A simple integrative electrophysiological model of bursting GnRH neurons

Csercsik, D ✉ [Csercsik, Dávid (Mechanizmustervez...), author]; Farkas, I [Farkas, Imre (Neurobiológia), author] Laboratory of Endocrine Neurobiology (IEM / DEN); Hrabovszky, E [Hrabovszky, Erik (Reproduktív endok...), author] Laboratory of Endocrine Neurobiology (IEM / DEN); Liposits, Z [Liposits, Zsolt (Neurobiológia, ne...), author] Laboratory of Endocrine Neurobiology (IEM / DEN); Faculty of Information Technology (PPCU)

English Article (Journal Article) Scientific
  • SJR Scopus - Cognitive Neuroscience: Q2
Identifiers
Fundings:
  • European Community’s Seventh Framework Program(FP7/ 2007-2013 under Grant Agreement 245009)
Subjects:
  • Basic medicine
In this paper a modular model of the GnRH neuron is presented. For the aim of simplicity, the currents corresponding to fast time scales and action potential generation are described by an impulsive system, while the slower currents and calcium dynamics are described by usual ordinary differential equations (ODEs). The model is able to reproduce the depolarizing afterpotentials, afterhyperpolarization, periodic bursting behavior and the corresponding calcium transients observed in the case of GnRH neurons.
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2025-02-25 12:26