https://m2.mtmt.hu/ hun 2026-05-01 16:07 JournalArticle 1618510 VALIDATED true 0 2014-08-14T20:05:10.000+0000 false 1618510 2025-12-21T01:49:58.325+0000 2019-11-13T18:07:44.095+0000 2011-06-28T19:24:29.000+0000 true 10020065 Hosszúfalusi Nóra /api/author/10020065 Author true 10020065 2019-11-13T18:07:44.116+0000 2019-11-13T18:07:44.116+0000 2013-03-11T13:21:17.000+0000 true 10019975 xRónaháty Zsófia_INAKTÍV /api/admin/10019975 Admin true 10019975 2019-11-13T18:07:44.104+0000 true 10026589 Tichy Rita /api/admin/10026589 Admin true 10026589 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Hosszufalusi, N Quantitative phenotypic and functional analyses of islet immune cells before and after diabetes onset in the BB rat true true /api/journal/1310 REVIEWED true false 1310 false 1310 true 0012-186X 1432-0428 Journal FOREIGN 36 11 1146 1154 1146 9 1993 Inflammatory cells invading islets are thought to be mediators of islet destruction in spontaneous autoimmune diabetes mellitus. Thus methods were developed to isolate and characterize in situ islet inflammatory cells from 75-95-day-old prediabetic and diabetic BB rats. Islet inflammatory cells were structurally examined using single- and double-colour flow cytometry. Functional studies consisted of cytolytic assays using normal rat islet target cells and in situ islet or spleen effector cells. Structural data reveal natural killer cells to be the major cell population (70%) of total immune cells present in inflamed islets during prediabetes. At diabetes onset, the natural killer cell population remained at a high level (47%), but an increasing population of T cells (40%) was noted also. Analyses of T-cell subsets before and after diabetes onset revealed CD4+ T cells as predominant (50-55% of total T cells) with double-negative (CD4- CD8-) T cells (25-30%) and CD8- T cells (15-20%) also present in significant quantities. Activated T cells accounted only for a minority of T cells (< 3% ). Functional studies indicate that in situ islet-derived cytolytic effector cells are more potent killers (ten-fold) of normal islet target cells than are splenic effector cells. These data suggest that in situ islet inflammatory cells (a) can be quantitatively studied both structurally and functionally; (b) express structural phenotypes differing substantially from splenic mononuclear cell populations; (c) are considerably more cytolytic than splenic effectors; and (d) should prove informative in determining the most significant autoimmune functional events prior to and during islet beta-cell destruction. 2011 true true true false false NONE 2025-12-21 false 13 0 13 10 0 13 11 11 11 13 13 10 10 10 3 0 13 10 13 10 0 3 3 Folyóiratcikk Journal Article 24 12 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 1993 0 1 1 1 1 1994 0 2 0 2 0 1995 0 1 1 1 1 1996 0 0 0 0 0 1997 0 1 1 1 1 1998 0 1 0 1 0 1999 0 1 1 1 1 2000 0 0 0 0 0 2001 0 0 0 0 0 2002 0 1 1 1 1 2003 0 1 1 1 1 2004 0 1 1 1 1 2005 0 0 0 0 0 2006 0 1 1 1 1 2007 0 0 0 0 0 2008 0 0 0 0 0 2009 0 0 0 0 0 2010 0 0 0 0 0 2011 0 1 1 1 1 2012 0 0 0 0 0 2013 0 0 0 0 0 2014 0 0 0 0 0 2015 0 0 0 0 0 2016 0 0 0 0 0 2017 0 0 0 0 0 2018 0 0 0 0 0 2019 0 0 0 0 0 2020 0 0 0 0 0 2021 0 1 1 1 1 false 10020065 false false false 2013-03-11T13:21:17.000+0000 2013-02-23T19:18:00.000+0000 1 7 0 6 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 1734987 /api/authorship/1734987 1 0.16666667 true false Author 10020065 /api/author/10020065 Hosszúfalusi Nóra true 10020065 true Hosszufalusi N true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 12950823 true PersonAuthorship 1734988 /api/authorship/1734988 2 0.16666667 false false Chan E true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 12950822 true PersonAuthorship 1734989 /api/authorship/1734989 3 0.16666667 false false Teruya M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 12950821 true PersonAuthorship 1734990 /api/authorship/1734990 4 0.16666667 false false Takei S true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 12950820 true PersonAuthorship 1734991 /api/authorship/1734991 5 0.16666667 false false Granger G true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 12950819 true PersonAuthorship 1734992 /api/authorship/1734992 6 0.167 false true true Charles M A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 12950818 true 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Keyword 1059157 /api/keyword/1059157 true 1059157 true Keyword 1554523 /api/keyword/1554523 true true /api/publication/1618510 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10020065"><a href="/gui2/?type=authors&mode=browse&sel=10020065" target="_blank">Hosszufalusi N (<span class="authorship-author-name">Hosszúfalusi Nóra</span> <span class="authorAux-mtmt"> Belgyógyászat, Diabetológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Chan E </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Teruya M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Takei S </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Granger G </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Charles M A ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;1618510" target="_blank">Quantitative phenotypic and functional analyses of islet immune cells before and after diabetes onset in the BB rat</a></div> <div> <span class="journal-title">DIABETOLOGIA</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0012-186X">0012-186X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1432-0428">1432-0428</a>)</span>: <span class="journal-volume">36</span> <span class="journal-issue">11</span> <span class="page"> pp 1146-1154 </span> <span class="year">(1993)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1007/BF00401059" target="_blank" href="https://doi.org/10.1007/BF00401059"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="A1993MC92100005" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/A1993MC92100005"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="0027361060" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-0027361060"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="8270129" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8270129&dopt=Abstract"> PubMed </a> </span> </span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 13</span> | Független: 10 | Függő: 3 | Nem jelölt: 0 | WoS jelölt: 11 | Scopus jelölt:&nbsp;11 | WoS/Scopus jelölt:&nbsp;13 | DOI jelölt:&nbsp;11 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;1618510&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 1618510</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> <span class="oldId">Régi azonosító: 1618510</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="lastModified">Utolsó módosítás: 2019.11.13. 19:07 Tichy Rita (SE_KK_Admin5_TR, admin) </div> </div></div>