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Chemicals/CAS: acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; hydroxypropylmethylcellulose, 9004-65-3; ibuprofen, 15687-27-1; indometacin, 53-86-1, 74252-25-8, 7681-54-1; piroxicam, 36322-90-4; Adhesives; Anti-Inflammatory Agents, Non-Steroidal; Cellulose, 9004-34-6; Gels
Tradenames: metolose
Manufacturers: Boots, United Kingdom; Reanal, Hungary
Megjegyzés-21327024
Chemicals/CAS: acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; hydroxypropylmethylcellulose, 9004-65-3; ibuprofen, 15687-27-1; indometacin, 53-86-1, 74252-25-8, 7681-54-1; piroxicam, 36322-90-4; Adhesives; Anti-Inflammatory Agents, Non-Steroidal; Cellulose, 9004-34-6; Gels
Tradenames: metolose
Manufacturers: Boots, United Kingdom; Reanal, Hungary
ENT Department, Szent Imre Hospital, Budapest, Hungary
Department of Pharmaceutics, Semmelweis University, Budapest, Hungary
Cited By :10
Export Date: 19 February 2021
CODEN: EJPBE
Correspondence Address: Makó, A.; ENT Department, , Budapest, Hungary; email: mc.adam@freemail.hu
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Formulation of thermoresponsive and bioadhesive gel for treatment of oesophageal pain and inflammation
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The aim of this study was the formulation and examination of a novel thermoresponsive and bioadhesive, in situ gelling drug delivery system, which can be used in the treatment of oesophageal pain and inflammation. A bioadhesive cellulose derivative (Metolose® 60SH) was used as a thermoresponsive material, because Metolose® has thermal gelation properties at certain temperature. The thermal gelation temperature (T2) of Metolose® 60SH 2 w/w% solution is above body temperature (65-66 °C), but by using different methods (Metolose® 60SH concentration, auxiliary materials), it can be shifted near to body temperature. The pH alteration between pH = 2-10 and the application of different alcohols did not influence the gelation temperature, but using water-soluble salts and changing the concentration of Metolose® 60SH solution between 2 and 3 w/w% the thermal gelation point could be decreased. Different NSAIDs were used as model drugs and which had not influence on thermal gelation temperature, but difference in in vitro liberation and penetration can be observed. In vitro adhesion test pointed out that the condition of investigated membrane can change the adhesion. Morphological test of oesophageal tissue showed that investigated materials had no irritative or tissue-damaging effect on the oesophageal mucosa even after 12 h. © 2008 Elsevier B.V. All rights reserved.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" > Makó, A </span> <span class="author-type"> </span> ; <span class="author-name" > Csóka, G </span> <span class="author-type"> </span> ; <span class="author-name" > Pásztor, E </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10008275"> <a href="/gui2/?type=authors&mode=browse&sel=10008275" target="_blank">Marton, S</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Horvai, G </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10008666"> <a href="/gui2/?type=authors&mode=browse&sel=10008666" target="_blank">Klebovich, I</a> </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;1485436" mtid="1485436" target="_blank">Formulation of thermoresponsive and bioadhesive gel for treatment of oesophageal pain and inflammation</a></div> <div class="pub-info"> <span class="journal-title">EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS</span> <span class="journal-volume">72</span> : <span class="journal-issue">1</span> <span class="page"> pp. 260-265. , 6 p. </span> <span class="year">(2009)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.ejpb.2008.10.018" target="_blank" href="https://doi.org/10.1016/j.ejpb.2008.10.018"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000265777400034" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000265777400034"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="62949084515" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-62949084515"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="19038337" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=19038337&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:1485436 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 12</span> | Független: 12 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 9 | Scopus jelölt: 10 | WoS/Scopus jelölt: 11 | DOI jelölt: 11 </div> </div> </div> </div><div class="JournalArticle Publication long-list">
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<div class="autype autype0"> <span class="author-name" >Makó A
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<div class="title"><a href="/gui2/?mode=browse¶ms=publication;1485436" target="_blank">Formulation of thermoresponsive and bioadhesive gel for treatment of oesophageal pain and inflammation</a></div> <div> <span class="journal-title">EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS</span>
<span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0939-6411">0939-6411</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1873-3441">1873-3441</a>)</span>:
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| <span class="status-data status-VALIDATED"> Egyeztetett
</span>
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| <span class="type-subtype">Folyóiratcikk
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<div class="lastModified">Utolsó módosítás: 2020.12.17. 16:05 Szuper Admin (admin)
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<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Megjegyzés-21537820
Chemicals/CAS: acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; hydroxypropylmethylcellulose, 9004-65-3; ibuprofen, 15687-27-1; indometacin, 53-86-1, 74252-25-8, 7681-54-1; piroxicam, 36322-90-4; Adhesives; Anti-Inflammatory Agents, Non-Steroidal; Cellulose, 9004-34-6; Gels
Tradenames: metolose
Manufacturers: Boots, United Kingdom; Reanal, Hungary...</pre>
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