https://m2.mtmt.hu/ hun 2026-05-02 06:51 JournalArticle 1498569 APPROVED true 0 2014-10-16T16:43:08.000+0000 false 1498569 2025-12-20T23:27:37.585+0000 2018-10-10T03:26:44.689+0000 2011-04-11T17:18:03.000+0000 true 10021050 Csúcs Gábor /api/author/10021050 Author true 10021050 2018-10-10T03:26:44.689+0000 2018-10-10T03:49:44.560+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Csucs, G Locomotion of fish epidermal keratocytes on spatially selective adhesion patterns true true /api/journal/947 REVIEWED true false 947 false 947 true 0886-1544 1097-0169 Journal FOREIGN 64 856 867 856 12 2007 Cell migration results from forces generated by assembly, contraction, and adhesion of the cytoskeleton. To address how these forces integrate in space and time, novel assays are required that allow spatial separation of the different force categories. We used micro-contact printing of fibronectin on glass substrates to study the effect of adhesion patterns on fish epidermal keratocytes locomotion. Cells migrated at similar speeds on homogeneously adhesive substrates and on patterns with 5 pm-wide adhesive stripes interleaved by non-adhesive stripes with a width varied between 5 and 13 pm. The leading edge protruded on adhesive stripes and lagged behind on non-adhesive stripes. On patterns with non-adhesive stripes wider than 13 pm cells halted, although the lamellipodium did not collapse. High correlation was found between the widths of protruding and lagging edge segments and the widths of the underlying stripes. We explain our data by the force balances between actin polymerization, contraction and adhesion on fibronectin stripes; and between actin polymerization, contraction and lamellipodium-internal elastic tension on non-adhesive stripes. We tested our model further by blocking lamellipodium actin network contraction and polymerization. In both experiments we observed that cells eventually lost their ability to move. However, the two perturbations induced distinct morphological responses. The data suggested that forces powering forward motion of keratocytes are largely associated with network assembly whereas contraction maintains cell polarity. This study establishes spatially selective adhesion substrates and cell morphological readouts as a means to elucidate the mechanical balance between substrate adhesion and cytoskeleton-internal tension in cell migration. true true true false false NONE 2025-12-21 false 29 0 29 28 0 29 29 29 8 29 29 28 28 28 1 0 29 28 29 28 0 2 2 Folyóiratcikk Journal Article 24 29 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2008 0 2 2 2 2 2009 0 1 0 1 0 2010 0 5 5 5 5 2011 0 1 1 1 1 2012 0 1 1 1 1 2013 0 3 3 3 3 2014 0 2 2 2 2 2015 0 2 2 2 2 2016 0 1 1 1 1 2017 0 5 5 5 5 2018 0 1 1 1 1 2019 0 1 1 1 1 2020 0 2 2 2 2 2021 0 1 1 1 1 2022 0 0 0 0 0 2023 0 0 0 0 0 2024 0 0 0 0 0 2025 0 1 1 1 1 Q2 false false false false 2013-05-24T18:18:00.000+0000 2013-02-23T19:18:00.000+0000 1 4 0 3 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 1502485 /api/authorship/1502485 1 0.33333334 true false Author 10021050 /api/author/10021050 Csúcs Gábor true 10021050 true Csucs G true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 12116123 true PersonAuthorship 1502486 /api/authorship/1502486 2 0.33333334 false false Quirin K true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 12116122 true PersonAuthorship 1502487 /api/authorship/1502487 3 0.33333334 false true Danuser G true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 12116121 true PublicationIdentifier 363882 /api/publicationidentifier/363882 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true false NO 10.1002/cm.20230 https://doi.org/10.1002/cm.20230 false 208537 true PublicationIdentifier 363881 /api/publicationidentifier/363881 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000250605000006 https://www.webofscience.com/wos/woscc/full-record/000250605000006 false 208538 true Classification 10545 /api/classification/10545 true true SjrRating 5872882 /api/sjrrating/5872882 75 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1307 /api/classificationexternal/1307 true 1307 true Q2 DIRECT true 5872882 true /api/publication/1498569 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10021050"><a href="/gui2/?type=authors&mode=browse&sel=10021050" target="_blank">Csucs G (<span class="authorship-author-name">Csúcs Gábor</span> <span class="authorAux-mtmt"> Biofizika, sejtbiológia, nanotechnológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Quirin K </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Danuser G </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;1498569" target="_blank">Locomotion of fish epidermal keratocytes on spatially selective adhesion patterns</a></div> <div> <span class="journal-title">CELL MOTILITY AND THE CYTOSKELETON</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0886-1544">0886-1544</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1097-0169">1097-0169</a>)</span>: <span class="journal-volume">64</span> <span class="page"> pp 856-867 </span> <span class="year">(2007)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:black" title="10.1002/cm.20230" target="_blank" href="https://doi.org/10.1002/cm.20230"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000250605000006" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000250605000006"> WoS </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cell Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Structural Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 29</span> | Független: 28 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 29 | Scopus jelölt:&nbsp;8 | WoS/Scopus jelölt:&nbsp;29 | DOI jelölt:&nbsp;29 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;1498569&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 1498569</span> | <span class="status-data status-APPROVED"> Nyilvános </span> <span class="oldId">Régi azonosító: 1498569</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS</span> </div> <div class="lastModified">Utolsó módosítás: 2018.10.10. 05:26 Szuper Admin (admin) </div> </div></div>