https://m2.mtmt.hu/ eng 2026-05-25 07:48 JournalArticle 1498568 APPROVED true 0 2014-10-16T16:19:10.000+0000 false 1498568 2026-05-14T09:15:10.124+0000 2014-10-16T16:19:10.000+0000 2011-04-11T17:18:02.000+0000 true 10021050 Csúcs Gábor /api/author/10021050 Author true 10021050 2018-10-20T16:22:38.712+0000 2018-10-20T16:22:38.712+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Kozak, K Kernelized Z' factor in multiparametric screening technology true true /api/journal/10011857 REVIEWED true false 10011857 false 10011857 true 1547-6286 1555-8584 Journal FOREIGN 7 5 615 620 615 6 2010 RNA interference (RNAi) high-content screening (HCS) enables massive parallel gene silencing and is increasingly being used to reveal novel connections between genes and disease-relevant phenotypes. The application of genome-scale RNAi relies on the development of high quality HCS assays. The Z' factor statistic provides a way to evaluate whether or not screening run conditions (reagents, protocols, instrumentation, kinetics and other conditions not directly related to the test compounds) are optimized. Z' factor, introduced by Zhang et al. 1 is a dimensionless value that represents both the variability and the dynamic range between two sets of sample control data. This paper describes a new extension of the Z' factor, which integrates multiple readouts for screening quality assessment. Currently presented multivariate Z' factor is based on linear projection, which may not be suitable for data with nonlinear structure. This paper proposes an algorithm which extends existing algorithm to deal with nonlinear data by using the kernel function. Using kernel methods for projections, multiple readouts are condensed to a single parameter, based on which the screening run quality is monitored. true true true false false NONE 2026-05-14 false 11 0 11 11 0 11 10 11 7 11 11 11 11 11 0 0 11 11 11 11 0 0 0 Folyóiratcikk Journal Article 24 11 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2013 0 1 1 1 1 2014 0 3 3 3 3 2015 0 0 0 0 0 2016 0 1 1 1 1 2017 0 2 2 2 2 2018 0 1 1 1 1 2019 0 1 1 1 1 2020 0 0 0 0 0 2021 0 1 1 1 1 2022 0 0 0 0 0 2023 0 1 1 1 1 Q1 false false false false 2013-05-24T18:18:00.000+0000 2013-02-23T19:18:00.000+0000 1 4 0 2 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 1502483 /api/authorship/1502483 1 0.5 true false Kozak K true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 12116119 true PersonAuthorship 1502484 /api/authorship/1502484 2 0.5 false true Author 10021050 /api/author/10021050 Csúcs Gábor true 10021050 true Csucs G true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 12116118 true PublicationIdentifier 363880 /api/publicationidentifier/363880 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000288456500018 https://www.webofscience.com/wos/woscc/full-record/000288456500018 false 208536 true Classification 10545 /api/classification/10545 true true SjrRating 5740727 /api/sjrrating/5740727 87 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1312 /api/classificationexternal/1312 true 1312 true Q1 DIRECT true 5740727 true /api/publication/1498568 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" >Kozak K </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10021050"><a href="/gui2/?type=authors&mode=browse&sel=10021050" target="_blank">Csucs G (<span class="authorship-author-name">Csúcs Gábor</span> <span class="authorAux-mtmt"> Biofizika, sejtbiológia, nanotechnológia</span>) </a> </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;1498568" target="_blank">Kernelized Z' factor in multiparametric screening technology</a></div> <div> <span class="journal-title">RNA BIOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1547-6286">1547-6286</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1555-8584">1555-8584</a>)</span>: <span class="journal-volume">7</span> <span class="journal-issue">5</span> <span class="page"> pp 615-620 </span> <span class="year">(2010)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000288456500018" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000288456500018"> WoS </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Cell Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 11</span> | Independent citation: 11 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 11 | Number of citations in Scopus:&nbsp;7 | WoS/Scopus assigned:&nbsp;11 | Number of citations with DOI:&nbsp;10 </div> <div class="mtid"><span class="long-pub-mtid">Publication: 1498568</span> | <span class="status-data status-APPROVED"> Published </span> <span class="oldId">Old id: 1498568</span> | Core | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">WOS</span> </div> <div class="lastModified">Last Modified: 2014.10.16. 18:19 Admin MTMT (admin) </div> </div></div>