https://m2.mtmt.hu/ hun 2026-05-01 20:53 JournalArticle 1498572 APPROVED true 0 2014-08-14T20:02:27.000+0000 false 1498572 2026-04-02T08:44:05.523+0000 2018-10-10T03:26:44.689+0000 2011-04-11T17:18:04.000+0000 true 10021050 Csúcs Gábor /api/author/10021050 Author true 10021050 2018-10-10T03:26:44.689+0000 2018-10-10T03:49:45.503+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Goffin, JM Focal adhesion size controls tension-dependent recruitment of alpha-smooth muscle actin to stress fibers true true /api/journal/2326 REVIEWED true false 2326 false 2326 true 0021-9525 1540-8140 Journal FOREIGN 172 2 259 268 259 10 2006 Expression of alpha-smooth muscle actin (alpha-SMA) renders fibroblasts highly contractile and hallmarks myofibroblast differentiation. We identify a-SMA as a mechanosensitive protein that is recruited to stress fibers under high tension. Generation of this threshold tension requires the anchoring of stress fibers at sites of 8-30-mu m-long "supermature" focal adhesions (suFAs), which exert a stress approximately fourfold higher (similar to 12nN/mu m(2)) on micropatterned deformable substrates than 2-6-mu m-long classical FAs. Inhibition of suFA formation by growing myobroblasts on substrates with a compliance of <= 11 kPa and on rigid micropatterns of 6-mu m-long classical FA islets confines alpha-SMA to the cytosol. Reincorporation of alpha-SMA into stress fibers is established by stretching 6-mu m-long classical FAs to 8.1-mu m-long suFA islets on extendable membranes; the same stretch producing 5.4-mu m-long classical FAs from initially 4-mu m-long islets is without effect. We propose that the different molecular composition and higher phosphorylation of FAs on supermature islets, compared with FAs on classical islets, accounts for higher stress resistance. true true true false false NONE 2026-04-02 false 534 0 533 491 0 532 530 534 156 534 533 492 491 492 42 0 534 492 533 491 0 1 1 Folyóiratcikk Journal Article 24 530 Könyvrészlet Chapter in Book 25 3 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 1 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2006 0 2 2 2 2 2007 0 20 16 20 16 2008 0 26 21 26 21 2009 0 14 13 14 13 2010 0 38 33 38 33 2011 0 37 35 37 35 2012 0 29 26 29 26 2013 0 32 30 32 30 2014 0 28 26 28 26 2015 0 26 23 26 23 2016 0 20 19 20 19 2017 0 37 36 37 36 2018 0 32 31 32 31 2019 0 36 35 36 35 2020 0 33 31 33 31 2021 0 30 28 30 28 2022 0 22 22 22 22 2023 0 28 25 28 25 2024 0 25 21 25 21 2025 0 17 17 17 17 2026 0 2 2 2 2 D1 false false false false 2013-05-24T18:18:00.000+0000 2013-02-23T19:18:00.000+0000 1 4 0 6 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 1502492 /api/authorship/1502492 1 0.16666667 true false Goffin JM true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 12116143 true PersonAuthorship 1502493 /api/authorship/1502493 2 0.16666667 false false Pittet P true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 12116142 true PersonAuthorship 1502494 /api/authorship/1502494 3 0.16666667 false false Author 10021050 /api/author/10021050 Csúcs Gábor true 10021050 true Csucs G true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 12116141 true PersonAuthorship 1502495 /api/authorship/1502495 4 0.16666667 false false Lussi JW true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 12116140 true PersonAuthorship 1502496 /api/authorship/1502496 5 0.16666667 false false Meister JJ true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 12116139 true PersonAuthorship 1502497 /api/authorship/1502497 6 0.16666667 false true Hinz B true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 12116138 true PublicationIdentifier 15046874 /api/publicationidentifier/15046874 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true NO 10.1083/jcb.200506179 https://doi.org/10.1083/jcb.200506179 false 12609499 true PublicationIdentifier 363885 /api/publicationidentifier/363885 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000234678500011 https://www.webofscience.com/wos/woscc/full-record/000234678500011 false 208543 true Classification 10545 /api/classification/10545 true true Classification 12548 /api/classification/12548 true true Classification 12215 /api/classification/12215 true true SjrRating 5931480 /api/sjrrating/5931480 7 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 true 2701 true D1 DIRECT true 5931480 true /api/publication/1498572 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Goffin JM </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pittet P </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10021050"><a href="/gui2/?type=authors&mode=browse&sel=10021050" target="_blank">Csucs G (<span class="authorship-author-name">Csúcs Gábor</span> <span class="authorAux-mtmt"> Biofizika, sejtbiológia, nanotechnológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lussi JW </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Meister JJ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hinz B </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;1498572" target="_blank">Focal adhesion size controls tension-dependent recruitment of alpha-smooth muscle actin to stress fibers</a></div> <div> <span class="journal-title">JOURNAL OF CELL BIOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0021-9525">0021-9525</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1540-8140">1540-8140</a>)</span>: <span class="journal-volume">172</span> <span class="journal-issue">2</span> <span class="page"> pp 259-268 </span> <span class="year">(2006)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:black" title="10.1083/jcb.200506179" target="_blank" href="https://doi.org/10.1083/jcb.200506179"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000234678500011" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000234678500011"> WoS </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cell Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 534</span> | Független: 492 | Függő: 42 | Nem jelölt: 0 | WoS jelölt: 534 | Scopus jelölt:&nbsp;156 | WoS/Scopus jelölt:&nbsp;534 | DOI jelölt:&nbsp;530 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;1498572&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 1498572</span> | <span class="status-data status-APPROVED"> Nyilvános </span> <span class="oldId">Régi azonosító: 1498572</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS</span> </div> <div class="lastModified">Utolsó módosítás: 2018.10.10. 05:26 Szuper Admin (admin) </div> </div></div>