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We examined 22 dogs before and four weeks after partial surgical closure of a single, large congenital portosystemic shunt (pss). Parameters measured to characterise the basal activity of the pituitary-adrenal axis were the cortisol:creatinine (C/C) ratio in home-sampled urine and total and free cortisol in plasma. The binding characteristics of cortisol binding globulin (CBG) in pooled pre- and postoperative plasma were also determined. Ammonia and bile acid concentrations were measured in plasma to characterise the liver perfusion and function. Clinical symptoms relevant to liver function, cortisol excess, and hepatic encephalopathy were recorded semiquantitatively using a standardized questionnaire. The dogs had hypercortisolism before surgery, which had normalized four weeks later The pre- and postoperative concentrations (means +/- SEM) were, respectively, 238 +/- 45 nM and 126 +/- 19 nM for total cortisol, 15.5 +/- 2.6 nM and 8.4 +/- 1.3 nM for free cortisol in plasma, 13.4 +/- 4.3 x 10(-6) and 3.9 +/- 0.4 x 10(-6) for C/C in urine. The pre- and postoperative Bmax values of CBG Were 41 and 79, and Kd values were 3.8 and 5.5. The concentrations of ammonia were 217 +/- 23 mu M and 32 +/- 3.1 mu M, and of bile acids 110 +/- 33 and 11.1 +/- 2.0 mu M, respectively We conclude that there is a close relation between portosystemic encephalopathy and hypercortisolism in dogs with pss and that both deviations resolve completely within four weeks of closure of the shunt.", "subjects" : [ { "otype" : "Classification", "mtid" : 12682, "link" : "/api/classification/12682", "label" : "Állatorvosi tudományok", "published" : true, "snippet" : true } ], "digital" : true, "printed" : null, "sourceYear" : 2011, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : true, "missingAuthor" : false, "oaType" : "NONE", "oaCheckDate" : "2024-02-16", "oaFree" : false, "oaByAuthor" : { "otype" : "Admin", "mtid" : 10052707, "link" : "/api/admin/10052707", "label" : "Szabó Dóra (SZIE MKK admin 5 - INAKTÍV)", "familyName" : "Szabó", "givenName" : "Dóra", 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