https://m2.mtmt.hu/ hun 2026-05-02 05:59 JournalArticle 1498565 ADMIN_APPROVED true 0 2014-12-18T13:35:22.000+0000 false 1498565 2026-01-12T10:01:33.709+0000 2022-09-14T09:57:33.959+0000 2011-04-11T17:18:00.000+0000 true 10021050 Csúcs Gábor /api/author/10021050 Author true 10021050 2018-10-20T16:22:38.561+0000 2018-10-20T16:22:38.561+0000 2022-09-14T09:57:33.973+0000 true 10014568 Vándor Andrea /api/admin/10014568 Admin true 10014568 Admin 10014568 /api/admin/10014568 Vándor Andrea true 10014568 true 2022-09-08T06:43:42.919+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Turgay, Y A classical NLS and the SUN domain contribute to the targeting of SUN2 to the inner nuclear membrane true true /api/journal/10014232 REVIEWED true false 10014232 false 10014232 true 0261-4189 1460-2075 Journal FOREIGN 29 14 2262 2275 2262 14 2010 Integral membrane proteins of the inner nuclear membrane (INM) are inserted into the endoplasmic reticulum membrane during their biogenesis and are then targeted to their final destination. We have used human SUN2 to delineate features that are required for INM targeting and have identified multiple elements that collectively contribute to the efficient localization of SUN2 to the nuclear envelope (NE). One such targeting element is a classical nuclear localization signal (cNLS) present in the N-terminal, nucleoplasmic domain of SUN2. A second motif proximal to the cNLS is a cluster of arginines that serves coatomer-mediated retrieval of SUN2 from the Golgi. Unexpectedly, also the C-terminal, lumenal SUN domain of SUN2 supports NE localization, showing that targeting elements are not limited to cytoplasmic or transmembrane domains of INM proteins. Together, SUN2 represents the first mammalian INM protein relying on a functional cNLS, a Golgi retrieval signal and a perinuclear domain to mediate targeting to the INM. The EMBO Journal (2010) 29, 2262-2275. doi:10.1038/emboj.2010.119; Published online 15 June 2010 2022 true true true false false NONE 2026-01-12 false true 10014931 Farkas Andrea /api/admin/10014931 Admin true 10014931 77 0 77 71 1 77 77 76 59 77 77 71 71 71 6 0 77 71 77 71 0 0 0 Folyóiratcikk Journal Article 24 77 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2011 0 8 8 8 8 2012 0 11 10 11 10 2013 0 6 5 6 5 2014 0 10 10 10 10 2015 0 7 5 7 5 2016 0 11 10 11 10 2017 0 2 2 2 2 2018 0 0 0 0 0 2019 0 5 5 5 5 2020 0 2 1 2 1 2021 0 1 1 1 1 2022 0 3 3 3 3 2023 0 6 6 6 6 2024 0 2 2 2 2 2025 0 3 3 3 3 D1 false false false false 2013-05-24T18:18:00.000+0000 2013-02-23T19:18:00.000+0000 2 9 0 7 0 true 10014568 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 1502457 /api/authorship/1502457 1 0.14285715 true false Turgay Y true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 12116087 true PersonAuthorship 1502458 /api/authorship/1502458 2 0.14285715 false false Ungricht R true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 12116086 true PersonAuthorship 1502459 /api/authorship/1502459 3 0.14285715 false false Rothballer A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 12116085 true PersonAuthorship 1502460 /api/authorship/1502460 4 0.14285715 false false Kiss A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 12116084 true PersonAuthorship 1502461 /api/authorship/1502461 5 0.14285715 false false Author 10021050 /api/author/10021050 Csúcs Gábor true 10021050 true Csucs G true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 12116083 true PersonAuthorship 1502462 /api/authorship/1502462 6 0.14285715 false false Author 10030964 /api/author/10030964 Horváth Péter true 10030964 true Horvath P true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 12116082 true PersonAuthorship 1502463 /api/authorship/1502463 7 0.14285715 false true Kutay U true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 12116081 true PublicationIdentifier 363875 /api/publicationidentifier/363875 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true false NO 10.1038/emboj.2010.119 https://doi.org/10.1038/emboj.2010.119 false 208530 true PublicationIdentifier 363874 /api/publicationidentifier/363874 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000280148500004 https://www.webofscience.com/wos/woscc/full-record/000280148500004 false 208531 true Classification 12125 /api/classification/12125 true true Classification 10545 /api/classification/10545 true true Classification 12548 /api/classification/12548 true true Classification 12215 /api/classification/12215 true true SjrRating 5761749 /api/sjrrating/5761749 10 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 true 2701 true D1 DIRECT true 5761749 true /api/publication/1498565 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" >Turgay Y </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ungricht R </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Rothballer A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kiss A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10021050"><a href="/gui2/?type=authors&mode=browse&sel=10021050" target="_blank">Csucs G (<span class="authorship-author-name">Csúcs Gábor</span> <span class="authorAux-mtmt"> Biofizika, sejtbiológia, nanotechnológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10030964"><a href="/gui2/?type=authors&mode=browse&sel=10030964" target="_blank">Horvath P (<span class="authorship-author-name">Horváth Péter</span> <span class="authorAux-mtmt"> biokémia,informatika</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kutay U </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;1498565" target="_blank">A classical NLS and the SUN domain contribute to the targeting of SUN2 to the inner nuclear membrane</a></div> <div> <span class="journal-title">EMBO JOURNAL</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0261-4189">0261-4189</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1460-2075">1460-2075</a>)</span>: <span class="journal-volume">29</span> <span class="journal-issue">14</span> <span class="page"> pp 2262-2275 </span> <span class="year">(2010)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:black" title="10.1038/emboj.2010.119" target="_blank" href="https://doi.org/10.1038/emboj.2010.119"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000280148500004" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000280148500004"> WoS </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Immunology and Microbiology (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 77</span> | Független: 71 | Függő: 6 | Nem jelölt: 0 | WoS jelölt: 76 | Scopus jelölt:&nbsp;59 | WoS/Scopus jelölt:&nbsp;77 | DOI jelölt:&nbsp;77 </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 1498565</span> | <span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span> <span class="oldId">Régi azonosító: 1498565</span> | Forrás | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS</span> </div> <div class="lastModified">Utolsó módosítás: 2022.09.14. 11:57 Vándor Andrea (VA, admin) </div> <div class="lockedBy">Központi kezelésű 2022.09.08. 08:43 Vándor Andrea (VA, admin) </div> </div></div>