid" : 1297655, "link" : "/api/reference/1297655", "label" : "20. Lazaridis, K.N., Pham, L., Vroman, B., De Groen, P.C., Larusso, N.F., Kinetic and molecular identification of sodium-dependent glucose transporter in normal rat cholangiocytes (1997) Am. J. Physiol., 272, pp. G1168-G1174. , (Gastrointest. Liver Physiol. 35)", "listPosition" : 20, "published" : false, "snippet" : true } ], "hasCitationDuplums" : false, "userChangeableUntil" : "2015-02-10T14:39:44.000+0000", "publishDate" : "2012-12-15T09:42:41.000+0000", "directInstitutesForSort" : "", "ownerAuthorCount" : 1, "ownerInstituteCount" : 12, "directInstituteCount" : 0, "authorCount" : 8, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/1680292", "label" : "Spirlì C et al. Functional polarity of Na+/H+ and Cl-/HCO3/- exchangers in a rat cholangiocyte cell line. (1998) AMERICAN JOURNAL OF PHYSIOLOGY: GASTROINTESTINAL AND LIVER PHYSIOLOGY 0193-1857 1522-1547 275 6 G1236-G1245", "template" : "