A new sample preparation method for determination of acidic drugs in sewage sludge
applying microwave assisted solvent extraction followed by gas chromatography-mass
spectrometry
This paper presents a new sample preparation procedure for determination of selected
acidic pharmaceuticals (ibuprofen, naproxen, ketoprofen, and diclofenac) in sewage
sludge using microwave assisted solvent extraction, dispersive matrix extraction (DME)
followed by the conventionally applied solid phase extraction (SPE), derivatization.
and gas chromatography-mass spectrometry. The recoveries calculated from analytical
data of spiked sludge samples changed in the range of 80-105%+/- 15% for the four
pharmaceuticals in mixed and activated sludge depending on the efficiency of the clean-up
procedure. The measured concentration values of ibuprofen and naproxen were identical
in the mixed and the activated sludge samples. However, ketoprofen and diclofenac
showed about twice as high concentration in activated sludge than in the mixed one
independently of the applied extraction method. The typical concentration ranges of
ibuprofen, naproxen, ketoprofen and diclofenac in sewage sludge were 10-30 ng/g, 30-50
ng/g, 50-130 ng/g, and 50-140 ng/g respectively. (C) 2009 Elsevier B.V. All rights
reserved.